| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mala M Shah, Michele Migliore, Ignacio Valencia, Edward C Cooper, David A Brow. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 22. 2008-06-24. PMID:18515424. |
recent evidence shows that kv7.2 and kv7.3 subunits are targeted to the axon initial segment of hippocampal neurons by association with ankyrin g. further, spontaneous mutations in these subunits that impair axonal targeting cause human neonatal epilepsy. |
2008-06-24 |
2023-08-12 |
human |
| Flavia Antonucci, Angelo Di Garbo, Elena Novelli, Ilaria Manno, Ferdinando Sartucci, Yuri Bozzi, Matteo Cale. Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy. Experimental neurology. vol 210. issue 2. 2008-06-20. PMID:18177862. |
mesial temporal lobe epilepsy (mtle) is often the result of an early insult that induces a reorganization in hippocampal circuitry leading, after a latent period, to chronic epilepsy. |
2008-06-20 |
2023-08-12 |
mouse |
| Flavia Antonucci, Angelo Di Garbo, Elena Novelli, Ilaria Manno, Ferdinando Sartucci, Yuri Bozzi, Matteo Cale. Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy. Experimental neurology. vol 210. issue 2. 2008-06-20. PMID:18177862. |
hippocampal rearrangements during the latent phase include neuronal loss, axonal and dendritic plasticity, neurogenesis, and cell repositioning, but the role of these changes in epilepsy development is unclear. |
2008-06-20 |
2023-08-12 |
mouse |
| Anna Paciorek, Andrzej Urbanik, Jacek Paciorek, Robert Chrzan, Stanisław Sztuk, Anna Zajac, Sławomir Kroczk. [The role of the magnetic resonance spectroscopy in the diagnosis of temporal lobe epilepsy]. Przeglad lekarski. vol 64. issue 11. 2008-06-05. PMID:18409412. |
in persons with epilepsy hmrs of the hippocampus may show the changes in specific metabolites. |
2008-06-05 |
2023-08-12 |
Not clear |
| Gustavo Rassier Isolan, Ney Azambuja, Eliseu Paglioli Neto, Eduardo Pagliol. [Hippocampal microsurgical anatomy regarding the selective amygdalohippocampectomy in the Niemeyer's technique perspective and preoperative method to maximize the corticotomy]. Arquivos de neuro-psiquiatria. vol 65. issue 4A. 2008-06-02. PMID:18094878. |
the deep knowledge of hippocampal microsurgical anatomy is paramount in epilepsy surgery. |
2008-06-02 |
2023-08-12 |
Not clear |
| Dragan Bajic, Chen Wang, Eva Kumlien, Peter Mattsson, Staffan Lundberg, Orvar Eeg-Olofsson, Raili Rainink. Incomplete inversion of the hippocampus--a common developmental anomaly. European radiology. vol 18. issue 1. 2008-05-13. PMID:17828540. |
incomplete inversion of the hippocampus, an imperfect fetal development, has been described in patients with epilepsy or severe midline malformations. |
2008-05-13 |
2023-08-12 |
human |
| Karel Deblaere, Eric Achte. Structural magnetic resonance imaging in epilepsy. European radiology. vol 18. issue 1. 2008-05-13. PMID:17899110. |
imaging focus will be on the diagnosis of hippocampal sclerosis and malformations of cortical development, two major causes of medically intractable focal epilepsy. |
2008-05-13 |
2023-08-12 |
Not clear |
| David C Henshall, Brona M Murph. Modulators of neuronal cell death in epilepsy. Current opinion in pharmacology. vol 8. issue 1. 2008-05-06. PMID:17827063. |
differing hippocampal expression of certain bcl-2 family genes, elevated endoplasmic reticulum stress chaperones, and death receptor pathway modulation in epilepsy patients support clinical relevance of this focus. |
2008-05-06 |
2023-08-12 |
mouse |
| Qin Wang, Dong Zhou, Bo Yan, Xu Lin, Shang-fu Zhan. [Expression of Merlin in cortex of temporal lobe and in hippocampal CA1 region of the Kindling Model of Epilepsy induced by corciaria lactone in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 37. issue 1. 2008-04-21. PMID:16468657. |
to explore the relationship between merlin and hippocampal sclerosis of temporal epilepsy. |
2008-04-21 |
2023-08-12 |
rat |
| Feng Guo, Na Yu, Ji-Qun Cai, Tim Quinn, Zhi-Hong Zong, Yan-Jun Zeng, Li-Ying Ha. Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat. Brain research bulletin. vol 75. issue 1. 2008-04-11. PMID:18158113. |
the results of this study may be of value in revealing components of the molecular mechanisms of hippocampal excitation that are related to genetic epilepsy. |
2008-04-11 |
2023-08-12 |
human |
| A D Wickenden, J L Krajewski, B London, P K Wagoner, W A Wilson, S Clark, R Roeloffs, G McNaughton-Smith, G C Rigdo. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:18089837. |
ica-27243 (1-10 microm) was found to reversibly suppress seizure-like activity in an ex vivo hippocampal slice model of epilepsy and demonstrated in vivo anticonvulsant activity (ed(50) = 8.4 mg/kg) in the mouse maximal electroshock epilepsy model. |
2008-04-07 |
2023-08-12 |
mouse |
| Maurizio Cavallaro, Jessica Mariani, Cesare Lancini, Elisa Latorre, Roberta Caccia, Francesca Gullo, Menella Valotta, Silvia DeBiasi, Laura Spinardi, Antonella Ronchi, Enzo Wanke, Silvia Brunelli, Rebecca Favaro, Sergio Ottolenghi, Silvia K Nicoli. Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants. Development (Cambridge, England). vol 135. issue 3. 2008-04-07. PMID:18171687. |
in humans, heterozygous sox2 deficiency is associated with eye abnormalities, hippocampal malformation and epilepsy. |
2008-04-07 |
2023-08-12 |
mouse |
| Cristina Richichi, Amy L Brewster, Roland A Bender, Timothy A Simeone, Qinqin Zha, Hong Z Yin, John H Weiss, Tallie Z Bara. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiology of disease. vol 29. issue 2. 2008-04-04. PMID:17964174. |
altered expression levels of the hcn channels - that conduct the hyperpolarization-activated current, i(h) - have been demonstrated in hippocampus of patients with severe temporal lobe epilepsy as well as in animal models of temporal lobe and absence epilepsies. |
2008-04-04 |
2023-08-12 |
Not clear |
| J A Silva, E M Goto, S R Perosa, G A Argañaraz, E A Cavalheiro, M G Naffah-Mazzacoratti, J B Pesquer. Kinin B1 receptors facilitate the development of temporal lobe epilepsy in mice. International immunopharmacology. vol 8. issue 2. 2008-04-03. PMID:18182226. |
in the present study, we evaluated the hippocampal expression of the remaining kinin receptor in b1 (b1ko) and b2 (b2ko) knockout mice strains during the development of pilocarpine epilepsy model. |
2008-04-03 |
2023-08-12 |
mouse |
| P A Williams, F E Dude. A chronic histopathological and electrophysiological analysis of a rodent hypoxic-ischemic brain injury model and its use as a model of epilepsy. Neuroscience. vol 149. issue 4. 2008-03-28. PMID:17935893. |
recent studies have shown that an h-i injury in perinatal rats causes hippocampal mossy fiber sprouting and epilepsy. |
2008-03-28 |
2023-08-12 |
rat |
| Jennifer D Simonotto, Stephen M Myers, Michael D Furman, Wendy M Norman, Zhao Liu, Thomas B DeMarse, Paul R Carney, William L Ditt. Coherence analysis over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2006. 2008-03-19. PMID:17946026. |
a total of 32 microwire electrodes were implanted bilaterally into the hippocampus of sprague-dawley rats, which were then stimulated in the manner prescribed for the chronic limbic epilepsy model. |
2008-03-19 |
2023-08-12 |
rat |
| Mitushi Mishra, Britta Jones, Jennifer D Simonotto, Michael D Furman, Wendy M Norman, Zhao Liu, Thomas B DeMarse, Paul R Carney, William L Ditt. Pre-ictal entropy analysis of microwire data from an animal model of limbic epilepsy. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2006. 2008-03-17. PMID:17946055. |
epilepsy is a common neurological disorder that can have damaging effects in the brain including over 50% loss of neuronal activity in the hippocampal regions of the ca1 and ca3. |
2008-03-17 |
2023-08-12 |
Not clear |
| Dominique M Durand, Alicia Jensen, Marom Bikso. Suppression of neural activity with high frequency stimulation. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2006. 2008-03-17. PMID:17946913. |
sinusoidal stimulation at 50 hz applied to the ca1 region of the hippocampus was observed to block epileptiform activity in three separate models of epilepsy induced by low-calcium, high potassium and picrotoxin (gaba a blocker). |
2008-03-17 |
2023-08-12 |
Not clear |
| Thomas P Sutula, F Edward Dude. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Progress in brain research. vol 163. 2008-03-14. PMID:17765737. |
seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been observed nearly universally in experimental models of limbic epilepsy and in the epileptic human hippocampus. |
2008-03-14 |
2023-08-12 |
human |
| Thomas P Sutula, F Edward Dude. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Progress in brain research. vol 163. 2008-03-14. PMID:17765737. |
the recognition that mossy fiber sprouting is induced after hippocampal injury and seizures and contributes conditionally to emergence of recurrent excitation has provided a conceptual framework for understanding how injury and seizure-induced circuit reorganization may contribute to paroxysmal network synchronization, epileptogenesis, and the consequences of repeated seizures, and thus has had a major influence on understanding of fundamental aspects of the epilepsies. |
2008-03-14 |
2023-08-12 |
human |