| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucie Barateau, Régis Lopez, Yves Dauvillier. Treatment Options for Narcolepsy. CNS drugs. vol 30. issue 5. 2017-04-13. PMID:27155860. |
in recent years, narcolepsy treatment has changed with the widespread use of modafinil/armodafinil for daytime sleepiness, antidepressants (selective serotonin and dual serotonin and noradrenalin reuptake inhibitors) for cataplexy, and sodium oxybate for both symptoms. |
2017-04-13 |
2023-08-13 |
Not clear |
| Meng Liu, Carlos Blanco-Centurion, Roda Rani Konadhode, Liju Luan, Priyattam J Shiroman. Orexin gene transfer into the amygdala suppresses both spontaneous and emotion-induced cataplexy in orexin-knockout mice. The European journal of neuroscience. vol 43. issue 5. 2016-12-13. PMID:26741960. |
cataplexy, a sudden loss of muscle tone during waking, is an important distinguishing symptom of narcolepsy and it is often triggered by strong emotions. |
2016-12-13 |
2023-08-13 |
mouse |
| Meng Liu, Carlos Blanco-Centurion, Roda Rani Konadhode, Liju Luan, Priyattam J Shiroman. Orexin gene transfer into the amygdala suppresses both spontaneous and emotion-induced cataplexy in orexin-knockout mice. The European journal of neuroscience. vol 43. issue 5. 2016-12-13. PMID:26741960. |
it suggests that manipulating amygdala pathways is a potential strategy for treating cataplexy in narcolepsy. |
2016-12-13 |
2023-08-13 |
mouse |
| Monica Moresco, Laura Natalia Riccardi, Fabio Pizza, Corrado Zenesini, Leonardo Caporali, Giuseppe Plazzi, Susi Pelott. Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1. Clinical neuropharmacology. vol 39. issue 1. 2016-10-11. PMID:26757307. |
narcolepsy type 1 (nt1) is a chronic hypersomnia clinically characterized by daytime sleepiness and cataplexy. |
2016-10-11 |
2023-08-13 |
Not clear |
| Yves Dauvilliers, Régis Lope. [MANAGEMENT OF CENTRAL HYPERSOMNIAS]. La Revue du praticien. vol 66. issue 6. 2016-09-22. PMID:27538329. |
in narcolepsy type 1, antidepressants such as inhibitors of the reuptake of serotonin and noradrenaline will be considered to improve cataplexy. |
2016-09-22 |
2023-08-13 |
Not clear |
| Elemer Szabad. GHB for cataplexy: Possible mode of action. Journal of psychopharmacology (Oxford, England). vol 29. issue 6. 2016-02-22. PMID:25735989. |
a troublesome symptom of narcolepsy is cataplexy, the sudden loss of muscle tone in response to strong emotions. |
2016-02-22 |
2023-08-13 |
Not clear |
| Francesca Letizia Rocca, Fabio Pizza, Emilia Ricci, Giuseppe Plazz. Narcolepsy during Childhood: An Update. Neuropediatrics. vol 46. issue 3. 2016-02-16. PMID:25961600. |
narcolepsy type 1 (nt1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations, and fragmented nocturnal sleep usually arising in adolescence or young adulthood. |
2016-02-16 |
2023-08-13 |
human |
| P H Luppi, O Clément, E Sapin, S V Garcia, C Peyron, P For. Animal models of REM dysfunctions: what they tell us about the cause of narcolepsy and RBD? Archives italiennes de biologie. vol 152. issue 2-3. 2015-11-09. PMID:25828684. |
conversely, cataplexy, one of the key symptoms of narcolepsy, is a striking sudden episode of muscle weakness triggered by emotions during wakefulness, and comparable to rem sleep atonia. |
2015-11-09 |
2023-08-13 |
Not clear |
| Hassana de Almeida Fonseca, Danielle Antunes Lopes, Danielle Pereira, Danilo Anunciatto Sguillar, Eduardo Lopes, Nilce Sanny Costa da Silva Behrens, Taís Figueiredo de Araújo Lima, Marcia Pradella-Hallinan, Juliana Castro, Sergio Tufik, Fernando Morgadinho Santos Coelh. The use of citalopram for the treatment of cataplexy. Sleep science (Sao Paulo, Brazil). vol 7. issue 1. 2015-10-20. PMID:26483901. |
cataplexy is the most specific symptom of narcolepsy, being characterized by a sudden and temporary loss of muscle tonus, triggered by episodes of emotion during vigil. |
2015-10-20 |
2023-08-13 |
Not clear |
| Nancy L Sega. Highlights from the 15th International Congress of Twin Studies/Twin Research: Differentiating MZ Co-twins Via SNPs; Mistaken Infant Twin-Singleton Hospital Registration; Narcolepsy With Cataplexy; Hearing Loss and Language Learning/Media Mentions: Broadway Musical Recalls Conjoined Hilton Twins; High Fashion Pair; Twins Turn 102; Insights From a Conjoined Twin Survivor. Twin research and human genetics : the official journal of the International Society for Twin Studies. vol 18. issue 1. 2015-10-09. PMID:25662422. |
this report is followed by summaries of research addressing the differentiation of mz co-twins by single nucleotide polymorphisms (snps), an unusual error in infant twin-singleton hospital registration, twins with childhood-onset narcolepsy with cataplexy, and the parenting effects of hearing loss in one co-twin. |
2015-10-09 |
2023-08-13 |
Not clear |
| Justin Liu, Florian T Merkle, Avni V Gandhi, James A Gagnon, Ian G Woods, Cindy N Chiu, Tomomi Shimogori, Alexander F Schier, David A Probe. Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). vol 142. issue 6. 2015-05-18. PMID:25725064. |
loss of neurons that express the neuropeptide hypocretin (hcrt) has been implicated in narcolepsy, a debilitating disorder characterized by excessive daytime sleepiness and cataplexy. |
2015-05-18 |
2023-08-13 |
mouse |
| Roland S Liblau, Anne Vassalli, Ali Seifinejad, Mehdi Taft. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. The Lancet. Neurology. vol 14. issue 3. 2015-04-28. PMID:25728441. |
narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of the hypocretin-producing neurons in the hypothalamus. |
2015-04-28 |
2023-08-13 |
Not clear |
| Elisa Favaron, Paolo Albon. [Episodes of apparent transient loss of consciousness: disorders a cardiologist should not ignore]. Giornale italiano di cardiologia (2006). vol 16. issue 1. 2015-03-20. PMID:25689746. |
clinical findings that suggest cataplexy include an emotional trigger - above all if the emotion is positive -, an "unreal" fall similar to that observed in patients with psychogenic pseudosyncope, repeated attacks in a daytime, symptoms of narcolepsy as the clinical context. |
2015-03-20 |
2023-08-13 |
Not clear |
| Astrid van der Heide, Willem Verduijn, Geert W Haasnoot, Jos J M Drabbels, Gert J Lammers, Frans H J Claa. HLA dosage effect in narcolepsy with cataplexy. Immunogenetics. vol 67. issue 1. 2015-03-11. PMID:25277311. |
narcolepsy with cataplexy is a sleep disorder caused by the loss of hypocretin-producing neurons in the hypothalamus. |
2015-03-11 |
2023-08-13 |
human |
| Massimiliano de Zambotti, Fabio Pizza, Naima Covassin, Stefano Vandi, Nicola Cellini, Luciano Stegagno, Giuseppe Plazz. Facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation. Journal of sleep research. vol 23. issue 4. 2014-11-09. PMID:24635684. |
facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation. |
2014-11-09 |
2023-08-12 |
Not clear |
| Massimiliano de Zambotti, Fabio Pizza, Naima Covassin, Stefano Vandi, Nicola Cellini, Luciano Stegagno, Giuseppe Plazz. Facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation. Journal of sleep research. vol 23. issue 4. 2014-11-09. PMID:24635684. |
narcolepsy with cataplexy is a complex sleep disorder that affects the modulation of emotions: cataplexy, the key symptom of narcolepsy, is indeed strongly linked with emotions that usually trigger the episodes. |
2014-11-09 |
2023-08-12 |
Not clear |
| Giuseppe Plazz. Dante's description of narcolepsy. Sleep medicine. vol 14. issue 11. 2014-07-08. PMID:24021161. |
taken together these signs are highly reminiscent of narcolepsy, a term coined in 1880 by gélineau to define a disease consisting of daytime irresistible sleep episodes with remarkable dream mentation, sleep paralysis, hallucinations, and cataplexy (falls triggered by strong emotions). |
2014-07-08 |
2023-08-12 |
Not clear |
| Alessandro Silvani, Stefano Bastianini, Chiara Berteotti, Giovanna Cenacchi, Ornella Leone, Viviana Lo Martire, Valentina Papa, Giovanna Zoccol. Sleep and cardiovascular phenotype in middle-aged hypocretin-deficient narcoleptic mice. Journal of sleep research. vol 23. issue 1. 2014-06-20. PMID:24033681. |
narcolepsy with cataplexy (nc) is a lifelong disorder caused by loss of hypothalamic hypocretin/orexin (hcrt) neurones, often starting in childhood. |
2014-06-20 |
2023-08-12 |
mouse |
| Sophie Bayard, Muriel Croisier Langenier, Yves Dauvillier. Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy. Sleep. vol 36. issue 9. 2014-04-25. PMID:23997366. |
effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy. |
2014-04-25 |
2023-08-12 |
Not clear |
| Sophie Bayard, Muriel Croisier Langenier, Yves Dauvillier. Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy. Sleep. vol 36. issue 9. 2014-04-25. PMID:23997366. |
to investigate the effect of psychostimulants on impulsivity, depressive symptoms, addiction, pathological gambling, and risk-taking using objective sensitivity tests in narcolepsy with cataplexy (nc). |
2014-04-25 |
2023-08-12 |
Not clear |