All Relations between Epilepsy and hippocampus

Publication Sentence Publish Date Extraction Date Species
Xuefei Zhang, Ting Zhao, Songxue Su, Lei Li, Yubing Zhang, Jiangyu Yan, Xiaoxiao Cui, Yanyan Sun, Jianyuan Zhao, Xiong Han, Jing Ca. An explanation of the role of pyroptosis playing in epilepsy. International immunopharmacology. vol 136. 2024-06-08. PMID:38850794. epilepsy is a severe central nervous system disorder characterized by an imbalance between neuronal excitation and inhibition, resulting in heightened neuronal excitability, particularly within the hippocampus. 2024-06-08 2024-06-11 Not clear
Annika Lehner, Lucas Hoffmann, Stefan Rampp, Roland Coras, Friedrich Paulsen, Renato Frischknecht, Hajo Hamer, Katrin Walther, Sebastian Brandner, Wiebke Hofer, Tom Pieper, Lea-Marie Reisch, Christian G Bien, Ingmar Blumck. Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy. Epilepsia open. 2024-06-07. PMID:38845524. age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy. 2024-06-07 2024-06-10 human
Qin Wang, Baijun Qin, Haichun Yu, Yueqiang Hu, Han Yu, Jie Zhong, Jinwen Liu, Chunyuan Yao, Jiawei Zeng, Jingjing Fan, Limei Dia. Advances in circular RNA in the pathogenesis of epilepsy. Neuroscience. 2024-06-06. PMID:38843987. this review provides an overview of circrnas considered to be playing regulatory roles in the process of epilepsy and to be involved in multiple biological epilepsy-related processes, such as hippocampal sclerosis, inflammatory response, cell apoptosis, synaptic remodeling, and cell proliferation and differentiation. 2024-06-06 2024-06-10 Not clear
Tiantian Lu, Xiuling Chen, Qin Zhang, Kun Shang, Xiaogui Yang, Wei Xian. Vitamin D Relieves Epilepsy Symptoms and Neuroinflammation in Juvenile Mice by Activating the mTOR Signaling Pathway via RAF1: Insights from Network Pharmacology and Molecular Docking Studies. Neurochemical research. 2024-06-05. PMID:38837094. experimental mouse models of epilepsy were established through intraperitoneal injection of pilocarpine, and in vitro injury models of hippocampal neurons were induced by glutamate (glu) stimulation. 2024-06-05 2024-06-07 mouse
Xuejing Hou, Shanshan Xiao, Xiaohong Xu, Mingze Qin, Xuebing Cheng, Xiangping X. Glycoprotein non-metastatic melanoma protein B (GPNMB) protects against neuroinflammation and neuronal loss in pilocarpine-induced epilepsy via the regulation of microglial polarization. Neuroscience. 2024-05-23. PMID:38782114. in conclusion, these results indicated that gpnmb suppressed epilepsy through repression of hippocampal neuroinflammation, suggesting that gpnmb might be considered the potential neurotherapeutic target for epilepsy management and play a protective role against epilepsy by modulating the polarization of microglia. 2024-05-23 2024-05-27 rat
Takamitsu Iwata, Takufumi Yanagisawa, Yuji Ikegaya, Jonathan Smallwood, Ryohei Fukuma, Satoru Oshino, Naoki Tani, Hui Ming Khoo, Haruhiko Kishim. Hippocampal sharp-wave ripples correlate with periods of naturally occurring self-generated thoughts in humans. Nature communications. vol 15. issue 1. 2024-05-22. PMID:38778048. local field potentials were recorded from the hippocampus of 10 patients with epilepsy for up to 15 days, and experience sampling was used to describe their association with ongoing thought patterns. 2024-05-22 2024-05-27 human
Alyssa B Danis, Ashlynn A Gallagher, Ashley N Anderson, Arielle Isakharov, Kathleen A Beeson, Eric Schnel. Altered Hippocampal Activation in Seizure-Prone eNeuro. vol 11. issue 5. 2024-05-15. PMID:38749701. altered hippocampal activation in seizure-prone the voltage-gated calcium channel subunit α2δ-2 controls calcium-dependent signaling in neurons, and loss of this subunit causes epilepsy in both mice and humans. 2024-05-15 2024-05-27 mouse
Xiang Li, Ning Liu, Di Wu, Shu Chang Li, Qing Wang, Dian-Wen Zhang, Lian-Lian Song, Min Huang, Xia Chen, Wei L. Hippocampal transcriptomic analyses reveal the potential antiapoptotic mechanism of a novel anticonvulsant agent Q808 on pentylenetetrazol-induced epilepsy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-13. PMID:38739991. hippocampal transcriptomic analyses reveal the potential antiapoptotic mechanism of a novel anticonvulsant agent q808 on pentylenetetrazol-induced epilepsy in rats. 2024-05-13 2024-05-27 rat
Ionuț-Flavius Bratu, Samuel Medina Villalon, Elodie Garnier, Christian-G Bénar, Fabrice Bartolome. How fast does the brain recover after an epileptic seizure? Annals of clinical and translational neurology. 2024-05-11. PMID:38730560. the average pat was 4.5 min, extending up to an hour and was highest in temporal epilepsy and hippocampal sclerosis. 2024-05-11 2024-05-27 Not clear
Chang Xiaoyu, Zhou Hongzhen, Peng Nan, Gao Tengwei, Gong Yanan, Guo Yan, La Haiyan, Ma Li, Wu Haiya, Wen Yujun, Zhang Ru. Benzyl isothiocyanate ameliorates cognitive function in mice of chronic temporal lobe epilepsy. Frontiers in neurology. vol 15. 2024-05-08. PMID:38715687. temporal lobe epilepsy (tle) is a prevalent refractory partial epilepsy seen in clinical practice, with most cases originating from the hippocampus and being characterized by impaired learning and memory. 2024-05-08 2024-05-27 mouse
Ream Alashjaie, Elizabeth N Kerr, Azhar AlShoumer, Cynthia Hawkins, Ivanna Yau, Shelly Weiss, Ayako Ochi, Hiroshi Otsubo, Pradeep Krishnan, Elysa Widjaja, George M Ibrahim, Elizabeth J Donner, Puneet Jai. Surgical outcomes in children with drug-resistant epilepsy and hippocampal sclerosis. Epilepsy research. vol 203. 2024-05-04. PMID:38703703. surgical outcomes in children with drug-resistant epilepsy and hippocampal sclerosis. 2024-05-04 2024-05-07 Not clear
Ream Alashjaie, Elizabeth N Kerr, Azhar AlShoumer, Cynthia Hawkins, Ivanna Yau, Shelly Weiss, Ayako Ochi, Hiroshi Otsubo, Pradeep Krishnan, Elysa Widjaja, George M Ibrahim, Elizabeth J Donner, Puneet Jai. Surgical outcomes in children with drug-resistant epilepsy and hippocampal sclerosis. Epilepsy research. vol 203. 2024-05-04. PMID:38703703. hippocampal sclerosis (hs) is a common surgical substrate in adult epilepsy surgery cohorts but variably reported in various pediatric cohorts. 2024-05-04 2024-05-07 Not clear
Giancarlo Di Gennaro, Andrea Romigi, Pier Paolo Quarato, Addolorata Mascia, Alfredo D'Aniello, Chiara Panzini, Sara Casciato, Liliana Grammaldo, Diego Centonze, Vincenzo Esposit. Prognostic value of scalp EEG ictal patterns in epilepsy surgery of hippocampal sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-05-02. PMID:38695967. prognostic value of scalp eeg ictal patterns in epilepsy surgery of hippocampal sclerosis. 2024-05-02 2024-05-04 Not clear
Ting Zhao, Xuefei Zhang, Xiaoxiao Cui, Songxue Su, Lei Li, Yanan Chen, Na Wang, Lei Sun, Jianyuan Zhao, Jiewen Zhang, Xiong Han, Jing Ca. Inhibiting the IRAK4/NF-κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy. Experimental neurology. 2024-04-30. PMID:38685307. inhibiting the irak4/nf-κb/nlrp3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy. 2024-04-30 2024-05-03 Not clear
Zheng Liu, Wei Huang, Man-Min Zhu, Zhong-Xiang Xu, Zu-Cai Xu, Chang-Yin Yu, Hao Huan. Mechanism of Robo1 in the pentylenetetrazol-kindled epilepsy mouse model. Ibrain. vol 9. issue 4. 2024-04-29. PMID:38680506. robo1 was increased in the hippocampus in the pentylenetetrazol-induced epilepsy mouse model; lentiviral robo1 knockdown prolonged the latency of seizure and reduced the seizure grade in mice and resulted in a decrease in dendritic spine density, while the number of mature dendritic spines was maintained. 2024-04-29 2024-05-01 mouse
Xuerui Kong, Gaohe Dai, Zhong Zeng, Yi Zhang, Jiarong Gu, Teng Ma, Nina Wang, Jinhai Gu, Yin Wan. Integrating Proteomics and Transcriptomics Reveals the Potential Pathways of Hippocampal Neuron Apoptosis in Dravet Syndrome Model Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674042. an important component contributing to the onset of epilepsy is the death of hippocampal neurons. 2024-04-27 2024-04-29 mouse
Gabriel S Stephens, Jin Park, Andrew Eagle, Jason You, Manuel Silva-Pérez, Chia-Hsuan Fu, Sumin Choi, Corey P St Romain, Chiho Sugimoto, Shelly A Buffington, Yi Zheng, Mauro Costa-Mattioli, Yin Liu, A J Robison, Jeannie Chi. Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. Progress in neurobiology. 2024-04-20. PMID:38642602. recurrent seizures lead to accumulation of the activity-dependent transcription factor ∆fosb in hippocampal dentate granule cells in both mouse models of epilepsy and mouse models of alzheimer's disease (ad), which is also associated with increased incidence of seizures. 2024-04-20 2024-04-23 mouse
Ryan M Jamiolkowski, Quynh-Anh Nguyen, Jordan S Farrell, Ryan J McGinn, David A Hartmann, Jeff J Nirschl, Mateo I Sanchez, Vivek P Buch, Ivan Soltes. The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy. Nature medicine. 2024-04-17. PMID:38632391. the fasciola cinereum of the hippocampal tail as an interventional target in epilepsy. 2024-04-17 2024-04-20 mouse
Ryan M Jamiolkowski, Quynh-Anh Nguyen, Jordan S Farrell, Ryan J McGinn, David A Hartmann, Jeff J Nirschl, Mateo I Sanchez, Vivek P Buch, Ivan Soltes. The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy. Nature medicine. 2024-04-17. PMID:38632391. we identified the fasciola cinereum (fc) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy. 2024-04-17 2024-04-20 mouse
Dan Li, Na Sun, Yingying Guo, Shaoping Huang, Chunyan Yin, Yanfeng Xiao, Weijun M. Investigating the Effects of Perampanel on Autophagy-mediated Regulation of GluA2 and PSD95 in Epilepsy. Molecular neurobiology. 2024-04-11. PMID:38602656. primary mouse hippocampal neurons were cultured and subjected to an epilepsy cell model. 2024-04-11 2024-04-13 mouse