| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kayo Mitsukawa, Michiko Terada, Ryuji Yamada, Taku Monjo, Tetsuaki Hiyoshi, Masanori Nakakariya, Yuichi Kajita, Tatsuya Ando, Tatsuki Koike, Haruhide Kimur. TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models. Scientific reports. vol 14. issue 1. 2024-09-06. PMID:39242684. |
narcolepsy type 1 (nt1) is associated with severe loss of orexin neurons and characterized by symptoms including excessive daytime sleepiness and cataplexy. |
2024-09-06 |
2024-09-10 |
mouse |
| Jiaqin Yu, Ting Shen, Zongshan Li, Tian Lv, Lisan Zhan. Immune Reconstitution Inflammatory Syndrome Due to HIV Treatment as a Potential Trigger: A Case Report with Late-Onset Narcolepsy. Nature and science of sleep. vol 16. 2024-08-20. PMID:39161889. |
narcolepsy type 1 (nt1) is a unique central sleepiness disorder that affects individuals with excessive daytime sleepiness (eds), cataplexy, sleep paralysis, and hypnagogic hallucinations. |
2024-08-20 |
2024-08-22 |
human |
| Andrea Bacelar, Oscar Fernandez, Eduardo Paradella, Raimundo Nonato Rodrigues, Claudia Roberta de Castro Moreno, Regina Alvareng. Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2024-08-16. PMID:39150697. |
we investigated the association of hla class ii-dr-dq alleles in a sample of patients with narcolepsy-cataplexy (narcolepsy type 1; nt1) and patients with narcolepsy without cataplexy (narcolepsy type 2; nt2) with a control group. |
2024-08-16 |
2024-08-18 |
human |
| Maxime Grenot, Alexis Roman, Villalba Manon, Anne-Laure Morel, Fort Patrice, Sebastien Arthaud, Paul-Antoine Libourel, Peyron Christell. Major Alteration Of Motor Control During Rem Sleep In Mice Models Of Sleep Disorders. Sleep. 2024-08-09. PMID:39121093. |
alteration of motor control during rem sleep has been extensively described in sleep disorders, in particular in isolated rem sleep behavior disorder (irbd) and narcolepsy type 1 (nt1). |
2024-08-09 |
2024-08-12 |
mouse |
| Akeem Sanni, Md Abdul Hakim, Mona Goli, Moyinoluwa Adeniyi, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechre. Serum ACS omega. vol 9. issue 30. 2024-08-05. PMID:39100283. |
serum the neurological condition known as narcolepsy type 1 (nt1) is an uncommon condition marked by extreme daytime sleepiness, cataplexy, sleep paralysis, hallucinations, disrupted nocturnal sleep, and low or undetectable levels of orexin in the csf fluid. |
2024-08-05 |
2024-08-07 |
Not clear |
| Maria Júlia Figueiró Reis, Giselle de Martin Truzzi, Maria Fernanda Naufel, Fernando Morgadinho Santos Coelh. Exploring the association between hypocretin-1 levels and bone mineral content in patients with narcolepsy: A cross-sectional study. Sleep medicine. vol 121. 2024-07-31. PMID:39084148. |
this study aimed to address anthropometric differences between patients with narcolepsy type 1 (nt1) and type 2 (nt2) and discrepancies in bone mineral content (bmc) as a function of hypocretin-1 (hcrt-1) measured in cerebrospinal fluid (csf). |
2024-07-31 |
2024-08-03 |
Not clear |
| Patrizia Congiu, Monica Puligheddu, Agata Maria Capodiferro, Stella Giulia Falqui, Ludovica Tamburrino, Michela Figorilli, Giuseppe Plazzi, Antonella Gaglian. Narcolepsy and pediatric acute-onset neuropsychiatric syndrome: A case report that suggests a putative link between the two disorders. Sleep medicine. vol 121. 2024-07-30. PMID:39079372. |
narcolepsy with cataplexy (nt1) is a rare hypothalamic disorder that presents with a dysregulation of the sleep-wake cycle (i.e., excessive daytime sleepiness and sleep and cataplectic attacks) and other motor, cognitive, psychiatric, metabolic, and autonomic disturbances, with putative autoimmune pathogenesis. |
2024-07-30 |
2024-08-02 |
Not clear |
| Yuqing Yuan, Xianhui Zhong, Qingqing Zhan, Tiantian Yin, Chengxin Ku, Yuxin Liu, Ziyi Yao, Fen Wang, Yongmin Ding, Liying Deng, Qing Ke, Liang Xi. Association between cytokines and symptoms of depression and anxiety in patients with type 1 narcolepsy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 126. 2024-07-28. PMID:39068820. |
earlier studies have shown that narcolepsy type 1 (nt1) is an autoimmune inflammatory disease and symptoms of depression and anxiety are closely related to fluctuations in inflammatory cytokines. |
2024-07-28 |
2024-08-02 |
Not clear |
| Ee-Rah Sung, Caroline B Maness, Jesse D Cook, Ana Maria Vascan, Danielle Moron, Prabhjyot Saini, David B Rye, David T Plante, Lynn Marie Trott. Validation and performance of the sleep inertia questionnaire in central disorders of hypersomnolence. Sleep medicine. vol 121. 2024-07-27. PMID:39067151. |
we evaluated the performance of the sleep inertia questionnaire (siq) in cdh, and how well it distinguished hypersomnolent groups from controls, and ih (idiopathic hypersomnia) from narcolepsy type 1 (nt1). |
2024-07-27 |
2024-08-02 |
Not clear |
| Brian T Harel, James J Gattuso, Robert D Latzman, Paul Maruff, Thomas E Scammell, Giuseppe Plazz. The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis. Sleep advances : a journal of the Sleep Research Society. vol 5. issue 1. 2024-07-22. PMID:39036743. |
people with narcolepsy type 1 (nt1), narcolepsy type 2 (nt2), and idiopathic hypersomnia (ih) often report cognitive impairment which can be quite burdensome but is rarely evaluated in routine clinical practice. |
2024-07-22 |
2024-07-24 |
Not clear |
| Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccol. Ageing-related modification of sleep and breathing in orexin-knockout narcoleptic mice. Journal of sleep research. 2024-07-20. PMID:39032099. |
narcolepsy type-1 (nt1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. |
2024-07-20 |
2024-07-24 |
mouse |
| Wei-Chih Chin, Yu-Shu Huang, I Tang, Chih-Huan Wan. Long-term follow-up of symptom and quality of life changes in patients with narcolepsy during and after the COVID-19 pandemic. Sleep and biological rhythms. vol 22. issue 3. 2024-07-04. PMID:38962790. |
patients with type 1 or type 2 narcolepsy (nt1, nt2) were retrospectively recruited and prospectively followed from 2020 to 2023. |
2024-07-04 |
2024-07-10 |
Not clear |
| Brian Tracey, Mark Culp, Stephan Fabregas, Emmanuel Mignot, Derek L Buhl, Dmitri Volfso. Novel biomarkers derived from the Maintenance of Wakefulness Test as predictors of sleepiness and response to treatment. Sleep. 2024-07-02. PMID:38954525. |
here, we explored microsleeps, sleep probability measures derived from automated sleep scoring, and quantitative electroencephalography (qeeg) features as additional mwt biomarkers of daytime sleepiness, using data from a phase 1b trial of the selective orexin receptor 2 agonist danavorexton (tak-925) in people with narcolepsy type 1 (nt1) or type 2 (nt2). |
2024-07-02 |
2024-07-06 |
Not clear |
| Brian Tracey, Mark Culp, Stephan Fabregas, Emmanuel Mignot, Derek L Buhl, Dmitri Volfso. Novel biomarkers derived from the Maintenance of Wakefulness Test as predictors of sleepiness and response to treatment. Sleep. 2024-07-02. PMID:38954525. |
the slopes of line-fits to both the log-transformed sleepiness score or log-transformed θ/α ratio correlated well to (inverse) mwt sol for nt1 (r = 0.93 and r = 0.83, respectively) and nt2 (r = 0.97 and r = 0.84, respectively), suggesting that individuals with narcolepsy have increased sleepiness immediately after lights-off. |
2024-07-02 |
2024-07-06 |
Not clear |
| Niels Christian Haubjerg Østerby, Niklas Rye Jørgensen, Poul Jørgen Jennu. Evaluating routine blood and cerebrospinal fluid samples in narcolepsy patients. Scandinavian journal of clinical and laboratory investigation. 2024-06-27. PMID:38934461. |
cerebrospinal fluid hypocretin-1 is proven to be a precise diagnostic marker of narcolepsy type 1 (nt1). |
2024-06-27 |
2024-06-29 |
Not clear |
| Samia Hamdan, Pontus Wasling, Alexander Lin. High-resolution HLA sequencing and hypocretin receptor 2 autoantibodies in narcolepsy type 1 and type 2. International journal of immunogenetics. 2024-06-20. PMID:38898624. |
narcolepsy is classified into type 1 (nt1) and type 2 (nt2). |
2024-06-20 |
2024-06-22 |
human |
| Yuanhang Pan, Xinbo Zhang, Xinyu Wen, Na Yuan, Li Guo, Yifan Shi, Yuanyuan Jia, Yanzhao Guo, Fengli Hao, Shuyi Qu, Ze Chen, Lei Yang, Xiaoli Wang, Yonghong Li. Development and validation of a machine learning model for prediction of comorbid major depression disorder among narcolepsy type 1. Sleep medicine. vol 119. 2024-06-16. PMID:38810481. |
major depression disorder (mdd) forms a common psychiatric comorbidity among patients with narcolepsy type 1 (nt1), yet its impact on patients with nt1 is often overlooked by neurologists. |
2024-06-16 |
2024-06-19 |
Not clear |
| Jieyang Yu, Yanan Zhang, Lijia Cai, Qingqing Sun, Wanru Li, Junfang Zhou, Jianmin Liang, Zan Wan. The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1. Nature and science of sleep. vol 16. 2024-06-14. PMID:38873239. |
this study aimed to evaluate nocturnal sleep structure and anxiety, depression, and fatigue in patients with narcolepsy type 1 (nt1). |
2024-06-14 |
2024-06-16 |
Not clear |
| Valerie Martinet, Laura Sinkunaite, Marie Bruynee. An Unusual Cause of Increasing Excessive Daytime Sleepiness in a CPAP-treated Obstructive Sleep Apnea Patient. Sleep science (Sao Paulo, Brazil). vol 17. issue 2. 2024-06-08. PMID:38846592. |
the onset of narcolepsy type 1 (nt1) occurs after 50 years of age in less than 2% of the cases. |
2024-06-08 |
2024-06-10 |
Not clear |
| Yuanhang Pan, Di Zhao, Xinbo Zhang, Na Yuan, Lei Yang, Yuanyuan Jia, Yanzhao Guo, Ze Chen, Zezhi Wang, Shuyi Qu, Junxiang Bao, Yonghong Li. Machine learning-Based model for prediction of Narcolepsy Type 1 in Patients with Obstructive Sleep Apnea with Excessive Daytime Sleepiness. Nature and science of sleep. vol 16. 2024-06-05. PMID:38836216. |
excessive daytime sleepiness (eds) forms a prevalent symptom of obstructive sleep apnea (osa) and narcolepsy type 1 (nt1), while the latter might always be overlooked. |
2024-06-05 |
2024-06-07 |
Not clear |