| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel B Putterman, Adam C Munhall, Laura B Kozell, John K Belknap, Steven W Johnso. Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 323. issue 1. 2007-11-05. PMID:17660384. |
evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of parkinson's disease. |
2007-11-05 |
2023-08-12 |
rat |
| Daniel B Putterman, Adam C Munhall, Laura B Kozell, John K Belknap, Steven W Johnso. Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 323. issue 1. 2007-11-05. PMID:17660384. |
our results show that given an adequate dose and magnitude of striatal dopamine depletion, levodopa produces dyskinesia with a continuous spectrum of severity. |
2007-11-05 |
2023-08-12 |
rat |
| Jenny E Westin, Linda Vercammen, Elissa M Strome, Christine Konradi, M Angela Cenc. Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biological psychiatry. vol 62. issue 7. 2007-10-29. PMID:17662258. |
spatiotemporal pattern of striatal erk1/2 phosphorylation in a rat model of l-dopa-induced dyskinesia and the role of dopamine d1 receptors. |
2007-10-29 |
2023-08-12 |
rat |
| Theresa A Zesiewicz, Kelly L Sullivan, Robert A Hause. Levodopa-induced dyskinesia in Parkinson's disease: epidemiology, etiology, and treatment. Current neurology and neuroscience reports. vol 7. issue 4. 2007-09-04. PMID:17618536. |
dyskinesia refers to involuntary movements other than tremor and most commonly consists of chorea that occurs when levodopa-derived dopamine is peaking in the brain ("peak-dose dyskinesia"). |
2007-09-04 |
2023-08-12 |
Not clear |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
here, we have evaluated the effect of transplants containing serotonin neurons, or a mixture of dopamine and serotonin neurons, on l-dopa-induced dyskinesias in 6-hydroxydopamine-lesioned animals. |
2007-08-20 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
as expected, dopamine neuron-rich grafts induced functional recovery, accompanied by a 60% reduction in l-dopa-induced dyskinesia that developed gradually over the first 10 weeks. |
2007-08-20 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
rats with serotonin-rich grafts with few dopamine neurons, in contrast, showed a progressive worsening of their l-dopa-induced dyskinesias over time, and no functional improvement. |
2007-08-20 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
we conclude that serotonin neurons in the grafts are likely to have a detrimental effect on l-dopa-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons. |
2007-08-20 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
dopamine released from 5-ht terminals is the cause of l-dopa-induced dyskinesia in parkinsonian rats. |
2007-07-24 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
removal of the serotonin afferents, or dampening of serotonin neuron activity by 5-ht1a and 5-ht1b agonist drugs, resulted in a near-complete block of the l-dopa-induced dyskinesias, suggesting that dysregulated dopamine release from serotonin terminals is the prime trigger of dyskinesia in the rat parkinson's disease model. |
2007-07-24 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
the potent synergistic effect of low doses of 5-ht1a and 5-ht1b agonists to suppress dyskinesia, without affecting the anti-parkinsonian effect of l-dopa in presence of spared dopamine terminals, suggests an early use of these drugs to counteract the development of dyskinesia in parkinson's disease patients. |
2007-07-24 |
2023-08-12 |
rat |
| M Angela Cenc. Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia. Trends in neurosciences. vol 30. issue 5. 2007-07-12. PMID:17400300. |
dopamine dysregulation of movement control in l-dopa-induced dyskinesia. |
2007-07-12 |
2023-08-12 |
Not clear |
| Irene A C Halkias, Ihtsham Haq, Zhigao Huang, Hubert H Fernande. When should levodopa therapy be initiated in patients with Parkinson's disease? Drugs & aging. vol 24. issue 4. 2007-07-09. PMID:17432922. |
levodopa has also consistently been shown to produce motor fluctuations (in particular dyskinesias) sooner than has been observed in pd patients, especially younger patients, given dopamine agonists initially. |
2007-07-09 |
2023-08-12 |
Not clear |
| Heinz Reichmann, Anja Bilsing, Reinhard Ehret, Wolfgang Greulich, Jörg B Schulz, Andreas Schwartz, Olivier Rasco. Ergoline and non-ergoline derivatives in the treatment of Parkinson's disease. Journal of neurology. vol 253 Suppl 4. 2007-07-03. PMID:16944356. |
especially de novo patients are treated with dopamine agonists to avoid dyskinesia. |
2007-07-03 |
2023-08-12 |
Not clear |
| Céline Guigoni, Evelyne Doudnikoff, Qin Li, Bertrand Bloch, Erwan Bezar. Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates. Neurobiology of disease. vol 26. issue 2. 2007-06-28. PMID:17350277. |
while we recently demonstrated that levodopa-induced dyskinesia results from increased dopamine d(1) receptor-mediated transmission, we also questioned the possible role of subcellular localization of d(1) and d(2) receptors in mediating these effects as we previously showed that d(1) receptors undergo differential trafficking in striatal neurons of non-dyskinetic pd patients. |
2007-06-28 |
2023-08-12 |
monkey |
| Céline Guigoni, Evelyne Doudnikoff, Qin Li, Bertrand Bloch, Erwan Bezar. Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates. Neurobiology of disease. vol 26. issue 2. 2007-06-28. PMID:17350277. |
our results rule out the hypothesis of a pathological overinternalization of dopamine receptors in levodopa-induced dyskinesia but raise the possibility for involvement of d(1) receptors in the priming phenomenon through massive and sudden internalization in response to the first ever administration of l-dopa and for an altered homologous desensitization mechanism in dyskinesia leading to an increased availability of d(1) receptors at membrane. |
2007-06-28 |
2023-08-12 |
monkey |
| Christopher Kenney, Joseph Jankovi. Rotigotine transdermal patch in the treatment of Parkinson's disease and restless legs syndrome. Expert opinion on pharmacotherapy. vol 8. issue 9. 2007-06-25. PMID:17563266. |
dopamine agonists are effective in delaying levodopa-induced dyskinesia in early parkinson's disease (pd) and reducing motor fluctuations in advanced pd. |
2007-06-25 |
2023-08-12 |
Not clear |
| Michael J Jackson, Lance A Smith, Ghassan Al-Barghouthy, Sarah Rose, Peter Jenne. Decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in MPTP-treated common marmosets. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17113078. |
current concepts suggest that pulsatile stimulation of dopamine receptors following l-dopa administration leads to priming for dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp)-treated primates, while continuous dopaminergic stimulation with long-acting dopamine agonists does not. |
2007-05-10 |
2023-08-12 |
Not clear |
| Michael J Jackson, Lance A Smith, Ghassan Al-Barghouthy, Sarah Rose, Peter Jenne. Decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in MPTP-treated common marmosets. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17113078. |
we investigated whether l-dopa-induced dyskinesia is reduced by switching to a dopamine agonist. |
2007-05-10 |
2023-08-12 |
Not clear |
| Robert A Hauser, Laurence Salin, Nolwenn Juhel, Victor L Konyag. Randomized trial of the triple monoamine reuptake inhibitor NS 2330 (tesofensine) in early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 3. 2007-05-01. PMID:17149725. |
in mptp (1-methyl 4-phenyl-tetrahydropyridine 1,2,3,6)-lesioned marmosets, dopamine reuptake inhibitors have been demonstrated to reverse parkinsonian signs without evoking established dyskinesia. |
2007-05-01 |
2023-08-12 |
human |