| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Fitton, R C Hee. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. vol 40. issue 5. 1991-04-11. PMID:2292234. |
clozapine has been shown to be of comparable, or on some criteria superior, therapeutic efficacy to perphenazine, levomepromazine, haloperidol and chlorpromazine in several short term comparative studies in patients with schizophrenia of predominantly acute symptomatology. |
1991-04-11 |
2023-08-11 |
Not clear |
| A Fitton, R C Hee. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. vol 40. issue 5. 1991-04-11. PMID:2292234. |
in accordance with current guidelines, clozapine therapy, performed in conjunction with close haematological monitoring, is indicated for the management of severe and chronic schizophrenia refractory to classic antipsychotic therapy, and in those unable to tolerate such therapy. |
1991-04-11 |
2023-08-11 |
Not clear |
| J M Herrera, J Costa, J Sramek, C He. Clozapine in refractory schizophrenia. Preliminary findings. Schizophrenia research. vol 1. issue 4. 1991-04-05. PMID:3154518. |
clozapine in refractory schizophrenia. |
1991-04-05 |
2023-08-11 |
Not clear |
| S Szymanski, J A Lieberman, D Picou, S Masiar, T Coope. A case report of cimetidine-induced clozapine toxicity. The Journal of clinical psychiatry. vol 52. issue 1. 1991-02-25. PMID:1988413. |
the authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia. |
1991-02-25 |
2023-08-11 |
Not clear |
| J A Lieberman, J Yunis, E Egea, R T Canoso, J M Kane, E J Yuni. HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia. Archives of general psychiatry. vol 47. issue 10. 1990-11-19. PMID:2222133. |
agranulocytosis develops in approximately 1% of patients with chronic schizophrenia treated with the atypical neuroleptic drug clozapine. |
1990-11-19 |
2023-08-11 |
Not clear |
| K G Terkelsen, R C Grosse. Estimating clozapine's cost to the nation. Hospital & community psychiatry. vol 41. issue 8. 1990-10-26. PMID:2169458. |
clozapine, an effective but expensive drug treatment for patients with severe, chronic schizophrenia who are unresponsive to conventional antipsychotics, is associated with a high risk of agranulocytosis, which is sometimes fatal. |
1990-10-26 |
2023-08-11 |
Not clear |
| P I Tiedtke, C Bischoff, W J Schmid. MK-801-induced stereotypy and its antagonism by neuroleptic drugs. Journal of neural transmission. General section. vol 81. issue 3. 1990-10-12. PMID:1975747. |
stereotypy is considered to represent an animal model of schizophrenia, and the antagonism of stereotypy with classical (haloperidol) as well as with atypical (clozapine) antipsychotic drugs is in accordance with the glutamate hypothesis of schizophrenia. |
1990-10-12 |
2023-08-11 |
Not clear |
| P Stephen. A review of clozapine: an antipsychotic for treatment-resistant schizophrenia. Comprehensive psychiatry. vol 31. issue 4. 1990-09-24. PMID:2201482. |
a review of clozapine: an antipsychotic for treatment-resistant schizophrenia. |
1990-09-24 |
2023-08-11 |
Not clear |
| J J Pere, D Chaumet-Riffau. [Clozapine and resistant schizophrenia]. L'Encephale. vol 16. issue 2. 1990-07-18. PMID:1972053. |
[clozapine and resistant schizophrenia]. |
1990-07-18 |
2023-08-11 |
rat |
| N Barrett, S Ormiston, V Molyneu. Clozapine: a new drug for schizophrenia. Journal of psychosocial nursing and mental health services. vol 28. issue 2. 1990-04-05. PMID:2407837. |
clozapine: a new drug for schizophrenia. |
1990-04-05 |
2023-08-11 |
Not clear |
| Clozapine for schizophrenia. The Medical letter on drugs and therapeutics. vol 32. issue 809. 1990-02-06. PMID:2403629. |
clozapine for schizophrenia. |
1990-02-06 |
2023-08-11 |
Not clear |
| FDA approves clozapine for treatment of schizophrenia; careful monitoring required. Hospital & community psychiatry. vol 40. issue 12. 1990-01-17. PMID:2591894. |
fda approves clozapine for treatment of schizophrenia; careful monitoring required. |
1990-01-17 |
2023-08-11 |
Not clear |
| H Y Meltze. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology. vol 99 Suppl. 1989-12-21. PMID:2682729. |
clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. |
1989-12-21 |
2023-08-11 |
Not clear |
| H Y Meltze. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology. vol 99 Suppl. 1989-12-21. PMID:2682729. |
it is proposed that schizophrenia may also involve a dysregulation of 5-ht2- and d-2-mediated neurotransmission, and that a more normal balance in serotonergic and dopaminergic neurotransmission is at least partially restored by clozapine. |
1989-12-21 |
2023-08-11 |
Not clear |
| D Naber, M Leppig, R Grohmann, H Hippiu. Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia--a retrospective study of 387 patients. Psychopharmacology. vol 99 Suppl. 1989-12-21. PMID:2813668. |
efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia--a retrospective study of 387 patients. |
1989-12-21 |
2023-08-11 |
Not clear |
| D Naber, M Leppig, R Grohmann, H Hippiu. Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia--a retrospective study of 387 patients. Psychopharmacology. vol 99 Suppl. 1989-12-21. PMID:2813668. |
medical charts of 387 in-patients (schizophrenia n = 284, tardive dyskinesia, td, n = 48), were analyzed to evaluate efficacy and adverse effects of clozapine. |
1989-12-21 |
2023-08-11 |
Not clear |
| L H Lindströ. A retrospective study on the long-term efficacy of clozapine in 96 schizophrenic and schizoaffective patients during a 13-year period. Psychopharmacology. vol 99 Suppl. 1989-12-21. PMID:2813670. |
the effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the psychiatric research center in uppsala. |
1989-12-21 |
2023-08-11 |
Not clear |
| L Ereshefsky, M D Watanabe, T K Tran-Johnso. Clozapine: an atypical antipsychotic agent. Clinical pharmacy. vol 8. issue 10. 1989-11-30. PMID:2572373. |
clozapine may be superior to other agents in the treatment of refractory schizophrenia and is associated with a negligible incidence of extrapyramidal symptoms. |
1989-11-30 |
2023-08-11 |
Not clear |
| J A Matte. Clozapine for refractory schizophrenia: an open study of 14 patients treated up to 2 years. The Journal of clinical psychiatry. vol 50. issue 10. 1989-11-09. PMID:2571612. |
clozapine for refractory schizophrenia: an open study of 14 patients treated up to 2 years. |
1989-11-09 |
2023-08-11 |
Not clear |
| J A Matte. Clozapine for refractory schizophrenia: an open study of 14 patients treated up to 2 years. The Journal of clinical psychiatry. vol 50. issue 10. 1989-11-09. PMID:2571612. |
in this study, 14 patients with refractory chronic schizophrenia were treated openly with clozapine up to 2 years; 8 did substantially better when given clozapine than they had when given other neuroleptics. |
1989-11-09 |
2023-08-11 |
Not clear |