| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Chen, Gianluca Ursini, Adrienne L Romer, Annchen R Knodt, Karleigh Mezeivtch, Ena Xiao, Giulio Pergola, Giuseppe Blasi, Richard E Straub, Joseph H Callicott, Karen F Berman, Ahmad R Hariri, Alessandro Bertolino, Venkata S Mattay, Daniel R Weinberge. Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29415119. |
we investigated in healthy volunteers whether schizophrenia polygenic risk score predicts hippocampal activity during simple memory encoding, which has been proposed as a risk-associated intermediate phenotype of schizophrenia. |
2019-06-28 |
2023-08-13 |
human |
| Qiang Chen, Gianluca Ursini, Adrienne L Romer, Annchen R Knodt, Karleigh Mezeivtch, Ena Xiao, Giulio Pergola, Giuseppe Blasi, Richard E Straub, Joseph H Callicott, Karen F Berman, Ahmad R Hariri, Alessandro Bertolino, Venkata S Mattay, Daniel R Weinberge. Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29415119. |
lower hippocampal activity in individuals with higher polygenic risk scores, consistent with previous studies reporting decreased hippocampal-parahippocampal activity during declarative memory tasks in patients with schizophrenia and in their healthy siblings. |
2019-06-28 |
2023-08-13 |
human |
| Qiang Chen, Gianluca Ursini, Adrienne L Romer, Annchen R Knodt, Karleigh Mezeivtch, Ena Xiao, Giulio Pergola, Giuseppe Blasi, Richard E Straub, Joseph H Callicott, Karen F Berman, Ahmad R Hariri, Alessandro Bertolino, Venkata S Mattay, Daniel R Weinberge. Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29415119. |
we conclude that polygenic risk scores derived from the most recent schizophrenia genome-wide association study predict significant variability in hippocampal activity during memory encoding in healthy participants. |
2019-06-28 |
2023-08-13 |
human |
| Qiang Chen, Gianluca Ursini, Adrienne L Romer, Annchen R Knodt, Karleigh Mezeivtch, Ena Xiao, Giulio Pergola, Giuseppe Blasi, Richard E Straub, Joseph H Callicott, Karen F Berman, Ahmad R Hariri, Alessandro Bertolino, Venkata S Mattay, Daniel R Weinberge. Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29415119. |
our findings validate mnemonic hippocampal activity as a genetic risk associated intermediate phenotype of schizophrenia, indicating that the aggregate neurobiological effect of schizophrenia risk alleles converges on this pattern of neural activity.awy004media15749593779001. |
2019-06-28 |
2023-08-13 |
human |
| Nina Vanessa Kraguljac, Matthew Carle, Michael A Frölich, Steve Tran, Michael A Yassa, David Matthew White, Abhishek Reddy, Adrienne Carol Laht. Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to N-Methyl-D-Aspartate Receptor Hypofunction. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 3. issue 3. 2019-06-27. PMID:29486864. |
converging evidence from neuroimaging and postmortem studies suggests that hippocampal subfields are differentially affected in schizophrenia. |
2019-06-27 |
2023-08-13 |
Not clear |
| C Perlini, M Bellani, B Besteher, I Nenadić, P Brambill. The neural basis of hostility-related dimensions in schizophrenia. Epidemiology and psychiatric sciences. vol 27. issue 6. 2019-06-27. PMID:30208981. |
imaging studies suggest malfunctioning of a neural circuitry including amygdala, striatum, prefrontal cortex, anterior cingulate cortex, insula and hippocampus to modulate hostile thoughts and behaviours, at least in the subgroup of patients with schizophrenia who exhibit high levels of urgency, impulsivity and aggressiveness. |
2019-06-27 |
2023-08-13 |
Not clear |
| Anthony A Grace, Felipe V Gome. The Circuitry of Dopamine System Regulation and its Disruption in Schizophrenia: Insights Into Treatment and Prevention. Schizophrenia bulletin. vol 45. issue 1. 2019-06-19. PMID:29385549. |
we found that the hippocampus in the methylazoxymethanol acetate (mam) rodent developmental disruption model of schizophrenia is hyperactive and dysrhythmic, possibly due to loss of parvalbumin interneurons, leading to a hyperresponsive dopamine system. |
2019-06-19 |
2023-08-13 |
human |
| Sharon S Lander, Usman Khan, Nicole Lewandowski, Darpan Chakraborty, Frank A Provenzano, Susana Mingote, Sergiy Chornyy, Francesca Frigerio, Pierre Maechler, Hanoch Kaphzan, Scott A Small, Stephen Rayport, Inna Gaisler-Salomo. Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction. Schizophrenia bulletin. vol 45. issue 1. 2019-06-19. PMID:29471549. |
brain imaging has revealed that the ca1 subregion of the hippocampus is hyperactive in prodromal and diagnosed patients with schizophrenia (scz), and that glutamate is a driver of this hyperactivity. |
2019-06-19 |
2023-08-13 |
mouse |
| J R Busch, S B Lundemose, N Lynnerup, C Jacobsen, M B Jørgensen, J Banne. Post-mortem MRI-based volumetry of the hippocampus in forensic cases of decedents with severe mental illness. Forensic science, medicine, and pathology. vol 15. issue 2. 2019-05-22. PMID:30828766. |
the group with schizophrenia had a statistically significant 9.5% decrease in mean hippocampal volume compared with control subjects, while the group with depression trended towards a reduced volume, but this difference was not statistically significant. |
2019-05-22 |
2023-08-13 |
human |
| Eva Pešlová, Radek Mareček, Daniel J Shaw, Tomáš Kašpárek, Martin Pail, Milan Brázdi. Hippocampal involvement in nonpathological déjà vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. Brain and behavior. vol 8. issue 7. 2019-05-07. PMID:29873197. |
another condition associated with hippocampal gmv reduction and dv alike disturbance in memory processing is schizophrenia (sch). |
2019-05-07 |
2023-08-13 |
human |
| Mandy Johnstone, Rana Feti. HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia. Cell stem cell. vol 22. issue 5. 2019-04-24. PMID:29727672. |
they developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity. |
2019-04-24 |
2023-08-13 |
human |
| Helene A Fachim, Umarat Srisawat, Caroline F Dalton, Gavin P Reynold. Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia. Epigenomics. vol 10. issue 5. 2019-04-05. PMID:29688033. |
greater pvalb methylation was found in schizophrenia hippocampus, while no differences were observed in prefrontal cortex. |
2019-04-05 |
2023-08-13 |
Not clear |
| Takayuki Yukawa, Yuriko Iwakura, Nobuyuki Takei, Mami Saito, Yuichiro Watanabe, Kazuhiko Toyooka, Michihiro Igarashi, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Shuji Iritani, Shin-Ichi Niwa, Ryoko Takeuchi, Hitoshi Takahashi, Akiyoshi Kakita, Toshiyuki Someya, Hiroyuki Naw. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Psychiatry research. vol 270. 2019-04-03. PMID:30551347. |
pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. |
2019-04-03 |
2023-08-13 |
human |
| Takayuki Yukawa, Yuriko Iwakura, Nobuyuki Takei, Mami Saito, Yuichiro Watanabe, Kazuhiko Toyooka, Michihiro Igarashi, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Shuji Iritani, Shin-Ichi Niwa, Ryoko Takeuchi, Hitoshi Takahashi, Akiyoshi Kakita, Toshiyuki Someya, Hiroyuki Naw. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Psychiatry research. vol 270. 2019-04-03. PMID:30551347. |
to explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. |
2019-04-03 |
2023-08-13 |
human |
| Hiram Tendilla-Beltrán, Rubén Antonio Vázquez-Roque, Andrea Judith Vázquez-Hernández, Linda Garcés-Ramírez, Gonzalo Flore. Exploring the Dendritic Spine Pathology in a Schizophrenia-related Neurodevelopmental Animal Model. Neuroscience. vol 396. 2019-04-01. PMID:30452973. |
neonatal ventral hippocampus lesion (nvhl) in the rat has been extensively used to examine some of the pathophysiological mechanisms of schizophrenia since it mimics several behaviors, as well as abnormalities in morphological corticolimbic neurons. |
2019-04-01 |
2023-08-13 |
rat |
| R Birnbaum, A E Jaffe, Q Chen, J H Shin, J E Kleinman, T M Hyde, D R Weinberge. Investigating the neuroimmunogenic architecture of schizophrenia. Molecular psychiatry. vol 23. issue 5. 2019-03-27. PMID:28485405. |
the current study used a systematic genetic approach to investigate the role of the immune system in a large sample of post-mortem brain of patients with schizophrenia: rna sequencing was performed to assess the differential expression of 561 immune genes and 20 immune pathways in dorsolateral prefrontal cortex (dlpfc) (144 schizophrenia and 196 control subjects) and hippocampus (83 schizophrenia and 187 control subjects). |
2019-03-27 |
2023-08-13 |
human |
| Shaina P Cahill, John Darby Cole, Ru Qi Yu, Jack Clemans-Gibbon, Jason S Snyde. Differential Effects of Extended Exercise and Memantine Treatment on Adult Neurogenesis in Male and Female Rats. Neuroscience. vol 390. 2019-03-21. PMID:30176321. |
adult neurogenesis has potential to ameliorate a number of disorders that negatively impact the hippocampus, including age-related cognitive decline, depression, and schizophrenia. |
2019-03-21 |
2023-08-13 |
rat |
| R Tao, K N Davis, C Li, J H Shin, Y Gao, A E Jaffe, M C Gondré-Lewis, D R Weinberger, J E Kleinman, T M Hyd. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. Molecular psychiatry. vol 23. issue 6. 2019-03-18. PMID:28485403. |
gad1 alternative transcripts and dna methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. |
2019-03-18 |
2023-08-13 |
human |
| R Tao, K N Davis, C Li, J H Shin, Y Gao, A E Jaffe, M C Gondré-Lewis, D R Weinberger, J E Kleinman, T M Hyd. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. Molecular psychiatry. vol 23. issue 6. 2019-03-18. PMID:28485403. |
alternative splicing of gad1 and epigenetic state appear to play roles in the developmental profile of gad1 expression and may contribute to gaba dysfunction in the pfc and hippocampus of patients with schizophrenia. |
2019-03-18 |
2023-08-13 |
human |
| Fionn Dunphy-Doherty, Siobhain M O'Mahony, Veronica L Peterson, Orla O'Sullivan, Fiona Crispie, Paul D Cotter, Peter Wigmore, Madeleine V King, John F Cryan, Kevin C F Fon. Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29104061. |
to this end the effects of social isolation (si; a well-validated animal model for schizophrenia)-induced changes in rat behavior were correlated with alterations in gut microbiota, hippocampal neurogenesis and brain cytokine levels. |
2019-03-12 |
2023-08-13 |
rat |