| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Forman, V M Lee, J Q Trojanowsk. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207421. |
the discovery of multiple tau gene mutations that are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 in many kindreds, as well as the demonstration that tau polymorphisms are genetic risk factors for sporadic tauopathies, directly implicate tau abnormalities in the onset/progression of neurodegenerative disease. |
2001-05-24 |
2023-08-12 |
Not clear |
| C X Gong, T Lidsky, J Wegiel, I Grundke-Iqbal, K Iqba. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain research. Brain research protocols. vol 6. issue 3. 2001-05-24. PMID:11223412. |
the abnormal hyperphosphorylation of microtubule-associated protein tau and its aggregation into neurofibrillary tangles in selective neurons is one of the major brain pathologies of alzheimer's disease and several other related neurodegenerative diseases. |
2001-05-24 |
2023-08-12 |
human |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
the discovery of mutations in the tau gene causing a distinct neurodegenerative disease in humans has firmly established the importance of the tau gene for neurodegenerative processes, not only in tauopathies but also in other degenerative disorders with tau pathology, such as corticobasal degeneration, supranuclear progressive paralysis, amyotropic lateral sclerosis, parkinsonism-dementia complex of guam, and alzheimer's disease. |
2001-05-03 |
2023-08-12 |
Not clear |
| G Esposito, P Viglino, M Novak, A Cattane. The solution structure of the C-terminal segment of tau protein. Journal of peptide science : an official publication of the European Peptide Society. vol 6. issue 11. 2001-04-26. PMID:11147714. |
pathological changes in the microtubule associated protein tau, leading to tau-containing filamentous lesions, are a major hallmark common to many types of human neurodegenerative diseases, including alzheimer's disease (ad). |
2001-04-26 |
2023-08-12 |
human |
| M L Garcia, D W Clevelan. Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Current opinion in cell biology. vol 13. issue 1. 2001-04-12. PMID:11163132. |
going new places using an old map: tau, microtubules and human neurodegenerative disease. |
2001-04-12 |
2023-08-12 |
human |
| S Hoye. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113614. |
this may indicate that the amyloid cascade hypothesis in not valid for sporadic alzheimer disease but that the formation of both, amyloidogenic derivatives and hyperphosphorylated tau protein is downstream the origin of this neurodegenerative disease. |
2001-03-29 |
2023-08-12 |
Not clear |
| N A Muma, J M Lee, L Gorman, B A Heidenreich, I Mitrovic, T C Napie. 6-hydroxydopamine-induced lesions of dopaminergic neurons alter the function of postsynaptic cholinergic neurons without changing cytoskeletal proteins. Experimental neurology. vol 168. issue 1. 2001-03-29. PMID:11170728. |
the neuropathological hallmarks of many neurodegenerative diseases are intraneuronal inclusions containing cytoskeletal proteins such as neurofilaments in lewy bodies in parkinson's disease and tau in neurofibrillary tangles in alzheimer's disease. |
2001-03-29 |
2023-08-12 |
rat |
| M Goedert, B Ghetti, M G Spillantin. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193179. |
filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2001-02-08 |
2023-08-12 |
human |
| B L Goode, M Chau, P E Denis, S C Feinstei. Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10984497. |
consistent with this hypothesis, regulatory mutations in the human tau gene that disrupt the normal balance between 3-repeat and 4-repeat tau isoform expression lead to a collection of neurodegenerative diseases known as ftdp-17 (fronto-temporal dementias and parkinsonism linked to chromosome 17), which are characterized by the formation of pathological tau filaments and neuronal cell death. |
2001-01-18 |
2023-08-12 |
human |
| B L Goode, M Chau, P E Denis, S C Feinstei. Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10984497. |
the relevance of isoform-specific structure and function to normal tau action and the onset of neurodegenerative disease are discussed. |
2001-01-18 |
2023-08-12 |
human |
| M G Spillantini, J C Van Swieten, M Goeder. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Neurogenetics. vol 2. issue 4. 2001-01-09. PMID:10983715. |
filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy and corticobasal degeneration. |
2001-01-09 |
2023-08-12 |
human |
| M van Slegtenhorst, J Lewis, M Hutto. The molecular genetics of the tauopathies. Experimental gerontology. vol 35. issue 4. 2000-12-22. PMID:10959034. |
the mechanism by which this common variability in the tau gene influences the development of these neurodegenerative diseases is unclear; however, it further suggests a central role for tau in the pathogenesis of several neurodegenerative conditions including alzheimer's disease (ad). |
2000-12-22 |
2023-08-12 |
Not clear |
| A Delacourte, L Bué. Tau pathology: a marker of neurodegenerative disorders. Current opinion in neurology. vol 13. issue 4. 2000-12-22. PMID:10970052. |
polymorphisms on the tau gene and the hierarchical invasion of neocortical areas by tau pathology in numerous sporadic neurodegenerative diseases also suggest that tau pathology is a primary pathogenic event in non-familial dementing diseases and a lead for solid diagnostic and therapeutic approaches. |
2000-12-22 |
2023-08-12 |
Not clear |
| H Ksiezak-Reding, D He, W Gordon-Krajcer, Y Kress, S Lee, D W Dickso. Induction of Alzheimer-specific Tau epitope AT100 in apoptotic human fetal astrocytes. Cell motility and the cytoskeleton. vol 47. issue 3. 2000-12-07. PMID:11056524. |
in alzheimer's and other neurodegenerative diseases, hyperphosphorylated tau accumulates in affected neuronal and glial cells in the form of paired helical filaments (phfs). |
2000-12-07 |
2023-08-12 |
human |
| M O Zemaitaitis, J M Lee, J C Troncoso, N A Mum. Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy. Journal of neuropathology and experimental neurology. vol 59. issue 11. 2000-12-07. PMID:11089576. |
double-label immunofluorescence demonstrated the colocalization of the cross-link and phf-tau in nft in pons of psp previous studies and present data are consistent with the hypothesis that transglutaminase-induced cross-linking may be a factor contributing to the abnormal polymerization and stabilization of tau in straight and phfs leading to neurofibrillary tangle formation in neurodegenerative diseases, including psp and ad. |
2000-12-07 |
2023-08-12 |
Not clear |
| M B Delisle, E Uro-Coste, J R Murrell, O Rascol, B Ghett. [Neurodegenerative disease associated with a mutation of codon 279 (N279K) in exon 10 of Tau protein]. Bulletin de l'Academie nationale de medecine. vol 184. issue 4. 2000-10-26. PMID:10989564. |
[neurodegenerative disease associated with a mutation of codon 279 (n279k) in exon 10 of tau protein]. |
2000-10-26 |
2023-08-12 |
Not clear |
| M B Delisle, E Uro-Coste, J R Murrell, O Rascol, B Ghett. [Neurodegenerative disease associated with a mutation of codon 279 (N279K) in exon 10 of Tau protein]. Bulletin de l'Academie nationale de medecine. vol 184. issue 4. 2000-10-26. PMID:10989564. |
the selectivity of neuronal death in hereditary diseases, when compared to data concerning sporadic neurodegenerative diseases which share similar clinical signs and neuropathological lesions, reinforces the hypothesis of an increased vulnerability of some neuronal populations which express specific sets of tau isoforms. |
2000-10-26 |
2023-08-12 |
Not clear |
| C Schwab, A J DeMaggio, N Ghoshal, L I Binder, J Kuret, P L McGee. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiology of aging. vol 21. issue 4. 2000-09-07. PMID:10924763. |
casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. |
2000-09-07 |
2023-08-12 |
Not clear |
| S Doré, S Kar, W H Zheng, R Quirio. Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke. Pharmaceutica acta Helvetiae. vol 74. issue 2-3. 2000-08-09. PMID:10812969. |
the effects, particularly those of igf-i on key markers of the alzheimer's (ad) brains namely cholinergic dysfunction, neuronal amyloid toxicity, tau phosphorylation and glucose metabolism suggest the potential usefulness of this growth factor in the treatment of neurodegenerative diseases. |
2000-08-09 |
2023-08-12 |
Not clear |
| K Yasojima, J Kuret, A J DeMaggio, E McGeer, P L McGee. Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814741. |
recently we have demonstrated that one family member, ckidelta, colocalizes with tau containing neurofibrillary tangles (nfts) and other tau deposits in a number of neurodegenerative diseases. |
2000-07-21 |
2023-08-12 |
Not clear |