| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Valeria Valsecchi, Giovanna Lombardi, Serenella Anzilotti, Giorgia Andreozzi, Antonia Scognamiglio, Rosa Sparaco, Elisa Perissutti, Beatrice Severino, Michele Gargiulo, Vincenzo Santagada, Giuseppe Pignatar. Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice. ACS pharmacology & translational science. vol 7. issue 7. 2024-07-18. PMID:39022351. |
the debilitating neurodegenerative disease known as amyotrophic lateral sclerosis (als) is characterized by the progressive loss of motor neurons (mns) in the brain, spinal cord, and motor cortex. |
2024-07-18 |
2024-07-20 |
mouse |
| Diana Wiesner, Simone Feldengut, Sarah Woelfle, Tobias M Boeckers, Albert C Ludolph, Francesco Roselli, Kelly Del Tredic. Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia. Acta neuropathologica communications. vol 12. issue 1. 2024-06-29. PMID:38943180. |
neuropeptide ff (npff)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia. |
2024-06-29 |
2024-07-02 |
human |
| Cara Sophie Schreiber, Ivo Wiesweg, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Berfin Schaumburg, Gülsah Gabriel, Franziska Richter, Christopher Käufe. Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model. EBioMedicine. vol 105. 2024-06-12. PMID:38865747. |
we previously demonstrated neuroinflammation in the olfactory bulb of intranasally infected hamsters, followed by alpha-synuclein and tau accumulation in cortex, thus mirroring pathogenesis of neurodegenerative diseases such as parkinson's or alzheimer's disease. |
2024-06-12 |
2024-06-15 |
Not clear |
| Bu-Yeo Kim, Eunjin Sohn, Mee-Young Lee, Woo-Young Jeon, Kyuhyung Jo, Yu Jin Kim, Soo-Jin Jeon. Neurodegenerative pathways and metabolic changes in the hippocampus and cortex of mice exposed to urban particulate matter: Insights from an integrated interactome analysis. The Science of the total environment. 2024-06-05. PMID:38839008. |
additionally, the cortex of upm-exposed mice shows more similarities with psychiatric disorders than with neurodegenerative diseases. |
2024-06-05 |
2024-06-08 |
mouse |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. |
amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. |
2024-03-19 |
2024-03-21 |
human |
| Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. |
2024-03-13 |
2024-03-16 |
mouse |
| Aleksandra Opęchowska, Kacper Karpiuk, Andrii Zahorodnii, Ewa Harasim-Symbor, Adrian Chabowski, Karolina Konstantynowicz-Nowick. Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats. Toxicology and applied pharmacology. 2024-02-09. PMID:38336253. |
our results strongly suggest the ability of cbd to reduce the formation of lipid inflammation precursors in rat cerebral cortex, as a primary event in the development of neurodegenerative diseases. |
2024-02-09 |
2024-02-12 |
rat |
| Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B Relvas, Ana M Sebastião, Sandra H Va. Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1 Neurobiology of disease. 2024-02-09. PMID:38336279. |
communication defects with astroglia contribute to early impairments in the motor cortex plasticity of sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (m1). |
2024-02-09 |
2024-02-12 |
Not clear |
| Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D'Alessandr. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Frontiers in molecular neuroscience. vol 16. 2024-01-31. PMID:38292023. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. |
2024-01-31 |
2024-02-02 |
mouse |
| Jian Lu, An-Xu He, Zhuo-Ying Jin, Meng Zhang, Zhong-Xin Li, Fan Zhou, Lin Ma, Hong-Ming Jin, Jia-Ying Wang, Xu She. Desloratadine alleviates ALS-like pathology in hSOD1 Acta pharmacologica Sinica. 2024-01-29. PMID:38286832. |
desloratadine alleviates als-like pathology in hsod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. |
2024-01-29 |
2024-02-01 |
Not clear |
| Samuel Lundt, Nannan Zhang, Luis Polo-Parada, Xinglong Wang, Shinghua Din. Dietary NMN supplementation enhances motor and NMJ function in ALS. Experimental neurology. 2024-01-24. PMID:38266764. |
amyotrophic lateral sclerosis (als) is an adult-onset neurodegenerative disease that causes the degeneration of motor neurons in the motor cortex and spinal cord. |
2024-01-24 |
2024-01-27 |
Not clear |
| Mala R Ananth, John D Gardus, Chuan Huang, Nikhil Palekar, Mark Slifstein, Laszlo Zaborszky, Ramin V Parsey, David A Talmage, Christine DeLorenzo, Lorna W Rol. Loss of septal cholinergic input to lateral entorhinal cortex is an early indicator of cognitive impairment. Research square. 2024-01-23. PMID:38260541. |
we focus on the cholinergic innervation of the entorhinal cortex (ec), a region that is recognized to be susceptible early in aging and neurodegenerative disease. |
2024-01-23 |
2024-01-25 |
mouse |
| Rachel Waller, Joanna J Bury, Charlie Appleby-Mallinder, Matthew Wyles, George Loxley, Aditi Babel, Saleh Shekari, Mbombe Kazoka, Helen Wollff, Ammar Al-Chalabi, Paul R Heath, Pamela J Shaw, Janine Kirb. Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162899. |
amyotrophic lateral sclerosis is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the motor cortex, brainstem and spinal cord. |
2024-01-01 |
2024-01-05 |
Not clear |
| Justin L Bollinger, Matthew J Horchar, Eric S Wohle. Repeated activation of pyramidal neurons in the prefrontal cortex alters microglial phenotype in male mice. The Journal of pharmacology and experimental therapeutics. 2023-12-21. PMID:38129124. |
aberrant neuronal activity in the cortex alters microglia phenotype and function in several contexts, including chronic psychological stress and neurodegenerative disease. |
2023-12-21 |
2023-12-24 |
mouse |
| Shani Blumenreich, Doreen Padan Ben-Yashar, Tali Shalit, Meital Kupervaser, Ivan Milenkovic, Tammar Joseph, Anthony H Futerma. Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1. Journal of neurochemistry. 2023-12-10. PMID:38071490. |
one protein, transglutaminase 1 (tgm1), which is elevated in a number of neurodegenerative diseases, was absent from the control group but was found at high levels in cbe-injected mice, and located in the extracellular matrix (ecm) in layer v of the cortex and intracellularly in purkinje cells in the cerebellum. |
2023-12-10 |
2023-12-17 |
mouse |
| Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Li. RABGGTB plays a critical role in ALS pathogenesis. Brain research bulletin. 2023-12-02. PMID:38042502. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease. |
2023-12-02 |
2023-12-10 |
Not clear |
| Lijun Zhou, Wenzhi Chen, Shishi Jiang, Renshi X. In Vitro Models of Amyotrophic Lateral Sclerosis. Cellular and molecular neurobiology. 2023-10-23. PMID:37870685. |
amyotrophic lateral sclerosis (als) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. |
2023-10-23 |
2023-11-08 |
Not clear |
| Hilary Piercy, Charlotte Nuttin. The experiences of parents of children diagnosed with cerebral adrenoleukodystrophy. Child: care, health and development. 2023-10-18. PMID:37850425. |
adrenoleukodystrophy (ald) is a rare x-linked neurodegenerative disease, affecting the brain, spinal cord and adrenal cortex. |
2023-10-18 |
2023-11-08 |
Not clear |
| Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila, Erika Gyenges. Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum. Journal of neuroinflammation. vol 20. issue 1. 2023-10-14. PMID:37833764. |
the basal forebrain cholinergic neurons (bfcn) provide the primary source of cholinergic innervation of the human cerebral cortex and may be differentially vulnerable in various neurodegenerative diseases. |
2023-10-14 |
2023-10-15 |
mouse |