| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Kyle, Pradip K Saha, Hannah M Brown, Lawrence C Chan, Monica J Justic. MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Human molecular genetics. vol 25. issue 14. 2017-07-20. PMID:27288453. |
rett syndrome (rtt; omim 312750), a progressive neurological disorder, is caused by mutations in methyl-cpg-binding protein 2 (mecp2; omim 300005), a ubiquitously expressed factor. |
2017-07-20 |
2023-08-13 |
mouse |
| Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, Weizhi Ji, Yi Eve Su. Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys. Cell. vol 169. issue 5. 2017-07-11. PMID:28525759. |
modeling rett syndrome using talen-edited mecp2 mutant cynomolgus monkeys. |
2017-07-11 |
2023-08-13 |
human |
| Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, Weizhi Ji, Yi Eve Su. Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys. Cell. vol 169. issue 5. 2017-07-11. PMID:28525759. |
here, we report detailed genotypes and phenotypes of talen-edited mecp2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, rett syndrome (rtt), which is caused by loss-of-function mutations in the human mecp2 gene. |
2017-07-11 |
2023-08-13 |
human |
| Hui Lu, Ryan T Ash, Lingjie He, Sara E Kee, Wei Wang, Dinghui Yu, Shuang Hao, Xiangling Meng, Kerstin Ure, Aya Ito-Ishida, Bin Tang, Yaling Sun, Daoyun Ji, Jianrong Tang, Benjamin R Arenkiel, Stelios M Smirnakis, Huda Y Zoghb. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. vol 91. issue 4. 2017-07-10. PMID:27499081. |
loss and gain of mecp2 cause similar hippocampal circuit dysfunction that is rescued by deep brain stimulation in a rett syndrome mouse model. |
2017-07-10 |
2023-08-13 |
mouse |
| Francesco Strati, Duccio Cavalieri, Davide Albanese, Claudio De Felice, Claudio Donati, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Massimo Pindo, Daniela Renzi, Lisa Rizzetto, Irene Stefanini, Antonio Calabrò, Carlotta De Filipp. Altered gut microbiota in Rett syndrome. Microbiome. vol 4. issue 1. 2017-07-05. PMID:27473171. |
rett syndrome (rtt), a progressive neurological disorder mainly caused by mutations in mecp2 gene, is commonly associated with gastrointestinal dysfunctions and constipation, suggesting a link between rtt's gastrointestinal abnormalities and the gut microbiota. |
2017-07-05 |
2023-08-13 |
human |
| Z Lim, J Downs, K Wong, C Ellaway, H Leonar. Expanding the clinical picture of the MECP2 Duplication syndrome. Clinical genetics. vol 91. issue 4. 2017-06-30. PMID:27247049. |
the international rett syndrome phenotype database (interrett), which collects information from caregivers and clinicians on individuals with rett syndrome and mecp2 associated disorders, was used as the data source. |
2017-06-30 |
2023-08-13 |
mouse |
| Christopher S Ward, Teng-Wei Huang, José A Herrera, Rodney C Samaco, Meagan R Pitcher, Alan Herron, Steven A Skinner, Walter E Kaufmann, Daniel G Glaze, Alan K Percy, Jeffrey L Neu. Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome. PloS one. vol 11. issue 11. 2017-06-30. PMID:27828991. |
loss of mecp2 causes urological dysfunction and contributes to death by kidney failure in mouse models of rett syndrome. |
2017-06-30 |
2023-08-13 |
mouse |
| Wei Zhai, Hong-xiu Hu, Liang Le, Feng-feng Zhuang, Ke-zhu Wang, Ying Zhao, Kai Wang, Xin-min Liu, Di’an Sun, Xiao-ying Wang, Shi-huan Kuang, Ke-ping H. Generation and analysis of the Rett syndrome-associated MeCP2- null rat model. Yi chuan = Hereditas. vol 38. issue 11. 2017-06-27. PMID:27867150. |
mecp2 mutations are associated with the rett syndrome (rtt). |
2017-06-27 |
2023-08-13 |
mouse |
| Teng-Wei Huang, Mikhail Y Kochukov, Christopher S Ward, Jonathan Merritt, Kaitlin Thomas, Tiffani Nguyen, Benjamin R Arenkiel, Jeffrey L Neu. Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194336. |
rett syndrome (rtt) is a neurodevelopmental disorder caused by mutations in methyl-cpg-binding protein 2 (mecp2). |
2017-06-26 |
2023-08-13 |
mouse |
| Ye Yang, Tugba G Kucukkal, Jing Li, Emil Alexov, Weiguo Ca. Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations. ACS chemical biology. vol 11. issue 10. 2017-06-22. PMID:27356039. |
binding analysis of methyl-cpg binding domain of mecp2 and rett syndrome mutations. |
2017-06-22 |
2023-08-13 |
Not clear |
| Mario Lucariello, Enrique Vidal, Silvia Vidal, Mauricio Saez, Laura Roa, Dori Huertas, Mercè Pineda, Esther Dalfó, Joaquin Dopazo, Paola Jurado, Judith Armstrong, Manel Estelle. Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype. Human genetics. vol 135. issue 12. 2017-06-22. PMID:27541642. |
classical rett syndrome (rtt) is a neurodevelopmental disorder where most of cases carry mecp2 mutations. |
2017-06-22 |
2023-08-13 |
caenorhabditis_elegans |
| Sabine Lagger, John C Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C Sowers, Malcolm D Walkinshaw, Adrian Bir. MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain. PLoS genetics. vol 13. issue 5. 2017-06-15. PMID:28498846. |
mutations in the gene encoding the methyl-cg binding protein mecp2 cause several neurological disorders including rett syndrome. |
2017-06-15 |
2023-08-13 |
mouse |
| Kelsey C Patterson, Virginia E Hawkins, Kara M Arps, Daniel K Mulkey, Michelle L Olse. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Human molecular genetics. vol 25. issue 15. 2017-06-12. PMID:27329765. |
since the identification of mecp2 as the causative gene in the majority of rett syndrome (rtt) cases, transgenic mouse models have played a critical role in our understanding of this disease. |
2017-06-12 |
2023-08-13 |
mouse |
| Surabi Veeraragavan, Ying-Wooi Wan, Daniel R Connolly, Shannon M Hamilton, Christopher S Ward, Sirena Soriano, Meagan R Pitcher, Christopher M McGraw, Sharon G Huang, Jennie R Green, Lisa A Yuva, Agnes J Liang, Jeffrey L Neul, Dag H Yasui, Janine M LaSalle, Zhandong Liu, Richard Paylor, Rodney C Samac. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Human molecular genetics. vol 25. issue 15. 2017-06-12. PMID:27365498. |
loss of mecp2 in the rat models regression, impaired sociability and transcriptional deficits of rett syndrome. |
2017-06-12 |
2023-08-13 |
mouse |
| Surabi Veeraragavan, Ying-Wooi Wan, Daniel R Connolly, Shannon M Hamilton, Christopher S Ward, Sirena Soriano, Meagan R Pitcher, Christopher M McGraw, Sharon G Huang, Jennie R Green, Lisa A Yuva, Agnes J Liang, Jeffrey L Neul, Dag H Yasui, Janine M LaSalle, Zhandong Liu, Richard Paylor, Rodney C Samac. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Human molecular genetics. vol 25. issue 15. 2017-06-12. PMID:27365498. |
mouse models of the transcriptional modulator methyl-cpg-binding protein 2 (mecp2) have advanced our understanding of rett syndrome (rtt). |
2017-06-12 |
2023-08-13 |
mouse |
| Yunjia Zhang, Mengmeng Chen, Zilong Qiu, Keping Hu, Warren McGee, Xiaoping Chen, Jianghong Liu, Li Zhu, Jane Y W. MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2. Protein & cell. vol 7. issue 7. 2017-06-05. PMID:27245166. |
both loss-of-function and gain-of-function mutations in the mecp2 gene lead to neurodevelopmental disorders such as rett syndrome, autism and mecp2 duplication syndrome. |
2017-06-05 |
2023-08-13 |
Not clear |
| Christopher M Johnson, Weiwei Zhong, Ningren Cui, Yang Wu, Hao Xing, Shuang Zhang, Chun Jian. Defects in brainstem neurons associated with breathing and motor function in the Mecp2R168X/Y mouse model of Rett syndrome. American journal of physiology. Cell physiology. vol 311. issue 6. 2017-06-05. PMID:27653984. |
rett syndrome (rtt) is an x-linked neurodevelopmental disorder caused mostly by disruption of the mecp2 gene. |
2017-06-05 |
2023-08-13 |
mouse |
| Annie Vogel Ciernia, Janine LaSall. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nature reviews. Neuroscience. vol 17. issue 7. 2017-05-25. PMID:27150399. |
increasing evidence points to a complex interplay between genes and the environment in autism spectrum disorder (asd), including rare de novo mutations in chromatin genes such as methyl-cpg binding protein 2 (mecp2) in rett syndrome. |
2017-05-25 |
2023-08-13 |
Not clear |
| Adam M Lopez, Jen-Chieh Chuang, Kenneth S Posey, Stephen D Turle. Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis. Brain research. vol 1654. issue Pt A. 2017-05-24. PMID:27789278. |
mutations in the x-linked gene methyl-cpg-binding protein 2 (mecp2) are the principal cause of rett syndrome, a progressive neurodevelopmental disorder afflicting 1 in 10,000 to 15,000 females. |
2017-05-24 |
2023-08-13 |
mouse |
| Dong Keon Yon, Ji Eun Park, Seung Jun Kim, Sung Han Shim, Kyu Young Cha. A sibship with duplication of Xq28 inherited from the mother; genomic characterization and clinical outcomes. BMC medical genetics. vol 18. issue 1. 2017-05-18. PMID:28302064. |
loss-of-function mutations in methyl-cpg-binding protein 2 (mecp2; mim *300005) results in the rett syndrome, whereas gain-of-function mutations are associated with the mecp2 duplication syndrome. |
2017-05-18 |
2023-08-13 |
Not clear |