All Relations between Dyskinesias and dopamine
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Species |
B Costall, R J Naylor, C Pycoc. Non-specific supersensitivity of striatal dopamine receptors after 6-hydroxydopamine lesion of the nigrostriatal pathway. European journal of pharmacology. vol 35. issue 2. 1976-04-19. PMID:942921. |
dyskinesias of the contralateral forelimb were induced by unilateral intrastriatal dopamine (100 mug) in a small proportion of non-lesioned rats: the effects were enhanced when dopamine (50-100 mug) was injected into the striatum ipsilateral to a 6-ohda lesion. |
1976-04-19 |
2023-08-11 |
rat |
B Costall, R J Naylo. Neuroleptic antagonism of dyskinetic phenomena. European journal of pharmacology. vol 33. issue 2. 1976-01-26. PMID:241654. |
the bilateral intrastriatal administration of dopamine to guinea pigs pretreated with nialamide-induced dyskinesias characterized by gnawing, biting and licking reactions, acute twisting of the head and neck, whole body or head and neck rocking movements, and a hyperactive state. |
1976-01-26 |
2023-08-11 |
Not clear |
A R Cools, G Hendriks, J Korte. The acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities. Journal of neural transmission. vol 36. issue 2. 1975-11-07. PMID:1151371. |
high doses of dopamine produced the subsequent development of three types of behavioural changes: an increase in the number of skilled manipulation movements (the dynamic phase); the appearance of a dystonic torticollis (the dystonic phase); and, finally, the appearance of an oro-lingual-facial dyskinesia and a number of dyskinetic activities in the extremities (the dyskinetic phase); low doses of dopamine solely produced the dynamic phase. |
1975-11-07 |
2023-08-11 |
monkey |
H L Klawans, P Crossett, N Dan. Effect of chronic amphetamine exposure on stereotyped behavior: implications for pathogenesis of l-dopa-induced dyskinesias. Advances in neurology. vol 9. 1975-10-07. PMID:1170714. |
this suggests that chronic striatal dopamine stimulation may induce striatal dopamine receptor site hypersensitivity and that this type of induced hypersensitivity may play a role in the development of l-dopa-induced dyskinesia. |
1975-10-07 |
2023-08-11 |
Not clear |
F S Messih. The relationship of dopamine excretion to chlorpromazine-induced dyskinesia in monkeys. Archives internationales de pharmacodynamie et de therapie. vol 209. issue 1. 1974-12-16. PMID:4416459. |
the relationship of dopamine excretion to chlorpromazine-induced dyskinesia in monkeys. |
1974-12-16 |
2023-08-11 |
monkey |