| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Yang, Nikolas L Jorstad, Christine Shiao, Makenzie K Cherne, Shawn B Khademi, Kathleen S Montine, Thomas J Montine, C Dirk Keen. Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation. Experimental and molecular pathology. vol 95. issue 1. 2013-09-12. PMID:23567123. |
myeloablative (mya) bone marrow transplantation (bmt) results in robust engraftment of bmt-derived cells in the central nervous system (cns) and is neuroprotective in diverse experimental models of neurodegenerative diseases of the brain and retina. |
2013-09-12 |
2023-08-12 |
mouse |
| Katharina Kranz, François Paquet-Durand, Reto Weiler, Ulrike Janssen-Bienhold, Karin Dede. Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones. PloS one. vol 8. issue 2. 2013-08-23. PMID:23468924. |
retinitis pigmentosa (rp) relates to a group of hereditary neurodegenerative diseases of the retina. |
2013-08-23 |
2023-08-12 |
mouse |
| Mei Li, Douglas Yasumura, Aye Aye K Ma, Michael T Matthes, Haidong Yang, Gregory Nielson, Yong Huang, Francis C Szoka, Matthew M Lavail, Marc I Diamon. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PloS one. vol 8. issue 2. 2013-08-05. PMID:23409115. |
by targeting rock with a new inhibitor, and testing its effects in a novel in vivo model, these results validate the in vivo efficacy of a therapeutic candidate, and establish the feasibility of using the retina as a readout for cns function in models of neurodegenerative disease. |
2013-08-05 |
2023-08-12 |
mouse |
| Francesco Parmeggiani, Mario R Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D'Angelo, Paolo Perri, Paolo De Palma, Katia De Nadai, Adolfo Sebastian. Mechanism of inflammation in age-related macular degeneration. Mediators of inflammation. vol 2012. 2013-07-29. PMID:23209345. |
in the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as amd. |
2013-07-29 |
2023-08-12 |
human |
| Barbara Lorber, Alessandra Guidi, James W Fawcett, Keith R Marti. Activated retinal glia mediated axon regeneration in experimental glaucoma. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21867754. |
glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina. |
2012-07-23 |
2023-08-12 |
rat |
| Kirstan A Vessey, Erica L Fletche. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253851. |
the p2x7 receptor (p2x7-r) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. |
2012-05-29 |
2023-08-12 |
mouse |
| Xue Cai, James F McGinni. Oxidative stress: the achilles' heel of neurodegenerative diseases of the retina. Frontiers in bioscience (Landmark edition). vol 17. 2012-04-03. PMID:22201850. |
oxidative stress: the achilles' heel of neurodegenerative diseases of the retina. |
2012-04-03 |
2023-08-12 |
Not clear |
| Caroline Kizilyaprak, Danièle Spehner, Didier Devys, Patrick Schult. The linker histone H1C contributes to the SCA7 nuclear phenotype. Nucleus (Austin, Tex.). vol 2. issue 5. 2012-03-06. PMID:21970987. |
spinocerebellar ataxia type 7 (sca7) is a neurodegenerative disease caused by a polyglutamine expansion in ataxin-7, a subunit of the saga coactivator, which leads to progressive neuronal dysfunction and cell death in cerebellum, brainstem and retina. |
2012-03-06 |
2023-08-12 |
mouse |
| Béatrice Joussemet, Brahim Belbellaa, Alexandra Mendes-Madeira, Thomas Bucher, Delphine Briot-Nivard, Laurence Dubreil, Marie-Anne Colle, Yan Cherel, Philippe Moullier, Fabienne Rollin. Neonatal systemic delivery of scAAV9 in rodents and large animals results in gene transfer to RPE cells in the retina. Experimental eye research. vol 93. issue 4. 2012-01-16. PMID:21723863. |
the ability of scaav2/9 to transduce simultaneously neurons in the central nervous system, and rpe cells in the retina, after neonatal systemic delivery, makes this approach potentially interesting for the treatment of infantile neurodegenerative diseases characterized by both neuronal and retinal damages. |
2012-01-16 |
2023-08-12 |
rat |
| Meng Liu, James Duggan, Thomas E Salt, M Francesca Cordeir. Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions. Experimental eye research. vol 92. issue 4. 2011-05-13. PMID:21310146. |
there is increasing evidence that neuronal changes occur both in retina and central visual targets in glaucoma and other neurodegenerative diseases such as alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
2011-05-13 |
2023-08-12 |
Not clear |
| Ekaterina Posokhova, Hongman Song, Marycharmain Belcastro, LeeAnn Higgins, Lauren R Bigley, Norman A Michaud, Kirill A Martemyanov, Maxim Sokolo. Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival. Molecular & cellular proteomics : MCP. vol 10. issue 1. 2011-04-06. PMID:20852191. |
these data for the first time demonstrate that normal cct function is ultimately required for the morphogenesis and survival of sensory neurons of the retina, and suggest the chaperonin cct deficiency as a potential, yet unexplored, cause of neurodegenerative diseases. |
2011-04-06 |
2023-08-12 |
mouse |
| K-G Schmidt, H Bergert, R H W Fun. Neurodegenerative diseases of the retina and potential for protection and recovery. Current neuropharmacology. vol 6. issue 2. 2010-06-17. PMID:19305795. |
neurodegenerative diseases of the retina and potential for protection and recovery. |
2010-06-17 |
2023-08-12 |
Not clear |
| K-G Schmidt, H Bergert, R H W Fun. Neurodegenerative diseases of the retina and potential for protection and recovery. Current neuropharmacology. vol 6. issue 2. 2010-06-17. PMID:19305795. |
recent advances in our understanding of the mechanisms in the cascade of events resulting in retinal cell death in ocular pathologies like glaucoma, diabetic retinopathy and age-related macular degeneration led to the common descriptive term of neurodegenerative diseases of the retina. |
2010-06-17 |
2023-08-12 |
Not clear |
| Jennifer J Stanke, Andy J Fische. Embryonic retinal cells and support to mature retinal neurons. Investigative ophthalmology & visual science. vol 51. issue 4. 2010-04-26. PMID:19892872. |
therefore, embryonic retinal cells could be applied as a cell-based survival therapy to treat neurodegenerative diseases of the retina. |
2010-04-26 |
2023-08-12 |
chicken |
| Yasuhiro Sakai, Takayuki Tanaka, Masaaki Seki, Shinya Okuyama, Takeo Fukuchi, Kanato Yamagata, Nobuyuki Takei, Hiroyuki Nawa, Haruki Ab. Cyclooxygenase-2 plays a critical role in retinal ganglion cell death after transient ischemia: real-time monitoring of RGC survival using Thy-1-EGFP transgenic mice. Neuroscience research. vol 65. issue 4. 2010-01-08. PMID:19698752. |
inhibition of cox-2 activity may therefore be an effective therapy for neurodegenerative diseases of the retina and optic nerve. |
2010-01-08 |
2023-08-12 |
mouse |
| Nicolas G Baza. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins, leukotrienes, and essential fatty acids. vol 81. issue 2-3. 2009-11-23. PMID:19520558. |
overall, these results support the concept that npd1 promotes brain and retina cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress abeta42-induced neurotoxicity and other forms of cell injury, which in turn fosters homeostasis during development in aging, as well as during the initiation and progression of neurodegenerative diseases. |
2009-11-23 |
2023-08-12 |
human |
| Edwin M Ston. Progress toward effective treatments for human photoreceptor degenerations. Current opinion in genetics & development. vol 19. issue 3. 2009-09-25. PMID:19414246. |
the retina is a very favorable system for the development of novel treatments for neurodegenerative disease because of its optical and physical accessibility as well as its highly ordered structure. |
2009-09-25 |
2023-08-12 |
human |
| James S Friedman, Joseph W Ray, Naushin Waseem, Kory Johnson, Matthew J Brooks, Therése Hugosson, Debra Breuer, Kari E Branham, Daniel S Krauth, Sara J Bowne, Lori S Sullivan, Vesna Ponjavic, Lotta Gränse, Ritu Khanna, Edward H Trager, Linn M Gieser, Dianna Hughbanks-Wheaton, Radu I Cojocaru, Noor M Ghiasvand, Christina F Chakarova, Magnus Abrahamson, Harald H H Göring, Andrew R Webster, David G Birch, Goncalo R Abecasis, Yang Fann, Shomi S Bhattacharya, Stephen P Daiger, John R Heckenlively, Sten Andréasson, Anand Swaroo. Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa. American journal of human genetics. vol 84. issue 6. 2009-07-02. PMID:19520207. |
retinitis pigmentosa (rp) refers to a genetically heterogeneous group of progressive neurodegenerative diseases that result in dysfunction and/or death of rod and cone photoreceptors in the retina. |
2009-07-02 |
2023-08-12 |
Not clear |
| Weijuan Yao, Lanping Amy Sun. Specific expression of E-Tmod (Tmod1) in horizontal cells: implications in neuronal cell mechanics and glaucomatous retina. Molecular & cellular biomechanics : MCB. vol 6. issue 1. 2009-05-13. PMID:19382537. |
the specific e-tmod expression suggests its role in protecting hcs from mechanical damages in certain eye diseases, such as glaucoma, a neurodegenerative disease of the retina characterized by an elevated iop. |
2009-05-13 |
2023-08-12 |
mouse |
| Markus H Kuehn, Chan Y Kim, Bing Jiang, Alina V Dumitrescu, Young H Kwo. Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Experimental eye research. vol 87. issue 2. 2008-12-04. PMID:18572163. |
while complement deposition in the retina may simply serve to aid phagocytosis of damaged rgc, activation of the complement cascade can also contribute to neuronal loss in neurodegenerative diseases. |
2008-12-04 |
2023-08-12 |
mouse |