| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaynor A Smith, Andreas Heuer, Stephen B Dunnett, Emma L Lan. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21946310. |
most of these tests predict dopamine depletion but only rotarod, spontaneous rotations, apomorphine-induced rotations and locomotor activities were significantly correlated with the development of dyskinesia at 6mg/kg and 25mg/kg l-dopa. |
2012-02-09 |
2023-08-12 |
mouse |
| Tom H Johnston, Emma L Lan. Experimental Models of l-DOPA-Induced Dyskinesia. International review of neurobiology. vol 98. 2012-01-18. PMID:21907083. |
strategies to avoid or minimize dyskinesia and other motor complications of chronic dopamine replacement therapy in parkinson's disease (pd) remain a significant unmet clinical need. |
2012-01-18 |
2023-08-12 |
Not clear |
| Diederik E Tenback, Peter N van Harte. Epidemiology and risk factors for (tardive) dyskinesia. International review of neurobiology. vol 98. 2012-01-18. PMID:21907089. |
dyskinesia can develop in patients with schizophrenia in the course of the disease with or without the use of antipsychotics.in patients with psychiatric disorders other than schizophrenia tardive dyskinesia (td) can develop in patients treated with antipsychotics or other drugs with dopamine d2 blocking properties. |
2012-01-18 |
2023-08-12 |
Not clear |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21946270. |
extent of pre-operative l-dopa-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. |
2011-12-20 |
2023-08-12 |
rat |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21946270. |
graft-induced dyskinesia has emerged as a problematic side effect after transplantation of fetal dopamine cells into the striatum of patients with parkinson's disease. |
2011-12-20 |
2023-08-12 |
rat |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21946270. |
we show that animals with intrastriatal grafts of fetal dopamine cells and severe pre-operative l-dopa-induced dyskinesia will reduce their l-dopa-induced dyskinesia scores by more than 75% but at the same time develop graft-induced dyskinesia of intermediate to strong severity. |
2011-12-20 |
2023-08-12 |
rat |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21946270. |
in contrast, animals with dopamine grafts of similar size but only mild pre-operative l-dopa-induced dyskinesia also developed graft-induced dyskinesia but this was very mild and of intermediate severity only in a single animal. |
2011-12-20 |
2023-08-12 |
rat |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21946270. |
our data suggest that patients with no or only mild l-dopa-induced dyskinesia may carry a lower risk for the development of graft-induced dyskinesia and therefore are better candidates to receive intracerebral grafts of fetal dopamine cells as compared to patients with more pronounced l-dopa-induced dyskinesia. |
2011-12-20 |
2023-08-12 |
rat |
| Morten V Madsen, Linda P Peacock, Thomas Werge, Maibritt B Andersen, Jesper T Andrease. Effects of cannabinoid CB1 receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:21029743. |
the present study explored the effects of cb(1) receptor ligands on oral dyskinesia induced by the dopamine d(1) receptor agonist skf81297 (skf) and acute dystonia induced by the dopamine d(2) receptor antagonist haloperidol in cebus apella monkeys. |
2011-11-22 |
2023-08-12 |
rat |
| Michael Feyder, Alessandra Bonito-Oliva, Gilberto Fison. L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission. Frontiers in behavioral neuroscience. vol 5. 2011-11-10. PMID:22028687. |
l-dopa-induced dyskinesia and abnormal signaling in striatal medium spiny neurons: focus on dopamine d1 receptor-mediated transmission. |
2011-11-10 |
2023-08-12 |
mouse |
| Michael Feyder, Alessandra Bonito-Oliva, Gilberto Fison. L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission. Frontiers in behavioral neuroscience. vol 5. 2011-11-10. PMID:22028687. |
accumulating evidence indicates that l-dopa-induced dyskinesia (lid) is primarily caused by the development of sensitized dopamine d1 receptor (d1r) transmission in the medium spiny neurons (msns) of the striatum. |
2011-11-10 |
2023-08-12 |
mouse |
| Maria Papathanou, Sarah Rose, Andrew McCreary, Peter Jenne. Induction and expression of abnormal involuntary movements is related to the duration of dopaminergic stimulation in 6-OHDA-lesioned rats. The European journal of neuroscience. vol 33. issue 12. 2011-10-24. PMID:21615558. |
dyskinesia induction in parkinson's disease (pd) appears less marked with long-acting dopamine agonists than with short-acting l-dopa, but the relationship to duration of drug action is unknown. |
2011-10-24 |
2023-08-12 |
rat |
| Ying-Zu Huang, John C Rothwell, Chin-Song Lu, Wen-Li Chuang, Rou-Shayn Che. Abnormal bidirectional plasticity-like effects in Parkinson's disease. Brain : a journal of neurology. vol 134. issue Pt 8. 2011-10-13. PMID:21742734. |
levodopa-induced dyskinesia is a major complication of long-term dopamine replacement therapy for parkinson's disease that becomes increasingly problematic in advanced parkinson's disease. |
2011-10-13 |
2023-08-12 |
human |
| E Hametner, K Seppi, W Poew. The clinical spectrum of levodopa-induced motor complications. Journal of neurology. vol 257. issue Suppl 2. 2011-10-03. PMID:21080188. |
in fact, it is most likely that non-physiological pulsatile stimulation of dopamine receptors, which is followed by various downstream alterations, plays a key role in the development of ld-induced motor response oscillations and dyskinesias. |
2011-10-03 |
2023-08-12 |
Not clear |
| Angelo Antonini, Giulia Ursino, Daniela Calandrella, Laura Bernardi, Mauro Pleban. Continuous dopaminergic delivery in Parkinson's disease. Journal of neurology. vol 257. issue Suppl 2. 2011-10-03. PMID:21080194. |
motor fluctuations and dyskinesias occur in the majority of patients with parkinson's disease (pd) and are likely to result from changes in dopamine production, storage and release, occurring as consequences of the nigrostriatal degenerative process. |
2011-10-03 |
2023-08-12 |
Not clear |
| Mildred D Gottwald, Michael J Aminof. Therapies for dopaminergic-induced dyskinesias in Parkinson disease. Annals of neurology. vol 69. issue 6. 2011-08-22. PMID:21681795. |
treatment with dopamine agonists such as pramipexole or ropinirole allows levodopa to be delayed, but once levodopa is added to the drug regimen the usual course of onset of dyskinesias is observed. |
2011-08-22 |
2023-08-12 |
Not clear |
| Nina Nevalainen, Sara Af Bjerkén, Martin Lundblad, Greg A Gerhardt, Ingrid Strömber. Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia. Journal of neurochemistry. vol 118. issue 1. 2011-08-12. PMID:21534956. |
dopamine release from serotonergic nerve fibers is reduced in l-dopa-induced dyskinesia. |
2011-08-12 |
2023-08-12 |
rat |
| Nina Nevalainen, Sara Af Bjerkén, Martin Lundblad, Greg A Gerhardt, Ingrid Strömber. Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia. Journal of neurochemistry. vol 118. issue 1. 2011-08-12. PMID:21534956. |
the patophysiology of dyskinesia is unclear; however, involvement of serotonergic nerve fibers in converting l-dopa to dopamine has been suggested. |
2011-08-12 |
2023-08-12 |
rat |
| David Lindenbach, Corinne Y Ostock, Karen L Eskow Jaunarajs, Kristin B Dupre, Christopher J Barnum, Nirmal Bhide, Christopher Bisho. Behavioral and cellular modulation of L-DOPA-induced dyskinesia by beta-adrenoceptor blockade in the 6-hydroxydopamine-lesioned rat. The Journal of pharmacology and experimental therapeutics. vol 337. issue 3. 2011-07-19. PMID:21402691. |
chronic dopamine replacement therapy in parkinson's disease (pd) leads to deleterious motor sequelae known as l-dopa-induced dyskinesia (lid). |
2011-07-19 |
2023-08-12 |
rat |
| Jayaraman Ra. Treatment of Levodopa-induced Dyskinesia. Current treatment options in neurology. vol 9. issue 3. 2011-07-14. PMID:17445498. |
the motor fluctuations and associated dyskinesia are due to progressive dopamine denervation, an unregulated pattern of release of dopamine in the synapse, fluctuating levels of receptor sensitivity, and fluctuating levels of dopamine receptor stimulation. |
2011-07-14 |
2023-08-12 |
Not clear |