| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroshi Yukitake, Tatsuhiko Fujimoto, Takashi Ishikawa, Atsushi Suzuki, Yuji Shimizu, Kentaro Rikimaru, Mitsuhiro Ito, Motohisa Suzuki, Haruhide Kimur. TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice. Pharmacology, biochemistry, and behavior. vol 187. 2020-07-21. PMID:31654653. |
orexin-producing neurons in the lateral hypothalamus are a critical regulator of sleep/wake states, and their loss is associated with narcolepsy type 1 (nt1). |
2020-07-21 |
2023-08-13 |
mouse |
| Eduardo Beltrán, Xuan-Hung Nguyen, Clémence Quériault, Lucie Barateau, Yves Dauvilliers, Klaus Dornmair, Roland S Libla. Shared T cell receptor chains in blood memory CD4 Journal of autoimmunity. vol 100. 2020-07-15. PMID:30948158. |
shared t cell receptor chains in blood memory cd4 convergent evidence points to the involvement of t cells in the pathogenesis of narcolepsy type 1 (nt1). |
2020-07-15 |
2023-08-13 |
Not clear |
| Rhîannan H Williams, Tomomi Tsunematsu, Alexia M Thomas, Kelsie Bogyo, Akihiro Yamanaka, Thomas S Kilduf. Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 47. 2020-07-01. PMID:31628177. |
narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (hcrt) system, either due to extensive loss of hcrt cells (type 1, nt1) or hypothesized hcrt signaling impairment (type 2, nt2). |
2020-07-01 |
2023-08-13 |
mouse |
| Patricia Franco, Yves Dauvilliers, Clara Odilia Inocente, Aurore Guyon, Carine Villanueva, Veronique Raverot, Sabine Plancoulaine, Jian-Sheng Li. Impaired histaminergic neurotransmission in children with narcolepsy type 1. CNS neuroscience & therapeutics. vol 25. issue 3. 2020-06-22. PMID:30225986. |
to assess whether brain histamine (ha) is also involved, we quantified the cerebrospinal fluid (csf) levels of ha and tele-methylhistamine (t-meha), the direct metabolite of ha between children with orexin-deficient narcolepsy type 1 (nt1) and controls. |
2020-06-22 |
2023-08-13 |
Not clear |
| Stefano Vandi, Sara Rodolfi, Fabio Pizza, Monica Moresco, Elena Antelmi, Raffaele Ferri, Emmanuel Mignot, Giuseppe Plazzi, Alessandro Silvan. Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1. Sleep. vol 42. issue 12. 2020-05-11. PMID:31353416. |
arterial blood pressure (abp) decreases during sleep compared with wakefulness and this change is blunted in mouse models of and adult patients with narcolepsy type 1 (nt1). |
2020-05-11 |
2023-08-13 |
mouse |
| Lucie Barateau, Sofiene Chenini, Elisa Evangelista, Isabelle Jaussent, Regis Lopez, Yves Dauvillier. Clinical autonomic dysfunction in narcolepsy type 1. Sleep. vol 42. issue 12. 2020-05-11. PMID:31418025. |
(1) to compare the presence of autonomic symptoms using the validated scopa-aut questionnaire in untreated patients with narcolepsy type 1 (nt1) to healthy controls, (2) to study the determinants of a high total scopa-aut score in nt1, and (3) to evaluate the effect of drug intake on scopa-aut results in nt1. |
2020-05-11 |
2023-08-13 |
Not clear |
| Alexander Lind, Daniel Eriksson, Omar Akel, Anita Ramelius, Lars Palm, Åke Lernmark, Olle Kämpe, Helena Elding Larsson, Nils Landegre. Screening for autoantibody targets in post-vaccination narcolepsy using proteome arrays. Scandinavian journal of immunology. vol 91. issue 4. 2020-03-30. PMID:32056243. |
narcolepsy type 1 (nt1) is a chronic sleep disorder caused by a specific loss of hypocretin-producing neurons. |
2020-03-30 |
2023-08-13 |
human |
| Mink Schinkelshoek, Rolf Fronczek, Willem Verduijn, Geert Haasnoot, Sebastiaan Overeem, Claire Donjacour, Astrid van der Heide, Dave Roelen, Frans Claas, Gert Jan Lammer. HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic. Journal of neuroimmunology. vol 342. 2020-03-24. PMID:32179327. |
we aimed to compare hla-dqb1-associations in narcolepsy type 1 (nt1) patients with disease onset before and after the 2009 h1n1 pandemic in a large dutch cohort. |
2020-03-24 |
2023-08-13 |
Not clear |
| Hilde T Juvodden, Dag Alnæs, Martina J Lund, Espen Dietrichs, Per M Thorsby, Lars T Westlye, Stine Knudse. Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing. Sleep. vol 42. issue 7. 2020-03-23. PMID:30923809. |
to assess brain activation patterns in response to fun-rated and neutral-rated movies we performed functional magnetic resonance imaging (fmri) during a humor-paradigm in narcolepsy type 1 (nt1) patients with cataplexy (muscle atonia triggered by emotions) and controls. |
2020-03-23 |
2023-08-13 |
Not clear |
| Alexander Lind, Omar Akel, Madeleine Wallenius, Anita Ramelius, Marlena Maziarz, Lue Ping Zhao, Daniel E Geraghty, Lars Palm, Åke Lernmark, Helena Elding Larsso. HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy. PloS one. vol 14. issue 10. 2020-03-10. PMID:31577807. |
the incidence of narcolepsy type 1 (nt1) increased in sweden following the 2009-2010 mass-vaccination with the influenza pandemrix-vaccine. |
2020-03-10 |
2023-08-13 |
human |
| Stefano Vandi, Fabio Pizza, Elena Antelmi, Giulia Neccia, Martina Iloti, Alice Mazzoni, Patrizia Avoni, Giuseppe Plazz. A standardized test to document cataplexy. Sleep medicine. vol 53. 2020-03-09. PMID:29276000. |
cataplexy is the pathognomonic symptom of narcolepsy type 1 (nt1). |
2020-03-09 |
2023-08-13 |
Not clear |
| Bei Huang, Zhenying Qian, Zongwen Wang, Jihui Zhang, Kun Chen, Tao Xu, Jijun Wang, David F Cechetto, Zhongxin Zhao, Huijuan W. Fluctuation of primary motor cortex excitability during cataplexy in narcolepsy. Annals of clinical and translational neurology. vol 6. issue 2. 2020-02-18. PMID:30847354. |
cataplexy is a complicated and dynamic process in narcolepsy type 1 (nt1) patients. |
2020-02-18 |
2023-08-13 |
Not clear |
| Fabio Pizza, Lucie Barateau, Isabelle Jaussent, Stefano Vandi, Elena Antelmi, Emmanuel Mignot, Yves Dauvilliers, Giuseppe Plazz. Validation of Multiple Sleep Latency Test for the diagnosis of pediatric narcolepsy type 1. Neurology. vol 93. issue 11. 2020-01-30. PMID:31405906. |
to validate polysomnographic markers (sleep latency and sleep-onset rem periods [soremps] at the multiple sleep latency test [mslt] and nocturnal polysomnography [psg]) for pediatric narcolepsy type 1 (nt1) against csf hypocretin-1 (hcrt-1) deficiency and presence of cataplexy, as no criteria are currently validated in children. |
2020-01-30 |
2023-08-13 |
Not clear |
| Claudio L A Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum, Gert Jan Lammers, Roland S Liblau, Pierre H Luppi, Geert Mayer, Thomas Pollmächer, Takeshi Sakurai, Federica Sallusto, Thomas E Scammell, Mehdi Tafti, Yves Dauvillier. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nature reviews. Neurology. vol 15. issue 9. 2020-01-29. PMID:31324898. |
narcolepsy type 1 (nt1) is characterized by excessive daytime sleepiness and cataplexy, accompanied by sleep-wake symptoms, such as hallucinations, sleep paralysis and disturbed sleep. |
2020-01-29 |
2023-08-13 |
Not clear |
| Claudio L A Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum, Gert Jan Lammers, Roland S Liblau, Pierre H Luppi, Geert Mayer, Thomas Pollmächer, Takeshi Sakurai, Federica Sallusto, Thomas E Scammell, Mehdi Tafti, Yves Dauvillier. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nature reviews. Neurology. vol 15. issue 9. 2020-01-29. PMID:31324898. |
data supporting the view of nt1 as a hypothalamic disorder affecting not only sleep-wake but also motor, psychiatric, emotional, cognitive, metabolic and autonomic functions are presented, along with uncertainties concerning the 'narcoleptic borderland', including narcolepsy type 2 (nt2). |
2020-01-29 |
2023-08-13 |
Not clear |
| Manuela Tondelli, Fabio Pizza, Anna Elisabetta Vaudano, Giuseppe Plazzi, Stefano Melett. Cortical and Subcortical Brain Changes in Children and Adolescents With Narcolepsy Type 1. Sleep. vol 41. issue 2. 2020-01-08. PMID:29244164. |
neuroimaging studies on structural alterations in patients with type 1 narcolepsy (nt1) have shown controversial and heterogeneous results. |
2020-01-08 |
2023-08-13 |
Not clear |
| Lucie Barateau, Régis Lopez, Yves Dauvillier. Clinical neurophysiology of CNS hypersomnias. Handbook of clinical neurology. vol 161. 2020-01-06. PMID:31307613. |
impaired neurotransmission of hypocretin/orexin (neuropeptides of the lateral hypothalamus) is involved in the neurobiology of narcolepsy with cataplexy (nt1). |
2020-01-06 |
2023-08-13 |
Not clear |
| Julian Lippert, Peter Young, Catharina Gross, Sven G Meuth, Bianca Dräger, Anja Schirmacher, Anna Heidbrede. Specific T-cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence. Sleep. vol 42. issue 2. 2019-12-17. PMID:30445542. |
an autoimmune-mediated process in the pathophysiology of narcolepsy type 1 (nt1) is highly suspicious, if this pathomechanism is transferable to other types of central disorders of hypersomnolence (cdh), is still controversial. |
2019-12-17 |
2023-08-13 |
Not clear |
| Lucie Barateau, Régis Lopez, Sofiene Chenini, Elisa Evangelista, Meriem Benkiran, Denis Mariano-Goulart, Isabelle Jaussent, Yves Dauvillier. Exploration of cardiac sympathetic adrenergic nerve activity in narcolepsy. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 130. issue 3. 2019-12-16. PMID:30573423. |
to compare cardiac sympathetic adrenergic nerve activity in patients with narcolepsy type 1 (nt1) and controls using |
2019-12-16 |
2023-08-13 |
Not clear |
| Zhongxing Zhang, Geert Mayer, Yves Dauvilliers, Giuseppe Plazzi, Fabio Pizza, Rolf Fronczek, Joan Santamaria, Markku Partinen, Sebastiaan Overeem, Rosa Peraita-Adrados, Antonio Martins da Silva, Karel Sonka, Rafael Del Rio-Villegas, Raphael Heinzer, Aleksandra Wierzbicka, Peter Young, Birgit Högl, Claudio L Bassetti, Mauro Manconi, Eva Feketeova, Johannes Mathis, Teresa Paiva, Francesca Canellas, Michel Lecendreux, Christian R Baumann, Lucie Barateau, Carole Pesenti, Elena Antelmi, Carles Gaig, Alex Iranzo, Laura Lillo-Triguero, Pablo Medrano-Martínez, José Haba-Rubio, Corina Gorban, Gianina Luca, Gert Jan Lammers, Ramin Khatam. Exploring the clinical features of narcolepsy type 1 versus narcolepsy type 2 from European Narcolepsy Network database with machine learning. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30006563. |
narcolepsy is a rare life-long disease that exists in two forms, narcolepsy type-1 (nt1) or type-2 (nt2), but only nt1 is accepted as clearly defined entity. |
2019-11-25 |
2023-08-13 |
Not clear |