| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murray Grossman, Jennifer Farmer, Susan Leight, Melissa Work, Peachie Moore, Vivianna Van Deerlin, Domenico Pratico, Christopher M Clark, H Branch Coslett, Anjan Chatterjee, James Gee, John Q Trojanowski, Virginia M-Y Le. Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease. Annals of neurology. vol 57. issue 5. 2005-06-24. PMID:15852395. |
we assessed cerebrospinal fluid (csf) levels of tau and other biomarkers of neurodegenerative disease. |
2005-06-24 |
2023-08-12 |
Not clear |
| Sasha F Levy, Adria C Leboeuf, Michelle R Massie, Mary Ann Jordan, Leslie Wilson, Stuart C Feinstei. Three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15671021. |
the microtubule-associated protein tau is implicated in the pathogenesis of many neurodegenerative diseases, including fronto-temporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), in which both rna splicing and amino acid substitution mutations in tau cause dominantly inherited early onset dementia. |
2005-06-21 |
2023-08-12 |
human |
| Yingzi Wang, Junning Wang, Lei Gao, Robert Lafyatis, Stefan Stamm, Athena Andreadi. Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15695522. |
tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a srp30c.srp55 complex that either recruits or antagonizes htra2beta1. |
2005-06-21 |
2023-08-12 |
Not clear |
| Dalinda Liazoghli, Sebastien Perreault, Kristina D Micheva, Mylène Desjardins, Nicole Lecler. Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons. The American journal of pathology. vol 166. issue 5. 2005-06-21. PMID:15855649. |
in several neurodegenerative diseases including alzheimer's disease, hyperphosphorylated tau accumulates in the somatodendritic compartment, self-aggregates, and forms neurofibrillary tangles. |
2005-06-21 |
2023-08-12 |
mouse |
| Gail V W Johnson, William H Stoothof. Tau phosphorylation in neuronal cell function and dysfunction. Journal of cell science. vol 117. issue Pt 24. 2005-06-20. PMID:15537830. |
there is significant evidence that a disruption of normal phosphorylation events results in tau dysfunction in neurodegenerative diseases, such as ad, and is a contributing factor to the pathogenic processes. |
2005-06-20 |
2023-08-12 |
Not clear |
| Gail V W Johnson, William H Stoothof. Tau phosphorylation in neuronal cell function and dysfunction. Journal of cell science. vol 117. issue Pt 24. 2005-06-20. PMID:15537830. |
identification of the protein kinases that phosphorylate tau in vivo in both physiological and pathological processes could provide potential therapeutic targets for the treatment of ad and other neurodegenerative diseases in which there is tau pathology. |
2005-06-20 |
2023-08-12 |
Not clear |
| Yasuhiro Nakagam. Inhibitors beta-amyloid-induced toxicity by modulating the Akt signaling pathway. Drug news & perspectives. vol 17. issue 10. 2005-06-14. PMID:15696230. |
among neurodegenerative diseases, alzheimer's disease is the most common and characterized by senile plaques and neurofibrillary tangles, which consist of beta-amyloid and hyperphosphorylated tau, respectively. |
2005-06-14 |
2023-08-12 |
Not clear |
| Angela L Guillozet-Bongaarts, Francisco Garcia-Sierra, Matthew R Reynolds, Peleg M Horowitz, Yifan Fu, Tianyi Wang, Michael E Cahill, Eileen H Bigio, Robert W Berry, Lester I Binde. Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiology of aging. vol 26. issue 7. 2005-05-20. PMID:15748781. |
the microtubule-associated protein, tau, is a highly soluble molecule that is nonetheless capable of self-association into filamentous deposits characteristic of a number of neurodegenerative diseases. |
2005-05-20 |
2023-08-12 |
Not clear |
| Ya-Li Zheng, Sashi Kesavapany, Maneth Gravell, Rebecca S Hamilton, Manfred Schubert, Niranjana Amin, Wayne Albers, Philip Grant, Harish C Pan. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. The EMBO journal. vol 24. issue 1. 2005-04-18. PMID:15592431. |
the extracellular aggregation of amyloid beta (abeta) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as alzheimer's disease (ad). |
2005-04-18 |
2023-08-12 |
Not clear |
| Armgard Uelhoff, Jörg Tatzelt, Adriano Aguzzi, Konstanze F Winklhofer, Christian Haas. A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15615717. |
several proteins linked to neurodegenerative diseases, such as the beta-amyloid precursor protein, amyloid beta-peptide, beta-secretase, and tau, undergo selective polarized sorting. |
2005-04-18 |
2023-08-12 |
Not clear |
| Arthur M Butt, Jennifer Dinsdal. Fibroblast growth factor 2 mediated disruption of myelin-forming oligodendrocytes in vivo is associated with increased tau immunoreactivity. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664117. |
the results identify a potential mechanism by which fgf2-mediated accumulation of tau disrupts the transport of myelin-related gene products, resulting in disruption and eventual loss of oligodendrocytes and myelin, which are features of ischemia and a variety of demyelinating and neurodegenerative diseases. |
2005-04-18 |
2023-08-12 |
rat |
| F Orosz, G G Kovács, A Lehotzky, J Oláh, O Vincze, J Ovád. TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments. Biology of the cell. vol 96. issue 9. 2005-04-14. PMID:15567525. |
the comparison of these characteristics with that of alpha-synuclein and tau, involved also in neurodegenerative diseases, suggested that although the primary sequences of these proteins are entirely different, there are similarities in their well-defined unstructured segments interrupted by "stabilization centres", phosphorylation and tubulin binding motives. |
2005-04-14 |
2023-08-12 |
human |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
abnormal filamentous tau deposits have been reported as a pathological characteristic in several other neurodegenerative diseases, including frontotemporal dementia, pick disease, alzheimer disease, argyrophilic grain disease, progressive supranuclear palsy, and corticobasal degeneration. |
2005-03-31 |
2023-08-12 |
mouse |
| Natalia Csokova, Rostislav Skrabana, Hans-Dieter Liebig, Anna Mederlyova, Peter Kontsek, Michal Nova. Rapid purification of truncated tau proteins: model approach to purification of functionally active fragments of disordered proteins, implication for neurodegenerative diseases. Protein expression and purification. vol 35. issue 2. 2005-03-29. PMID:15135415. |
rapid purification of truncated tau proteins: model approach to purification of functionally active fragments of disordered proteins, implication for neurodegenerative diseases. |
2005-03-29 |
2023-08-12 |
Not clear |
| J Avila, M Pérez, F Lim, A Gómez-Ramos, F Hernández, J J Luca. Tau in neurodegenerative diseases: tau phosphorylation and assembly. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15639780. |
tau in neurodegenerative diseases: tau phosphorylation and assembly. |
2005-03-01 |
2023-08-12 |
mouse |
| J Avila, M Pérez, F Lim, A Gómez-Ramos, F Hernández, J J Luca. Tau in neurodegenerative diseases: tau phosphorylation and assembly. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15639780. |
the possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. |
2005-03-01 |
2023-08-12 |
mouse |
| Anja Schneider, Gilda Wright Araújo, Katarina Trajkovic, Martin M Herrmann, Doron Merkler, Eva-Maria Mandelkow, Robert Weissert, Mikael Simon. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. The Journal of biological chemistry. vol 279. issue 53. 2005-02-25. PMID:15494405. |
hyperphosphorylation and pathological aggregation of microtubule-associated protein tau is a common feature of many neurodegenerative diseases with axonal degeneration including alzheimer's disease. |
2005-02-25 |
2023-08-12 |
rat |
| Athena Andreadi. Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615629. |
tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. |
2005-02-03 |
2023-08-12 |
mouse |
| Athena Andreadi. Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615629. |
moreover, aberrations in tau splicing regulation directly cause several neurodegenerative diseases. |
2005-02-03 |
2023-08-12 |
mouse |
| Garth F Hall, Jun Ya. Modeling tauopathy: a range of complementary approaches. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615641. |
the large group of neurodegenerative diseases which feature abnormal metabolism and accumulation of tau protein (tauopathies) characteristically produce a multiplicity of cellular and systemic abnormalities in human patients. |
2005-02-03 |
2023-08-12 |
human |