| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Erk, Andreas Meyer-Lindenberg, David E J Linden, Thomas Lancaster, Sebastian Mohnke, Oliver Grimm, Franziska Degenhardt, Peter Holmans, Andrew Pocklington, Phöbe Schmierer, Leila Haddad, Thomas W Mühleisen, Manuel Mattheisen, Stephanie H Witt, Nina Romanczuk-Seiferth, Heike Tost, Björn H Schott, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Andreas Heinz, Henrik Walte. Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects. NeuroImage. vol 94. 2015-02-06. PMID:24642287. |
since cacna1c variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the cacna1c gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by cacna1c variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. |
2015-02-06 |
2023-08-12 |
human |
| D M Bortz, C V Jørgensen, J D Mikkelsen, J P Brun. Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood. Neuropharmacology. vol 84. 2015-02-02. PMID:24747179. |
cognitive deficits in schizophrenia (sz) reflect maturational disruptions within a neural system that includes the ventral hippocampus (vh), nucleus accumbens (nac), basal forebrain, and prefrontal cortex (pfc). |
2015-02-02 |
2023-08-13 |
rat |
| Judith M Reichel, Sabine Nissel, Gabriela Rogel-Salazar, Anna Mederer, Karola Käfer, Benedikt T Bedenk, Henrik Martens, Rebecca Anders, Jens Grosche, Dominik Michalski, Wolfgang Härtig, Carsten T Wotja. Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus. Frontiers in behavioral neuroscience. vol 8. 2015-01-28. PMID:25628548. |
gabaergic interneurons are proposed to play a central role in the etiology and progression of schizophrenia; however, the specific mechanisms and the time-line of symptom development as well as the distinct involvement of cortical and hippocampal gabaergic interneurons in the etiology of schizophrenia-related symptoms are still not conclusively resolved. |
2015-01-28 |
2023-08-13 |
mouse |
| Yuanyuan You, Liguang Sun, Bo Peng, Yan Li, Songbin Ben, Shuang Ga. Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead. Neural regeneration research. vol 7. issue 25. 2015-01-27. PMID:25624822. |
in the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo, on hippocampal disrupted-in- schizophrenia 1 expression. |
2015-01-27 |
2023-08-13 |
mouse |
| Robin Nguyen, Mark D Morrissey, Vivek Mahadevan, Janine D Cajanding, Melanie A Woodin, John S Yeomans, Kaori Takehara-Nishiuchi, Jun Chul Ki. Parvalbumin and GAD65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 45. 2015-01-20. PMID:25378161. |
parvalbumin and gad65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia. |
2015-01-20 |
2023-08-13 |
mouse |
| Robin Nguyen, Mark D Morrissey, Vivek Mahadevan, Janine D Cajanding, Melanie A Woodin, John S Yeomans, Kaori Takehara-Nishiuchi, Jun Chul Ki. Parvalbumin and GAD65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 45. 2015-01-20. PMID:25378161. |
hyperactivity within the ventral hippocampus (vhpc) has been linked to both psychosis in humans and behavioral deficits in animal models of schizophrenia. |
2015-01-20 |
2023-08-13 |
mouse |
| Robin Nguyen, Mark D Morrissey, Vivek Mahadevan, Janine D Cajanding, Melanie A Woodin, John S Yeomans, Kaori Takehara-Nishiuchi, Jun Chul Ki. Parvalbumin and GAD65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 45. 2015-01-20. PMID:25378161. |
together, these findings establish a causal role for vhpc gaba neurons in controlling behaviors relevant to schizophrenia and suggest a functional dissociation between the gabaergic mechanisms involved in hippocampal modulation of sensorimotor processes. |
2015-01-20 |
2023-08-13 |
mouse |
| YeeWen Candace Wu, Xin Du, Maarten van den Buuse, Rachel A Hil. Sex differences in the adolescent developmental trajectory of parvalbumin interneurons in the hippocampus: a role for estradiol. Psychoneuroendocrinology. vol 45. 2015-01-12. PMID:24845187. |
reduced hippocampal expression of the gabaergic interneuron marker, parvalbumin (pv), and gaba synthesizing enzyme, gad67, are consistently reported in schizophrenia. |
2015-01-12 |
2023-08-13 |
mouse |
| Peter J Siekmeier, David P vanMaane. Dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 7. 2014-12-29. PMID:24469592. |
dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study. |
2014-12-29 |
2023-08-12 |
Not clear |
| Marc T Pisansky, Robert J Wickham, Jianjun Su, Stephanie Fretham, Li-Lian Yuan, Mu Sun, Jonathan C Gewirtz, Michael K Georgief. Iron deficiency with or without anemia impairs prepulse inhibition of the startle reflex. Hippocampus. vol 23. issue 10. 2014-12-23. PMID:23733517. |
ultimately, evidence of reduced ppi in both of our models may offer insights into the roles of fetal id and the hippocampus in the pathophysiology of schizophrenia. |
2014-12-23 |
2023-08-12 |
mouse |
| Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N Gangadha. Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? PloS one. vol 9. issue 5. 2014-12-22. PMID:24787542. |
relationship between interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? |
2014-12-22 |
2023-08-13 |
Not clear |
| Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N Gangadha. Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? PloS one. vol 9. issue 5. 2014-12-22. PMID:24787542. |
there is a substantial lack of knowledge on how genetic predisposition to elevated il-6 expression effects hippocampal structure in schizophrenia patients. |
2014-12-22 |
2023-08-13 |
Not clear |
| Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N Gangadha. Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? PloS one. vol 9. issue 5. 2014-12-22. PMID:24787542. |
in this first-time study, we evaluated the relationship between functional polymorphism rs1800795 of il-6 and hippocampal gray matter volume in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. |
2014-12-22 |
2023-08-13 |
Not clear |
| Rossana Ganzola, Michel Maziade, Simon Duchesn. Hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: research synthesis. Schizophrenia research. vol 156. issue 1. 2014-12-22. PMID:24794883. |
hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: research synthesis. |
2014-12-22 |
2023-08-13 |
human |
| b' A Gallo, C Bouchard, P-P Rompr\\xc3\\xa. Animals with a schizophrenia-like phenotype are differentially sensitive to the motivational effects of cannabinoid agonists in conditioned place preference. Behavioural brain research. vol 268. 2014-12-16. PMID:24755307.' |
we chose to study this problematic using a neurodevelopmental model of schizophrenia: neonatal ventral hippocampus lesions (nvhl). |
2014-12-16 |
2023-08-13 |
rat |
| Pierre Lavenex, Pamela Banta Lavenex, Grégoire Favr. What animals can teach clinicians about the hippocampus. Frontiers of neurology and neuroscience. vol 34. 2014-12-16. PMID:24777129. |
abnormalities in hippocampal structure and function have been reported in a number of human neuropathological and neurodevelopmental disorders, including alzheimer's disease, autism spectrum disorders, down syndrome, epilepsy, and schizophrenia. |
2014-12-16 |
2023-08-13 |
human |
| Pierre Lavenex, Pamela Banta Lavenex, Grégoire Favr. What animals can teach clinicians about the hippocampus. Frontiers of neurology and neuroscience. vol 34. 2014-12-16. PMID:24777129. |
we focus on studies of gene expression in distinct hippocampal regions that shed light on some basic mechanisms that might contribute to the etiology of schizophrenia. |
2014-12-16 |
2023-08-13 |
human |
| Frauke Nees, Sebastian T Pohlac. Functional MRI studies of the hippocampus. Frontiers of neurology and neuroscience. vol 34. 2014-12-16. PMID:24777133. |
besides the importance of such studies for basic research, the investigation of hippocampal (dys)function has clinical relevance for diseases ranging from neurological disorders such as alzheimer's disease or epilepsy to mental disorders such as schizophrenia or anxiety disorders. |
2014-12-16 |
2023-08-13 |
human |
| Jiewei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue-Bin Zheng, Xiongjian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, Tetsuro Ohmori, Jin-Xin Bei, Siow-Ann Chong, Jimmy Lee, Zhiqiang Li, Jianjun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing S. An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278305. |
an evaluation of association between a novel hippocampal biology related snp (rs7294919) and schizophrenia. |
2014-12-10 |
2023-08-12 |
Not clear |
| Jiewei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue-Bin Zheng, Xiongjian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, Tetsuro Ohmori, Jin-Xin Bei, Siow-Ann Chong, Jimmy Lee, Zhiqiang Li, Jianjun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing S. An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278305. |
the single nucleotide polymorphism (snp) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. |
2014-12-10 |
2023-08-12 |
Not clear |