| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL. Clinical Research Group for VHL in Japan. Human molecular genetics. vol 4. issue 12. 1996-07-08. PMID:8634692. |
germline mutations in the von hippel-lindau disease (vhl) gene in japanese vhl. |
1996-07-08 |
2023-08-12 |
Not clear |
| Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL. Clinical Research Group for VHL in Japan. Human molecular genetics. vol 4. issue 12. 1996-07-08. PMID:8634692. |
the von hippel-lindau disease (vhl) gene is a putative tumor suppressor gene responsible for vhl, an autosomal dominantly inherited multitumor syndrome. |
1996-07-08 |
2023-08-12 |
Not clear |
| Z Zhuang, M R Emmert-Buck, M J Roth, J Gnarra, W M Linehan, L A Liotta, I A Lubensk. von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens. Human pathology. vol 27. issue 2. 1996-06-07. PMID:8617456. |
however, chromosome 3p at the von hippel-lindau disease (vhl) gene locus (3p25-26) has not been previously implicated in the development or progression of sporadic colorectal carcinoma. |
1996-06-07 |
2023-08-12 |
human |
| R F Chuaqui, Z Zhuang, M R Emmert-Buck, B R Bryant, F Nogales, F A Tavassoli, M J Merin. Genetic analysis of synchronous mucinous tumors of the ovary and appendix. Human pathology. vol 27. issue 2. 1996-06-07. PMID:8617458. |
the authors analyzed microsatellites on chromosome 17q 21.3-22 (nm23), 3p 25-26 (von hippel lindau disease [vhl] gene), and 5q 21-22 (d5s346 locus) in 12 synchronous ovarian and appendiceal mucinous lesions. |
1996-06-07 |
2023-08-12 |
Not clear |
| N Kley, J Whaley, B R Seizinge. Neurofibromatosis type 2 and von Hippel-Lindau disease: from gene cloning to function. Glia. vol 15. issue 3. 1996-03-27. PMID:8586465. |
the search for the genes causing two hereditary tumor syndromes of the nervous system, neurofibromatosis type 2 (nf2) and von hippel-lindau disease (vhl), has recently culminated in the cloning of both disease genes. |
1996-03-27 |
2023-08-12 |
human |
| D J Gross, N Avishai, V Meiner, D Filon, B Zbar, D Abeliovic. Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene. The Journal of clinical endocrinology and metabolism. vol 81. issue 1. 1996-02-20. PMID:8550742. |
in the patient with the chemodectoma, a cerebellar hemangioblastoma became manifest 25 yr after his initial diagnosis with pheochromocytoma, leading only then to a clinical diagnosis of von hippel-lindau disease (vhl). |
1996-02-20 |
2023-08-12 |
human |
| M Z Gilcrease, L Schmidt, B Zbar, L Truong, M Rutledge, T M Wheele. Somatic von Hippel-Lindau mutation in clear cell papillary cystadenoma of the epididymis. Human pathology. vol 26. issue 12. 1996-01-23. PMID:8522307. |
because clear cell papillary cystadenoma is similar to renal cell carcinoma histologically, and because both occur as components of the von hippel-lindau disease complex, the authors analyzed both cases for the presence of mutations in the vhl gene. |
1996-01-23 |
2023-08-12 |
Not clear |
| C A Thrash-Bingham, H Salazar, J J Freed, R E Greenberg, K D Tarto. Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology. Cancer research. vol 55. issue 24. 1996-01-22. PMID:8521412. |
this result indicates that the mutation of a tumor suppressor gene on 3p, most likely von hippel-lindau disease (vhl), may be necessary but is not sufficient for the development of nonpapillary renal cell carcinoma. |
1996-01-22 |
2023-08-12 |
Not clear |
| T Kishida, T M Stackhouse, F Chen, M I Lerman, B Zba. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer research. vol 55. issue 20. 1995-11-08. PMID:7553625. |
the von hippel-lindau disease (vhl) gene is a novel tumor suppressor gene that plays a role in the pathogenesis of renal cell carcinomas and hemangioblastomas of the central nervous system. |
1995-11-08 |
2023-08-12 |
monkey |
| S Michelini, M Urbanek, M Dean, D Goldma. Polymorphism and genetic mapping of the human oxytocin receptor gene on chromosome 3. American journal of medical genetics. vol 60. issue 3. 1995-11-07. PMID:7573168. |
the ca repeat polymorphism we detected was used to map the the human oxytocin receptor to chromosome 3p25-3p26, in a region which contains several important genes, including loci for von hippel-lindau disease (vhl) and renal cell carcinoma. |
1995-11-07 |
2023-08-12 |
human |
| D R Duan, J S Humphrey, D Y Chen, Y Weng, J Sukegawa, S Lee, J R Gnarra, W M Linehan, R D Klausne. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 14. 1995-08-10. PMID:7604013. |
the human vhl tumor suppressor gene has been implicated in the inherited disorder von hippel-lindau disease and in sporadic renal carcinoma. |
1995-08-10 |
2023-08-12 |
human |
| B Zba. Genetic techniques in the diagnosis of carcinomas of the kidney. Seminars in nephrology. vol 15. issue 1. 1995-06-16. PMID:7754256. |
the gene responsible for the commonest form of kidney carcinoma has been isolated by study of families with von hippel-lindau disease (vhl). |
1995-06-16 |
2023-08-12 |
Not clear |
| F Chen, T Kishida, M Yao, T Hustad, D Glavac, M Dean, J R Gnarra, M L Orcutt, F M Duh, G Glen. Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype. Human mutation. vol 5. issue 1. 1995-05-30. PMID:7728151. |
von hippel-lindau disease (vhl) is an inherited neoplastic disease characterized by a predisposition to develop retinal angiomas, central nervous system hemangioblastomas, renal cell carcinomas, pancreatic cysts, and pheochromocytomas. |
1995-05-30 |
2023-08-12 |
Not clear |
| Z Zhuang, P Bertheau, M R Emmert-Buck, L A Liotta, J Gnarra, W M Linehan, I A Lubensk. A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size. The American journal of pathology. vol 146. issue 3. 1995-04-11. PMID:7887444. |
amplification of dna from selected cell populations was demonstrated by detecting a loss of heterozygosity (loh) at the von hippel-lindau disease (vhl) gene in an atypical renal lesion and a renal cell carcinoma in a kidney of a vhl patient. |
1995-04-11 |
2023-08-12 |
Not clear |
| J Gao, J G Naglich, J Laidlaw, J M Whaley, B R Seizinger, N Kle. Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential organization of the human von Hippel-Lindau disease gene. Cancer research. vol 55. issue 4. 1995-03-14. PMID:7850784. |
the human von hippel-lindau disease (vhl) gene has recently been identified and, based on the nucleotide sequence of a partial cdna clone, has been predicted to encode a novel protein with as yet unknown functions [f. latif et al., science (washington dc), 260: 1317-1320, 1993]. |
1995-03-14 |
2023-08-12 |
mouse |
| M J Gaffey, S E Mills, J C Boy. Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease. The American journal of surgical pathology. vol 18. issue 12. 1994-12-15. PMID:7977949. |
the occurrence of an aggressive papillary middle ear/temporal bone tumor (apmet) and a benign adnexal papillary tumor of probable mesonephric origin (apmo) in a patient with von hippel-lindau disease (vhl) is reported. |
1994-12-15 |
2023-08-12 |
Not clear |
| S J Payne, F M Richards, E R Mahe. A PCR generated AccI RFLP in the 3' untranslated region of the von Hippel-Lindau disease (VHL) tumour suppressor gene. Human molecular genetics. vol 3. issue 2. 1994-07-18. PMID:7911705. |
a pcr generated acci rflp in the 3' untranslated region of the von hippel-lindau disease (vhl) tumour suppressor gene. |
1994-07-18 |
2023-08-12 |
Not clear |
| F M Richards, F Latif, M I Lerman, B Zbar, E R Mahe. TaqI and PstI RFLPs in the von Hippel-Lindau disease gene (VHL). Human molecular genetics. vol 2. issue 10. 1994-02-03. PMID:7903582. |
taqi and psti rflps in the von hippel-lindau disease gene (vhl). |
1994-02-03 |
2023-08-12 |
Not clear |
| P A Crossey, K Foster, F M Richards, M E Phipps, F Latif, K Tory, M H Jones, E Bentley, R Kumar, M I Lerma. Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours. Human genetics. vol 93. issue 1. 1994-02-03. PMID:8270255. |
molecular genetic investigations of the mechanism of tumourigenesis in von hippel-lindau disease: analysis of allele loss in vhl tumours. |
1994-02-03 |
2023-08-12 |
Not clear |
| M Yao, F Latif, M L Orcutt, I Kuzmin, T Stackhouse, F W Zhou, K Tory, F M Duh, F Richards, E Mahe. von Hippel-Lindau disease: identification of deletion mutations by pulsed-field gel electrophoresis. Human genetics. vol 92. issue 6. 1994-01-21. PMID:8262521. |
von hippel-lindau disease (vhl) is an inherited multisystem neoplastic disorder. |
1994-01-21 |
2023-08-12 |
Not clear |