| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Huang, Xing Zhang, Ling Chen, Bo Xu Ren, Feng Ru Tan. Frontiers in bioscience (Landmark edition). vol 28. issue 2. 2023-03-03. PMID:36866558. |
ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. |
2023-03-03 |
2023-08-14 |
Not clear |
| Shuo Huang, Qianyan He, Xin Sun, Yang Qu, Reziya Abuduxukuer, Jiaxin Ren, Kejia Zhang, Yi Yang, Zhen-Ni Gu. DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury By Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis. Current neurovascular research. 2023-02-28. PMID:36852812. |
dl-3-n-butylphthalide (nbp) is an effective medicine for ischemic stroke that reduces cell apoptosis and improves long-term prognosis. |
2023-02-28 |
2023-08-14 |
Not clear |
| Huiwen Zheng, Xin Guo, Shaomeng Kang, Zhongda Li, Tian Tian, Jianhua Li, Fudi Wang, Peng Yu, Shiyang Chang, Yan-Zhong Chan. Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke. Cell death & disease. vol 14. issue 2. 2023-02-25. PMID:36841833. |
our data demonstrated that fpn1 knockout in ecs decreased the brain iron levels in mice, attenuated the oxidative stress and inflammatory responses after stroke, and inhibited both ferroptosis and apoptosis, ultimately alleviating neurological impairment and decreasing cerebral infarct volume during the acute phase of ischemic stroke. |
2023-02-25 |
2023-08-14 |
mouse |
| Hongfa Cheng, Yawen Zhang, Xiaoyao Guo, Xuan Wang, Hanyu Wang, Hui Zhao, Lei Wang, Haiyan Zou, Qiuxia Zhan. Study on Neuroprotective Mechanism of Houshiheisan in Ischemic Stroke Based on Transcriptomics and Experimental Verification. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-16. PMID:36793760. |
effective inhibition of neuronal apoptosis by activating the erk1/2-creb signaling pathway may be a potential mechanism for hshs in the treatment of ischemic stroke. |
2023-02-16 |
2023-08-14 |
rat |
| Wanli Ji, Yaoxin Ren, Xiaolian Wei, Xiangxiang Ding, Yihan Dong, Bin Yua. Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway. Scientific reports. vol 13. issue 1. 2023-02-16. PMID:36797398. |
ischemic stroke protected by iso-1 inhibition of apoptosis via mitochondrial pathway. |
2023-02-16 |
2023-08-14 |
rat |
| Wanli Ji, Yaoxin Ren, Xiaolian Wei, Xiangxiang Ding, Yihan Dong, Bin Yua. Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway. Scientific reports. vol 13. issue 1. 2023-02-16. PMID:36797398. |
in summary, iso-1 may inhibit neuronal apoptosis through the endogenous mitochondrial pathway and reduce the injury of brain i/r after ischemic stroke. |
2023-02-16 |
2023-08-14 |
rat |
| Yan Li, Chengyu Zou, Chen Chen, Sixuan Li, Ziyu Zhu, Qiuyue Fan, Rui Pang, Fengshi Li, Zengai Chen, Zhenghong Wang, Weifeng Yu, Junying Yuan, Peiying L. Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 5. 2023-01-24. PMID:36693098. |
genetic depletion of myeloid-derived mif in perioperative ischemic stroke (pis) mice with mcao following a surgical insult leads to significant reduction in ecs apoptosis and necroptosis and the associated bbb disruption. |
2023-01-24 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Bo Wang, Yuanyuan Liu, Yansong Guo, Hui Lu, Xiqi Li. Inhibition of PI3K/Akt/mTOR signaling by NDRG2 contributes to neuronal apoptosis and autophagy in ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 32. issue 3. 2023-01-18. PMID:36652790. |
inhibition of pi3k/akt/mtor signaling by ndrg2 contributes to neuronal apoptosis and autophagy in ischemic stroke. |
2023-01-18 |
2023-08-14 |
rat |
| Zhen-Kun Gao, Xin-Ya Shen, Yu Han, Yi-Sha Guo, Kai Li, Xia B. Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke. Translational neuroscience. vol 13. issue 1. 2023-01-13. PMID:36636513. |
pre-ischemic exercise prevents inflammation and apoptosis by inhibiting mapk pathway in ischemic stroke. |
2023-01-13 |
2023-08-14 |
Not clear |
| Yi-Syue Tsou, Jing-Huei Lai, Kai-Yun Chen, Cheng-Fu Chang, Chi-Chen Huan. Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614118. |
accordingly, our results suggest that rapamycin provides neuroprotective benefits not only by ameliorating pathological tdp-43 levels, but also by reversing mitochondrial function and attenuating cell apoptosis in ischemic stroke. |
2023-01-08 |
2023-08-14 |
rat |
| Lei Zhang, Tai Zhou, Qiaorong Ji, Li He, Yan Lan, Lei Ding, Li Li, Zhongcheng Wan. Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway. Molecular biology reports. 2023-01-07. PMID:36611117. |
myricetin improves apoptosis after ischemic stroke via inhibiting mapk-erk pathway. |
2023-01-07 |
2023-08-14 |
Not clear |
| Lei Zhang, Tai Zhou, Qiaorong Ji, Li He, Yan Lan, Lei Ding, Li Li, Zhongcheng Wan. Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway. Molecular biology reports. 2023-01-07. PMID:36611117. |
neuroprotectants are clinically used to reduce neuronal apoptosis in ischemic stroke. |
2023-01-07 |
2023-08-14 |
Not clear |
| Shuyuan Huang, Lu Liu, Xiaodong Tang, Shulan Xie, Xinrui Li, Xianhui Kang, Shengmei Zh. Research progress on the role of hormones in ischemic stroke. Frontiers in immunology. vol 13. 2022-12-26. PMID:36569944. |
hormones regulate neuronal plasticity, promote neurotrophic factor formation, reduce cell death, apoptosis, inflammation, excitotoxicity, oxidative and nitrative stress, and brain edema in ischemic stroke. |
2022-12-26 |
2023-08-14 |
Not clear |
| Lei Wang, Xu Zhang, Xiaoxing Xiong, Hua Zhu, Ran Chen, Shudi Zhang, Gang Chen, Zhihong Jia. Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552584. |
cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. |
2022-12-23 |
2023-08-14 |
Not clear |
| Tan Lijuan, Cao Xiaolu, Wan Xin, He Yuying, Lan Xi, Yang Xiliang, Wang Ting, Min Zhenli, Zou Y. Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents. Fitoterapia. 2022-12-23. PMID:36563762. |
these results suggest that compound 8 may have a good inhibitory effect on apoptosis and tissue structurel disorders induced by cerebral ischemia-reperfusion, so as to reduce the injury caused by ischemic stroke. |
2022-12-23 |
2023-08-14 |
rat |
| Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Ping Ping Han, Xia B. Pre-ischaemic treatment with enriched environment alleviates acute neuronal injury by inhibiting endoplasmic reticulum stress-dependent autophagy and apoptosis. Neuroscience. 2022-12-22. PMID:36549603. |
the decrease in activating transcription factor 4(atf4), c/ebp homologous protein (chop), and phospho-c-jun n-terminal kinases(p-jnk) expression suggested ee pretreatment might inhibit autophagy and apoptosis via modulating er stress-mediated perk-atf4-chop and ire1-jnk signal pathways, which provides a new idea for the prevention of the deleterious cerebral and functional consequences of ischemic stroke. |
2022-12-22 |
2023-08-14 |
rat |
| Ruheng Wei, Lijuan Song, Zhuyue Miao, Kexin Liu, Guangyuan Han, Haifei Zhang, Dong Ma, Jianjun Huang, Hao Tian, Baoguo Xiao, Cungen M. Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R. Cells. vol 11. issue 23. 2022-12-11. PMID:36496986. |
in the process of ischemic stroke (is), cellular macroautophagy/autophagy and apoptosis play a vital role in neuroprotection against it. |
2022-12-11 |
2023-08-14 |
Not clear |
| Chao-Chao Yu, Le-Bin Liu, Shi-Yuan Chen, Xiao-Fei Wang, Li Wang, Yan-Jun D. Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence. Aging and disease. vol 13. issue 6. 2022-12-05. PMID:36465168. |
the underlying pathophysiology of ischemic stroke is highly complicated and correlates with various pathological processes, including neuroinflammation, oxidative stress injury, altered cell apoptosis and autophagy, excitotoxicity, and acidosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Weizhuo Lu, Jiyue We. H Metabolic brain disease. 2022-12-05. PMID:36469178. |
in the pathological process of ischemic stroke, the up-regulation of ras homolog gene family, member a (rhoa) and its downstream effector, ras homolog gene family (rho)-associated coiled coil-containing kinase (rock), contribute to the neuroinflammation, blood-brain barrier (bbb) dysfunction, neuronal apoptosis, axon growth inhibition and astrogliosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Nana Tan, Wenqiang Xin, Min Huang, Yuling Ma. Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells. Frontiers in neurology. vol 13. 2022-11-25. PMID:36425795. |
moreover, a notion will be given to mscs participating in multiple pathological processes, such as increasing cell survival angiogenesis and suppressing cell apoptosis and autophagy in several phases of ischemic stroke, consequently promoting neurological function recovery. |
2022-11-25 |
2023-08-14 |
Not clear |