| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary A Walker, J Robin Highley, Margaret M Esiri, Brendan McDonald, Helen C Roberts, Suzanne P Evans, Timothy J Cro. Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophrenia. The American journal of psychiatry. vol 159. issue 5. 2002-06-03. PMID:11986137. |
it has been suggested that the primary focus of the pathological process in schizophrenia is on the limbic system, and there have been several postmortem reports of changes in the histological structure or volume of the hippocampus, as well as a larger number of mri reports of volume reductions. |
2002-06-03 |
2023-08-12 |
Not clear |
| Melissa Frumin, Polina Golland, Ron Kikinis, Yoshio Hirayasu, Dean F Salisbury, John Hennen, Chandlee C Dickey, Mark Anderson, Ferenc A Jolesz, W Eric L Grimson, Robert W McCarley, Martha E Shento. Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder. The American journal of psychiatry. vol 159. issue 5. 2002-06-03. PMID:11986146. |
the corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. |
2002-06-03 |
2023-08-12 |
Not clear |
| Haiyun Xu, Hong Qing, Wenfu Lu, David Keegan, J Steven Richardson, Jennifer Chlan-Fourney, Xin Min L. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neuroscience letters. vol 321. issue 1-2. 2002-05-23. PMID:11872258. |
these results suggest that the chronic administration of quetiapine could be neuroprotective to hippocampal neurons in schizophrenia and this effect may be related to its antipsychotic effect in patients with schizophrenia. |
2002-05-23 |
2023-08-12 |
rat |
| F M Benes, M S Todtenkopf, P Kostoulako. GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732702. |
recent postmortem studies have suggested that changes in the regulation of kainate-sensitive glutamate receptors (kainate receptors) in the hippocampus may play a role in schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| D J Stone, J P Walsh, R Sebro, R Stevens, H Pantazopolous, F M Bene. Effects of pre- and postnatal corticosterone exposure on the rat hippocampal GABA system. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732703. |
several lines of evidence have implicated prenatal stress and the hippocampal gaba system in the pathophysiology of schizophrenia, and prenatal stress is believed to increase the risk for schizophrenia through alterations of this neurotransmitter. |
2002-05-07 |
2023-08-12 |
rat |
| S Hecker. Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732705. |
neuroimaging studies of the hippocampus in schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| S Hecker. Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732705. |
three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| S Hecker. Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732705. |
hippocampal volume reduction is now one of the most consistent structural abnormalities found in schizophrenia: it is present at the onset of the illness and, to a lesser degree, in first-degree relatives of schizophrenic probands. |
2002-05-07 |
2023-08-12 |
Not clear |
| S Hecker. Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732705. |
these results of neuroimaging studies complement evidence from post-mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| D R Medoff, H H Holcomb, A C Lahti, C A Tamming. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732707. |
probing the human hippocampus using rcbf: contrasts in schizophrenia. |
2002-05-07 |
2023-08-12 |
human |
| D R Medoff, H H Holcomb, A C Lahti, C A Tamming. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732707. |
regional cerebral blood flow (rcbf) data from two pet-15o water schizophrenia studies were analyzed using individually placed, magnetic resonance (mr)-guided hippocampal volumes of interest (voi). |
2002-05-07 |
2023-08-12 |
human |
| D R Medoff, H H Holcomb, A C Lahti, C A Tamming. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732707. |
this suggests that schizophrenia is associated with elevated rcbf in the hippocampus, which "normalizes" with antipsychotic drug treatment. |
2002-05-07 |
2023-08-12 |
human |
| D R Medoff, H H Holcomb, A C Lahti, C A Tamming. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732707. |
these data show an abnormality of hippocampal function in schizophrenia and suggest that this abnormality may be associated with the pathophysiology of the illness. |
2002-05-07 |
2023-08-12 |
human |
| R Green. Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732709. |
circuit analysis of nmdar hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. |
2002-05-07 |
2023-08-12 |
rat |
| R Green. Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732709. |
data from circuit analysis of the effects of the antagonism of nmda receptors in the ca1 region of the hippocampus of rats in vitro suggest a hypothesis concerning cortical circuit dysfunction responsible for nmda antagonist-dependent psychosis, relevant to the psychosis associated with schizophrenia. |
2002-05-07 |
2023-08-12 |
rat |
| N A Schmaju. Hippocampal dysfunction in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732711. |
hippocampal dysfunction in schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| N A Schmaju. Hippocampal dysfunction in schizophrenia. Hippocampus. vol 11. issue 5. 2002-05-07. PMID:11732711. |
although not necessarily primary to the disease, hippocampal dysfunction in schizophrenia is suggested by morphological changes in the hippocampal formation reported in schizophrenic patients. |
2002-05-07 |
2023-08-12 |
Not clear |
| Sudabeh Shirazi-Southall, Dana Ellen Rodriguez, George G Nomiko. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 5. 2002-05-07. PMID:11927183. |
some atypical antipsychotic drugs appear to improve cognitive function in schizophrenia and since acetylcholine (ach) is of importance in cognition, we used in vivo microdialysis to examine the effects of antipsychotics administered acutely (sc or ip) at pharmacologically comparable doses on ach outflow in the hippocampus of the rat. |
2002-05-07 |
2023-08-12 |
rat |
| Barbara K Lipska, Nader D Halim, Pavan N Segal, Daniel R Weinberge. Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923448. |
rats with neonatal excitotoxic damage of the ventral hippocampus display in adulthood a variety of abnormalities reminiscent of schizophrenia and are used as an animal model of this disorder. |
2002-04-08 |
2023-08-12 |
rat |
| Philip R Szeszko, Rael D Strous, Robert S Goldman, Manzar Ashtari, Kevin H Knuth, Jeffrey A Lieberman, Robert M Bilde. Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophrenia. The American journal of psychiatry. vol 159. issue 2. 2002-03-06. PMID:11823263. |
neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophrenia. |
2002-03-06 |
2023-08-12 |
Not clear |