| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Su, Danqi Yang, Yu Hu, Ying Yuan, Le Son. Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy. Open life sciences. vol 18. issue 1. 2023-07-24. PMID:37483428. |
the effect of berberine on the increase of muscle tissue, improving metabolic disorders, reducing the expression of inflammatory factors, and suppressing sarcopenia insulin resistance (ir) were reversed by sirt1/mitophagy inhibitors. |
2023-07-24 |
2023-08-14 |
mouse |
| Miles D Witham, Antoneta Granic, Ewan Pearson, Sian M Robinson, Avan A Saye. Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia - A Narrative Review. Drugs & aging. 2023-07-24. PMID:37486575. |
this review summarises shared pathophysiology between sarcopenia and diabetes mellitus, including the effects of advanced glycation end products, mitochondrial dysfunction, chronic inflammation and changes to the insulin signalling pathway. |
2023-07-24 |
2023-08-14 |
human |
| Maryam Taheri, Philip D Chilibeck, Stephen M Cornis. A Brief Narrative Review of the Underlying Mechanisms Whereby Omega-3 Fatty Acids May Influence Skeletal Muscle: From Cell Culture to Human Interventions. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447252. |
age-related reduction in skeletal muscle mass, strength, and function (i.e., sarcopenia) is a result of pathophysiological processes that include inflammation, alteration of molecular signaling for muscle protein synthesis and degradation, changes in insulin sensitivity, as well as altered skeletal muscle satellite cell activity. |
2023-07-14 |
2023-08-14 |
human |
| Sang Yoon Lee, Jaewon Beom, Jun Hwan Choi, Hak Chul Jang, EunYoung Kim, Keewon Kim, Miji Kim, Ga Yang Shim, Chang Won Won, Jae-Young Li. Effectiveness and clinical application of multidisciplinary combined exercise and nutrition intervention for sarcopenic older adults with metabolic syndrome: study protocol for a multicentre randomised controlled trial. BMJ open. vol 13. issue 7. 2023-07-14. PMID:37451728. |
insulin resistance may play a key role in the increased frequency of sarcopenia associated with metabolic disorders. |
2023-07-14 |
2023-08-14 |
Not clear |
| Milian Chen, Ying Cao, Guang Ji, Li Zhan. Lean nonalcoholic fatty liver disease and sarcopenia. Frontiers in endocrinology. vol 14. 2023-07-10. PMID:37424859. |
the pathological features of lean nafld such as visceral obesity, insulin resistance, and metabolic inflammation are inducers of sarcopenia, whereas loss of muscle mass and function further exacerbates ectopic fat accumulation and lean nafld. |
2023-07-10 |
2023-08-14 |
Not clear |
| Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wan. Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. Aging cell. 2023-07-05. PMID:37403750. |
the causal influence of sarcopenia on cardiometabolic disease and alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. |
2023-07-05 |
2023-08-14 |
human |
| Huiling Chen, Xiaojing Huang, Meiyuan Dong, Song Wen, Ligang Zhou, Xinlu Yua. The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 16. 2023-06-06. PMID:37275941. |
type 2 diabetes is characterized by insulin resistance, chronic inflammation, accumulation of advanced glycation products and increased oxidative stress, which can negatively affect skeletal muscle mass, strength and function leading to sarcopenia. |
2023-06-06 |
2023-08-14 |
Not clear |
| Kaixi Ding, Wei Jiang, Dingqi Li, Chaofang Lei, Chunping Xiong, Ming Le. Bibliometric analysis of geriatric sarcopenia therapies: Highlighting publication trends and leading-edge research directions. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. vol 26. issue 3. 2023-05-18. PMID:37201435. |
the newest hot subjects in the study about geriatric sarcopenia therapy include malnutrition, obesity, insulin resistance, and cancer. |
2023-05-18 |
2023-08-14 |
human |
| Ricardo Aparecido Baptista Nucci, Victor Abou Nehmi Filho, Wilson Jacob-Filho, José Pinhata Otoch, Ana Flávia Marçal Pesso. Role of Nutritional Supplements on Gut-Muscle Axis Across Age: a Mini-Review. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 57. issue 3. 2023-05-16. PMID:37190847. |
insulin resistance, hormonal changes, and impaired muscle satellite cell activation contribute to sarcopenia, and high levels of fat mass also play a role in the pathogenesis of sarcopenia. |
2023-05-16 |
2023-08-14 |
Not clear |
| Fuyuko Takahashi, Yoshitaka Hashimoto, Hiroshi Okada, Yuriko Kondo, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fuku. Dental care and oral conditions are associated with the prevalence of sarcopenia in people with type 2 diabetes: a cross-sectional study. BMC endocrine disorders. vol 23. issue 1. 2023-04-07. PMID:37029386. |
insulin resistance, which is closely associated with type 2 diabetes mellitus (t2dm), is a cause of sarcopenia and people with t2dm have a high risk of sarcopenia. |
2023-04-07 |
2023-08-14 |
Not clear |
| Ana Andres-Hernando, Christina Cicerchi, Gabriela E Garcia, David J Orlicky, Peter Stenvinkel, Richard J Johnson, Miguel A Lanasp. Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease. iScience. vol 26. issue 4. 2023-03-30. PMID:36994079. |
here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the muscle-specific isoform of amp deaminase, ampd1. |
2023-03-30 |
2023-08-14 |
mouse |
| Ana Andres-Hernando, Christina Cicerchi, Gabriela E Garcia, David J Orlicky, Peter Stenvinkel, Richard J Johnson, Miguel A Lanasp. Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease. iScience. vol 26. issue 4. 2023-03-30. PMID:36994079. |
our data provide molecular and metabolic evidence supporting the use of strategies aimed to improve insulin sensitivity and to block ampd1 to prevent sarcopenia in subjects with ckd. |
2023-03-30 |
2023-08-14 |
mouse |
| Zi-Jian Liu, Cui-Feng Zh. Causal relationship between insulin resistance and sarcopenia. Diabetology & metabolic syndrome. vol 15. issue 1. 2023-03-15. PMID:36918975. |
causal relationship between insulin resistance and sarcopenia. |
2023-03-15 |
2023-08-14 |
Not clear |
| Zi-Jian Liu, Cui-Feng Zh. Causal relationship between insulin resistance and sarcopenia. Diabetology & metabolic syndrome. vol 15. issue 1. 2023-03-15. PMID:36918975. |
several studies have shown that insulin resistance may be an important mechanism in the pathogenesis of induced muscle attenuation and that, conversely, sarcopenia can lead to insulin resistance. |
2023-03-15 |
2023-08-14 |
Not clear |
| Zi-Jian Liu, Cui-Feng Zh. Causal relationship between insulin resistance and sarcopenia. Diabetology & metabolic syndrome. vol 15. issue 1. 2023-03-15. PMID:36918975. |
in this paper, the pathogenesis of sarcopenia is analyzed, the possible intrinsic causal relationship between sarcopenia and insulin resistance examined, and research progress expounded to provide a basis for the clinical diagnosis, treatment, and study of the mechanism of sarcopenia. |
2023-03-15 |
2023-08-14 |
Not clear |
| Alan J Sinclair, Ahmed H Abdelhafi. Metabolic Impact of Frailty Changes Diabetes Trajectory. Metabolites. vol 13. issue 2. 2023-02-25. PMID:36837914. |
this phenotype is characterised by increased insulin resistance and a synergistic increase in the cardiovascular risk more than that induced by obesity or sarcopenia alone. |
2023-02-25 |
2023-08-14 |
Not clear |
| Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Satoru Saito, Atsushi Nakajima, Masato Yoned. Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease. Nutrients. vol 15. issue 4. 2023-02-25. PMID:36839249. |
in nafld, sarcopenia is closely associated with insulin resistance and results from the atrophy of skeletal muscle, an insulin target organ. |
2023-02-25 |
2023-08-14 |
Not clear |
| Lina Sun, Junling Fu, Zhijing Mu, Xiaoye Duan, Piu Chan, Shuangling Xi. Association between body fat and sarcopenia in older adults with type 2 diabetes mellitus: A cross-sectional study. Frontiers in endocrinology. vol 14. 2023-02-13. PMID:36777353. |
to investigate the association between body fat (bf%) and sarcopenia in older adults with type 2 diabetes mellitus (t2dm) and potential link with increased levels of inflammatory indicators and insulin resistance. |
2023-02-13 |
2023-08-14 |
Not clear |
| Michael S Sagmeister, Lorraine Harper, Rowan S Hard. Cortisol excess in chronic kidney disease - A review of changes and impact on mortality. Frontiers in endocrinology. vol 13. 2023-02-03. PMID:36733794. |
ckd is common and associated with a wide array of complications including higher mortality, cardiovascular disease, hypertension, insulin resistance, dyslipidemia, sarcopenia, osteoporosis, aberrant immune function, cognitive impairment, mood disturbances and poor sleep quality. |
2023-02-03 |
2023-08-14 |
Not clear |
| Neoma T Boardman, Giulia Trani, Marco Scalabrin, Vanina Romanello, Rob C I Wüs. Intra-cellular to inter-organ mitochondrial communication in striated muscle in health and disease. Endocrine reviews. 2023-02-01. PMID:36725366. |
impaired mitochondrial function and communication are central in common heart and skeletal muscle pathologies, including cardiomyopathies, insulin resistance, and sarcopenia. |
2023-02-01 |
2023-08-14 |
Not clear |