| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuri Masaoka, Dennis Velakoulis, Warrick J Brewer, Vanessa L Cropley, Cali F Bartholomeusz, Alison R Yung, Barnaby Nelson, Dominic Dwyer, Cassandra M J Wannan, Masahiko Izumizaki, Patrick D McGorry, Stephen J Wood, Christos Panteli. Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation? Psychiatry research. vol 289. 2021-02-01. PMID:32387788. |
we speculate that larger hippocampus and rectus in early schizophrenia are indicative of swelling, potentially caused by an active neurochemical or immunological process, such as inflammation or neurotoxicity, which is associated with impaired olfactory ability. |
2021-02-01 |
2023-08-13 |
human |
| Runfang Xie, Shijun Hong, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. Ketamine Affects the Expression of ErbB4 in the Hippocampus and Prefrontal Cortex of Rats. Journal of molecular neuroscience : MN. vol 70. issue 6. 2021-01-22. PMID:32096126. |
this study investigated the effect of ketamine on the expression of erbb4 (considered a schizophrenia candidate gene) in the hippocampus and prefrontal cortex of rats. |
2021-01-22 |
2023-08-13 |
rat |
| Stéfan du Plessis, Frederika Scheffler, Hilmar Luckhoff, Laila Asmal, Sanja Kilian, Lebogang Phahladira, Robin Emsle. Childhood trauma and hippocampal subfield volumes in first-episode schizophrenia and healthy controls. Schizophrenia research. vol 215. 2021-01-18. PMID:31653582. |
childhood trauma and hippocampal subfield volumes in first-episode schizophrenia and healthy controls. |
2021-01-18 |
2023-08-13 |
Not clear |
| Stéfan du Plessis, Frederika Scheffler, Hilmar Luckhoff, Laila Asmal, Sanja Kilian, Lebogang Phahladira, Robin Emsle. Childhood trauma and hippocampal subfield volumes in first-episode schizophrenia and healthy controls. Schizophrenia research. vol 215. 2021-01-18. PMID:31653582. |
childhood trauma and schizophrenia are both associated with neuroanatomical abnormalities in the hippocampus, a stress-sensitive structure vulnerable to developmental insults. |
2021-01-18 |
2023-08-13 |
Not clear |
| Stéfan du Plessis, Frederika Scheffler, Hilmar Luckhoff, Laila Asmal, Sanja Kilian, Lebogang Phahladira, Robin Emsle. Childhood trauma and hippocampal subfield volumes in first-episode schizophrenia and healthy controls. Schizophrenia research. vol 215. 2021-01-18. PMID:31653582. |
however, few studies have evaluated the effects of childhood trauma exposure on hippocampal morphometry in minimally treated first-episode schizophrenia patients. |
2021-01-18 |
2023-08-13 |
Not clear |
| Francesca Prestori, Ileana Montagna, Egidio D'Angelo, Lisa Mapell. The Optogenetic Revolution in Cerebellar Investigations. International journal of molecular sciences. vol 21. issue 7. 2021-01-13. PMID:32260234. |
the main issues addressed by these studies are the cerebellar role in epilepsy (through connections to the hippocampus and the temporal lobe), schizophrenia and cognition, working memory for decision making, and social behavior. |
2021-01-13 |
2023-08-13 |
Not clear |
| Frank A Provenzano, Jia Guo, Melanie M Wall, Xinyang Feng, Hannah C Sigmon, Gary Brucato, Michael B First, Douglas L Rothman, Ragy R Girgis, Jeffrey A Lieberman, Scott A Smal. Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia. Biological psychiatry. vol 87. issue 3. 2021-01-06. PMID:31771861. |
hippocampal pathology in clinical high-risk patients and the onset of schizophrenia. |
2021-01-06 |
2023-08-13 |
human |
| Inwoo Hwang, Jee-Yin Ah. Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1 International journal of molecular sciences. vol 21. issue 7. 2021-01-06. PMID:32283721. |
in the hippocampus of postmortem schizophrenia (sz) patients, the most notable finding is the deregulation of gad67 along with differential regulation of epigenetic factors associated with glutamate decarboxylase 67 (gad67) expression. |
2021-01-06 |
2023-08-13 |
Not clear |
| Boris-Stephan Rauchmann, Farhad Ghaseminejad, Daniel Keeser, Katriona Keller-Varady, Thomas Schneider-Axmann, Shun Takahashi, Temmuz Karali, Gunther Helms, Peter Dechent, Isabel Maurus, Alkomiet Hasan, Thomas Wobrock, Birgit Ertl-Wagner, Andrea Schmitt, Berend Malchow, Peter Falka. The impact of endurance training and table soccer on brain metabolites in schizophrenia. Brain imaging and behavior. vol 14. issue 2. 2021-01-04. PMID:31686308. |
at baseline, in both schizophrenia groups naa/tcr was lower in the left dlpfc and left hippocampus and glx/tcr was lower in the hippocampus than in the healthy controls. |
2021-01-04 |
2023-08-13 |
Not clear |
| E Kale Edmiston, Yanzhuo Song, Miao Chang, Zhiyang Yin, Qian Zhou, Yifang Zhou, Xiaowei Jiang, Shengnan Wei, Ke Xu, Yanqing Tang, Fei Wan. Hippocampal Resting State Functional Connectivity in Patients With Schizophrenia and Unaffected Family Members. Frontiers in psychiatry. vol 11. 2020-12-17. PMID:32425819. |
hippocampal resting state functional connectivity in patients with schizophrenia and unaffected family members. |
2020-12-17 |
2023-08-13 |
human |
| E Kale Edmiston, Yanzhuo Song, Miao Chang, Zhiyang Yin, Qian Zhou, Yifang Zhou, Xiaowei Jiang, Shengnan Wei, Ke Xu, Yanqing Tang, Fei Wan. Hippocampal Resting State Functional Connectivity in Patients With Schizophrenia and Unaffected Family Members. Frontiers in psychiatry. vol 11. 2020-12-17. PMID:32425819. |
the hippocampus is an important candidate region in the study of functional connectivity alterations in schizophrenia (sz) given its role as a functional hub for multiple brain networks. |
2020-12-17 |
2023-08-13 |
human |
| Peter Falkai, Florian Raabe, Bernhard Bogerts, Thomas Schneider-Axmann, Berend Malchow, Laura Tatsch, Verena Huber, Lenka Slapakova, Henrik Dobrowolny, Christoph Schmitz, Ludovico Cantuti-Castelvetri, Mikael Simons, Johann Steiner, Andrea Schmit. Association between altered hippocampal oligodendrocyte number and neuronal circuit structures in schizophrenia: a postmortem analysis. European archives of psychiatry and clinical neuroscience. vol 270. issue 4. 2020-11-30. PMID:31552495. |
association between altered hippocampal oligodendrocyte number and neuronal circuit structures in schizophrenia: a postmortem analysis. |
2020-11-30 |
2023-08-13 |
Not clear |
| Peter Falkai, Florian Raabe, Bernhard Bogerts, Thomas Schneider-Axmann, Berend Malchow, Laura Tatsch, Verena Huber, Lenka Slapakova, Henrik Dobrowolny, Christoph Schmitz, Ludovico Cantuti-Castelvetri, Mikael Simons, Johann Steiner, Andrea Schmit. Association between altered hippocampal oligodendrocyte number and neuronal circuit structures in schizophrenia: a postmortem analysis. European archives of psychiatry and clinical neuroscience. vol 270. issue 4. 2020-11-30. PMID:31552495. |
therefore, we used stepwise logistic regression with subsequent multivariate stepwise linear regression and bivariate correlation to analyze oligodendrocyte and neuron numbers in the posterior hippocampal subregions ca1, ca2/3, ca4, dentate gyrus, and subiculum and volumes of the hippocampal ca region, cingulum, anterior and mediodorsal thalamus and hypothalamus in postmortem brains of 10 schizophrenia patients and 11 age- and gender-matched healthy controls. |
2020-11-30 |
2023-08-13 |
Not clear |
| Runfang Xie, Jiming Xie, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. Journal of molecular neuroscience : MN. vol 70. issue 2. 2020-11-19. PMID:31897968. |
mtor expression in hippocampus and prefrontal cortex is downregulated in a rat model of schizophrenia induced by chronic administration of ketamine. |
2020-11-19 |
2023-08-13 |
rat |
| Chin Wai Hui, Haley A Vecchiarelli, Étienne Gervais, Xiao Luo, Félix Michaud, Lisa Scheefhals, Kanchan Bisht, Kaushik Sharma, Lisa Topolnik, Marie-Ève Trembla. Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192308. |
our previous findings utilizing a maternal immune activation (mia) mouse model of schizophrenia revealed exacerbated anxiety-like behavior and sensorimotor gating deficits in adult male offspring that were associated with increased microglial reactivity and inflammation in the hippocampal dentate gyrus (dg). |
2020-11-17 |
2023-08-13 |
mouse |
| Guangfei Li, Xiaowei Han, Wenwen Gao, Zeyu Song, Shuai Zhao, Feiyi Sun, Hong Ma, Ailing Cui, Xiaoying Tang, Guolin M. Influence of EGR3 Transfection on Imaging and Behavior in Rats and Therapeutic Effect of Risperidone in Schizophrenia Model. Frontiers in psychiatry. vol 11. 2020-11-17. PMID:33192626. |
we injected the early growth response gene (egr3) into the bilateral hippocampus to build a schizophrenia rat model. |
2020-11-17 |
2023-08-13 |
rat |
| David Y Suh, Simon N Vandekar, Stephan Heckers, Suzanne N Aver. Visual exploration differences during relational memory encoding in early psychosis. Psychiatry research. vol 287. 2020-10-27. PMID:32200141. |
the ability to bind items into a relational memory is dependent on the hippocampus, a region that is abnormal in schizophrenia. |
2020-10-27 |
2023-08-13 |
human |
| David Y Suh, Simon N Vandekar, Stephan Heckers, Suzanne N Aver. Visual exploration differences during relational memory encoding in early psychosis. Psychiatry research. vol 287. 2020-10-27. PMID:32200141. |
however, the hippocampus is also involved in exploratory behavior, leaving open the question whether relational memory deficits in schizophrenia are due to failure of relational binding or diminished visual exploration of individual items during encoding. |
2020-10-27 |
2023-08-13 |
human |
| Elisa Guma, Jill Rocchetti, Gabriel A Devenyi, Arnaud Tanti, Axel P Mathieu, Jason P Lerch, Guillaume Elgbeili, Blandine Courcot, Naguib Mechawar, M Mallar Chakravarty, Bruno Giro. Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:31127135. |
clinical research has shown that chronic antipsychotic drug (apd) treatment further decreases cortical gray matter and hippocampus volume, and increases striatal and ventricular volume in patients with schizophrenia. |
2020-10-20 |
2023-08-13 |
mouse |
| Tiril P Gurholt, Vera Lonning, Stener Nerland, Kjetil N Jørgensen, Unn K Haukvik, Clara Alloza, Celso Arango, Claudia Barth, Carrie E Bearden, Michael Berk, Hannes Bohman, Orwa Dandash, Covadonga M Díaz-Caneja, Carl T Edbom, Theo G M van Erp, Anne-Kathrin J Fett, Sophia Frangou, Benjamin I Goldstein, Anahit Grigorian, Neda Jahanshad, Anthony C James, Joost Janssen, Cecilie Johannessen, Katherine H Karlsgodt, Matthew J Kempton, Peter Kochunov, Lydia Krabbendam, Marinos Kyriakopoulos, Mathias Lundberg, Bradley J MacIntosh, Bjørn Rishovd Rund, Runar E Smelror, Alysha Sultan, Christian K Tamnes, Sophia I Thomopoulos, Ariana Vajdi, Kirsten Wedervang-Resell, Anne M Myhre, Ole A Andreassen, Paul M Thompson, Ingrid Agart. Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium. Human brain mapping. 2020-10-07. PMID:33017498. |
intracranial volume was lower in both early-onset schizophrenia (d = -0.34) and affective psychosis (d = -0.42), and early-onset schizophrenia showed lower hippocampal (d = -0.24) and higher pallidum (d = 0.29) volumes. |
2020-10-07 |
2023-08-13 |
Not clear |