| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elias Wagner, John M Kane, Christoph U Correll, Oliver Howes, Dan Siskind, William G Honer, Jimmy Lee, Peter Falkai, Thomas Schneider-Axmann, Alkomiet Hasa. Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia -Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group. Schizophrenia bulletin. vol 46. issue 6. 2021-10-25. PMID:32421188. |
clozapine combination and augmentation strategies in patients with schizophrenia -recommendations from an international expert survey among the treatment response and resistance in psychosis (trrip) working group. |
2021-10-25 |
2023-08-13 |
Not clear |
| Elias Wagner, John M Kane, Christoph U Correll, Oliver Howes, Dan Siskind, William G Honer, Jimmy Lee, Peter Falkai, Thomas Schneider-Axmann, Alkomiet Hasa. Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia -Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group. Schizophrenia bulletin. vol 46. issue 6. 2021-10-25. PMID:32421188. |
evidence for the management of inadequate clinical response to clozapine in treatment-resistant schizophrenia is sparse. |
2021-10-25 |
2023-08-13 |
Not clear |
| R J Flanagan, J Lally, S Gee, R Lyon, S Every-Palme. Clozapine in the treatment of refractory schizophrenia: a practical guide for healthcare professionals. British medical bulletin. vol 135. issue 1. 2021-10-25. PMID:32885238. |
clozapine in the treatment of refractory schizophrenia: a practical guide for healthcare professionals. |
2021-10-25 |
2023-08-13 |
Not clear |
| R J Flanagan, J Lally, S Gee, R Lyon, S Every-Palme. Clozapine in the treatment of refractory schizophrenia: a practical guide for healthcare professionals. British medical bulletin. vol 135. issue 1. 2021-10-25. PMID:32885238. |
clozapine remains the only medication licensed for treating refractory schizophrenia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Leslie Citrome, Jan Volavk. Specific Anti-hostility Effects of Atypical Antipsychotics in Persons with Schizophrenia: From Clozapine to Cariprazine. Harvard review of psychiatry. vol 29. issue 1. 2021-10-25. PMID:33417374. |
specific anti-hostility effects of atypical antipsychotics in persons with schizophrenia: from clozapine to cariprazine. |
2021-10-25 |
2023-08-13 |
Not clear |
| Deanna L Kelly, Olga Y Ponomareva, Marie Mackowick, Matthew Glassman, Jaeboon Park, Myriam Navarro-De La Vega, Heidi J Wehring, Gopal Vya. Feasibility and patient-reported satisfaction using a novel point-of-care fingerstick method for monitoring absolute neutrophil count for clozapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 33. issue 2. 2021-10-25. PMID:33878286. |
clozapine is an effective antipsychotic for treatment-resistant schizophrenia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Zsuzsanna Belteczki, Julia Ujvari, Peter Dom. Clozapine Withdrawal-Induced Malignant Catatonia or Neuroleptic Malignant Syndrome: A Case Report and a Brief Review of the Literature. Clinical neuropharmacology. vol 44. issue 4. 2021-10-25. PMID:34132673. |
furthermore, we present the case of a 29-year-old male patient with schizophrenia in whom a malignant catatonic episode/neuroleptic malignant syndrome (with negativism, stupor, mutism, autonomic signs [eg, fever, hyperhidrosis], and elevated creatine kinase levels) began 5 days after the patient decided arbitrarily to cease his clozapine treatment. |
2021-10-25 |
2023-08-13 |
Not clear |
| Amir Krivoy, Eromona Whiskey, Henrietta Webb-Wilson, Dan Joyce, Derek K Tracy, Fiona Gaughran, James H MacCabe, Sukhwinder S Shergil. Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations. Therapeutic advances in psychopharmacology. vol 11. 2021-10-23. PMID:34676067. |
outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations. |
2021-10-23 |
2023-08-13 |
Not clear |
| Amir Krivoy, Eromona Whiskey, Henrietta Webb-Wilson, Dan Joyce, Derek K Tracy, Fiona Gaughran, James H MacCabe, Sukhwinder S Shergil. Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations. Therapeutic advances in psychopharmacology. vol 11. 2021-10-23. PMID:34676067. |
clozapine is the only medication licenced for treating patients with treatment-refractory schizophrenia. |
2021-10-23 |
2023-08-13 |
Not clear |
| Dan Siskind, Anthony W Russell, Shuichi Suetani, Dylan Flaws, Steve Kisely, Vikas Moudgil, Korinne Northwood, Gail Robinson, James G Scott, Terry Stedman, Nicola Warren, Karl Winckel, Peter Cosgrove, Andrea Bake. CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine. Therapeutic advances in psychopharmacology. vol 11. 2021-10-22. PMID:34671454. |
comet: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine. |
2021-10-22 |
2023-08-13 |
Not clear |
| F Williams, F Lenihan, A Row. Continuing clozapine treatment after a diagnosis of cardiomyopathy. Irish journal of psychological medicine. vol 38. issue 3. 2021-10-21. PMID:34465403. |
a patient in a medium secure psychiatric unit with a 19-year history of treatment-resistant schizophrenia and violence whose mental illness only responded to clozapine, was noted to have a sustained tachycardia. |
2021-10-21 |
2023-08-13 |
Not clear |
| Barbara Iruretagoyena, Carmen Paz Castañeda, Cristian Mena, Camila Diaz, Ruben Nachar, Juan Pablo Ramirez-Mahaluf, Alfonso González-Valderrama, Juan Undurraga, James H Maccabe, Nicolas A Crossle. Predictors of clozapine discontinuation at 2 years in treatment-resistant schizophrenia. Schizophrenia research. vol 235. 2021-10-19. PMID:34340062. |
predictors of clozapine discontinuation at 2 years in treatment-resistant schizophrenia. |
2021-10-19 |
2023-08-13 |
Not clear |
| Noraly Stam, Heidi Taipale, Antti Tanskanen, Luka Isphording, Cynthia Okhuijsen-Pfeifer, Catharina C M Schuiling-Veninga, Jens H J Bos, Bert J Bijker, Jari Tiihonen, Jurjen J Luyk. Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics. Clinical and translational science. vol 13. issue 6. 2021-10-15. PMID:32441836. |
although clozapine treatment is often discontinued due to limited efficacy or low tolerability, there is a lack of guidelines and evidence on treatment options after discontinuation of clozapine in patients with schizophrenia. |
2021-10-15 |
2023-08-13 |
human |
| Noraly Stam, Heidi Taipale, Antti Tanskanen, Luka Isphording, Cynthia Okhuijsen-Pfeifer, Catharina C M Schuiling-Veninga, Jens H J Bos, Bert J Bijker, Jari Tiihonen, Jurjen J Luyk. Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics. Clinical and translational science. vol 13. issue 6. 2021-10-15. PMID:32441836. |
registry data from a prescription database representative of the dutch population (1996-2017) was collected to investigate persistence in patients with schizophrenia who had been using clozapine for ≥ 90 days. |
2021-10-15 |
2023-08-13 |
human |
| Graham Blackman, Ebenezer Oloyede, Mark Horowitz, Robert Harland, David Taylor, James MacCabe, Philip McGuir. Reducing the Risk of Withdrawal Symptoms and Relapse Following Clozapine Discontinuation-Is It Feasible to Develop Evidence-Based Guidelines? Schizophrenia bulletin. 2021-10-15. PMID:34651184. |
clozapine is the only antipsychotic that is effective in treatment-resistant schizophrenia. |
2021-10-15 |
2023-08-13 |
Not clear |
| Mariana Fioramonte, Guilherme Reis-de-Oliveira, Caroline Brandão-Teles, Daniel Martins-de-Souz. A glimpse on the architecture of hnRNP C1/C2 interaction network in cultured oligodendrocytes. Biochimica et biophysica acta. Proteins and proteomics. vol 1869. issue 12. 2021-10-12. PMID:34403818. |
hnrnps were shown differentially regulated on schizophrenia postmortem brain tissue as well as in cultured oligodendrocytes treated with clozapine, a common antipsychotic used in schizophrenia treatment. |
2021-10-12 |
2023-08-13 |
Not clear |
| Basile Chrétien, Véronique Lelong-Boulouard, Sylvain Chantepie, Marion Sassier, Mickael Bertho, Perrine Brazo, Xavier Humbert, Joachim Alexandre, Sophie Fedrizzi, Charles Dolladill. Haematologic malignancies associated with clozapine Psychological medicine. vol 51. issue 9. 2021-10-11. PMID:32036793. |
haematologic malignancies associated with clozapine clozapine is mainly used in patients with treatment-resistant schizophrenia and may lead to potentially severe haematologic adverse events, such as agranulocytosis. |
2021-10-11 |
2023-08-13 |
Not clear |
| Elias Wagner, Spyridon Siafis, Piyumi Fernando, Peter Falkai, William G Honer, Astrid Röh, Dan Siskind, Stefan Leucht, Alkomiet Hasa. Efficacy and safety of clozapine in psychotic disorders-a systematic quantitative meta-review. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34552059. |
clozapine appears to have superior effects on positive, negative, and overall symptoms and relapse rates in schizophrenia (treatment-resistant and non-treatment-resistant subpopulations) compared to first-generation antipsychotics (fgas) and to pooled fgas/second-generation antipsychotics (sgas) in treatment-resistant schizophrenia (trs). |
2021-10-11 |
2023-08-13 |
Not clear |
| Elias Wagner, Spyridon Siafis, Piyumi Fernando, Peter Falkai, William G Honer, Astrid Röh, Dan Siskind, Stefan Leucht, Alkomiet Hasa. Efficacy and safety of clozapine in psychotic disorders-a systematic quantitative meta-review. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34552059. |
our meta-review outlines the superior overall efficacy of clozapine compared to fgas and most other sgas in schizophrenia and suggests beneficial efficacy outcomes in bipolar disorder and parkinson's disease psychosis (pdp). |
2021-10-11 |
2023-08-13 |
Not clear |
| Masataka Kikuchi, Takanobu Nakazawa, Makoto Kinoshita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Ryota Hashimoto, Shusuke Numat. Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine. Frontiers in psychiatry. vol 12. 2021-10-08. PMID:34616320. |
methylation analysis in monozygotic twins with treatment-resistant schizophrenia and discordant responses to clozapine. |
2021-10-08 |
2023-08-13 |
Not clear |