| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Biscarini, Stefano Vandi, Corrado Zenesini, Luca Vignatelli, Francesca Citeroni, Elena Antelmi, Christian Franceschini, Lucie Barateau, Yves Dauvilliers, Emmanuel Mignot, Giuseppe Plazzi, Fabio Pizz. Use of Portable 24-Hour Polysomnography as Alternative Diagnostic Tool for Narcolepsy Type 1 in Adults and Children. Neurology. vol 104. issue 7. 2025-03-13. PMID:40080737. |
the diagnosis of narcolepsy type 1 (nt1) currently requires the multiple sleep latency test (mslt), or a nocturnal sleep-onset rem period (soremp) combined with typical cataplexy, or alternatively the determination of csf hypocretin-1 (csf-hcrt-1) deficiency. |
2025-03-13 |
2025-03-16 |
Not clear |
| Giuseppe Plazzi, Geert Mayer, Ralf Bodenschatz, Enrica Bonanni, Alessandro Cicolin, Giacomo Della Marca, Pierluigi Dolso, Luigi Ferini Strambi, Raffaele Ferri, Peter Geisler, Svenja Happe, Anna Heidbreder, Jürgen Herold, Ulf Kallweit, Laurène Leclair-Visonneau, Katharina Lederer, Claudio Liguori, Johan Meurling, Liborio Parrino, Paola Proserpio, Monica Puligheddu, Maria Antonia Quera Salva, Jan Remi, Andrea Romigi, Sven Rupprecht, Maria Antonietta Savarese, Jean-Luc Schaff, Michele Terzaghi, Yaroslav Winter, Christian Caussé, Irène Collin, Isabelle Lecomte, Yves Dauvillier. Interim analysis of a post-authorization safety study of pitolisant in treating narcolepsy: A real-world European study. Sleep medicine. vol 129. 2025-02-20. PMID:39978240. |
narcolepsy is a chronic sleep disorder characterized mainly by excessive daytime sleepiness (eds) and cataplexy in the case of narcolepsy type 1 (nt1). |
2025-02-20 |
2025-02-23 |
Not clear |
| Giuseppe Plazzi, Geert Mayer, Ralf Bodenschatz, Enrica Bonanni, Alessandro Cicolin, Giacomo Della Marca, Pierluigi Dolso, Luigi Ferini Strambi, Raffaele Ferri, Peter Geisler, Svenja Happe, Anna Heidbreder, Jürgen Herold, Ulf Kallweit, Laurène Leclair-Visonneau, Katharina Lederer, Claudio Liguori, Johan Meurling, Liborio Parrino, Paola Proserpio, Monica Puligheddu, Maria Antonia Quera Salva, Jan Remi, Andrea Romigi, Sven Rupprecht, Maria Antonietta Savarese, Jean-Luc Schaff, Michele Terzaghi, Yaroslav Winter, Christian Caussé, Irène Collin, Isabelle Lecomte, Yves Dauvillier. Interim analysis of a post-authorization safety study of pitolisant in treating narcolepsy: A real-world European study. Sleep medicine. vol 129. 2025-02-20. PMID:39978240. |
pitolisant is a histamine 3 receptor antagonist/inverse agonist that reduces eds and cataplexy in patients with narcolepsy. |
2025-02-20 |
2025-02-23 |
Not clear |
| Vyacheslav Dyachu. The Role and Mechanisms of the Hypocretin System in Zebrafish ( International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796111. |
the distinctive pathologies associated with the disruption of hcrt neurons are narcolepsy and cataplexy, which are caused by the loss of hypocretin neurons that produce hcrt. |
2025-01-11 |
2025-01-14 |
zebrafish |
| Trishna Sharma, Annette C Kestner, Abhishek Redd. First Episode Psychosis in a Teen with Narcolepsy and Cataplexy. Psychopharmacology bulletin. vol 55. issue 1. 2025-01-02. PMID:39744411. |
narcolepsy with cataplexy (nt1) is a sleep disorder very rarely associated with early-onset psychosis. |
2025-01-02 |
2025-01-04 |
Not clear |
| Julie Martens, Maarten Van Den Bossch. Very late onset narcolepsy type 1: a case report and review of the literature. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2025-01-02. PMID:39745488. |
narcolepsy type 1 (nt1) is a clinical syndrome defined by recurrent episodes of excessive daytime sleepiness (eds), episodes of cataplexy, hypnagogic hallucinations, and sleep paralysis. |
2025-01-02 |
2025-01-04 |
Not clear |
| Wenqi Xu, Wenting Ding, Yu Zhang, Shuanshuan Wang, Xianyu Yan, Yirui Xu, Xiaoying Zhi, Rongzeng Li. The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39595997. |
narcolepsy type 1 (nt1) is an uncommon, persistent sleep disorder distinguished by significant daytime sleepiness, episodes of cataplexy, and irregularities in rapid eye movement sleep. |
2024-11-27 |
2024-11-29 |
Not clear |
| Suresh Kotaga. Peering beyond hypersomnia and cataplexy of childhood narcolepsy: the role of sleep-dependent memory consolidation. Sleep. 2024-11-14. PMID:39540654. |
peering beyond hypersomnia and cataplexy of childhood narcolepsy: the role of sleep-dependent memory consolidation. |
2024-11-14 |
2024-11-17 |
Not clear |
| Lewis J Kas. Hypnosis: An aid in working with patients with narcolepsy. The American journal of clinical hypnosis. vol 66. issue 4. 2024-10-28. PMID:39466898. |
narcolepsy is a primary neurological sleep disorder characterized by excessive daytime sleepiness, and in a majority of patients, cataplexy, which is sudden muscle weakness brought on by strong emotion. |
2024-10-28 |
2024-10-31 |
Not clear |
| Lewis J Kas. Hypnosis: An aid in working with patients with narcolepsy. The American journal of clinical hypnosis. vol 66. issue 4. 2024-10-28. PMID:39466898. |
in addition to medication, however, this article describes promising roles for clinical hypnosis in the care of young patients with narcolepsy, including through teaching them how to have more control over their sleepiness and the emotions that can induce cataplexy, while minimizing side effects that can occur when using narcolepsy medication. |
2024-10-28 |
2024-10-31 |
Not clear |
| Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikaw. Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. Sleep. 2024-10-23. PMID:39441998. |
pharmacological inhibition of histamine n-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. |
2024-10-23 |
2024-10-26 |
mouse |
| Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikaw. Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. Sleep. 2024-10-23. PMID:39441998. |
however, the effects of pharmacological hnmt inhibition on mouse behaviour, including the sleep-wake cycle and cataplexy, in a mouse model of narcolepsy have not yet been investigated. |
2024-10-23 |
2024-10-26 |
mouse |
| Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikaw. Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. Sleep. 2024-10-23. PMID:39441998. |
in addition, metoprine has a greater therapeutic effect on cataplexy than pitolisant, which induces histamine release in the brain, and has been approved for patients with narcolepsy. |
2024-10-23 |
2024-10-26 |
mouse |
| Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikaw. Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. Sleep. 2024-10-23. PMID:39441998. |
these data demonstrate that hnmt inhibition has a strong effect on wakefulness, demonstrating therapeutic potential against cataplexy in narcolepsy. |
2024-10-23 |
2024-10-26 |
mouse |
| Pengxin Hu, Yuqing Yuan, Yu Zou, Ruifang Xiong, Jiankun Dai, Xihai Zhao, Liang Xie, Xiaoping Tan. Alterations in the DTI-ALPS index and choroid plexus volume are associated with clinical symptoms in participants with narcolepsy type 1. Sleep medicine. vol 124. 2024-10-20. PMID:39427503. |
narcolepsy type 1 (nt1) is a sleep disorder characterized by excessive daytime sleepiness accompanied by cataplexy. |
2024-10-20 |
2024-10-23 |
human |
| Marieke Vringer, Jingru Zhou, Jari K Gool, Denise Bijlenga, Gert Jan Lammers, Rolf Fronczek, Mink S Schinkelshoe. Recent insights into the pathophysiology of narcolepsy type 1. Sleep medicine reviews. vol 78. 2024-09-06. PMID:39241492. |
narcolepsy type 1 (nt1) is a sleep-wake disorder in which people typically experience excessive daytime sleepiness, cataplexy and other sleep-wake disturbances impairing daily life activities. |
2024-09-06 |
2024-09-10 |
Not clear |
| Kayo Mitsukawa, Michiko Terada, Ryuji Yamada, Taku Monjo, Tetsuaki Hiyoshi, Masanori Nakakariya, Yuichi Kajita, Tatsuya Ando, Tatsuki Koike, Haruhide Kimur. TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models. Scientific reports. vol 14. issue 1. 2024-09-06. PMID:39242684. |
narcolepsy type 1 (nt1) is associated with severe loss of orexin neurons and characterized by symptoms including excessive daytime sleepiness and cataplexy. |
2024-09-06 |
2024-09-10 |
mouse |
| Michael J Thorpy, Jerome M Siegel, Yves Dauvillier. REM sleep in narcolepsy. Sleep medicine reviews. vol 77. 2024-08-26. PMID:39186901. |
rem sleep disturbances can manifest as cataplexy (in narcolepsy type 1), sleep paralysis, sleep-related hallucinations, rem sleep behavior disorder, abnormal dreams, polysomnographic evidence of rem sleep disruption with sleep-onset rem periods, and fragmented rem sleep. |
2024-08-26 |
2024-08-30 |
Not clear |
| Jiaqin Yu, Ting Shen, Zongshan Li, Tian Lv, Lisan Zhan. Immune Reconstitution Inflammatory Syndrome Due to HIV Treatment as a Potential Trigger: A Case Report with Late-Onset Narcolepsy. Nature and science of sleep. vol 16. 2024-08-20. PMID:39161889. |
narcolepsy type 1 (nt1) is a unique central sleepiness disorder that affects individuals with excessive daytime sleepiness (eds), cataplexy, sleep paralysis, and hypnagogic hallucinations. |
2024-08-20 |
2024-08-22 |
human |
| Andrea Bacelar, Oscar Fernandez, Eduardo Paradella, Raimundo Nonato Rodrigues, Claudia Roberta de Castro Moreno, Regina Alvareng. Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2024-08-16. PMID:39150697. |
we investigated the association of hla class ii-dr-dq alleles in a sample of patients with narcolepsy-cataplexy (narcolepsy type 1; nt1) and patients with narcolepsy without cataplexy (narcolepsy type 2; nt2) with a control group. |
2024-08-16 |
2024-08-18 |
human |