| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marc Morissette, Pershia Samadi, Abdallah Hadj Tahar, Nancy Bélanger, Thérèse Di Paol. Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 3. 2010-06-24. PMID:20026151. |
in conclusion, our results showed that in mptp monkeys, loss of striatal dopamine decreased akt/gsk3 signaling and that increased phosphorylation of akt and gsk3beta was associated with l-dopa-induced dyskinesias. |
2010-06-24 |
2023-08-12 |
monkey |
| Takahiro Iizuka, Fumihiko Sakai, Hideki Mochizuk. [Update on anti-NMDA receptor encephalitis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 4. 2010-06-17. PMID:20420172. |
considering the symptomatology of anti-nmdar encephalitis and the results of cell culture analysis, we speculate that the overall antibody-mediated inhibition of nmdars expressed on gabaergic interneurons, glutamatergic neurons and dopaminergic neurons may cause neuropsychiatric symptoms and dyskinesias via dopamine and glutamate dysregulation. |
2010-06-17 |
2023-08-12 |
Not clear |
| Xuebing Cao, Toru Yasuda, Subramaniam Uthayathas, Ray L Watts, M Maral Mouradian, Hideki Mochizuki, Stella M Pap. Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 21. 2010-06-15. PMID:20505100. |
long-term dopamine replacement therapy in parkinson's disease leads to the development of disabling involuntary movements named dyskinesias that are related to adaptive changes in striatal signaling pathways. |
2010-06-15 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Ana Muñoz, Deniz Kirik, Anders Björklun. Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187238. |
this mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. |
2010-06-14 |
2023-08-12 |
Not clear |
| Tom H Johnston, Susan H Fox, Matthew J McIldowie, Matthew J Piggott, Jonathan M Brotchi. Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 333. issue 3. 2010-06-11. PMID:20231306. |
long-term motor complications of dopamine replacement, such as l-dopa-induced dyskinesia (lid) and reduced quality of l-dopa action, remain obstacles in the treatment of parkinson's disease. |
2010-06-11 |
2023-08-12 |
monkey |
| Kayhan A Tayarani-Binazir, Michael J Jackson, Sarah Rose, C Warren Olanow, Peter Jenne. Pramipexole combined with levodopa improves motor function but reduces dyskinesia in MPTP-treated common marmosets. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 3. 2010-06-02. PMID:20108359. |
reduced expression of dyskinesia is observed in levodopa-primed mptp-treated common marmosets when dopamine agonists are used to replace levodopa. |
2010-06-02 |
2023-08-12 |
Not clear |
| V Puente, O De Fabregues, C Oliveras, G Ribera, C Pont-Sunyer, R Vivanco, G Cucurella, E Giralt, T Delgado, C Garcia, A Seoane, R Camp. Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson's disease: impact on control of fluctuations and quality of life. Parkinsonism & related disorders. vol 16. issue 3. 2010-05-24. PMID:19762271. |
patients had severe motor fluctuations and dyskinesias and had previously received treatment with oral levodopa and dopamine agonists. |
2010-05-24 |
2023-08-12 |
Not clear |
| Katherine E Soderstrom, Jennifer A O'Malley, Nathan D Levine, Caryl E Sortwell, Timothy J Collier, Kathy Steece-Collie. Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105237. |
impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. |
2010-05-17 |
2023-08-12 |
rat |
| Katherine E Soderstrom, Jennifer A O'Malley, Nathan D Levine, Caryl E Sortwell, Timothy J Collier, Kathy Steece-Collie. Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105237. |
however, analyses of vibrissae-induced forelimb use, levodopa-induced dyskinesias and graft-induced dyskinesias showed significant improvement in rats with dopamine grafts associated with preserved striatal dendritic spine density. |
2010-05-17 |
2023-08-12 |
rat |
| Hanna S Lindgren, Daniel R Andersson, Sören Lagerkvist, Hans Nissbrandt, M Angela Cenc. L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050978. |
l-dopa-induced dopamine efflux in the striatum and the substantia nigra in a rat model of parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. |
2010-04-30 |
2023-08-12 |
rat |
| Hanna S Lindgren, Daniel R Andersson, Sören Lagerkvist, Hans Nissbrandt, M Angela Cenc. L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050978. |
l-dopa-induced dyskinesia in parkinson's disease is associated with large increases in brain dopamine (da) levels following drug dosing, but the precise significance of this phenomenon is not understood. |
2010-04-30 |
2023-08-12 |
rat |
| Kenya Nishioka, Mounir Kefi, Barbara Jasinska-Myga, Christian Wider, Carles Vilariño-Güell, Owen A Ross, Michael G Heckman, Lefkos T Middleton, Lianna Ishihara-Paul, Rachel A Gibson, Rim Amouri, Samia Ben Yahmed, Samia Ben Sassi, Mourad Zouari, Ghada El Euch, Matthew J Farrer, Faycal Hentat. A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 4. 2010-04-26. PMID:19726410. |
in comparison with genetically undefined patients, lrrk2 mutation carriers had more severe motor symptoms (median unified parkinson's disease rating scale scores approximately 1.6 times higher, p<0.001), a higher rate of dyskinesia (or 4.21, p=0.002) and use of dopamine agonists (or 3.64, p<0.001), and less postural tremor (or 0.21, p<0.001). |
2010-04-26 |
2023-08-12 |
Not clear |
| Robert A Hause. New considerations in the medical management of early Parkinson's disease: impact of recent clinical trials on treatment strategy. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082983. |
dopamine agonists provide moderate symptomatic benefit, delay the need for levodopa, and delay the emergence of motor complications, especially dyskinesia. |
2010-03-31 |
2023-08-12 |
Not clear |
| M Angela Cenci, K Elisabet Ohlin, Daniella Rylande. Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083009. |
the development of l-dopa-induced dyskinesia (lid) is attributed to plastic responses triggered by dopamine (da) receptor stimulation in the parkinsonian brain. |
2010-03-31 |
2023-08-12 |
rat |
| Fabrizio Stocch. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083012. |
similarly, continuous infusion of dopamine agonists ropinirole and rodigotine reduces dyskinesia associated with intermittent doses of oral formulations of the same drug. |
2010-03-31 |
2023-08-12 |
monkey |
| Michael John Jackson, Terrance H Andree, Matthew Hansard, Diane C Hoffman, Mark R Hurtt, John H Kehne, Thomas A Pitler, Lance A Smith, Gary Stack, Peter Jenne. The dopamine D(2) receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with L-dopa. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 1. 2010-03-24. PMID:19809864. |
dopamine replacement therapy in parkinson's disease (pd) using l-dopa is invariably associated with a loss of drug efficacy ("wearing off") and the onset of dyskinesia. |
2010-03-24 |
2023-08-12 |
marmoset |
| Tomas Björklund, Thomas Carlsson, Erik Ahlm Cederfjäll, Manolo Carta, Deniz Kiri. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20129936. |
this approach has been shown to be efficient in restoring motor function and reducing established dyskinesias in rats with a partial lesion of the nigrostriatal dopamine projection. |
2010-03-16 |
2023-08-12 |
rat |
| Tomas Björklund, Thomas Carlsson, Erik Ahlm Cederfjäll, Manolo Carta, Deniz Kiri. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20129936. |
the tyrosine hydroxylase plus guanosine-5'-triphosphate cyclohydrolase-1 treated animals were resistant to developing dyskinesias upon peripheral l-3,4-dihydroxyphenylalanine drug challenge, which is consistent with the interpretation that continuous dopamine stimulation resulted in a normalization of the post-synaptic response. |
2010-03-16 |
2023-08-12 |
rat |
| Naoya Hamaue, Akihiko Ogata, Mutsuko Terado, Shirou Tsuchida, Ichiro Yabe, Hidenao Sasaki, Masahiko Hirafuji, Hiroko Togashi, Takashi Aok. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain research. vol 1309. 2010-02-26. PMID:19879254. |
to combat the dyskinesia and wearing-off, levodopa is used together with a dopamine (da) receptor agonist, and the amount of levodopa is decreased. |
2010-02-26 |
2023-08-12 |
rat |
| Mohamed Khalil Tamim, Pershia Samadi, Marc Morissette, Laurent Grégoire, Bazoumana Ouattara, Daniel Lévesque, Claude Rouillard, Thérèse Di Paol. Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. Neuropharmacology. vol 58. issue 1. 2010-02-25. PMID:19576910. |
dopamine denervation in parkinson's disease and repeated levodopa (l-dopa) administration that induces dyskinesias are associated with an enhancement of basal ganglia neuropeptide transmission. |
2010-02-25 |
2023-08-12 |
monkey |