| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy Jeffrey, Hannah D'Cunha, Masatoshi Suzuk. Blood Level of Glial Fibrillary Acidic Protein (GFAP) Does not Correlate With Disease Progression in a Rat Model of Familial ALS (SOD1 Frontiers in neurology. vol 9. 2020-09-30. PMID:30487774. |
blood level of glial fibrillary acidic protein (gfap) does not correlate with disease progression in a rat model of familial als (sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by specific loss of motor neurons in the spinal cord and brain stem. |
2020-09-30 |
2023-08-13 |
rat |
| Natallia Makarava, Jennifer Chen-Yu Chang, Rajesh Kushwaha, Ilia V Baskako. Region-Specific Response of Astrocytes to Prion Infection. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31649496. |
reactive astrogliosis, routinely observed immunohistochemically as an increase in glial fibrillary acidic protein (gfap) signal, is a well-documented feature of chronic neuroinflammation associated with neurodegenerative diseases. |
2020-09-30 |
2023-08-13 |
mouse |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Patrick Oeckl, Steffen Halbgebauer, Sarah Anderl-Straub, Petra Steinacker, André M Huss, Hermann Neugebauer, Christine A F von Arnim, Janine Diehl-Schmid, Timo Grimmer, Johannes Kornhuber, Piotr Lewczuk, Adrian Danek, Albert C Ludolph, Markus Ott. Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30594925. |
serum gfap was increased in ad (p < 0.001) and dlb/pdd (p < 0.01), and cerebrospinal fluid gfap was increased in all neurodegenerative diseases (p < 0.001). |
2020-03-02 |
2023-08-13 |
Not clear |
| Janyerkye Tulyeu, Moe Tamaura, Eriko Jimbo, Hiroko Shimbo, Kyoko Takano, Mizue Iai, Sumimasa Yamashita, Tomohide Goto, Noriko Aida, Etsuro Tokuhiro, Takanori Yamagata, Hitoshi Osak. Aggregate formation analysis of GFAP Brain & development. vol 41. issue 2. 2019-05-01. PMID:30213442. |
aggregate formation analysis of gfap alexander disease (axd) is a neurodegenerative disease in astrocytes caused by a mutation in the gene encoding glial fibrillary acidic protein, gfap. |
2019-05-01 |
2023-08-13 |
Not clear |
| Ayumi Matsumoto, Janyerkye Tulyeu, Rieko Furukawa, Chika Watanabe, Yukifumi Monden, Yasuyuki Nozaki, Masato Mori, Michito Namekawa, Eriko F Jimbo, Toshinori Aihara, Takanori Yamagata, Hitoshi Osak. A case of severe Alexander disease with de novo c. 239 T > C, p.(F80S), in GFAP. Brain & development. vol 40. issue 7. 2018-10-22. PMID:29573842. |
alexander disease (axd) is a progressive neurodegenerative disease caused by a mutation in the glial fibrillary acid protein (gfap) gene. |
2018-10-22 |
2023-08-13 |
Not clear |
| Jennifer M Gass, Anvir Cheema, Jessica Jackson, Patrick R Blackburn, Jay Van Gerpen, Paldeep S Atwa. Novel GFAP Variant in Adult-onset Alexander Disease With Progressive Ataxia and Palatal Tremor. The neurologist. vol 22. issue 6. 2018-07-24. PMID:29095329. |
alexander disease is a rare neurodegenerative disease caused by variants in the glial fibrillary acidic protein gene (gfap). |
2018-07-24 |
2023-08-13 |
Not clear |
| Ni-Hsuan Lin, Albee Messing, Ming-Der Pern. Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP. PloS one. vol 12. issue 7. 2017-09-25. PMID:28700643. |
alexander disease (axd) is a neurodegenerative disease caused by heterozygous mutations in the gfap gene, which encodes the major intermediate filament protein of astrocytes. |
2017-09-25 |
2023-08-13 |
mouse |
| Reyna I Martinez-De Luna, Ray Y Ku, Alexandria M Aruck, Francesca Santiago, Andrea S Viczian, Diego San Mauro, Michael E Zube. Müller glia reactivity follows retinal injury despite the absence of the glial fibrillary acidic protein gene in Xenopus. Developmental biology. vol 426. issue 2. 2017-09-22. PMID:26996101. |
glial fibrillary acidic protein (gfap) is a type iii intermediate filament protein and is up-regulated in glia of the nervous system in response to injury and during neurodegenerative diseases. |
2017-09-22 |
2023-08-13 |
xenopus_laevis |
| Yan Fan, Johnny J H. HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity. The Journal of biological chemistry. vol 291. issue 43. 2017-05-22. PMID:27609518. |
taken together, these results show for the first time that tat promotes lysosomal exocytosis in astrocytes and causes neurotoxicity through gfap activation and er stress induction in astrocytes and suggest a common cascade through which aberrant astrocytosis/gfap up-regulation potentiates neurotoxicity and contributes to neurodegenerative diseases. |
2017-05-22 |
2023-08-13 |
mouse |
| Christine M LaPash Daniels, Elizabeth Paffenroth, Elizabeth V Austin, Konstantin Glebov, Diana Lewis, Jochen Walter, Albee Messin. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease. PloS one. vol 10. issue 9. 2016-06-09. PMID:26378915. |
alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (gfap). |
2016-06-09 |
2023-08-13 |
mouse |
| Rodrigo S Hernández, Rocío Sarasa, Adolfo Toledano, Juan J Badiola, Marta Monzó. Morphological approach to assess the involvement of astrocytes in prion propagation. Cell and tissue research. vol 358. issue 1. 2015-06-11. PMID:24931403. |
the close relationship between prpsc and gfap hiperimmunoreactivity and purkinje cells, alongside the evident thickening of their neurites at terminal stages demonstrated in this study, suggest that these neurons are the main target of this neurodegenerative disease. |
2015-06-11 |
2023-08-13 |
Not clear |
| Martina Moeton, Regina Kanski, Oscar M J A Stassen, Jacqueline A Sluijs, Dirk Geerts, Paula van Tijn, Gerhard Wiche, Miriam E van Strien, Elly M Ho. Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 7. 2014-09-25. PMID:24696300. |
the gfap gene is alternatively spliced, and expression of gfap is highly regulated during development, on brain damage, and in neurodegenerative diseases. |
2014-09-25 |
2023-08-13 |
human |
| Christine M LaPash Daniels, Elizabeth V Austin, Danica E Rockney, Elizabeth M Jacka, Tracy L Hagemann, Delinda A Johnson, Jeffrey A Johnson, Albee Messin. Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 31. 2012-10-15. PMID:22855800. |
alexander disease is a fatal neurodegenerative disease caused by dominant mutations in glial fibrillary acidic protein (gfap). |
2012-10-15 |
2023-08-12 |
mouse |
| Yasuhiro Yoshii, Asako Otomo, Lei Pan, Masato Ohtsuka, Shinji Hadan. Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS. Neuroscience research. vol 70. issue 3. 2012-05-04. PMID:21453731. |
increased production of gfap is a hallmark of astrogliosis in neurodegenerative diseases such as amyotrophic lateral sclerosis (als). |
2012-05-04 |
2023-08-12 |
mouse |
| Andrew O Koob, Amy D Paulino, Eliezer Maslia. GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with alpha-synuclein. Neuroscience letters. vol 469. issue 1. 2010-03-09. PMID:19932737. |
astrocytes present at neural synapses are thought to contribute to synaptogenesis through cholesterol release and normally exhibit increased glial fibrillary acid protein (gfap) reactivity and apolipoprotein e (apoe) expression in neurodegenerative disease states. |
2010-03-09 |
2023-08-12 |
human |
| Sarah Jesse, Petra Steinacker, Lukas Cepek, Christine A F von Arnim, Hayrettin Tumani, Stefan Lehnert, Hans A Kretzschmar, Michael Baier, Markus Ott. Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19433893. |
apart from pathophysiological aspects, gfap in particular might serve as an additional diagnostic tool for ad, due to the fact that this protein does not correlate to established markers like tau and amyloid-beta such that analysis of gfap may be useful for further differential diagnostic approaches in neurodegenerative diseases. |
2009-12-15 |
2023-08-12 |
Not clear |
| Tomokatsu Yoshida, Hiroshi Sasayama, Masanori Nakagaw. The process of inducing GFAP aggregates in astrocytoma-derived cells is different between R239C and R416W mutant GFAP. A time-lapse recording study. Neuroscience letters. vol 458. issue 1. 2009-08-03. PMID:19379794. |
alexander disease (alx) is a rare neurodegenerative disease caused by the gene mutations encoding glial fibrillary acidic protein (gfap). |
2009-08-03 |
2023-08-12 |
Not clear |
| Ronald K H Liem, Albee Messin. Dysfunctions of neuronal and glial intermediate filaments in disease. The Journal of clinical investigation. vol 119. issue 7. 2009-07-30. PMID:19587456. |
in this review, we focus on the ifs of glial cells (primarily gfap) and neurons as well as their relationship to different neurodegenerative diseases. |
2009-07-30 |
2023-08-12 |
Not clear |
| Asa Widestrand, Jonas Faijerson, Ulrika Wilhelmsson, Peter L P Smith, Lizhen Li, Carina Sihlbom, Peter S Eriksson, Milos Pekn. Increased neurogenesis and astrogenesis from neural progenitor cells grafted in the hippocampus of GFAP-/- Vim-/- mice. Stem cells (Dayton, Ohio). vol 25. issue 10. 2007-12-27. PMID:17628017. |
after neurotrauma, ischemia, or neurodegenerative disease, astrocytes upregulate their expression of the intermediate filament proteins glial fibrillary acidic protein (gfap), vimentin (vim), and nestin. |
2007-12-27 |
2023-08-12 |
mouse |