| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Oddone, Luca Rossetti, Mariacristina Parravano, Diego Sbardella, Massimo Coletta, Lucia Ziccardi, Gloria Roberti, Carmela Carnevale, Dario Romano, Gianluca Manni, Vincenzo Paris. Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review. Pharmaceuticals (Basel, Switzerland). vol 14. issue 3. 2021-04-13. PMID:33804675. |
the rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. |
2021-04-13 |
2023-08-13 |
Not clear |
| Peipei Mu, Yuting Liu, Shimin Jiang, Jin Gao, Shen Sun, Li Li, Dianshuai Ga. Glial cell line-derived neurotrophic factor alters lipid composition and protein distribution in MPP+-injured differentiated SH-SY5Y cells. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32356318. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and striatum. |
2021-04-06 |
2023-08-13 |
Not clear |
| Ka Young Kim, Keun-A Chan. Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-06. PMID:33440873. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. |
2021-04-06 |
2023-08-13 |
mouse |
| Hyunjun Park, Keun-A Chan. Therapeutic Potential of Repeated Intravenous Transplantation of Human Adipose-Derived Stem Cells in Subchronic MPTP-Induced Parkinson's Disease Mouse Model. International journal of molecular sciences. vol 21. issue 21. 2021-03-26. PMID:33143234. |
parkinson's disease (pd) is the second most common neurodegenerative disease, which is clinically and pathologically characterized by motor dysfunction and the loss of dopaminergic neurons in the substantia nigra, respectively. |
2021-03-26 |
2023-08-13 |
mouse |
| Zhihui Wan, Junxuan Xu, Yunpeng Huang, Yanhong Zhai, Zhijun Ma, Bing Zhou, Zheng Ca. Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster. Biochemical and biophysical research communications. vol 532. issue 2. 2021-03-18. PMID:32873392. |
parkinson's disease (pd) is the second most common progressive neurodegenerative disease, which is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2021-03-18 |
2023-08-13 |
drosophila_melanogaster |
| Sema Arisoy, Ozgun Sayiner, Tansel Comoglu, Deniz Onal, Ozbeyen Atalay, Bilge Pehlivanogl. Pharmaceutical development and technology. vol 25. issue 6. 2021-03-12. PMID:32141798. |
parkinson's disease (pd) is a neurodegenerative disease which is characterized by the loss of dopaminergic neurons in the brain. |
2021-03-12 |
2023-08-13 |
Not clear |
| Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zh. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in International journal of molecular medicine. vol 47. issue 4. 2021-03-10. PMID:33649797. |
mir‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-10 |
2023-08-13 |
Not clear |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Francesco Alviano, Michele Di Mauro, Angela Di Baldassarre, Barbara Ghinass. Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage. International journal of molecular sciences. vol 21. issue 18. 2021-03-05. PMID:32916865. |
degeneration of dopaminergic neurons represents the cause of many neurodegenerative diseases, with increasing incidence worldwide. |
2021-03-05 |
2023-08-13 |
human |
| Yunlong Zhang, Xingjun Meng, Zhigang Jiao, Yan Liu, Xiuping Zhang, Shaogang Q. Generation of a Novel Mouse Model of Parkinson's Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31909584. |
parkinson's disease (pd) is a common neurodegenerative disease that is characterized by pathological dopaminergic (da) neuronal death and α-synuclein aggregation. |
2021-03-03 |
2023-08-13 |
mouse |
| Damon Young, Michael Popiolek, Patrick Trapa, Kari R Fonseca, Julie Brevard, David L Gray, Rouba Koza. D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects. ACS chemical neuroscience. vol 11. issue 4. 2021-03-03. PMID:31971364. |
parkinson's disease is a progressive neurodegenerative disease characterized by striatal dopaminergic loss. |
2021-03-03 |
2023-08-13 |
Not clear |
| Ikuko Miyazaki, Masato Asanum. [Therapeutic strategy for Parkinson's disease: targeting zinc-binding protein in astrocytes]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 156. issue 2. 2021-03-02. PMID:33642534. |
parkinson's disease (pd) is a progressive neurodegenerative disease with motor symptoms, such as tremor, akinesia/bradykinesia, rigidity and postural instability due to a loss of nigrostriatal dopaminergic neurons; pd patients also exhibit non-motor symptoms, such as hyposmia, orthostatic hypotension and constipation, which precede motor symptoms. |
2021-03-02 |
2023-08-13 |
Not clear |
| Friederike Ostendorf, Judith Metzdorf, Ralf Gold, Aiden Haghikia, Lars Tönge. Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 25. issue 11. 2021-03-01. PMID:32481507. |
the pathological mechanisms triggered thereby change neuronal function in neurodegenerative diseases including dopaminergic neurons in parkinson´s disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Chiara Lenzi, Ileana Ramazzina, Isabella Russo, Alice Filippini, Saverio Bettuzzi, Federica Rizz. The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process. International journal of molecular sciences. vol 21. issue 19. 2021-03-01. PMID:33003328. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the presence of proteinaceous aggregates of αsynuclein (αsyn) in the dopaminergic neurons. |
2021-03-01 |
2023-08-13 |
Not clear |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Nagoor Meeran Mf, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33081327. |
parkinson's disease, the second common neurodegenerative disease is clinically characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) with upregulation of neuroinflammatory markers and oxidative stress. |
2021-02-25 |
2023-08-13 |
rat |
| Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chan. Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability. Cells. vol 9. issue 5. 2021-02-24. PMID:32429337. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective dopaminergic (daergic) neuronal degeneration in the substantia nigra (sn) and proteinaceous α-synuclein-positive lewy bodies and lewy neuritis. |
2021-02-24 |
2023-08-13 |
mouse |
| Yeonghoon Son, Ye Ji Jeong, Na-Rae Shin, Se Jong Oh, Kyung Rok Nam, Hyung-Do Choi, Jae Yong Choi, Hae-June Le. Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. International journal of molecular sciences. vol 21. issue 15. 2021-02-19. PMID:32756440. |
thus, our findings show that administering plx3397 to aged 5xfad mice could prevent amyloid pathology, concomitant with the rescue of dopaminergic signaling, suggesting that targeting microglia may serve as a useful therapeutic option for neurodegenerative diseases, including ad. |
2021-02-19 |
2023-08-13 |
mouse |
| Dominika Fričová, Jennifer A Korchak, Abba C Zubai. Challenges and translational considerations of mesenchymal stem/stromal cell therapy for Parkinson's disease. NPJ Regenerative medicine. vol 5. issue 1. 2021-02-13. PMID:33298940. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the presence of lewy bodies, which gives rise to motor and non-motor symptoms. |
2021-02-13 |
2023-08-13 |
Not clear |
| Akio Mori, Yuzuru Imai, Nobutaka Hattor. Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease. International journal of molecular sciences. vol 21. issue 9. 2021-02-10. PMID:32392751. |
parkinson's disease (pd) is the second most common neurodegenerative disease; it is characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of neuronal inclusions, mainly consisting of α-synuclein (α-syn) fibrils in the affected regions. |
2021-02-10 |
2023-08-13 |
Not clear |
| Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeon. Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. Stem cells international. vol 2021. 2021-02-10. PMID:33552161. |
pd is a chronic age-related neurodegenerative disease (ndd) characterized by loss of dopaminergic neurons in the substantia nigra (sn) and abnormal accumulation of |
2021-02-10 |
2023-08-13 |
human |
| Ying Chen, Jiabing Shen, Kaifu Ke, Xiaosu G. Clinical potential and current progress of mesenchymal stem cells for Parkinson's disease: a systematic review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 41. issue 5. 2021-02-08. PMID:31919699. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease characterized by severe dyskinesia due to a progressive loss of dopaminergic neurons along the nigro-striatal pathway. |
2021-02-08 |
2023-08-13 |
Not clear |