| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Hashimoto, H Hashimoto, N Shintani, S Chiba, S Hattori, T Okada, M Nakajima, K Tanaka, N Kawagishi, K Nemoto, T Mori, T Ohnishi, H Noguchi, H Hori, T Suzuki, N Iwata, N Ozaki, T Nakabayashi, O Saitoh, A Kosuga, M Tatsumi, K Kamijima, D R Weinberger, H Kunugi, A Bab. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Molecular psychiatry. vol 12. issue 11. 2008-01-09. PMID:17387318. |
this allele of the pacap gene, which is overrepresented in schizophrenia patients, was associated with reduced hippocampal volume and poorer memory performance. |
2008-01-09 |
2023-08-12 |
mouse |
| Akemichi Bab. [Molecular pharmacologic approaches to functional analysis of new biological target molecules for drug discovery]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 127. issue 10. 2008-01-07. PMID:17917422. |
based on these experimental findings, a genetic association study in schizophrenia patients revealed that the single-nucleotide polymorphisms of the pacap gene are significantly associated with the hypofunction of the hippocampus. |
2008-01-07 |
2023-08-12 |
mouse |
| Andreas Reif, Angelika Schmitt, Sabrina Fritzen, Klaus-Peter Lesc. Neurogenesis and schizophrenia: dividing neurons in a divided mind? European archives of psychiatry and clinical neuroscience. vol 257. issue 5. 2007-12-26. PMID:17468935. |
pertinent studies in humans failed to confirm a role of reduced hippocampal neural stem cell proliferation (nsp) in depression but suggest a contribution to the pathophysiology of schizophrenia. |
2007-12-26 |
2023-08-12 |
mouse |
| Kunio Yuii, Michio Suzuki, Masayoshi Kurach. Stress sensitization in schizophrenia. Annals of the New York Academy of Sciences. vol 1113. 2007-12-20. PMID:17584979. |
it has been reported that volume reductions in the amygdala, hippocampus, superior temporal gyrus, and anterior parietal cortex common to both patient groups may represent the vulnerability to schizophrenia, while volume loss of the prefrontal cortex, posterior parietal cortex, cingulate, insula, and fusiform cortex preferentially observed in schizophrenia may be critical for overt manifestation of psychosis (dr. suzuki). |
2007-12-20 |
2023-08-12 |
human |
| Monica Beneyto, Lars V Kristiansen, Akinwunmi Oni-Orisan, Robert E McCullumsmith, James H Meador-Woodruf. Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 9. 2007-11-29. PMID:17299517. |
receptor binding showed nmda receptor subsites particularly affected in the hippocampus, where mk801 binding was reduced in schizophrenia and bd, and mdl105,519 and cgp39653 binding were increased in bd and mdd, respectively. |
2007-11-29 |
2023-08-12 |
human |
| Daniel J Lodge, Anthony A Grac. Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942737. |
aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. |
2007-11-08 |
2023-08-12 |
rat |
| Daniel J Lodge, Anthony A Grac. Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942737. |
here, we demonstrate in an animal model of schizophrenia that a pathologically enhanced drive from the ventral hippocampus (vhipp) can result in aberrant dopamine neuron signaling. |
2007-11-08 |
2023-08-12 |
rat |
| Daniel J Lodge, Anthony A Grac. Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942737. |
these data provide a direct link between hippocampal dysfunction and the hyper-responsivity of the da system that is believed to underlie the augmented response to amphetamine in animal models and psychosis in schizophrenia patients. |
2007-11-08 |
2023-08-12 |
rat |
| Ann Olincy, Karen E Steven. Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17714692. |
the predilection for schizophrenia patients to be extremely heavy cigarette smokers may be related to their attempt to compensate for a reduction in hippocampal alpha7 nicotinic cholinergic receptors by delivering exogenous ligand to the remaining receptors. |
2007-11-06 |
2023-08-12 |
mouse |
| Xin Duan, Jay H Chang, Shaoyu Ge, Regina L Faulkner, Ju Young Kim, Yasuji Kitabatake, Xiao-bo Liu, Chih-Hao Yang, J Dedrick Jordan, Dengke K Ma, Cindy Y Liu, Sundar Ganesan, Hwai-Jong Cheng, Guo-li Ming, Bai Lu, Hongjun Son. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. vol 130. issue 6. 2007-11-01. PMID:17825401. |
here, we investigated roles of disrupted-in-schizophrenia 1 (disc1), a schizophrenia susceptibility gene, in adult hippocampal neurogenesis. |
2007-11-01 |
2023-08-12 |
Not clear |
| Kuei-Yuan Tseng, Barbara L Lewis, Barbara K Lipska, Patricio O'Donnel. Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biological psychiatry. vol 62. issue 7. 2007-10-29. PMID:17207473. |
a neonatal ventral hippocampal lesion (nvhl) induces behavioral and physiological anomalies mimicking pathophysiological changes of schizophrenia. |
2007-10-29 |
2023-08-12 |
rat |
| Ricardo Llorente, Lorena Arranz, Eva-María Marco, Enrique Moreno, Marta Puerto, Carmen Guaza, Mónica De la Fuente, Maria-Paz Vivero. Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats. Psychoneuroendocrinology. vol 32. issue 6. 2007-10-18. PMID:17553622. |
maternal deprivation [24h on postnatal day 9] might represent an animal model of schizophrenia and behavioural and neurochemical alterations observed in adulthood may be mediated by hippocampal impairments induced by abnormally increased glucocorticoids due to neonatal stress. |
2007-10-18 |
2023-08-12 |
rat |
| Handan Gunduz-Bruce, Philip R Szeszko, Ralitza Gueorguieva, Manzar Ashtari, Delbert G Robinson, John M Kane, Robert M Bilde. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17490857. |
cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. |
2007-10-11 |
2023-08-12 |
human |
| Handan Gunduz-Bruce, Philip R Szeszko, Ralitza Gueorguieva, Manzar Ashtari, Delbert G Robinson, John M Kane, Robert M Bilde. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17490857. |
the etiology of hippocampal volumetric reductions in schizophrenia is largely unknown. |
2007-10-11 |
2023-08-12 |
human |
| Handan Gunduz-Bruce, Philip R Szeszko, Ralitza Gueorguieva, Manzar Ashtari, Delbert G Robinson, John M Kane, Robert M Bilde. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17490857. |
high levels of glucocorticoids are known to affect hippocampal volume in disorders such as cushing's syndrome, but the relationship between cortisol and hippocampal volumes has not been studied in schizophrenia. |
2007-10-11 |
2023-08-12 |
human |
| Handan Gunduz-Bruce, Philip R Szeszko, Ralitza Gueorguieva, Manzar Ashtari, Delbert G Robinson, John M Kane, Robert M Bilde. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17490857. |
we obtained diurnal salivary cortisol levels and mri images to explore the link between cortisol levels and regional hippocampal volumes in healthy controls (n=29) and subjects with first episode schizophrenia (n=16) at the time of first admission. |
2007-10-11 |
2023-08-12 |
human |
| Handan Gunduz-Bruce, Philip R Szeszko, Ralitza Gueorguieva, Manzar Ashtari, Delbert G Robinson, John M Kane, Robert M Bilde. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17490857. |
our findings do not suggest a robust association between cortisol levels and hippocampal volumes in a first episode schizophrenia sample. |
2007-10-11 |
2023-08-12 |
human |
| Raquel E Gur, Matcheri S Keshavan, Stephen M Lawri. Deconstructing psychosis with human brain imaging. Schizophrenia bulletin. vol 33. issue 4. 2007-10-11. PMID:17548845. |
replicated findings in schizophrenia include reduced whole-brain and hippocampal volume as potential vulnerability markers, with further progression at onset; reduced n-acetyl aspartate concentrations in hippocampus and prefrontal cortex; striatal dopamine d(2) receptors upregulation; and alteration in the relation between frontal and temporal activation. |
2007-10-11 |
2023-08-12 |
human |
| William J Panenka, Babak Khorram, Alasdair M Barr, Geoffrey N Smith, Donna J Lang, Lili C Kopala, Robert A Vandorpe, William G Hone. A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17570643. |
a longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. |
2007-10-11 |
2023-08-12 |
Not clear |
| William J Panenka, Babak Khorram, Alasdair M Barr, Geoffrey N Smith, Donna J Lang, Lili C Kopala, Robert A Vandorpe, William G Hone. A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Schizophrenia research. vol 94. issue 1-3. 2007-10-11. PMID:17570643. |
previous studies have reported that hippocampal volumes correlate with symptom severity in schizophrenia. |
2007-10-11 |
2023-08-12 |
Not clear |