| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashna Talwar, Emily Estes, Rajender Aparasu, Doodipala Samba Redd. Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis. Experimental neurology. 2022-10-07. PMID:36206805. |
in this study, we evaluated the overall clinical potential of oral cbd to treat refractory epilepsy in patients with dravet syndrome (ds), lennox-gastaut syndrome (lgs), and tuberous sclerosis complex (tsc) through a systematic review and meta-analysis. |
2022-10-07 |
2023-08-14 |
Not clear |
| Rosa Chiara Goisis, Angela Chiavegato, Marta Gomez-Gonzalo, Iacopo Marcon, Linda Maria Requie, Petra Scholze, Giorgio Carmignoto, Gabriele Los. GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome. Frontiers in cellular neuroscience. vol 16. 2022-08-08. PMID:35936501. |
dravet syndrome (ds) is a rare autosomic encephalopathy with epilepsy linked to na |
2022-08-08 |
2023-08-14 |
mouse |
| Cecil D Hahn, Yuwu Jiang, Vicente Villanueva, Marta Zolnowska, Dimitrios Arkilo, Samuel Hsiao, Mahnaz Asgharnejad, Dennis Dlugo. A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox-Gastaut syndrome (ELEKTRA). Epilepsia. 2022-07-16. PMID:35841234. |
dravet syndrome (ds) and lennox-gastaut syndrome (lgs) are rare treatment-resistant childhood epilepsies classed as developmental and epileptic encephalopathies. |
2022-07-16 |
2023-08-14 |
Not clear |
| Antonio Gil-Nagel, Mercè Falip, Rocío Sánchez-Carpintero, María Reyes Abad-Sazatornil, José Luis Poveda, José Ángel Aibar, Elena Cardenal-Muñoz, Luis Miguel Aras, Rosa Sánchez, Arantxa Sancho-López, José Luis Trillo-Mata, María Torrejón, Alicia Gi. The contribution of fenfluramine to the treatment of Dravet syndrome in Spain through Multi-Criteria Decision Analysis. Epilepsy & behavior : E&B. vol 132. 2022-05-19. PMID:35588562. |
dravet syndrome (ds) is a severe, developmental epileptic encephalopathy (dee) that begins in infancy and is characterized by pharmaco-resistant epilepsy and neurodevelopmental delay. |
2022-05-19 |
2023-08-13 |
Not clear |
| Rogério R Gerbatin, Joana Augusto, Halima Boutouil, Cristina R Reschke, David C Henshal. Life-span characterization of epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene. Experimental neurology. 2022-04-29. PMID:35487274. |
dravet syndrome (ds) is a catastrophic form of paediatric epilepsy associated with multiple comorbidities mainly caused by mutations in the scn1a gene. |
2022-04-29 |
2023-08-13 |
mouse |
| Rogério R Gerbatin, Joana Augusto, Halima Boutouil, Cristina R Reschke, David C Henshal. Life-span characterization of epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene. Experimental neurology. 2022-04-29. PMID:35487274. |
mice that are haploinsufficient for scn1a faithfully model each stage of ds, although various aspects have not been fully described, including the temporal appearance and sex differences of the epilepsy and comorbidities. |
2022-04-29 |
2023-08-13 |
mouse |
| Rogério R Gerbatin, Joana Augusto, Halima Boutouil, Cristina R Reschke, David C Henshal. Life-span characterization of epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene. Experimental neurology. 2022-04-29. PMID:35487274. |
the aim of the present study was to investigate the epilepsy landscape according to the progression of ds and the long-term co-morbidities in the scn1a(+/-) |
2022-04-29 |
2023-08-13 |
mouse |
| Maria Cristina Bisi, Roberto Di Marco, Francesca Ragona, Francesca Darra, Marilena Vecchi, Stefano Masiero, Alessandra Del Felice, Rita Stagn. Quantitative Characterization of Motor Control during Gait in Dravet Syndrome Using Wearable Sensors: A Preliminary Study. Sensors (Basel, Switzerland). vol 22. issue 6. 2022-03-26. PMID:35336311. |
dravet syndrome (ds) is a rare and severe form of genetic epilepsy characterized by cognitive and behavioural impairments and progressive gait deterioration. |
2022-03-26 |
2023-08-13 |
human |
| R Albaradie, D N Baig, S Bashi. Sodium voltage-gated channel alpha subunit 9 mutation in epilepsy. European review for medical and pharmacological sciences. vol 25. issue 24. 2022-01-04. PMID:34982449. |
in humans, gene mutations in voltage-gated sodium channels can cause a range of epileptic symptoms, including genetic (generalized) epilepsy with febrile seizures plus (gefs+) and dravet syndrome (ds). |
2022-01-04 |
2023-08-13 |
Not clear |
| Dana Craiu, Zvonka Rener Primec, Lieven Lagae, Federico Vigevano, Eugen Trinka, Nicola Specchio, Sophia Bakhtadze, Cristina Cazacu, Tanja Golli, Sameer M Zuber. Vaccination and childhood epilepsies. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 36. 2021-12-18. PMID:34922162. |
the evidence relating vaccination to febrile seizures and epilepsy is evaluated with an emphasis on febrile seizures (fs), dravet syndrome (ds), west syndrome, and other developmental and epileptic encephalopathies. |
2021-12-18 |
2023-08-13 |
Not clear |
| Elena Cardenal-Muñoz, Stéphane Auvin, Vicente Villanueva, J Helen Cross, Sameer M Zuberi, Lieven Lagae, José Ángel Aiba. Guidance on Dravet Syndrome from Infant to Adult Care: Road Map for Treatment Planning in Europe. Epilepsia open. 2021-12-09. PMID:34882995. |
evidence suggests that optimal treatment of seizures in ds may improve outcomes, even though neurodevelopmental impairments are the likely result of both the underlying genetic variant and the epilepsy. |
2021-12-09 |
2023-08-13 |
Not clear |
| Anna Ka-Yee Kwong, Virginia Chun-Nei Wong, Sheila Suet-Na Wong, Vanessa Loi-Yan Chu, Saskia Koene, Jan Smeitink, Cheuk-Wing Fun. High FGF-21 level in a cohort of 22 patients with Dravet Syndrome-Possible relationship with the disease outcomes. Epilepsia open. vol 6. issue 4. 2021-12-07. PMID:34379890. |
dravet syndrome (ds) is a severe and intractable form of epilepsy with prolonged seizures which may evolve to other seizure types and associated with mild-to-severe intellectual disabilities. |
2021-12-07 |
2023-08-13 |
Not clear |
| Wei Shan, Guipeng An, Qian Ren, Qun Wan. Generation of SCN1B knock out induced pluripotent stem cell (iPSC) line (refractory epilepsy syndrome and Brugada syndrome related cell line). Stem cell research. vol 56. 2021-11-25. PMID:34583279. |
variants in scn1b resulted in genetic epilepsy with febrile seizures plus, severe dravet syndrome (ds), brugadasyndrome, atrial arrhythmias, and long qt-syndrome. |
2021-11-25 |
2023-08-13 |
human |
| David Emes, Anke Hüls, Nicole Baumer, Mara Dierssen, Shiela Puri, Lauren Russell, Stephanie L Sherman, Andre Strydom, Stefania Bargagna, Ana Cláudia Brandão, Alberto C S Costa, Patrick T Feany, Brian Allen Chicoine, Sujay Ghosh, Anne-Sophie Rebillat, Giuseppina Sgandurra, Diletta Valentini, Tilman R Rohrer, Johannes Levin, Monica Lakhanpaul, On Behalf Of The Trisomy Research Society Covid-Initiative Study Grou. COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey. Journal of clinical medicine. vol 10. issue 21. 2021-11-18. PMID:34768645. |
older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric covid-19 patients with ds, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. |
2021-11-18 |
2023-08-13 |
Not clear |
| Júlia Sala-Coromina, Miquel Raspall-Chaure, Anna Marcé-Grau, Alejandro Martinez de la Ossa, Alfons Macay. Early-onset eyelid stereotypies are a frequent and distinctive feature in Dravet syndrome. Seizure. vol 92. 2021-11-16. PMID:34521063. |
dravet syndrome (ds) is a severe infantile-onset epilepsy syndrome featuring drug resistant epilepsy, global developmental delay and intellectual disability. |
2021-11-16 |
2023-08-13 |
Not clear |
| Siu Hing Lo, Andrew Lloyd, Jade Marshall, Kishan Vya. Patient and Caregiver Health State Utilities in Lennox-Gastaut Syndrome and Dravet Syndrome. Clinical therapeutics. 2021-11-14. PMID:34774333. |
lennox-gastaut syndrome (lgs) and dravet syndrome (ds) are rare, treatment-resistant forms of epilepsy characterized by childhood onset of seizures. |
2021-11-14 |
2023-08-13 |
Not clear |
| Huifang Zhao, Shuai Li, Lang He, Feng Tang, Xiaobo Han, Weiyue Deng, Zuoxian Lin, Rongqi Huang, Zhiyuan L. Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome. Molecular neurobiology. 2021-11-12. PMID:34766239. |
dravet syndrome (ds) is a form of severe childhood-onset refractory epilepsy typically caused by a heterozygous loss-of-function mutation. |
2021-11-12 |
2023-08-13 |
human |
| Nicole Chemaly, Mathieu Kuchenbuch, Théo Teng, Elodie Marie, Gianluca D'Onofrio, Tommaso Lo Barco, Isabella Brambilla, Silke Flege, Anne-Sophie Hallet, Rima Nabbou. A European pilot study in Dravet Syndrome to delineate what really matters for the patients and families. Epilepsia open. 2021-11-08. PMID:34747137. |
we conducted a prospective european multicentre study based on a 11-closed questions' survey developed by the french reference centre for rare epilepsies and ds patients' advocacy groups. |
2021-11-08 |
2023-08-13 |
Not clear |
| Christine S Cheah, Megan A Beckman, William A Catterall, John C Oakle. Sharp-Wave Ripple Frequency and Interictal Epileptic Discharges Increase in Tandem During Thermal Induction of Seizures in a Mouse Model of Genetic Epilepsy. Frontiers in cellular neuroscience. vol 15. 2021-11-05. PMID:34733140. |
dravet syndrome (ds) is a genetic, infantile-onset epilepsy with refractory seizures and severe cognitive impairment. |
2021-11-05 |
2023-08-13 |
mouse |
| Jennifer C Wong, Lindsey Shapiro, Jacquelyn T Thelin, Elizabeth C Heaton, Rokon U Zaman, Martin J D'Souza, Kevin S Murnane, Andrew Escay. Nanoparticle encapsulated oxytocin increases resistance to induced seizures and restores social behavior in Scn1a-derived epilepsy. Neurobiology of disease. vol 147. 2021-11-01. PMID:33189882. |
de novo loss-of-function mutations in the voltage-gated sodium channel scn1a are the main cause of ds, while genetic epilepsy with febrile seizures plus (gefs+), also characterized by early-life fss and afebrile epilepsy, is typically caused by inherited mutations that alter the biophysical properties of scn1a. |
2021-11-01 |
2023-08-13 |
mouse |