| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucia M Li, Eleftheria Kodosaki, Amanda Heslegrave, Henrik Zetterberg, Neil Graham, Karl Zimmerman, Eyal Soreq, Thomas Parker, Elena Garbero, Frederico Moro, Sandra Magnoni, Guido Bertolini, David J Loane, David J Shar. High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury. Brain : a journal of neurology. 2024-09-26. PMID:39323289. |
these were neuronal markers (calbindin2, uch-l1, visinin-like protein1), astroglial markers (s100b, gfap), neurodegenerative disease proteins (total tau, ptau231, psen1, amyloid-beta-42, 14-3-3γ), inflammatory cytokines (il16, ccl2, ficolin2), cell signalling (sfrp1), cell metabolism (mdh1) and autophagy related (sequestome1) proteins. |
2024-09-26 |
2024-09-28 |
human |
| Dianjun Liu, Xiangwen Yao, Hao Zhan. Effect of general anesthesia drugs on GFAP/Iba-1 expression: a meta-analysis. American journal of translational research. vol 16. issue 8. 2024-09-12. PMID:39262705. |
glial fibrillary acidic protein (gfap) is a marker associated with astrocyte activation and plays a role in various pathologic processes, including traumatic brain injury, stroke, and neurodegenerative diseases. |
2024-09-12 |
2024-09-14 |
Not clear |
| Goksu Ozcelikay-Akyildiz, Leyla Karadurmus, Ahmet Cetinkaya, İnci Uludag, Burcu Ozcan, Mehmet Altay Unal, Mustafa Kemal Sezginturk, Sibel A Ozka. The Evaluation of Clinical Applications for the Detection of the Alzheimer's Disease Biomarker GFAP. Critical reviews in analytical chemistry. 2024-08-23. PMID:39178137. |
increased levels of gfap in the serum can function as blood markers and be an effective prognostic indicator to help diagnose neurological conditions early on, from stroke to neurodegenerative diseases. |
2024-08-23 |
2024-08-26 |
human |
| Lu Zhao, Qi Qiu, Shaowei Zhang, Feng Yan, Xia L. Tau pathology mediate the plasma biomarkers and cognitive function in patients with mild cognitive impairment. Experimental gerontology. 2024-08-11. PMID:39128687. |
glial fibrillary acidic protein (gfap) and neurofilament light (nfl) are putative non-amyloid biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. |
2024-08-11 |
2024-08-14 |
Not clear |
| Daniela Andriuta, Julie Ottoy, Myuri Ruthirakuhan, Ginelle Feliciano, Allison A Dilliott, Robert A Hegele, Fuqiang Gao, Paula M McLaughlin, Jennifer S Rabin, Madeline Wood Alexander, Christopher J M Scott, Vanessa Yhap, Courtney Berezuk, Miracle Ozzoude, Walter Swardfager, Julia Zebarth, M Carmela Tartaglia, Ekaterina Rogaeva, David F Tang-Wai, Leanne Casaubon, Sanjeev Kumar, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Corinne E Fischer, Michael Borrie, Ayman Hassan, Malcolm A Binns, Morris Freedman, Howard Chertkow, Elizabeth Finger, Andrew Frank, Robert Bartha, Sean Symons, Henrik Zetterberg, Richard H Swartz, Mario Masellis, Sandra E Black, Joel Ramire. Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-07-04. PMID:38961774. |
perivascular spaces, plasma gfap, and speeded executive function in neurodegenerative diseases. |
2024-07-04 |
2024-07-10 |
Not clear |
| Daniela Andriuta, Julie Ottoy, Myuri Ruthirakuhan, Ginelle Feliciano, Allison A Dilliott, Robert A Hegele, Fuqiang Gao, Paula M McLaughlin, Jennifer S Rabin, Madeline Wood Alexander, Christopher J M Scott, Vanessa Yhap, Courtney Berezuk, Miracle Ozzoude, Walter Swardfager, Julia Zebarth, M Carmela Tartaglia, Ekaterina Rogaeva, David F Tang-Wai, Leanne Casaubon, Sanjeev Kumar, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Corinne E Fischer, Michael Borrie, Ayman Hassan, Malcolm A Binns, Morris Freedman, Howard Chertkow, Elizabeth Finger, Andrew Frank, Robert Bartha, Sean Symons, Henrik Zetterberg, Richard H Swartz, Mario Masellis, Sandra E Black, Joel Ramire. Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-07-04. PMID:38961774. |
we investigated the effect of perivascular spaces (pvs) volume on speeded executive function (sef), as mediated by white matter hyperintensities (wmh) volume and plasma glial fibrillary acidic protein (gfap) in neurodegenerative diseases. |
2024-07-04 |
2024-07-10 |
Not clear |
| Zhuoran Zhang, Xiaoyan Li, Limin Ma, Shanshan Wang, Jingsi Zhang, Yue Zhou, Xin Guo, Qiao Ni. LNC000152 Mediates Aluminum-Induced Proliferation of Reactive Astrocytes. ACS omega. vol 9. issue 10. 2024-03-18. PMID:38496998. |
studies of various neurodegenerative diseases have confirmed that the expression changes in gfap are associated with nerve injury. |
2024-03-18 |
2024-03-20 |
rat |
| Koos de Wit, Diederick J van Doorn, Bregje Mol, Lonneke A van Vught, Frederik Nevens, Ulrich Beuers, Cyriel Y Ponsioen, Charlotte E Teunissen, R Bart Takkenber. Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis. Annals of hepatology. 2024-03-09. PMID:38460714. |
neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (nfl) and glial fibrillary acidic protein (gfap) in body fluids, including blood plasma. |
2024-03-09 |
2024-03-12 |
Not clear |
| Xiaoxiao Zheng, Jingyao Yang, Yiwei Hou, Xinye Shi, Kangding Li. Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP). European journal of medical research. vol 29. issue 1. 2024-01-12. PMID:38216970. |
the reason plasma gfap could serve as a promising biomarker for diagnosis and prediction of alzheimer's disease (ad) is that it effectively distinguished ad dementia from multiple neurodegenerative diseases and predicted the individual risk of ad progression. |
2024-01-12 |
2024-01-15 |
Not clear |
| Taylor G Brown, Mackenzie N Thayer, Jillian G VanTreeck, Nicole Zarate, Damyan W Hart, Sarah Heilbronner, Rocio Gomez-Pasto. Striatal spatial heterogeneity, clustering, and white matter association of GFAP Frontiers in cellular neuroscience. vol 17. 2023-05-15. PMID:37187609. |
striatal spatial heterogeneity, clustering, and white matter association of gfap huntington's disease (hd) is a neurodegenerative disease that primarily affects the striatum, a brain region that controls movement and some forms of cognition. |
2023-05-15 |
2023-08-14 |
Not clear |
| Shaoyu Yen, Hong-Yi Wu, Yuhling Wang, Chih-Mao Huang, Changwei W Wu, Jyh-Horng Chen, Lun-De Lia. Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques. iScience. vol 26. issue 4. 2023-04-10. PMID:37035001. |
western blot results in the exe group showed significant increases in bdnf, gfap, and neun levels and significant decreases in neurodegenerative disease markers. |
2023-04-10 |
2023-08-14 |
rat |
| b' Cristina Hern\\xc3\\xa1ndez, Olga Sim\\xc3\\xb3-Servat, Massimo Porta, Jakob Grauslund, Simon P Harding, Ulrik Frydkjaer-Olsen, Jos\\xc3\\xa9 Garc\\xc3\\xada-Arum\\xc3\\xad, Lu\\xc3\\xadsa Ribeiro, Peter Scanlon, Jos\\xc3\\xa9 Cunha-Vaz, Rafael Sim\\xc3\\xb. Serum glial fibrillary acidic protein and neurofilament light chain as biomarkers of retinal neurodysfunction in early diabetic retinopathy: results of the EUROCONDOR study. Acta diabetologica. 2023-03-24. PMID:36959506.' |
serum glial fibrillary acidic protein (gfap) and neurofilament light chain (nfl) are biomarkers of underlying neuroinflammatory and neurodegenerative disease processes. |
2023-03-24 |
2023-08-14 |
human |
| Inge M W Verberk, Malika B Laarhuis, Karlijn A van den Bosch, Jarith L Ebenau, Mardou van Leeuwenstijn, Niels D Prins, Philip Scheltens, Charlotte E Teunissen, Wiesje M van der Flie. Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study. The Lancet. Healthy longevity. vol 2. issue 2. 2022-09-13. PMID:36098162. |
serum glial fibrillary acidic protein (gfap) and neurofilament light (nfl) are putative non-amyloid blood-based biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. |
2022-09-13 |
2023-08-14 |
Not clear |
| Eleni Rebelos, Eero Rissanen, Marco Bucci, Olli Jääskeläinen, Miikka-Juhani Honka, Lauri Nummenmaa, Diego Moriconi, Sanna Laurila, Paulina Salminen, Sanna-Kaisa Herukka, Tarun Singhal, Pirjo Nuutil. Circulating neurofilament is linked with morbid obesity, renal function, and brain density. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35551210. |
neurofilament light chain (nfl) is a novel biomarker reflecting neuroaxonal damage and associates with brain atrophy, and glial fibrillary acidic protein (gfap) is a marker of astrocytic activation, associated with several neurodegenerative diseases. |
2022-05-13 |
2023-08-13 |
human |
| Goksu Ozcelikay, María Gamella, Mehmet Altay Unal, Kıvılcım Gucuyener, Ana Montero-Calle, Rodrigo Barderas, José M Pingarrón, Susana Campuzano, Sibel A Ozka. Assisting dementia diagnosis through the electrochemical immunosensing of glial fibrillary acidic protein. Talanta. vol 246. 2022-05-13. PMID:35561530. |
glial fibrillary acidic protein (gfap) is a member of the intermediate filament family of proteins with increased levels in serum and cerebrospinal fluid of patients with alzheimer disease (ad) and other neurodegenerative diseases (nds), such as vascular dementia (vd). |
2022-05-13 |
2023-08-13 |
Not clear |
| Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa, Jordi Clarimón, Maria Carmona-Iragui, Juan Fortea, Alberto Lleó, Daniel Alcole. Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia. Translational neurodegeneration. vol 10. issue 1. 2021-12-11. PMID:34893073. |
studies of glial fibrillary acidic protein (gfap), an astrocytic damage marker, may help advance our understanding of different neurodegenerative diseases. |
2021-12-11 |
2023-08-13 |
Not clear |
| Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kon. GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 13. 2021-10-26. PMID:33753498. |
together, these findings demonstrate that hyperpalmitoylated gfap plays critical roles in regulating the pathogenesis of astrogliosis and neurodegeneration in the cns, and most importantly, pinpointing that cysteine-291 in gfap might be a valuable pharmaceutical target for treating incl and other potential neurodegenerative diseases. |
2021-10-26 |
2023-08-13 |
mouse |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
alexander disease (axd) caused by mutations in the coding region of gfap is a neurodegenerative disease characterized by astrocyte dysfunction, gfap aggregation, and rosenthal fiber accumulation. |
2021-07-19 |
2023-08-13 |
mouse |
| Breton M Asken, Lawren VandeVrede, Julio C Rojas, Corrina Fonseca, Adam M Staffaroni, Fanny M Elahi, Cutter A Lindbergh, Alexandra C Apple, Michelle You, Sophia Weiner-Light, Nivetha Brathaban, Nicole Fernandes, Adam L Boxer, Bruce L Miller, Howie J Rosen, Joel H Kramer, Kaitlin B Casalett. Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment. Journal of the International Neuropsychological Society : JINS. 2021-06-30. PMID:34158138. |
there are minimal data directly comparing plasma neurofilament light (nfl) and glial fibrillary acidic protein (gfap) in aging and neurodegenerative disease research. |
2021-06-30 |
2023-08-13 |
Not clear |
| Mahdi Ramezani, Alireza Komaki, Nasrin Hashemi-Firouzi, Keywan Mortezaee, Nafiseh Faraji, Zoleikha Golipoo. Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease. Journal of chemical neuroanatomy. vol 108. 2021-04-02. PMID:32470495. |
furthermore, there was a significant rise in gfap and beta tubulin and substantial fall in microglial cells in the bmscs in comparison with mt-bmscs.stem cell therapy has been proposed as an effective strategy for neurodegenerative diseases,but its therapeutic features are restricted.it has been shown that the pretreatment of mscs with melatonin partly would boost cells efficiency and thereby alleviate ad complications such as memory and cognition. |
2021-04-02 |
2023-08-13 |
rat |