| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaaki Sasaoka, Katsuki Nakamura, Masamitsu Shimazawa, Yasushi Ito, Makoto Araie, Hideaki Har. Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Experimental eye research. vol 86. issue 5. 2008-09-15. PMID:18378230. |
from these results, we suggest that glaucoma may lead to changes in glial function not only in the retina, but also in the visual pathway, and that such central nervous system changes may be a hallmark of neuropathy in glaucoma, as in other neurodegenerative diseases. |
2008-09-15 |
2023-08-12 |
monkey |
| M Fernanda Insua, M Victoria Simón, Andrés Garelli, Beatriz de Los Santos, Nora P Rotstein, Luis E Polit. Trophic factors and neuronal interactions regulate the cell cycle and Pax6 expression in Müller stem cells. Journal of neuroscience research. vol 86. issue 7. 2008-07-08. PMID:18189319. |
the finding that müller cells have stem cell properties in the retina has led to the hypothesis that they might be a source for replacing neurons lost in neurodegenerative diseases. |
2008-07-08 |
2023-08-12 |
rat |
| M Joe Phillips, Tiffany A Walker, Hee-Young Choi, Amanda E Faulkner, Moon K Kim, Sheree S Sidney, Amber P Boyd, John M Nickerson, Jeffrey H Boatright, Machelle T Pardu. Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. Investigative ophthalmology & visual science. vol 49. issue 5. 2008-06-09. PMID:18436848. |
recently, the bile acid tauroursodeoxycholic acid (tudca) has been shown to have antiapoptotic properties in neurodegenerative diseases, including those of the retina. |
2008-06-09 |
2023-08-12 |
mouse |
| Christian Schmeer, Alexandra Kretz, Stefan Isenman. Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors for the treatment of retinal and eye diseases. CNS & neurological disorders drug targets. vol 6. issue 4. 2007-10-29. PMID:17691985. |
many neurodegenerative diseases particularly affect the retina and other ocular structures and are the cause for blindness. |
2007-10-29 |
2023-08-12 |
Not clear |
| J García-Campos, A Villena, F Díaz, L Vidal, M Moreno, I Pérez de Varga. Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs. Histology and histopathology. vol 22. issue 12. 2007-09-14. PMID:17701920. |
glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. |
2007-09-14 |
2023-08-12 |
rat |
| D M Inman, P J Horne. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. vol 55. issue 9. 2007-07-25. PMID:17457855. |
these data show that, in contrast to gliosis in other cns trauma and neurodegenerative diseases, glaucomatous changes in retina do not include substantive cell proliferation. |
2007-07-25 |
2023-08-12 |
mouse |
| Ulkan Kilic, Ertugrul Kilic, Anne Järve, Zeyun Guo, Annett Spudich, Katja Bieber, Uxue Barzena, Claudio L Bassetti, Hugo H Marti, Dirk M Herman. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 48. 2006-12-21. PMID:17135405. |
in view that axotomy-induced rgc death occurs slowly and considering that rgcs are cns-derived neurons, we predict the clinical implementation of vegf in neurodegenerative diseases of both brain and retina. |
2006-12-21 |
2023-08-12 |
mouse |
| Cassandra L Schlamp, Yan Li, Joel A Dietz, Katherine T Janssen, Robert W Nickell. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC neuroscience. vol 7. 2006-11-14. PMID:17018142. |
glaucoma is a chronic neurodegenerative disease of the retina, characterized by the degeneration of axons in the optic nerve and retinal ganglion cell apoptosis. |
2006-11-14 |
2023-08-12 |
mouse |
| Olga Lorena German, María Fernanda Insua, Claudia Gentili, Nora P Rotstein, Luis E Polit. Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. Journal of neurochemistry. vol 98. issue 5. 2006-10-03. PMID:16923163. |
identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. |
2006-10-03 |
2023-08-12 |
Not clear |
| Xian Zhang, Dirk Jones, F Gonzalez-Lim. Neurodegeneration produced by rotenone in the mouse retina: a potential model to investigate environmental pesticide contributions to neurodegenerative diseases. Journal of toxicology and environmental health. Part A. vol 69. issue 18. 2006-08-16. PMID:16864419. |
neurodegeneration produced by rotenone in the mouse retina: a potential model to investigate environmental pesticide contributions to neurodegenerative diseases. |
2006-08-16 |
2023-08-12 |
mouse |
| Anna-Lena Ström, Lars Forsgren, Monica Holmber. A role for both wild-type and expanded ataxin-7 in transcriptional regulation. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:15936949. |
spinocerebellar ataxia type 7 (sca7) is a neurodegenerative disease primarily affecting the brainstem, retina and purkinje cells of the cerebellum. |
2006-03-09 |
2023-08-12 |
Not clear |
| Anna-Lena Ström, Lars Forsgren, Monica Holmber. Identification and characterization of Spinocerebellar Ataxia Type 7 (SCA7) isoform SCA7b in mice. Biochimica et biophysica acta. vol 1731. issue 3. 2006-02-03. PMID:16297465. |
spinocerebellar ataxia type 7 (sca7) is a neurodegenerative disease primarily affecting the cerebellum, brainstem and retina. |
2006-02-03 |
2023-08-12 |
mouse |
| G Malek, L V Johnson, B E Mace, P Saloupis, D E Schmechel, D W Rickman, C A Toth, P M Sullivan, C Bowes Rickma. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 33. 2005-10-25. PMID:16079201. |
age-related macular degeneration (amd) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the western world. |
2005-10-25 |
2023-08-12 |
mouse |
| Ai Ling Wang, Albert C H Yu, Lok Ting Lau, Chong Lee, Le Meng Wu, Xiu'An Zhu, Mark O M Ts. Minocycline inhibits LPS-induced retinal microglia activation. Neurochemistry international. vol 47. issue 1-2. 2005-09-01. PMID:15904993. |
retinal neurodegenerative disease involves an inflammatory response in the retina characterized by an increase in inflammatory cytokines and activation of microglia. |
2005-09-01 |
2023-08-12 |
Not clear |
| Srimoyee Ghosh, Mel B Fean. Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Human molecular genetics. vol 13. issue 18. 2005-03-15. PMID:15254017. |
cell-type specificity is a salient feature of all neurodegenerative diseases; however, most work to date in the drosophila models have been performed in the retina. |
2005-03-15 |
2023-08-12 |
human |
| P Guarneri, C Cascio, D Russo, S D'Agostino, G Drago, G Galizzi, G De Leo, F Piccoli, M Guarneri, R Guarner. Neurosteroids in the retina: neurodegenerative and neuroprotective agents in retinal degeneration. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993046. |
recent research has revealed that steroids may influence the onset and progression of some retinal disorders as well as neurodegenerative diseases and, as in brain, they accumulate in the retina via a local synthesis (neurosteroids) and metabolism of blood-circulating steroid hormones. |
2004-03-25 |
2023-08-12 |
Not clear |
| Ruth B Wheeler, Julie D Sharp, Roger A Schultz, John M Joslin, Ruth E Williams, Sara E Mol. The gene mutated in variant late-infantile neuronal ceroid lipofuscinosis (CLN6) and in nclf mutant mice encodes a novel predicted transmembrane protein. American journal of human genetics. vol 70. issue 2. 2002-02-26. PMID:11727201. |
the neuronal ceroid lipofuscinoses (ncls) are a group of autosomal recessive neurodegenerative diseases characterized by the accumulation of autofluorescent lipopigment in various tissues and by progressive cell death in the brain and retina. |
2002-02-26 |
2023-08-12 |
mouse |
| G Yvert, K S Lindenberg, S Picaud, G B Landwehrmeyer, J A Sahel, J L Mande. Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Human molecular genetics. vol 9. issue 17. 2000-12-22. PMID:11030754. |
among the eight progressive neurodegenerative diseases caused by polyglutamine expansions, spinocerebellar ataxia type 7 (sca7) is the only one to display degeneration in both brain and retina. |
2000-12-22 |
2023-08-12 |
mouse |
| S C Lane, R D Jolly, D E Schmechel, J Alroy, R M Boustan. Apoptosis as the mechanism of neurodegeneration in Batten's disease. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764595. |
this is the first inherited neurodegenerative disease involving brain and retina in which apoptosis has been established as the mechanism of neuronal and photoreceptor cell death in both humans and animal models. |
1996-09-19 |
2023-08-12 |
mouse |