| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N J Brugman, D Cohen, R H de Vrie. [Diabetes mellitus after treatment with clozapine]. Nederlands tijdschrift voor geneeskunde. vol 144. issue 9. 2000-04-05. PMID:10719549. |
in a 40-year old patient with schizophrenia treated with sustained-action perfenazine for schizophrenia, diabetes mellitus type 2 and hypertension developed when clozapine was added to the regimen. |
2000-04-05 |
2023-08-12 |
Not clear |
| V M Rodriguez, M L Catalina, J A García-Noblejas, P Cuest. Schizophrenic syndromes and clozapine response in treatment-resistant schizophrenia. Psychiatry research. vol 77. issue 1. 2000-03-31. PMID:10710171. |
schizophrenic syndromes and clozapine response in treatment-resistant schizophrenia. |
2000-03-31 |
2023-08-12 |
Not clear |
| P E Keck, S M Strakowski, S L McElro. The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility, and suicidality in patients with schizophrenia. The Journal of clinical psychiatry. vol 61 Suppl 3. 2000-03-22. PMID:10724127. |
for this article, the available literature regarding the efficacy of clozapine, risperidone, olanzapine, quetiapine, and ziprasidone in the treatment of depression, hostility, and suicidality in patients with schizophrenia was reviewed. |
2000-03-22 |
2023-08-12 |
Not clear |
| P E Keck, S M Strakowski, S L McElro. The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility, and suicidality in patients with schizophrenia. The Journal of clinical psychiatry. vol 61 Suppl 3. 2000-03-22. PMID:10724127. |
these studies suggest that atypical antipsychotics may exert therapeutic effects on depression and hostility as well as psychosis and that clozapine and olanzapine may reduce suicidality in patients with schizophrenia. |
2000-03-22 |
2023-08-12 |
Not clear |
| M Masellis, V S Basile, V Ozdemir, H Y Meltzer, F M Macciardi, J L Kenned. Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine. Biological psychiatry. vol 47. issue 3. 2000-03-17. PMID:10682223. |
the reintroduction of clozapine, the prototype of atypical antipsychotics, in the late 1980s has led to significant advances in the pharmacological management of schizophrenia. |
2000-03-17 |
2023-08-12 |
Not clear |
| S V Zimmet, R D Strous, E S Burgess, S Kohnstamm, A I Gree. Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653215. |
effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. |
2000-03-15 |
2023-08-12 |
Not clear |
| S V Zimmet, R D Strous, E S Burgess, S Kohnstamm, A I Gree. Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653215. |
the authors report data from a retrospective survey of substance use in 58 patients treated with clozapine who had a history of comorbid schizophrenia (or schizoaffective disorder) and substance use disorder. |
2000-03-15 |
2023-08-12 |
Not clear |
| J A Worrel, P A Marken, S E Beckman, V L Ruehte. Atypical antipsychotic agents: a critical review. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 57. issue 3. 2000-03-09. PMID:10674777. |
clozapine remains the standard agent for treatment-resistant schizophrenia. |
2000-03-09 |
2023-08-12 |
Not clear |
| S A Chong, G J Remington, K Z Bezchlibnyk-Butle. Effect of clozapine on polypharmacy. Psychiatric services (Washington, D.C.). vol 51. issue 2. 2000-03-06. PMID:10655014. |
prescribing patterns for a group of outpatients with schizophrenia were surveyed for changes after the initiation of clozapine. |
2000-03-06 |
2023-08-12 |
Not clear |
| R Rosenheck, D Evans, L Herz, J Cramer, W Xu, J Thomas, W Henderson, D Charne. How long to wait for a response to clozapine: a comparison of time course of response to clozapine and conventional antipsychotic medication in refractory schizophrenia. Schizophrenia bulletin. vol 25. issue 4. 2000-03-03. PMID:10667741. |
how long to wait for a response to clozapine: a comparison of time course of response to clozapine and conventional antipsychotic medication in refractory schizophrenia. |
2000-03-03 |
2023-08-12 |
Not clear |
| R Rosenheck, D Evans, L Herz, J Cramer, W Xu, J Thomas, W Henderson, D Charne. How long to wait for a response to clozapine: a comparison of time course of response to clozapine and conventional antipsychotic medication in refractory schizophrenia. Schizophrenia bulletin. vol 25. issue 4. 2000-03-03. PMID:10667741. |
a double-blind trial compared clozapine and haloperidol in patients with schizophrenia who were refractory to conventional antipsychotic medication and were hospitalized for 30 to 364 days at 15 veteran affairs medical centers during the year before study entry. |
2000-03-03 |
2023-08-12 |
Not clear |
| J G Kilian, K Kerr, C Lawrence, D S Celermaje. Myocarditis and cardiomyopathy associated with clozapine. Lancet (London, England). vol 354. issue 9193. 2000-02-29. PMID:10584719. |
clozapine is effective for resistant schizophrenia. |
2000-02-29 |
2023-08-12 |
Not clear |
| E Spina, A Avenoso, G Facciolà, M G Scordo, M Ancione, A G Madia, A Ventimiglia, E Perucc. Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663421. |
relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics. |
2000-02-25 |
2023-08-12 |
Not clear |
| S Oerther, S Ahleniu. Atypical antipsychotics and dopamine D(1) receptor agonism: an in vivo experimental study using core temperature measurements in the rat. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640312. |
it is suggested that stimulation of da d(1) receptors, presumably in the prefrontal cortex, is a distinguishing feature of clozapine responsible for its favorable profile on cognitive functioning in schizophrenia. |
2000-02-22 |
2023-08-12 |
rat |
| K S Earnst, S F Taylor, I C Smet, R S Goldman, R Tandon, S Beren. The effects of typical antipsychotics, clozapine, and risperidone on neuropsychological test performance in schizophrenia. Schizophrenia research. vol 40. issue 3. 2000-02-18. PMID:10638864. |
the effects of typical antipsychotics, clozapine, and risperidone on neuropsychological test performance in schizophrenia. |
2000-02-18 |
2023-08-12 |
Not clear |
| P Tibbo, K Gendeman. Improvement of obsessions and compulsions with clozapine in an individual with schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 44. issue 10. 2000-02-15. PMID:10637686. |
improvement of obsessions and compulsions with clozapine in an individual with schizophrenia. |
2000-02-15 |
2023-08-12 |
Not clear |
| B Buur-Rasmussen, K Brøse. Cytochrome P450 and therapeutic drug monitoring with respect to clozapine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 6. 2000-02-08. PMID:10625111. |
clozapine is an atypical antipsychotic drug that is mainly used for the treatment of refractory schizophrenia. |
2000-02-08 |
2023-08-12 |
Not clear |
| M Markianos, J Hatzimanolis, L Lykoura. Switch from neuroleptics to clozapine does not influence pituitary-gonadal axis hormone levels in male schizophrenic patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 6. 2000-02-08. PMID:10625122. |
we measured the plasma levels of testosterone (tst), lh, fsh, as well as of prolactin (prl) and cortisol (cort), in a group of male patients with schizophrenia during treatment with classical neuroleptics with no satisfactory therapeutic response (31 pts, age 30.3+/-8.5, range 18-50), and 6 weeks later, after switch to treatment with clozapine (clz) in doses from 100 to 600 mg daily (mean 328 mg). |
2000-02-08 |
2023-08-12 |
Not clear |
| G Gobbi, L Janir. Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647096. |
clozapine is an atypical antipsychotic drug active on both positive and negative symptoms of schizophrenia which has a unique serotonergic and dopaminergic profile. |
2000-02-02 |
2023-08-12 |
Not clear |
| M Velasco, A Luchsinge. Dopamine: pharmacologic and therapeutic aspects. American journal of therapeutics. vol 5. issue 1. 2000-01-31. PMID:10099036. |
clozapine is used for treating schizophrenia. |
2000-01-31 |
2023-08-12 |
Not clear |