| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' V Kor\\xc3\\xadnkov\\xc3\\xa1, V Novotn\\xc3\\xb. [Maintenance therapy in schizophrenia using clozapine]. Ceskoslovenska psychiatrie. vol 87. issue 2. 1991-10-30. PMID:1913953.' |
the authors describe the results of an intraindividual comparison of clozapine in 11 patients with the diagnosis of schizophrenia (according to icd-9), 7 men, mean age 30.5 years with previous neuroleptic treatment. |
1991-10-30 |
2023-08-11 |
Not clear |
| J M Kan. New developments in the pharmacologic treatment of schizophrenia: editor's introduction. Schizophrenia bulletin. vol 17. issue 2. 1991-10-03. PMID:1679250. |
topics discussed include: the role of blood levels; alternative somatic treatments for nonresponding patients; the role of clozapine; putative mechanisms of action of novel antipsychotics; an overview of potential antipsychotic drugs under development; new findings in maintenance treatment; a review of the impact of neuroleptic treatment on the long-term course of schizophrenia; and a discussion of obstacles which must be overcome to ensure that the promise of treatment research can be fully realized. |
1991-10-03 |
2023-08-11 |
Not clear |
| J M Kan. [Clozapine in the treatment of schizophrenia]. L'Encephale. vol 17 Spec No 2. 1991-09-11. PMID:1864262. |
[clozapine in the treatment of schizophrenia]. |
1991-09-11 |
2023-08-11 |
Not clear |
| S Lundström, P Persso. [Clozapine treatment in schizophrenia. A safety system is needed to prevent side effects]. Lakartidningen. vol 88. issue 30-31. 1991-09-09. PMID:1865717. |
[clozapine treatment in schizophrenia. |
1991-09-09 |
2023-08-11 |
Not clear |
| M W Jan. Clozapine. Pharmacotherapy. vol 11. issue 3. 1991-09-04. PMID:1677765. |
clozapine was superior to chlorpromazine in the treatment of refractory schizophrenia that failed to respond to previous neuroleptic therapy. |
1991-09-04 |
2023-08-11 |
Not clear |
| H Y Meltzer, L D Alphs, B Bastani, L F Ramirez, K Kwo. Clinical efficacy of clozapine in the treatment of schizophrenia. Pharmacopsychiatry. vol 24. issue 2. 1991-08-19. PMID:1852789. |
clinical efficacy of clozapine in the treatment of schizophrenia. |
1991-08-19 |
2023-08-11 |
Not clear |
| H S Lee, K Y Kwon, L D Alphs, H Y Meltze. Effect of clozapine on psychogenic polydipsia in chronic schizophrenia. Journal of clinical psychopharmacology. vol 11. issue 3. 1991-08-09. PMID:2066464. |
effect of clozapine on psychogenic polydipsia in chronic schizophrenia. |
1991-08-09 |
2023-08-11 |
Not clear |
| L Friedman, L Knutson, M Shurell, H Y Meltze. Prefrontal sulcal prominence is inversely related to response to clozapine in schizophrenia. Biological psychiatry. vol 29. issue 9. 1991-07-25. PMID:2049485. |
prefrontal sulcal prominence is inversely related to response to clozapine in schizophrenia. |
1991-07-25 |
2023-08-11 |
Not clear |
| S R Kay, J P Lindenmaye. Stability of psychopathology dimensions in chronic schizophrenia: response to clozapine treatment. Comprehensive psychiatry. vol 32. issue 1. 1991-04-15. PMID:2001618. |
stability of psychopathology dimensions in chronic schizophrenia: response to clozapine treatment. |
1991-04-15 |
2023-08-11 |
Not clear |
| A Fitton, R C Hee. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. vol 40. issue 5. 1991-04-11. PMID:2292234. |
clinical studies have shown clozapine to be effective in suppressing both the positive and negative symptoms of schizophrenia and to be associated with an extremely low incidence of extrapyramidal side effects. |
1991-04-11 |
2023-08-11 |
Not clear |
| A Fitton, R C Hee. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. vol 40. issue 5. 1991-04-11. PMID:2292234. |
clozapine has been shown to be of comparable, or on some criteria superior, therapeutic efficacy to perphenazine, levomepromazine, haloperidol and chlorpromazine in several short term comparative studies in patients with schizophrenia of predominantly acute symptomatology. |
1991-04-11 |
2023-08-11 |
Not clear |
| A Fitton, R C Hee. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. vol 40. issue 5. 1991-04-11. PMID:2292234. |
in accordance with current guidelines, clozapine therapy, performed in conjunction with close haematological monitoring, is indicated for the management of severe and chronic schizophrenia refractory to classic antipsychotic therapy, and in those unable to tolerate such therapy. |
1991-04-11 |
2023-08-11 |
Not clear |
| J M Herrera, J Costa, J Sramek, C He. Clozapine in refractory schizophrenia. Preliminary findings. Schizophrenia research. vol 1. issue 4. 1991-04-05. PMID:3154518. |
clozapine in refractory schizophrenia. |
1991-04-05 |
2023-08-11 |
Not clear |
| S Szymanski, J A Lieberman, D Picou, S Masiar, T Coope. A case report of cimetidine-induced clozapine toxicity. The Journal of clinical psychiatry. vol 52. issue 1. 1991-02-25. PMID:1988413. |
the authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia. |
1991-02-25 |
2023-08-11 |
Not clear |
| J A Lieberman, J Yunis, E Egea, R T Canoso, J M Kane, E J Yuni. HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia. Archives of general psychiatry. vol 47. issue 10. 1990-11-19. PMID:2222133. |
agranulocytosis develops in approximately 1% of patients with chronic schizophrenia treated with the atypical neuroleptic drug clozapine. |
1990-11-19 |
2023-08-11 |
Not clear |
| K G Terkelsen, R C Grosse. Estimating clozapine's cost to the nation. Hospital & community psychiatry. vol 41. issue 8. 1990-10-26. PMID:2169458. |
clozapine, an effective but expensive drug treatment for patients with severe, chronic schizophrenia who are unresponsive to conventional antipsychotics, is associated with a high risk of agranulocytosis, which is sometimes fatal. |
1990-10-26 |
2023-08-11 |
Not clear |
| P I Tiedtke, C Bischoff, W J Schmid. MK-801-induced stereotypy and its antagonism by neuroleptic drugs. Journal of neural transmission. General section. vol 81. issue 3. 1990-10-12. PMID:1975747. |
stereotypy is considered to represent an animal model of schizophrenia, and the antagonism of stereotypy with classical (haloperidol) as well as with atypical (clozapine) antipsychotic drugs is in accordance with the glutamate hypothesis of schizophrenia. |
1990-10-12 |
2023-08-11 |
Not clear |
| P Stephen. A review of clozapine: an antipsychotic for treatment-resistant schizophrenia. Comprehensive psychiatry. vol 31. issue 4. 1990-09-24. PMID:2201482. |
a review of clozapine: an antipsychotic for treatment-resistant schizophrenia. |
1990-09-24 |
2023-08-11 |
Not clear |
| J J Pere, D Chaumet-Riffau. [Clozapine and resistant schizophrenia]. L'Encephale. vol 16. issue 2. 1990-07-18. PMID:1972053. |
[clozapine and resistant schizophrenia]. |
1990-07-18 |
2023-08-11 |
rat |
| N Barrett, S Ormiston, V Molyneu. Clozapine: a new drug for schizophrenia. Journal of psychosocial nursing and mental health services. vol 28. issue 2. 1990-04-05. PMID:2407837. |
clozapine: a new drug for schizophrenia. |
1990-04-05 |
2023-08-11 |
Not clear |