| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomoko Andoh-Noda, Michiko O Inouye, Kunio Miyake, Takeo Kubota, Hideyuki Okano, Wado Akamats. Modeling Rett Syndrome Using Human Induced Pluripotent Stem Cells. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:27071793. |
rett syndrome (rtt) is one of a group of neurodevelopmental disorders typically characterized by deficits in the x-linked gene mecp2 (methyl-cpg binding protein 2). |
2017-10-04 |
2023-08-13 |
mouse |
| b' Alexia Mart\\xc3\\xadnez de Paz, Juan Ausi\\xc3\\xb. MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome. Advances in experimental medicine and biology. vol 978. 2017-09-27. PMID:28523538.' |
mecp2, a modulator of neuronal chromatin organization involved in rett syndrome. |
2017-09-27 |
2023-08-13 |
Not clear |
| b' Alexia Mart\\xc3\\xadnez de Paz, Juan Ausi\\xc3\\xb. MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome. Advances in experimental medicine and biology. vol 978. 2017-09-27. PMID:28523538.' |
mecp2 mutations alter its chromatin-binding dynamics and/or impair the ability of the protein to interact with some of its partners, resulting in rett syndrome (rtt). |
2017-09-27 |
2023-08-13 |
Not clear |
| Aida Obiols-Guardia, Sònia Gui. The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome. Advances in experimental medicine and biology. vol 978. 2017-09-27. PMID:28523539. |
rett syndrome is a neurodevelopmental disorder characterized by loss of function mutations in the x-linked gene encoding for methyl-cpg-binding protein 2 (mecp2). |
2017-09-27 |
2023-08-13 |
human |
| Jenny Downs, David Forbes, Michael Johnson, Helen Leonar. How can clinical ethics guide the management of comorbidities in the child with Rett syndrome? Journal of paediatrics and child health. vol 52. issue 8. 2017-09-20. PMID:27243819. |
rett syndrome is a rare disorder caused by a mutation in the mecp2 gene. |
2017-09-20 |
2023-08-13 |
Not clear |
| Janaina S de Souza, Cassiano Carromeu, Laila B Torres, Bruno H S Araujo, Fernanda R Cugola, Rui M B Maciel, Alysson R Muotri, Gisele Giannocc. IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3. Human molecular genetics. vol 26. issue 2. 2017-09-20. PMID:28007906. |
rett syndrome (rtt) is an x-linked neurodevelopmental disorder in which the mecp2 (methyl cpg-binding protein 2) gene is mutated. |
2017-09-20 |
2023-08-13 |
human |
| Janine M Lamonica, Deborah Y Kwon, Darren Goffin, Polina Fenik, Brian S Johnson, Yue Cui, Hengyi Guo, Sigrid Veasey, Zhaolan Zho. Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes. The Journal of clinical investigation. vol 127. issue 5. 2017-09-11. PMID:28394263. |
mutations in the x-linked gene encoding methyl-cpg-binding protein 2 (mecp2) cause rett syndrome (rtt), a neurological disorder affecting cognitive development, respiration, and motor function. |
2017-09-11 |
2023-08-13 |
mouse |
| Peijie Lin, Laura Nicholls, Hassan Assareh, Zhiming Fang, Timothy G Amos, Richard J Edwards, Amelia A Assareh, Irina Voineag. Transcriptome analysis of human brain tissue identifies reduced expression of complement complex C1Q Genes in Rett syndrome. BMC genomics. vol 17. 2017-09-01. PMID:27267200. |
mecp2, the gene mutated in the majority of rett syndrome cases, is a transcriptional regulator that can activate or repress transcription. |
2017-09-01 |
2023-08-13 |
mouse |
| Jifang Tao, Hao Wu, Amanda A Coronado, Elizabeth de Laittre, Emily K Osterweil, Yi Zhang, Mark F Bea. Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 47. 2017-08-18. PMID:27881780. |
rett syndrome (rtt) is caused by mutations in the gene encoding methyl-cpg binding protein 2 (mecp2), an epigenetic regulator of mrna transcription. |
2017-08-18 |
2023-08-13 |
mouse |
| Fang Du, Minh Vu Chuong Nguyen, Ariel Karten, Christy A Felice, Gail Mandel, Nurit Balla. Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation. Human molecular genetics. vol 25. issue 9. 2017-08-17. PMID:26908602. |
germline mutations in the x-linked gene, methyl-cpg-binding protein 2 (mecp2), underlie most cases of rett syndrome (rtt), an autism spectrum disorder affecting approximately one in 10 000 female live births. |
2017-08-17 |
2023-08-13 |
mouse |
| J David Sweatt, Carol A Tamming. An epigenomics approach to individual differences and its translation to neuropsychiatric conditions. Dialogues in clinical neuroscience. vol 18. issue 3. 2017-08-15. PMID:27757063. |
these two disorders provide an interesting compare-and-contrast example regarding possible epigenotypic regulation of behavior: whereas rett syndrome is clearly established as being caused by disruption of the function of an epigenetic "reader" of the dna cytosine methylome-methyl-cpg-binding protein 2 (mecp2)-the case for a role for epigenetic mechanisms in schizophrenia is still quite speculative. |
2017-08-15 |
2023-08-13 |
Not clear |
| Somnath Pandey, Kevin Pruit. Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 95. issue 3. 2017-08-15. PMID:28177766. |
functional assessment of mecp2 in rett syndrome and cancers of breast, colon, and prostate. |
2017-08-15 |
2023-08-13 |
Not clear |
| Somnath Pandey, Kevin Pruit. Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 95. issue 3. 2017-08-15. PMID:28177766. |
ever since the first report that mutations in methyl-cpg-binding protein 2 (mecp2) causes rett syndrome (rtt), a severe neurological disorder in females world-wide, there has been a keen interest to gain a comprehensive understanding of this protein. |
2017-08-15 |
2023-08-13 |
Not clear |
| Yochai Wolf, Sigalit Boura-Halfon, Nina Cortese, Zhana Haimon, Hadas Sar Shalom, Yael Kuperman, Vyacheslav Kalchenko, Alexander Brandis, Eyal David, Yifat Segal-Hayoun, Louise Chappell-Maor, Avraham Yaron, Steffen Jun. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nature immunology. vol 18. issue 6. 2017-08-15. PMID:28459435. |
mice that lacked the gene encoding mecp2, which is associated with rett syndrome, in macrophages did not show signs of neurodevelopmental disorder but displayed spontaneous obesity, which was linked to impaired function of brown adipose tissue (bat). |
2017-08-15 |
2023-08-13 |
mouse |
| Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin, Li-Huei Tsa. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nature neuroscience. vol 19. issue 11. 2017-08-10. PMID:27428650. |
mutations in mecp2 cause the neurodevelopmental disorder rett syndrome (rtt). |
2017-08-10 |
2023-08-13 |
Not clear |
| Melissa Mahgoub, Megumi Adachi, Kanzo Suzuki, Xihui Liu, Ege T Kavalali, Maria H Chahrour, Lisa M Monteggi. MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors. Nature neuroscience. vol 19. issue 11. 2017-08-10. PMID:27668390. |
moreover, hdac1- and hdac2-dependent regulation of sapap3 expression requires mecp2, the gene involved in the pathophysiology of rett syndrome. |
2017-08-10 |
2023-08-13 |
mouse |
| Ruth R Shah, Adrian P Bir. MeCP2 mutations: progress towards understanding and treating Rett syndrome. Genome medicine. vol 9. issue 1. 2017-08-07. PMID:28212680. |
mecp2 mutations: progress towards understanding and treating rett syndrome. |
2017-08-07 |
2023-08-13 |
Not clear |
| Ruth R Shah, Adrian P Bir. MeCP2 mutations: progress towards understanding and treating Rett syndrome. Genome medicine. vol 9. issue 1. 2017-08-07. PMID:28212680. |
rett syndrome is a profound neurological disorder caused by mutations in the mecp2 gene, but preclinical research has indicated that it is potentially treatable. |
2017-08-07 |
2023-08-13 |
Not clear |
| Alison A Williams, Vera J Mehler, Christina Mueller, Fernando Vonhoff, Robin White, Carsten Duc. Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations. PloS one. vol 11. issue 7. 2017-07-31. PMID:27442528. |
mutations causing rett syndrome and related neurodevelopmental disorders have been identified along the entire mecp2 locus, but symptoms vary depending on mutation type and location. |
2017-07-31 |
2023-08-13 |
human |
| Tommaso Patriarchi, Sonia Amabile, Elisa Frullanti, Elisa Landucci, Caterina Lo Rizzo, Francesca Ariani, Mario Costa, Francesco Olimpico, Johannes W Hell, Flora M Vaccarino, Alessandra Renieri, Ilaria Melon. Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. European journal of human genetics : EJHG. vol 24. issue 6. 2017-07-26. PMID:26443267. |
rett syndrome (rtt) is a severe neurodevelopmental disorder associated with mutations in either mecp2, cdkl5 or foxg1. |
2017-07-26 |
2023-08-13 |
mouse |