| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Rajicic, Lucia A A Giannini, Emma Gerrits, Renee van Buuren, Shamiram Melhem, Johan A Slotman, Annemieke J M Rozemuller, Bart J L Eggen, John C van Swieten, Harro Seelaa. WDR49-Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration and Alzheimer's Disease. Glia. 2024-12-20. PMID:39705191. |
in a postmortem cohort of tdp-43 proteinopathies (12 grn, 11 c9orf72, 9 sporadic tdp-43), tauopathies (13 mapt, 8 sporadic tau), 10 ad, and four controls, immunohistochemistry and immunofluorescence were performed for wdr49 and pathological inclusions on frontal, temporal, and occipital cortical sections. |
2024-12-20 |
2024-12-23 |
Not clear |
| C Alexander Sandhof, Heide F B Murray, M Catarina Silva, Stephen J Haggart. Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-12-05. PMID:39638711. |
moreover, the accumulation of pathological tau proteoforms in the brain concurring with disease progression is a key feature of multiple neurodegenerative diseases, called tauopathies, like frontotemporal dementia (ftd) where autosomal dominant mutations in the tau encoding mapt gene provide clear evidence of a causal role for tau dysfunction. |
2024-12-05 |
2024-12-08 |
Not clear |
| Pranshul Sethi, Ronald Darwin C, Ramakrishna Borra, Shahin Vahora, Ankur Vashi, Rajesh Kumar Mukherjee, Belide Pavani, Gaurav Tiwar. Mechanistic Insights into Tau Protein-Mediated Regulation of Oxidative Stress. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 40. 2024-10-08. PMID:39379150. |
while the causes of the more prevalent sporadic late-onset variants and the connections between tau hyperphosphorylation and neurodegeneration remain largely unknown, mutations in the microtubule-associated protein tau (mapt) gene have been identified in familial cases of early-onset tauopathies. |
2024-10-08 |
2024-10-11 |
Not clear |
| Kondalarao Bankapalli, Ruth E Thomas, Evelyn S Vincow, Gillian Milstein, Laura V Fisher, Leo J Pallanc. A Drosophila model for mechanistic investigation of tau protein spread. Disease models & mechanisms. vol 17. issue 9. 2024-10-01. PMID:39350752. |
previous work indicates that specific protein components of these aggregates are toxic, including tau (encoded by mapt) in alzheimer's disease and related tauopathies. |
2024-10-01 |
2024-10-03 |
drosophila_melanogaster |
| Bryan Hurtle, Christopher J Donnelly, Xin Zhang, Amantha Thathia. Live-cell visualization of tau aggregation in human neurons. Communications biology. vol 7. issue 1. 2024-09-14. PMID:39277689. |
alzheimer's disease (ad) and more than twenty other dementias, termed tauopathies, are pathologically defined by insoluble aggregates of the microtubule-associated protein tau (mapt). |
2024-09-14 |
2024-09-18 |
human |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Gavesh Rajapaksha, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons. Autophagy. 2024-08-22. PMID:39171695. |
hyperphosphorylation and aggregation of mapt (microtubule-associated protein tau) is a pathogenic hallmark of tauopathies and a defining feature of alzheimer disease (ad). |
2024-08-22 |
2024-08-24 |
mouse |
| Owen Dando, Robert McGeachan, Jamie McQueen, Paul Baxter, Nathan Rockley, Hannah McAlister, Adharsh Prasad, Xin He, Declan King, Jamie Rose, Phillip B Jones, Jane Tulloch, Siddharthan Chandran, Colin Smith, Giles Hardingham, Tara L Spires-Jone. Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-08-21. PMID:39164997. |
mutations in the mapt gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with parkinsonism). |
2024-08-21 |
2024-08-23 |
Not clear |
| Anukool A Bhopatkar, Nemil Bhatt, Md Anzarul Haque, Rhea Xavier, Leiana Fung, Cynthia Jerez, Rakez Kaye. MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability. Protein science : a publication of the Protein Society. vol 33. issue 9. 2024-08-15. PMID:39145409. |
mapt mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability. |
2024-08-15 |
2024-08-17 |
Not clear |
| Anukool A Bhopatkar, Nemil Bhatt, Md Anzarul Haque, Rhea Xavier, Leiana Fung, Cynthia Jerez, Rakez Kaye. MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability. Protein science : a publication of the Protein Society. vol 33. issue 9. 2024-08-15. PMID:39145409. |
mutations within the mapt gene that encodes the tau protein form the genetic backdrop for familial forms of tauopathies, such as frontotemporal dementia (ftd), but the molecular consequences of such alterations and their pathological effects are unclear. |
2024-08-15 |
2024-08-17 |
Not clear |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
aggregation of the microtubule-associated protein tau (mapt) is the hallmark pathology in a spectrum of neurodegenerative disorders collectively called tauopathies. |
2024-07-12 |
2024-07-14 |
Not clear |
| Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton, Matthew C Baker, Hannah L Macpherson, Raquel Real, Alexandra I Soto-Beasley, Kin Mok, Tamas Revesz, Elizabeth A Christopher, Michael DeTure, William W Seeley, Edward B Lee, Matthew P Frosch, Laura Molina-Porcel, Tamar Gefen, Javier Redding-Ochoa, Bernardino Ghetti, Andrew C Robinson, Christopher Kobylecki, James B Rowe, Thomas G Beach, Andrew F Teich, Julia L Keith, Istvan Bodi, Glenda M Halliday, Marla Gearing, Thomas Arzberger, Christopher M Morris, Charles L White, Naguib Mechawar, Susana Boluda, Ian R MacKenzie, Catriona McLean, Matthew D Cykowski, Shih-Hsiu J Wang, Caroline Graff, Rashed M Nagra, Gabor G Kovacs, Giorgio Giaccone, Manuela Neumann, Lee-Cyn Ang, Agostinho Carvalho, Huw R Morris, Rosa Rademakers, John A Hardy, Dennis W Dickson, Jonathan D Rohrer, Owen A Ros. MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631765. |
mapt has two distinct haplotypes, h1 and h2; the mapt h1 haplotype is the major genetic risk factor for four-repeat tauopathies (eg, progressive supranuclear palsy and corticobasal degeneration), and the mapt h2 haplotype is protective for these disorders. |
2024-04-17 |
2024-04-20 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein tau, encoded by the gene mapt. |
2024-03-30 |
2024-04-02 |
Not clear |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
point mutations in the microtubule associated protein tau (mapt) gene cause dominantly inherited tauopathies, and most predispose it to aggregate. |
2023-11-11 |
2023-11-20 |
mouse |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Reshma Bhagat, Miguel A Minaya, Arun Renganathan, Muneshwar Mehra, Jacob Marsh, Rita Martinez, Abdallah M Eteleeb, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Celeste M Karc. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Molecular psychiatry. 2023-09-21. PMID:37730840. |
in a subset of tauopathies, rare mutations in the mapt gene, which encodes the tau protein, are sufficient to cause disease; however, the events downstream of mapt mutations are poorly understood. |
2023-09-21 |
2023-10-07 |
mouse |
| Reshma Bhagat, Miguel A Minaya, Arun Renganathan, Muneshwar Mehra, Jacob Marsh, Rita Martinez, Abdallah M Eteleeb, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Celeste M Karc. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Molecular psychiatry. 2023-09-21. PMID:37730840. |
rescuing snhg8 expression leads to reduced stress granule formation and reduced tia1 levels in immortalized cells and in mapt mutant neurons, suggesting that dysregulation of this non-coding rna is a causal factor driving stress granule formation via tia1 in tauopathies. |
2023-09-21 |
2023-10-07 |
mouse |
| Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbrach. Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735138. |
tauopathies such as alzheimer's disease (ad) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (mapt) aggregating into neurofibrillary tangles (nfts). |
2023-09-21 |
2023-10-07 |
mouse |