| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nisha Nagarkatti, Laxmikant S Deshpande, Dawn S Carter, Robert J DeLorenz. Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20597971. |
in the sprague-dawley rat pilocarpine model of status epilepticus-induced acquired epilepsy, intracellular calcium has been shown to increase in hippocampal neurons during status epilepticus and remain elevated well past the duration of the injury in those animals that develop epilepsy. |
2011-01-13 |
2023-08-12 |
rat |
| Gregory S Parks, Sean M Okumura, Krupa Gohil, Olivier Civell. Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. Neuroscience letters. vol 484. issue 2. 2011-01-13. PMID:20709149. |
following pilocarpine injection, mch(1)r-wt mice experienced clonic seizures and most had tonic seizures and entered status epilepticus, while all mch(1)r-ko mice were completely resistant to these effects. |
2011-01-13 |
2023-08-12 |
mouse |
| Henry H C Lee, Rachel Jurd, Stephen J Mos. Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Molecular and cellular neurosciences. vol 45. issue 2. 2010-12-14. PMID:20600929. |
consistent with our in vitro studies, induction of status epilepticus (se) in mice using pilocarpine, a machr agonist, induces large deficits in the cell surface stability of kcc2 together with enhanced tyrosine phosphorylation. |
2010-12-14 |
2023-08-12 |
mouse |
| Jian Xin Liu, Yong Cheng Tang, Yong Liu, Feng Ru Tan. Status epilepticus alters hippocampal PKAbeta and PKAgamma expression in mice. Seizure. vol 19. issue 7. 2010-12-02. PMID:20630779. |
to investigate the localization and progressive changes of cyclic-amp dependent protein kinase (cpka) in the mouse hippocampus at acute stages during and after pilocarpine induced status epilepticus. |
2010-12-02 |
2023-08-12 |
mouse |
| Eduardo Pineda, Don Shin, Raman Sankar, Andrey M Mazarat. Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. Epilepsia. vol 51 Suppl 3. 2010-08-03. PMID:20618414. |
we established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (se) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent with a depressive state: behavioral equivalents of anhedonia and despair, dysregulation of the hypothalamus-pituitary-adrenal (hpa) axis, and compromised raphe-hippocampal serotonergic transmission. |
2010-08-03 |
2023-08-12 |
rat |
| Yue Zhang, Guo-En Cai, Qian Yang, Qin-Chi Lu, Sheng-Tian Li, Gong J. Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model. Epilepsy & behavior : E&B. vol 17. issue 4. 2010-07-22. PMID:20332069. |
to explore the mechanism underlying the development of learning deficits in patients with epilepsy, we generated a mouse model for temporal lobe epilepsy by intraperitoneally injecting mice with pilocarpine with lithium chloride, and investigated time-dependent changes in both contextual fear memory of those model mice and long-term potentiation (ltp) in hippocampal ca1 neurons 1 day, 2 weeks, and 6 weeks after the onset of status epilepticus (se). |
2010-07-22 |
2023-08-12 |
mouse |
| Teemu Laitinen, Alejandra Sierra, Asla Pitkänen, Olli Gröh. Diffusion tensor MRI of axonal plasticity in the rat hippocampus. NeuroImage. vol 51. issue 2. 2010-07-12. PMID:20211740. |
brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. |
2010-07-12 |
2023-08-12 |
rat |
| Andrey M Mazarati, Eduardo Pineda, Don Shin, Delia Tio, Anna N Taylor, Raman Sanka. Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19900553. |
we examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between tle and depression, which developed in wistar rats following pilocarpine status epilepticus (se). |
2010-06-15 |
2023-08-12 |
human |
| Youting Lin, Jingjing Xu, Lili Cao, Yuxiang Han, Jing Gao, Nanchang Xie, Xiuhe Zhao, Hong Jiang, Zhaofu Ch. Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine. Neuroscience letters. vol 474. issue 1. 2010-06-01. PMID:20206232. |
mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine. |
2010-06-01 |
2023-08-12 |
rat |
| Eduardo M Goto, Marcelo de Paula Silva, Sandra R Perosa, Gustavo A Argañaraz, João B Pesquero, Esper A Cavalheiro, Maria G Naffah-Mazzacoratti, Vicente P C Teixeira, José A Silv. Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: implications for seizure blockade. Neuropeptides. vol 44. issue 2. 2010-05-25. PMID:20064661. |
hippocampi were removed 6h (acute phase), 12h (late acute), 5d (silent) and 60d (chronic) after status epilepticus (se) onset, and from animals that received pilocarpine but did not develop se (partial group). |
2010-05-25 |
2023-08-12 |
rat |
| Rizângela Lyne Mendes de Freitas, Itala Mônica de Sales Santos, Geane Felix de Souza, Adriana da Rocha Tomé, Gláucio Barros Saldanha, Rivelilson Mendes de Freita. Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19800952. |
we studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (se) induced by pilocarpine. |
2010-05-06 |
2023-08-12 |
rat |
| X E Ndode-Ekane, N Hayward, O Gröhn, A Pitkäne. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20004712. |
we induced status epilepticus (se) with pilocarpine in adult rats, and investigated endothelial cell proliferation (brdu and rat endothelial cell antigen-1 (reca-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (nissl staining), neurogenesis (doublecortin (dcx) immunohistochemistry), and mossy fiber sprouting (timm staining) in the hippocampus at different time points post-se. |
2010-05-04 |
2023-08-12 |
human |
| X E Ndode-Ekane, N Hayward, O Gröhn, A Pitkäne. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20004712. |
the total length of hippocampal blood vessels was decreased by 17% at 2 d after status epilepticus (se) induced by pilocarpine in adult rats (p<0.05 as compared to controls) which was not accompanied by alterations in hippocampal blood volume (bv) and flow (bf). |
2010-05-04 |
2023-08-12 |
human |
| Wojciech Zgrajka, Dorota Nieoczym, Mirosław Czuczwar, Jacek Kiś, Wojciech Brzana, Piotr Wlaź, Waldemar A Tursk. Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. Epilepsy research. vol 88. issue 2-3. 2010-05-03. PMID:20015615. |
seizures and status epilepticus were induced by pilocarpine in adult male wistar rats. |
2010-05-03 |
2023-08-12 |
rat |
| Hsiu-Ling Tsai, Chen-Nen Chang, Sue-Joan Chan. The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. Brain & development. vol 32. issue 1. 2010-04-08. PMID:19342187. |
pilocarpine (pc), a muscarinic receptor agonist, is used for the induction of experimental models of status epilepticus (se) for studying the type of seizure-induced brain injury and other neuropathophysiological mechanisms of related disorder. |
2010-04-08 |
2023-08-12 |
cat |
| Steve C Danzer, Xiaoping He, Andreas W Loepke, James O McNamar. Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus. vol 20. issue 1. 2010-03-09. PMID:19294647. |
these studies revealed significant increases in the frequency of giant boutons with satellite boutons 2 days and 1 month after pilocarpine status epilepticus, and increases in giant bouton area at 1 month. |
2010-03-09 |
2023-08-12 |
mouse |
| Maira L Foresti, Gabriel M Arisi, Khurshed Katki, Andres Montañez, Russell M Sanchez, Lee A Shapir. Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. Journal of neuroinflammation. vol 6. 2010-03-05. PMID:20034406. |
in this work ccr2 and ccl2 expression were examined following status epilepticus (se) induced by pilocarpine injection. |
2010-03-05 |
2023-08-12 |
Not clear |
| Fulvio A Scorza, Ricardo M Arida, Maria da Graça Naffah-Mazzacoratti, Débora A Scerni, Lineu Calderazzo, Esper A Cavalheir. The pilocarpine model of epilepsy: what have we learned? Anais da Academia Brasileira de Ciencias. vol 81. issue 3. 2010-03-03. PMID:19722008. |
the systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of eeg and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (srss). |
2010-03-03 |
2023-08-12 |
human |
| Jonna Soerensen, Anton Pekcec, Christina Fuest, Astrid Nickel, Heidrun Potschk. Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. Epilepsy research. vol 87. issue 2-3. 2010-02-18. PMID:19767176. |
pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. |
2010-02-18 |
2023-08-12 |
rat |
| G G Gurkoff, C C Giza, D Shin, S Auvin, R Sankar, D A Hovd. Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19695311. |
to determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (pc)-induced status epilepticus at 1, 6 or 24 h post tbi. |
2010-02-12 |
2023-08-12 |
rat |