| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Wittebol-Post, F J Hes, C J Lip. The eye in von Hippel-Lindau disease. Long-term follow-up of screening and treatment: recommendations. Journal of internal medicine. vol 243. issue 6. 1998-08-13. PMID:9681858. |
von hippel-lindau disease (vhl) is an autosomal dominant tumour syndrome caused by germline mutations of the vhl tumour suppressor gene located on chromosome 3p25-26. |
1998-08-13 |
2023-08-12 |
Not clear |
| I Flamme, M Krieg, K H Plat. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. The American journal of pathology. vol 153. issue 1. 1998-07-23. PMID:9665461. |
hemangioblastomas, the most frequent manifestation of the hereditary von hippel-lindau disease (vhl), are highly vascularized tumors of the central nervous system. |
1998-07-23 |
2023-08-12 |
Not clear |
| S C Clifford, K Czapla, F M Richards, D J O'Donoghue, E R Mahe. Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes. British journal of cancer. vol 77. issue 9. 1998-07-09. PMID:9652757. |
somatic von hippel-lindau disease tumour-suppressor gene (vhl) mutations are frequently detected in sporadic clear cell renal cell carcinomas (rcc), and germline vhl mutations are the commonest cause of familial clear cell rcc. |
1998-07-09 |
2023-08-12 |
human |
| F Sköldberg, L Grimelius, E R Woodward, F Rorsman, E W Van Schothorst, O Winqvist, F A Karlsson, G Akerström, O Kämpe, E S Huseby. A family with hereditary extra-adrenal paragangliomas without evidence for mutations in the von Hippel-Lindau disease or ret genes. Clinical endocrinology. vol 48. issue 1. 1998-03-30. PMID:9509062. |
to characterize a family with hereditary paraganglioma, and to search for germline mutations in the von hippel-lindau disease (vhl) tumour suppressor gene and the ret proto-oncogene. |
1998-03-30 |
2023-08-12 |
Not clear |
| Y Chrétien, D Chauveau, S Richard, D Droz, J M Correas, A Mejean, B Dufour, J P Grünfel. [Treatment of von Hippel-Lindau disease with renal involvement]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. vol 7. issue 6. 1998-03-02. PMID:9490138. |
to try to define when and what type of operation should be performed in von hippel-lindau disease (vhl) with renal involvement. |
1998-03-02 |
2023-08-12 |
Not clear |
| C Béroud, D Joly, C Gallou, F Staroz, M T Orfanelli, C Junie. Software and database for the analysis of mutations in the VHL gene. Nucleic acids research. vol 26. issue 1. 1998-02-18. PMID:9399847. |
mutations of the vhl gene were described at first in the heritable von hippel-lindau disease and in the sporadic renal cell carcinoma (rcc). |
1998-02-18 |
2023-08-12 |
Not clear |
| M Los, C J Aarsman, L Terpstra, D Wittebol-Post, C J Lips, G H Blijham, E E Voes. Elevated ocular levels of vascular endothelial growth factor in patients with von Hippel-Lindau disease. Annals of oncology : official journal of the European Society for Medical Oncology. vol 8. issue 10. 1998-01-29. PMID:9402176. |
von hippel lindau disease (vhl) is a rare autosomal dominant inherited disorder characterized by highly vascularized tumors in various organs. |
1998-01-29 |
2023-08-12 |
Not clear |
| H P Neumann, B U Bender, W Schultze-Seemann, T Krause, C Altehoefer, R Scheremet, M Orszagh, G Schwarzkopf, A Januszewicz, G Janetschek, P Riegle. The kidney and von Hippel-Lindau disease: impact of molecular genetic analysis of the VHL gene for clinical management. Contributions to nephrology. vol 122. 1998-01-27. PMID:9399049. |
the kidney and von hippel-lindau disease: impact of molecular genetic analysis of the vhl gene for clinical management. |
1998-01-27 |
2023-08-12 |
Not clear |
| H Brauch, W Hoeppner, H Jähnig, T Wöhl, D Engelhardt, F Spelsberg, M M Ritte. Sporadic pheochromocytomas are rarely associated with germline mutations in the vhl tumor suppressor gene or the ret protooncogene. The Journal of clinical endocrinology and metabolism. vol 82. issue 12. 1998-01-13. PMID:9398721. |
pheochromocytoma is a tumor that may occur sporadically or may be a manifestation of a hereditary disease, such as von hippel-lindau disease (vhl) and multiple endocrine neoplasia (men) type 2. |
1998-01-13 |
2023-08-12 |
Not clear |
| T Prayer Galetti, L D'Arrigo, L De Zorzi, T Patarnell. [Heredity in renal and prostatic neoplasia]. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. vol 69. issue 4. 1997-12-30. PMID:9417296. |
the most common cause of inherited rcc is the von hippel lindau disease (vhl) a dominantly inherited multisystem disorder characterized by retinal and cerebellar hemangioblastomas, pheochromocytomas, pancreatic cysts and rcc. |
1997-12-30 |
2023-08-12 |
mouse |
| R Stratmann, M Krieg, R Haas, K H Plat. Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. Journal of neuropathology and experimental neurology. vol 56. issue 11. 1997-12-10. PMID:9370235. |
because hemangioblastomas develop in patients with von hippel-lindau disease, and mutations of the von hippel-lindau tumor suppressor (vhl) gene have also been reported in sporadic hemangioblastomas, we investigated vhl expression in normal cerebellum and in hemangioblastomas and tested the hypothesis that mutations in the vhl gene lead to upregulation of vege we observed constitutive expression of vhl mrna, but downregulation of vegf mrna in the postnatal cerebellum. |
1997-12-10 |
2023-08-12 |
human |
| B U Bender, C Altehöfer, A Januszewicz, R Gärtner, H Schmidt, M M Hoffmann, P H Heidemann, H P Neuman. Functioning thoracic paraganglioma: association with Von Hippel-Lindau syndrome. The Journal of clinical endocrinology and metabolism. vol 82. issue 10. 1997-11-17. PMID:9329368. |
to determine whether the pheochromocytoma-associated syndromes von hippel-lindau disease (vhl) and multiple endocrine neoplasia type 2 (men 2) play a role in the development of thoracic functioning paragangliomas, germline dna from five unselected patients with this rare tumor was analyzed for mutations in the genes that predispose to vhl and men 2. |
1997-11-17 |
2023-08-12 |
Not clear |
| O Hin. [VHL gene and TSC 2 gene]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 24. issue 11. 1997-10-17. PMID:9309130. |
in this article, i reviewed von hippel-lindau disease (vhl) gene and tuberous sclerosis 2 (tsc 2) gene. |
1997-10-17 |
2023-08-12 |
human |
| J R Gnarra, J M Ward, F D Porter, J R Wagner, D E Devor, A Grinberg, M R Emmert-Buck, H Westphal, R D Klausner, W M Lineha. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 17. 1997-09-17. PMID:9256442. |
inheritance of an inactivated form of the vhl tumor suppressor gene predisposes patients to develop von hippel-lindau disease, and somatic vhl inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. |
1997-09-17 |
2023-08-12 |
mouse |
| A van den Berg, C H Buy. Involvement of multiple loci on chromosome 3 in renal cell cancer development. Genes, chromosomes & cancer. vol 19. issue 2. 1997-07-21. PMID:9171996. |
this subtype constitutes most sporadic rcc and rcc as part of the von hippel-lindau disease caused by germline mutations of vhl at 3p25. |
1997-07-21 |
2023-08-12 |
mouse |
| P L Choyke, G M Glenn, J P Wagner, I A Lubensky, K Thakore, B Zbar, W M Linehan, M M Walthe. Epididymal cystadenomas in von Hippel-Lindau disease. Urology. vol 49. issue 6. 1997-07-14. PMID:9187702. |
epididymal cystadenomas (ecs) are frequently found in association with von hippel-lindau disease (vhl), but little has been reported about their sonographic appearance. |
1997-07-14 |
2023-08-12 |
Not clear |
| L Schmidt, F M Duh, F Chen, T Kishida, G Glenn, P Choyke, S W Scherer, Z Zhuang, I Lubensky, M Dean, R Allikmets, A Chidambaram, U R Bergerheim, J T Feltis, C Casadevall, A Zamarron, M Bernues, S Richard, C J Lips, M M Walther, L C Tsui, L Geil, M L Orcutt, T Stackhouse, J Lipan, L Slife, H Brauch, J Decker, G Niehans, M D Hughson, H Moch, S Storkel, M I Lerman, W M Linehan, B Zba. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature genetics. vol 16. issue 1. 1997-06-16. PMID:9140397. |
hprc is histologically and genetically distinct from two other causes of inherited renal carcinoma, von hippel-lindau disease (vhl) and the chromosome translocation (3;8). |
1997-06-16 |
2023-08-12 |
Not clear |
| M Wenzel, J Enczmann, M Uhrberg, A Hernández, U Wiese, R Ackermann, B Schmitz-Draeger, T Ebert, P Werne. Screening for renal carcinoma associated mutations in the von Hippel-Lindau tumor suppressor gene by temperature gradient gel electrophoresis. Electrophoresis. vol 18. issue 1. 1997-06-12. PMID:9059819. |
approximately 57% of all renal carcinomas of the clear cell type analyzed revealed a mutation in the von hippel-lindau disease (vhl) gene. |
1997-06-12 |
2023-08-12 |
Not clear |
| A Garcia, X Matias-Guiu, R Cabezas, A Chico, J Prat, M Baiget, A De Leiv. Molecular diagnosis of von Hippel-Lindau disease in a kindred with a predominance of familial phaeochromocytoma. Clinical endocrinology. vol 46. issue 3. 1997-06-05. PMID:9156047. |
to study the presence of germline mutations in the von hippel-lindau gene (vhl) in a kindred with a predominance of familial phaeochromocytoma in order to confirm the diagnosis of von hippel-lindau disease (vhld) as well as to identify asymptomatic members. |
1997-06-05 |
2023-08-12 |
Not clear |
| T J Manski, D K Heffner, G M Glenn, N J Patronas, A T Pikus, D Katz, R Lebovics, K Sledjeski, P L Choyke, B Zbar, W M Linehan, E H Oldfiel. Endolymphatic sac tumors. A source of morbid hearing loss in von Hippel-Lindau disease. JAMA. vol 277. issue 18. 1997-05-20. PMID:9145719. |
isolated reports suggest a possible association of endolymphatic sac tumors (elsts), which are extremely rare in the general population, with von hippel-lindau disease (vhl). |
1997-05-20 |
2023-08-12 |
Not clear |