| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsunori Kobayashi, Tsuyoshi Takagi, Shunsuke Ishii, Hidenori Suzuki, Tsuyoshi Miyakaw. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular brain. vol 11. issue 1. 2019-01-07. PMID:30285890. |
the dentate gyrus of the hippocampus has been implicated in the pathophysiological basis of neuropsychiatric disorders including schizophrenia. |
2019-01-07 |
2023-08-13 |
mouse |
| Peter J Siekmeie. An in Silico, Biomarker-Based Method for the Evaluation of Virtual Neuropsychiatric Drug Effects. Neural computation. vol 29. issue 4. 2019-01-02. PMID:28181877. |
here we describe such a methodology, using as an example a biophysically detailed computational model of hippocampus that is made to generate putative schizophrenia biomarkers by the inclusion of a number of neuropathological changes that have been associated with the illness (nmda system deficit, decreased neural connectivity, hyperdopaminergia). |
2019-01-02 |
2023-08-13 |
Not clear |
| Mei Huang, Sunoh Kwon, Lakshmi Rajagopal, Wenqi He, Herbert Y Meltze. 5-HT Psychopharmacology. vol 235. issue 10. 2018-12-31. PMID:30066135. |
5-ht the effect of atypical antipsychotic drugs (aapds), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (cias), has been suggested to be due, in part, to enhancing release of dopamine (da), acetylcholine (ach), and glutamate (glu) in cortex and hippocampus. |
2018-12-31 |
2023-08-13 |
Not clear |
| Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Haruo Fujino, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimot. Subcortical association with memory performance in schizophrenia: a structural magnetic resonance imaging study. Translational psychiatry. vol 8. issue 1. 2018-12-18. PMID:29317603. |
although several studies have reported a relationship between memory performance and hippocampal volume, only a few structural magnetic resonance imaging (mri) studies have investigated the relationship between memory performance and subcortical structures other than hippocampus in patients with schizophrenia. |
2018-12-18 |
2023-08-13 |
human |
| Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Haruo Fujino, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimot. Subcortical association with memory performance in schizophrenia: a structural magnetic resonance imaging study. Translational psychiatry. vol 8. issue 1. 2018-12-18. PMID:29317603. |
verbal immediate recall/delayed recall scores in patients with schizophrenia were significantly correlated not only with hippocampal volume (left: r = 0.34; right: r = 0.28/left: r = 0.33; right: r = 0.31), but also with na volume (left: r = 0.24; right: r = 0.25/left: r = 0.26; right: r = 0.27). |
2018-12-18 |
2023-08-13 |
human |
| Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Haruo Fujino, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimot. Subcortical association with memory performance in schizophrenia: a structural magnetic resonance imaging study. Translational psychiatry. vol 8. issue 1. 2018-12-18. PMID:29317603. |
the present investigation with a large sample size did not only replicate hippocampal volume and memory association, but also found that na volume is associated with memory performances in schizophrenia. |
2018-12-18 |
2023-08-13 |
human |
| Valentina Baglivo, Bo Cao, Benson Mwangi, Marcella Bellani, Cinzia Perlini, Antonio Lasalvia, Nicola Dusi, Chiara Bonetto, Doriana Cristofalo, Franco Alessandrini, Giada Zoccatelli, Elisa Ciceri, Lamonaca Dario, Ceccato Enrico, Pileggi Francesca, Fausto Mazzi, Santonastaso Paolo, Matteo Balestrieri, Jair C Soares, Mirella Ruggeri, Paolo Brambill. Hippocampal Subfield Volumes in Patients With First-Episode Psychosis. Schizophrenia bulletin. vol 44. issue 3. 2018-12-11. PMID:29897598. |
hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Kathryn M Gill, Sarah A Miller, Anthony A Grac. Impaired contextual fear-conditioning in MAM rodent model of schizophrenia. Schizophrenia research. vol 195. 2018-11-26. PMID:28927551. |
the methylazoxymethanol acetate (mam) rodent neurodevelopmental model of schizophrenia exhibits aberrant dopamine system activation attributed to hippocampal dysfunction. |
2018-11-26 |
2023-08-13 |
rat |
| Jibran Y Khokhar, Travis P Tod. Behavioral predictors of alcohol drinking in a neurodevelopmental rat model of schizophrenia and co-occurring alcohol use disorder. Schizophrenia research. vol 194. 2018-11-13. PMID:28285734. |
in order to begin to understand the cognitive and reward-related changes that may contribute to alcohol drinking, this study was designed to address: 1) latent inhibition; 2) conditioning; and 3) extinction of autoshaping in a neurodevelopmental rat model with relevance to co-occurring schizophrenia and alcohol use disorders, the neonatal ventral hippocampal lesioned (nvhl) rat. |
2018-11-13 |
2023-08-13 |
rat |
| Ming Teng Koh, Yi Shao, Sharon Rosenzweig-Lipson, Michela Gallaghe. Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia. Schizophrenia research. vol 193. 2018-11-09. PMID:28634087. |
we examined whether targeting increased neural activity with the antiepileptic agent, levetiracetam, would benefit memory performance in a preclinical model of schizophrenia that has been shown to exhibit hyperactivity in the hippocampus. |
2018-11-09 |
2023-08-13 |
rat |
| Jiaxian Zhang, Yu Jing, Hu Zhang, David K Bilkey, Ping Li. Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia research. vol 192. 2018-11-05. PMID:28526281. |
earlier research has demonstrated that maternal immune activation (mia; a risk factor for schizophrenia) alters arginine metabolism in the prefrontal cortex and hippocampus of the adult offspring. |
2018-11-05 |
2023-08-13 |
rat |
| E H Chang, K Fernando, L W E Yeung, K Barbari, T-S S Chandon, A K Malhotr. Single point mutation on the gene encoding dysbindin results in recognition deficits. Genes, brain, and behavior. vol 17. issue 5. 2018-10-30. PMID:29227583. |
dtnbp1 encodes dysbindin protein, which is localized to synaptic sites and is reduced in the prefrontal cortex and hippocampus of patients with schizophrenia, indicating a potential role in schizophrenia etiology. |
2018-10-30 |
2023-08-13 |
mouse |
| Duygu Kirtaş, Rukiye Filiz Karadağ, Melike Ceyhan Balci Şengül, Yılmaz Kiroğl. 1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients. Turkish journal of medical sciences. vol 46. issue 3. 2018-09-18. PMID:27513267. |
the aim of this study was to compare metabolite levels of the dorsolateral prefrontal cortex (dlpfc), anterior cingulate gyrus (acg), thalamus, and hippocampus in patients with chronic schizophrenia (csps) and first psychotic episode patients (feps) by the use of magnetic resonance spectroscopy (mrs). |
2018-09-18 |
2023-08-13 |
Not clear |
| Melissa L Perreault, Theresa Fan, Tomek J Banasikowski, Anthony A Grace, Susan R Georg. The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction. The European journal of neuroscience. vol 46. issue 4. 2018-09-06. PMID:28677227. |
deficits in neuronal network synchrony in hippocampus and prefrontal cortex have been widely demonstrated in disorders of cognitive dysfunction, including schizophrenia and alzheimer's disease. |
2018-09-06 |
2023-08-13 |
rat |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
schizophrenia (scz) is a neuropsychiatric disorder that is linked to social behavioral deficits and other negative symptoms associated with hippocampal synaptic dysfunction. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
synaptic mechanism of schizophrenia is characterized by loss of hippocampal n-methyl-d-aspartate receptor (nmdar) activity (nmdar hypofunction) and dendritic spines. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
previous studies show that genetic deletion of hippocampal synaptic regulatory calcium-calmodulin dependent kinase ii alpha (camkiiα) cause synaptic and behavioral defects associated with schizophrenia in mice. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
inflammatory and neurotropic receptors) alter camkiiα function (phosphorylation) relative to hippocampal nmdar activity in schizophrenia is poorly understood. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
here, we examined the relationship between toll-like receptor (tlr4; inflammatory), insulin-like growth factor receptor 1 (igf-1r; neurotropic) and camkiiα expression in the hippocampus of behaviorally deficient schizophrenic mice after we induced schizophrenia through nmdar inhibition. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
our results show that a sustained igf-1r expression may preserve the synaptic activity of camkiiα while tlr4 signaling ablates hippocampal camkiiα expression in nmdar hypofunction schizophrenia. |
2018-08-31 |
2023-08-13 |
mouse |