| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S W Lewis, L Davies, P B Jones, T R E Barnes, R M Murray, R Kerwin, D Taylor, K P Hayhurst, A Markwick, H Lloyd, G Dun. Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment. Health technology assessment (Winchester, England). vol 10. issue 17. 2006-10-26. PMID:16707074. |
randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment. |
2006-10-26 |
2023-08-12 |
Not clear |
| Mohamed Sabaawi, Nirbhay N Singh, Jose de Leo. Guidelines for the use of clozapine in individuals with developmental disabilities. Research in developmental disabilities. vol 27. issue 3. 2006-10-25. PMID:16040229. |
we present a set of guidelines to ensure proper utilization of clozapine in individuals with developmental disabilities, because it can offer them therapeutic advantages similar to those observed in people with schizophrenia. |
2006-10-25 |
2023-08-12 |
Not clear |
| Mansour Razminia, Yasser Salem, Sivasubramaniam Devaki, Nilamben Shah, Sandeep Khosl. Clozapine induced myopericarditis: early recognition improves clinical outcome. American journal of therapeutics. vol 13. issue 3. 2006-10-19. PMID:16772769. |
clozapine is an atypical dibenzodiazepine antipsychotic used for resistant schizophrenia. |
2006-10-19 |
2023-08-12 |
Not clear |
| Narsimha R Pinninti, Catherine J Datt. Cognitive behavior therapy and clozapine synergy in an older adult with schizophrenia? The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 14. issue 8. 2006-10-13. PMID:16864560. |
cognitive behavior therapy and clozapine synergy in an older adult with schizophrenia? |
2006-10-13 |
2023-08-12 |
Not clear |
| L N Gorobets, L G Ermolaeva, A V Litvino. [Reproductive dysfunctions in female patients during therapy with atypical antipsychotics]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 106. issue 8. 2006-10-10. PMID:16972595. |
to specify interrelations between clinical and hormonal aspects of reproductive dysfunctions appearing during therapy with atypical antipsychotic agents (clozapine, olanzapine, quetiapine), 131 female patients with paranoid schizophrenia and schizoaffective disorder have been studied. |
2006-10-10 |
2023-08-12 |
Not clear |
| Christina Kurre Olsen, Mads Kreilgaard, Michael Didrikse. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16782180. |
concordantly, augmentation of the nmda receptor function by glycine-site agonists such as d-serine and d-cycloserine has been reported to improve negative symptoms and some cognitive deficits in schizophrenia patients when added to conventional antipsychotic treatment, although they appear less effective when combined with clozapine specifically. |
2006-10-05 |
2023-08-12 |
rat |
| Christina Kurre Olsen, Mads Kreilgaard, Michael Didrikse. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16782180. |
in contrast, administration of the ampakine cx-516 (which positively modulate the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptor) as an adjuvant to clozapine, has been shown to exert some beneficial action on the negative symptoms and cognitive deficits in schizophrenia. |
2006-10-05 |
2023-08-12 |
rat |
| Marc Ziegenbein, Iris T Callies. Clozapine and ziprasidone: a useful combination in patients with treatment-resistant schizophrenia. The Journal of neuropsychiatry and clinical neurosciences. vol 18. issue 2. 2006-09-28. PMID:16720806. |
clozapine and ziprasidone: a useful combination in patients with treatment-resistant schizophrenia. |
2006-09-28 |
2023-08-12 |
Not clear |
| Avril Pereira, Brian Dea. Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis. Biochemical pharmacology. vol 72. issue 6. 2006-09-26. PMID:16844094. |
clozapine, an atypical antipsychotic drug effective in treatment of refractory schizophrenia causes potentially life-threatening agranulocytosis. |
2006-09-26 |
2023-08-12 |
human |
| Philip J Tyson, Keith R Laws, Kenneth A Flowers, Agi Tyson, Ann M Mortime. Cognitive function and social abilities in patients with schizophrenia: relationship with atypical antipsychotics. Psychiatry and clinical neurosciences. vol 60. issue 4. 2006-09-20. PMID:16884450. |
comparisons were done for matched schizophrenia patients who were on antipsychotics with (i) an affinity for multiple receptors (olanzapine, clozapine, quetiapine) versus those that have preferential affinity for dopamine receptors (risperidone, amisulpride); and patients on medication with (ii) a high affinity for serotonin (5ht-2a) receptors (risperidone, olanzapine, clozapine) versus those with a low (or no) affinity for 5ht-2a receptors (quetiapine, amisulpride). |
2006-09-20 |
2023-08-12 |
Not clear |
| Ying-Qiang Xiang, Zhang-Jin Zhang, Yong-Zhen Weng, Yi-Min Zhai, Wen-Biao Li, Zhuo-Ji Cai, Qing-Rong Tan, Chuan-Yue Wan. Serum concentrations of clozapine and norclozapine in the prediction of relapse of patients with schizophrenia. Schizophrenia research. vol 83. issue 2-3. 2006-09-19. PMID:16524698. |
serum concentrations of clozapine and norclozapine in the prediction of relapse of patients with schizophrenia. |
2006-09-19 |
2023-08-12 |
human |
| Mei Huang, Zhu Li, Junji Ichikawa, Jin Dai, Herbert Y Meltze. Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex. Brain research. vol 1099. issue 1. 2006-09-19. PMID:16824491. |
previous studies have shown that atypical apds (e.g., clozapine) preferentially increases dopamine (da) and acetylcholine (ach) efflux in rat medial prefrontal cortex (mpfc) and hippocampus (hip), both of which have been suggested to contribute to their ability to improve cognition in patients with schizophrenia. |
2006-09-19 |
2023-08-12 |
rat |
| Alan I Gree. Treatment of schizophrenia and comorbid substance abuse: pharmacologic approaches. The Journal of clinical psychiatry. vol 67 Suppl 7. 2006-09-19. PMID:16961422. |
recent data suggest that the atypical antipsychotic clozapine and perhaps other atypical agents may lessen substance use in patients with schizophrenia. |
2006-09-19 |
2023-08-12 |
Not clear |
| Zhong Zhao, Hanna Ksiezak-Reding, Silvana Riggio, Vahram Haroutunian, Giulio M Pasinett. Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction. Schizophrenia research. vol 84. issue 1. 2006-09-08. PMID:16581231. |
in animal model, clozapine ameliorates irbeta deficits at the gsk-3 alpha/beta level, which may justify its role in treatment of schizophrenia. |
2006-09-08 |
2023-08-12 |
mouse |
| Rael D Strous, Marina Kupchik, Suzana Roitman, Sima Schwartz, Noach Gonen, Roberto Mester, Abraham Weizman, Baruch Spiva. Comparison between risperidone, olanzapine, and clozapine in the management of chronic schizophrenia: a naturalistic prospective 12-week observational study. Human psychopharmacology. vol 21. issue 4. 2006-08-31. PMID:16783815. |
comparison between risperidone, olanzapine, and clozapine in the management of chronic schizophrenia: a naturalistic prospective 12-week observational study. |
2006-08-31 |
2023-08-12 |
Not clear |
| Rael D Strous, Marina Kupchik, Suzana Roitman, Sima Schwartz, Noach Gonen, Roberto Mester, Abraham Weizman, Baruch Spiva. Comparison between risperidone, olanzapine, and clozapine in the management of chronic schizophrenia: a naturalistic prospective 12-week observational study. Human psychopharmacology. vol 21. issue 4. 2006-08-31. PMID:16783815. |
risperidone, olanzapine, and clozapine are three atypical antipsychotic medications commonly used in the management of chronic schizophrenia. |
2006-08-31 |
2023-08-12 |
Not clear |
| Rael D Strous, Marina Kupchik, Suzana Roitman, Sima Schwartz, Noach Gonen, Roberto Mester, Abraham Weizman, Baruch Spiva. Comparison between risperidone, olanzapine, and clozapine in the management of chronic schizophrenia: a naturalistic prospective 12-week observational study. Human psychopharmacology. vol 21. issue 4. 2006-08-31. PMID:16783815. |
one hundred thirty-one patients (76 m, 55 f) with dsmi-v schizophrenia or schizoaffective disorder were treated with risperidone (n = 38), olanzapine (n = 38), or clozapine (n = 55). |
2006-08-31 |
2023-08-12 |
Not clear |
| Stéphane Potvin, Emmanuel Stip, Olivier Lipp, Robert Elie, Adham Mancini-Marië, Marie-France Demers, Marc-André Roy, Roch-Hugo Bouchard, Alain Gendro. Quetiapine in patients with comorbid schizophrenia-spectrum and substance use disorders: an open-label trial. Current medical research and opinion. vol 22. issue 7. 2006-08-29. PMID:16834826. |
preliminary evidence suggests that clozapine relieves the craving for psychoactive substances in schizophrenia patients. |
2006-08-29 |
2023-08-12 |
Not clear |
| Soumitra Shankar Datta, Sudhir Kuma. Clozapine-responsive cluster headache. Neurology India. vol 54. issue 2. 2006-08-28. PMID:16804270. |
here we present a case of schizophrenia with comorbid headache treated with clozapine. |
2006-08-28 |
2023-08-12 |
Not clear |
| F M Theisen, S Gebhardt, T Brömel, B Otto, W Heldwein, M Heinzel-Gutenbrunner, J-C Krieg, H Remschmidt, M Tschöp, J Hebebran. A prospective study of serum ghrelin levels in patients treated with clozapine. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 10. 2006-08-18. PMID:15959857. |
we investigated serum ghrelin levels (sgl) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. |
2006-08-18 |
2023-08-12 |
Not clear |