| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Goedert, Ross Jake. Mutations causing neurodegenerative tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615642. |
tau is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. |
2005-02-03 |
2023-08-12 |
human |
| Stuart C Feinstein, Leslie Wilso. Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615645. |
interest in the microtubule-associated protein tau stems from its critical roles in neural development and maintenance, as well as its role in alzheimer's, ftdp-17 and related neurodegenerative diseases. |
2005-02-03 |
2023-08-12 |
Not clear |
| William H Stoothoff, Gail V W Johnso. Tau phosphorylation: physiological and pathological consequences. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615646. |
the microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative diseases, and most notably alzheimer's disease. |
2005-02-03 |
2023-08-12 |
Not clear |
| William H Stoothoff, Gail V W Johnso. Tau phosphorylation: physiological and pathological consequences. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615646. |
this review focuses on recent literature pertaining to the regulation of tau phosphorylation and function in cell culture and animal model systems, and the role that a dysregulation of tau phosphorylation may play in the neuronal dysfunction and death that occur in neurodegenerative diseases that have tau pathology. |
2005-02-03 |
2023-08-12 |
Not clear |
| Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. |
tau becomes characteristically altered both functionally and structurally in several neurodegenerative diseases now collectively called tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Max Holzer, Molly Craxton, Ross Jakes, Thomas Arendt, Michel Goeder. Tau gene (MAPT) sequence variation among primates. Gene. vol 341. 2005-01-13. PMID:15474313. |
filamentous tau deposits are a defining feature of a number of human neurodegenerative diseases. |
2005-01-13 |
2023-08-12 |
human |
| Lucie I Bruijn, Pavan K Krishnamurthy, Jean-Marc Gall. Distinct patterns of tau-dependent process formation in mammalian cell lines. Neuroreport. vol 15. issue 14. 2005-01-11. PMID:15371738. |
these results suggest that cell-specific factors are involved in tau-dependent microtubule organization, a notion that could facilitate functional assessment of tau abnormalities associated with neurodegenerative disease. |
2005-01-11 |
2023-08-12 |
Not clear |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
the group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (mapt). |
2004-12-22 |
2023-08-12 |
Not clear |
| Nigel J Cairns, Virginia M-Y Lee, John Q Trojanowsk. The cytoskeleton in neurodegenerative diseases. The Journal of pathology. vol 204. issue 4. 2004-12-16. PMID:15495240. |
abundant abnormal aggregates of cytoskeletal proteins are neuropathological signatures of many neurodegenerative diseases that are broadly classified by filamentous aggregates of neuronal intermediate filament (if) proteins, or by inclusions containing the microtubule-associated protein (map) tau. |
2004-12-16 |
2023-08-12 |
human |
| Nigel J Cairns, Virginia M-Y Lee, John Q Trojanowsk. The cytoskeleton in neurodegenerative diseases. The Journal of pathology. vol 204. issue 4. 2004-12-16. PMID:15495240. |
the discovery of mutations in neuronal if and tau genes firmly establishes the importance of neuronal if proteins and tau in the pathogenesis of neurodegenerative diseases. |
2004-12-16 |
2023-08-12 |
human |
| Nigel J Cairns, Virginia M-Y Lee, John Q Trojanowsk. The cytoskeleton in neurodegenerative diseases. The Journal of pathology. vol 204. issue 4. 2004-12-16. PMID:15495240. |
thus, if and tau abnormalities are linked directly to the aetiology and pathogenesis of neurodegenerative diseases. |
2004-12-16 |
2023-08-12 |
human |
| Nigel J Cairns, Virginia M-Y Lee, John Q Trojanowsk. The cytoskeleton in neurodegenerative diseases. The Journal of pathology. vol 204. issue 4. 2004-12-16. PMID:15495240. |
as reviewed here, the identification of molecular genetic defects and biochemical alterations in cytoskeletal proteins of human neurodegenerative diseases has facilitated experimental studies and will promote the development of assays of molecules which inhibit abnormal neuronal if and tau protein inclusions. |
2004-12-16 |
2023-08-12 |
human |
| Prudence M Stanford, William S Brooks, Erdahl T Teber, Marianne Hallupp, Catriona McLean, Glenda M Halliday, Ralph N Martins, John B J Kwok, Peter R Schofiel. Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. Journal of neurology. vol 251. issue 9. 2004-12-13. PMID:15372253. |
other neurodegenerative diseases, including progressive supranuclear palsy (psp) and corticobasal degeneration (cbd), are also characterised by insoluble tau neuropathology. |
2004-12-13 |
2023-08-12 |
Not clear |
| Prudence M Stanford, William S Brooks, Erdahl T Teber, Marianne Hallupp, Catriona McLean, Glenda M Halliday, Ralph N Martins, John B J Kwok, Peter R Schofiel. Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. Journal of neurology. vol 251. issue 9. 2004-12-13. PMID:15372253. |
this study sought to determine the nature and frequency of tau gene mutations in an affected proband cohort of patients within this spectrum of neurodegenerative diseases. |
2004-12-13 |
2023-08-12 |
Not clear |
| Andrew Singleton, Amanda Myers, John Hard. The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases. Human molecular genetics. vol 13 Spec No 1. 2004-11-29. PMID:14976159. |
loci underlying autosomal dominant forms of most neurodegenerative disease have been identified: prion mutations cause gerstmann straussler syndrome and hereditary creuzfeldt-jakob disease, tau mutations cause autosomal dominant frontal temporal dementia, and alpha-synuclein mutations cause autosomal dominant parkinson's disease. |
2004-11-29 |
2023-08-12 |
Not clear |
| Shigetsugu Hatakeyama, Masaki Matsumoto, Takumi Kamura, Miyuki Murayama, Du-Hua Chui, Emmanuel Planel, Ryosuke Takahashi, Keiichi I Nakayama, Akihiko Takashim. U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447663. |
neurofibrillary tangles (nfts), which are composed of hyperphosphorylated and ubiquitylated tau, are exhibited at regions where neuronal loss occurs in neurodegenerative diseases; however, the mechanisms of nft formation remain unknown. |
2004-11-15 |
2023-08-12 |
Not clear |
| Michel Goeder. Tau protein and neurodegeneration. Seminars in cell & developmental biology. vol 15. issue 1. 2004-10-26. PMID:15036206. |
tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. |
2004-10-26 |
2023-08-12 |
Not clear |
| Anastasia Levchenko, Yves Robitaille, Michael J Strong, Guy A Roulea. TAU mutations are not a predominant cause of frontotemporal dementia in Canadian patients. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 31. issue 3. 2004-10-18. PMID:15376481. |
frontotemporal dementia is a neurodegenerative disease affecting mostly the frontal and/or temporal lobes, with neuronal loss and intraneuronal and/or intraglial inclusions composed of hyperphosphorylated microtubule-associated protein tau and ubiquitin. |
2004-10-18 |
2023-08-12 |
Not clear |
| Jonathan C Cruz, Li-Huei Tsa. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Current opinion in neurobiology. vol 14. issue 3. 2004-09-28. PMID:15194121. |
recently developed animal models that display this deregulated cdk5 activity reveal the intimate involvement of cdk5 in tau pathology and neuronal cell death, and underscore the importance of phosphorylation in the progression of neurodegenerative diseases. |
2004-09-28 |
2023-08-12 |
Not clear |
| Hirotaka Yoshida, C James Hastie, Hilary McLauchlan, Philip Cohen, Michel Goeder. Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK). Journal of neurochemistry. vol 90. issue 2. 2004-09-03. PMID:15228592. |
microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative diseases commonly referred to as tauopathies. |
2004-09-03 |
2023-08-12 |
Not clear |