| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikola A Bowden, Rodney J Scott, Paul A Toone. Altered gene expression in the superior temporal gyrus in schizophrenia. BMC genomics. vol 9. 2008-06-30. PMID:18445270. |
the stg connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia. |
2008-06-30 |
2023-08-12 |
Not clear |
| Stephen M Lawrie, Andrew M McIntosh, Jeremy Hall, David G C Owens, Eve C Johnston. Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk. Schizophrenia bulletin. vol 34. issue 2. 2008-06-27. PMID:18227083. |
there is good evidence for subtle abnormalities of hippocampal and ventricle volume in relatives that are not as marked as the deficits in schizophrenia. |
2008-06-27 |
2023-08-12 |
human |
| Colm McDonald, Brendan Dineen, Brian Hallaha. Meta-analysis of brain volumes in unaffected first-degree relatives of patients with schizophrenia overemphasizes hippocampal deficits. Archives of general psychiatry. vol 65. issue 5. 2008-06-09. PMID:18458212. |
meta-analysis of brain volumes in unaffected first-degree relatives of patients with schizophrenia overemphasizes hippocampal deficits. |
2008-06-09 |
2023-08-12 |
Not clear |
| Yoshiyuki Asai, Akihiro Takano, Hiroshi Ito, Yoshiro Okubo, Masato Matsuura, Akihiko Otsuka, Hidehiko Takahashi, Tomomichi Ando, Shigeo Ito, Ryosuke Arakawa, Kunihiko Asai, Tetsuya Suhar. GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit. Schizophrenia research. vol 99. issue 1-3. 2008-05-27. PMID:18042347. |
gaba(a)/bz receptor including alpha5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia. |
2008-05-27 |
2023-08-12 |
human |
| Tomás R Guilarte, Dima A Hammoud, Jennifer L McGlothan, Brian S Caffo, Catherine A Foss, Alan P Kozikowski, Martin G Pompe. Dysregulation of glutamate carboxypeptidase II in psychiatric disease. Schizophrenia research. vol 99. issue 1-3. 2008-05-27. PMID:18191545. |
a significant difference in gcpii levels was also observed between schizophrenia relative to bipolar disorder and depressed subjects in the hippocampus-stratum lucidum and between schizophrenia and bipolar in the ca2 region of the hippocampus, with bipolar and depressed subjects expressing higher levels of gcpii than subjects with schizophrenia. |
2008-05-27 |
2023-08-12 |
human |
| Hans-Gert Bernstein, Uwe Lendeckel, Henrik Dobrowolny, Renate Stauch, Johann Steiner, Gisela Grecksch, Axel Becker, Gustav F Jirikowski, Bernhard Bogert. Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia. Psychoneuroendocrinology. vol 33. issue 3. 2008-05-13. PMID:18191906. |
in rats with a neonatal lesion of the ventral hippocampus (a widely used animal model of schizophrenia), we found an increased neuronal expression of beacon in the paraventricular and supraoptic nuclei. |
2008-05-13 |
2023-08-12 |
human |
| Mitsuyuki Matsumoto, Richard E Straub, Stefano Marenco, Kristin K Nicodemus, Shun-Ichiro Matsumoto, Akihiko Fujikawa, Sosuke Miyoshi, Miwako Shobo, Shinji Takahashi, Junko Yarimizu, Masatoshi Yuri, Masashi Hiramoto, Shuji Morita, Hiroyuki Yokota, Takeshi Sasayama, Kazuhiro Terai, Masayasu Yoshino, Akira Miyake, Joseph H Callicott, Michael F Egan, Andreas Meyer-Lindenberg, Lucas Kempf, Robyn Honea, Radha Krishna Vakkalanka, Jun Takasaki, Masazumi Kamohara, Takatoshi Soga, Hideki Hiyama, Hiroyuki Ishii, Ayako Matsuo, Shintaro Nishimura, Nobuya Matsuoka, Masato Kobori, Hitoshi Matsushime, Masao Katoh, Kiyoshi Furuichi, Daniel R Weinberge. The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 16. 2008-05-12. PMID:18413613. |
minor alleles of two sreb2 snps, located in intron 2 and in the 3' utr, were overtransmitted to schizophrenia patients in a family-based sample and showed an allele load association with reduced hippocampal gray matter volume in patients. |
2008-05-12 |
2023-08-12 |
mouse |
| Pedro Dorado, Eva M Peñas-Lledó, Adrián Lleren. CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits. Pharmacogenomics. vol 8. issue 11. 2008-04-28. PMID:18034624. |
additionally, cyp2d6 is involved in the metabolism of endogenous substrates in the brain, and reported to be located in regions such as the cortex, hippocampus and cerebellum, which are impaired in schizophrenia. |
2008-04-28 |
2023-08-12 |
human |
| James G Bilsland, Alan Wheeldon, Andrew Mead, Petr Znamenskiy, Sarah Almond, Kerry A Waters, Matthew Thakur, Vahri Beaumont, Timothy P Bonnert, Robert Heavens, Paul Whiting, George McAllister, Ignacio Munoz-Sanjua. Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17487225. |
altogether, these results suggest that alk functions in the adult brain to regulate the function of the frontal cortex and hippocampus and identifies alk as a new target for psychiatric indications, such as schizophrenia and depression, with an underlying deregulated monoaminergic signalling. |
2008-04-23 |
2023-08-12 |
mouse |
| Hak-Jae Kim, Hae Jeong Park, Kyung Hee Jung, Ju Yeon Ban, Jehyun Ra, Jong Woo Kim, Jin Kyung Park, Bong-Keun Choe, Sung Vin Yim, Yunhee Kim Kwon, Joo-Ho Chun. Association study of polymorphisms between DISC1 and schizophrenia in a Korean population. Neuroscience letters. vol 430. issue 1. 2008-04-08. PMID:17997036. |
to further clarify schizophrenia (scz), disrupted in schizophrenia 1 (disc1) is a promising candidate gene expressed predominantly within the hippocampus. |
2008-04-08 |
2023-08-12 |
Not clear |
| William S Stone, Larry J Seidma. Toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal function. Schizophrenia bulletin. vol 34. issue 1. 2008-04-03. PMID:17504777. |
toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal function. |
2008-04-03 |
2023-08-12 |
Not clear |
| Cynthia Shannon Weickert, Debora A Rothmond, Thomas M Hyde, Joel E Kleinman, Richard E Strau. Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophrenia research. vol 98. issue 1-3. 2008-03-31. PMID:17961984. |
we examined dysbindin-1 mrna in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field ca3, but not in ca1. |
2008-03-31 |
2023-08-12 |
Not clear |
| Isabella Braun, Just Genius, Heinz Grunze, Andreas Bender, Hans-Jürgen Möller, Dan Rujesc. Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17601703. |
with special reference to the hippocampus, these data show that a prolonged application of low-dose nmda receptor antagonist could, in part, mimic some neuropathologic findings in human schizophrenia, thus strengthening the idea that (sub-) chronic nmda receptor antagonism in animals is a viable approach in mimicking aspects of schizophrenia. |
2008-03-04 |
2023-08-12 |
human |
| Archana Sheth, Sabina Berretta, Nicholas Lange, Howard Eichenbau. The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty. Hippocampus. vol 18. issue 2. 2008-03-03. PMID:17960646. |
consistent with this evidence, and with data indicating amygdala modulation of hippocampal activity, animal model investigations have shown that a disruption of amygdala activity induces neurochemical changes in the hippocampus that are similar to those detected in subjects with schizophrenia. |
2008-03-03 |
2023-08-12 |
human |
| J Roig Llesuy, M L Olondo Zulueta, E Parellada Rodó. Cavum septum pellucidum in schizophrenia: a case report. Actas espanolas de psiquiatria. vol 35. issue 6. 2008-02-19. PMID:18004677. |
different structural alterations of the central nervous system (cns), such as an increase in ventricular size, decrease in hippocampus and amygdala volume, and other abnormalities that are probably secondary to a loss of neuronal mass and neuropili (axons and dendrite ramifications) linked to a precocious alteration in neurodevelopment are described in patients with schizophrenia in greater proportion than in the general population. |
2008-02-19 |
2023-08-12 |
human |
| A Ahnaou, S Nayak, A Heylen, D Ashton, W H I M Drinkenbur. Sleep and EEG profile in neonatal hippocampal lesion model of schizophrenia. Physiology & behavior. vol 92. issue 3. 2008-02-01. PMID:17524434. |
sleep and eeg profile in neonatal hippocampal lesion model of schizophrenia. |
2008-02-01 |
2023-08-12 |
rat |
| A Ahnaou, S Nayak, A Heylen, D Ashton, W H I M Drinkenbur. Sleep and EEG profile in neonatal hippocampal lesion model of schizophrenia. Physiology & behavior. vol 92. issue 3. 2008-02-01. PMID:17524434. |
thus, the data indicate that neonatal lesion of ventral hippocampus did not mimic sleep abnormalities observed in schizophrenia, however this rodent model may model some eeg features seen in schizophrenia such as a frontally pronounced slowing of the slow eeg activity in delta and theta frequency bands. |
2008-02-01 |
2023-08-12 |
rat |
| Giuseppina Rametti, Nuria Segarra, Carme Junqué, Nuria Bargalló, Xavier Caldú, Naroa Ibarretxe, Miguel Bernard. Left posterior hippocampal density reduction using VBM and stereological MRI procedures in schizophrenia. Schizophrenia research. vol 96. issue 1-3. 2008-01-23. PMID:17604968. |
left posterior hippocampal density reduction using vbm and stereological mri procedures in schizophrenia. |
2008-01-23 |
2023-08-12 |
Not clear |
| Giuseppina Rametti, Nuria Segarra, Carme Junqué, Nuria Bargalló, Xavier Caldú, Naroa Ibarretxe, Miguel Bernard. Left posterior hippocampal density reduction using VBM and stereological MRI procedures in schizophrenia. Schizophrenia research. vol 96. issue 1-3. 2008-01-23. PMID:17604968. |
structural deficits in the hippocampus have been implicated in the pathophysiology of schizophrenia. |
2008-01-23 |
2023-08-12 |
Not clear |
| Shiny V Mathew, Amanda J Law, Barbara K Lipska, Martha I Dávila-García, Eduardo D Zamora, Shruti N Mitkus, Radhakrishna Vakkalanka, Richard E Straub, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyd. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Human molecular genetics. vol 16. issue 23. 2008-01-22. PMID:17884806. |
we examined the effects of four disease-associated single-nucleotide polymorphisms (snps) in the 5' region of the nrg1 gene on nachr alpha7 mrna transcript expression in both the dorsolateral prefrontal cortex (dlpfc) and hippocampus of normal controls and patients with schizophrenia using quantitative real-time pcr. |
2008-01-22 |
2023-08-12 |
human |