| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Denham Harma. Alzheimer's disease: role of aging in pathogenesis. Annals of the New York Academy of Sciences. vol 959. 2002-06-04. PMID:11976212. |
brain lesions in both sporadic ad (sad) and familial ad (fad) are the same, and in the same distribution pattern, as those in individuals with down syndrome (ds) and in smaller numbers in nondemented older individuals. |
2002-06-04 |
2023-08-12 |
Not clear |
| b' Jean Grozdea, France De La Farge, Georges Bourrouillou, Mady Calot, Jean P Cambus, Pierre Valdigui\\xc3\\xa. Maternal serum urea resistant alkaline phosphatase in Down syndrome pregnancy. Early human development. vol 67. issue 1-2. 2002-05-30. PMID:11893436.' |
the normal levels of alkaline phosphatase (ap) activity in maternal serum are virtually the same as those observed in down syndrome (ds) pregnancies at 14-20 weeks' gestation. |
2002-05-30 |
2023-08-12 |
Not clear |
| Seong Hwan Kim, Kurt Krapfenbauer, Myeong Sook Cheon, Michael Fountoulakis, Nigel J Cairns, Gert Lube. Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Neuroscience letters. vol 321. issue 3. 2002-05-29. PMID:11880199. |
central histaminergic deficits may contribute to the cognitive impairment of neurodegenerative disorders including alzheimer's disease (ad) and down syndrome (ds). |
2002-05-29 |
2023-08-12 |
human |
| Yoko Otsuka, Masayuki Ito, Masaru Yamaguchi, Shigeno Saito, Kagumi Uesu, Kazutaka Kasai, Yoshimitsu Abiko, Junichi Meg. Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. Mechanisms of ageing and development. vol 123. issue 6. 2002-05-17. PMID:11850029. |
it is well known that down syndrome (ds) is a premature ageing syndrome. |
2002-05-17 |
2023-08-12 |
Not clear |
| Eli Carmeli, Shlomo Kessel, Raymond Coleman, Moshe Ayalo. Effects of a treadmill walking program on muscle strength and balance in elderly people with Down syndrome. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 57. issue 2. 2002-05-14. PMID:11818429. |
in elderly adults with down syndrome (ds), the maintenance of muscle strength, endurance, and dynamic balance are important to ensure quality of life and functional independence. |
2002-05-14 |
2023-08-12 |
Not clear |
| M Bajo, B C Yoo, N Cairns, M Gratzer, G Lube. Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease. Amino acids. vol 21. issue 3. 2002-05-07. PMID:11764410. |
using immune-histochemical techniques the altered expression of nfs in down syndrome (ds) and alzheimer's disease (ad) has been already published but as no corresponding systematic immune-chemical study has been reported yet, we decided to determine proteins levels of three nfs in several brain regions of ds and ad brain. |
2002-05-07 |
2023-08-12 |
Not clear |
| L A Hyde, L S Crni. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behavioral neuroscience. vol 115. issue 6. 2002-05-07. PMID:11770055. |
all individuals with down syndrome (ds) eventually develop the neuropathology of alzheimer's disease (ad), which is characterized by a premature loss of basal forebrain cholinergic neurons. |
2002-05-07 |
2023-08-12 |
mouse |
| J Wegiel, I Kuchna, T Wisniewski, M J de Leon, B Reisberg, T Pirttila, T Kivimaki, T Lehtimak. Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome. Acta neuropathologica. vol 103. issue 4. 2002-05-07. PMID:11904752. |
study of the hippocampal formation of 82 subjects, including 25 control subjects from 33 to 83 years of age, 34 subjects with alzheimer disease (ad) from 65 to 89 years of age, and 23 subjects with down syndrome (ds) from 33 to 72 years of age, revealed hippocampal vasculopathy with fibrosis and calcification (vfc) in 40% of control, 59% of ad, and 4% of ds subjects. |
2002-05-07 |
2023-08-12 |
human |
| Jacek M Polski, Csaba Galambos, Gordon B Gale, Cherie H Dunphy, H Lance Evans, Jacqueline R Batania. Acute megakaryoblastic leukemia after transient myeloproliferative disorder with clonal karyotype evolution in a phenotypically normal neonate. Journal of pediatric hematology/oncology. vol 24. issue 1. 2002-05-02. PMID:11902741. |
we report a case of transient myeloproliferative disorder (tmd) in a neonate without features of down syndrome (ds) with clonal karyotype evolution, after apparent spontaneous resolution of tmd, but eventually progressing to acute megakaryoblastic leukemia (amkl). |
2002-05-02 |
2023-08-12 |
Not clear |
| K Schuchter, E Hafner, G Stangl, M Metzenbauer, D Höfinger, K Philip. The first trimester 'combined test' for the detection of Down syndrome pregnancies in 4939 unselected pregnancies. Prenatal diagnosis. vol 22. issue 3. 2002-04-30. PMID:11920896. |
the high detection rate (dr) for down syndrome (ds) pregnancies which can be achieved by measuring fetal nuchal translucency (nt) early in pregnancy can be improved by combining it with placental hormones [pregnancy-associated plasma protein a (papp-a) and free beta-human chorionic gonadotrophin (fbeta-hcg)] and maternal age ('combined test'). |
2002-04-30 |
2023-08-12 |
Not clear |
| Vee P Prasher, Adam Huxley, M S Haqu. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease--pilot study. International journal of geriatric psychiatry. vol 17. issue 3. 2002-04-30. PMID:11921156. |
this study investigated the safety and efficacy of the drug to treat down syndrome (ds) adults with mild to moderate ad. |
2002-04-30 |
2023-08-12 |
Not clear |
| Renu Jain, David C Thomasma, Rasa Raga. Down syndrome: still a social stigma. American journal of perinatology. vol 19. issue 2. 2002-04-29. PMID:11938484. |
down syndrome (ds) is a commonly occurring chromosomal abnormality. |
2002-04-29 |
2023-08-12 |
Not clear |
| Renu Jain, David C Thomasma, Rasa Raga. Down syndrome: still a social stigma. American journal of perinatology. vol 19. issue 2. 2002-04-29. PMID:11938484. |
to the end of greater acceptance, we suggest a ritual at birth that might improve the acceptance of the ds child into the family and the community and hence help improve social attitudes toward down syndrome. |
2002-04-29 |
2023-08-12 |
Not clear |
| G M Barlow, B Micales, G E Lyons, J R Korenber. Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain. Cytogenetics and cell genetics. vol 94. issue 3-4. 2002-04-16. PMID:11856873. |
down syndrome (ds) is a major cause of mental retardation and is associated with characteristic well-defined although subtle brain abnormalities, many of which arise after birth, with particular defects in the cortex, hippocampus and cerebellum. |
2002-04-16 |
2023-08-12 |
mouse |
| G M Barlow, B Micales, G E Lyons, J R Korenber. Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain. Cytogenetics and cell genetics. vol 94. issue 3-4. 2002-04-16. PMID:11856873. |
the neural cell adhesion molecule dscam (down syndrome cell adhesion molecule) maps to 21q22.2-->q22.3, a region associated with ds mental retardation, and is expressed largely in the neurons of the central and peripheral nervous systems during development. |
2002-04-16 |
2023-08-12 |
mouse |
| S Arbuzova, H Cuckle, R Mueller, I Sehm. Familial Down syndrome: evidence supporting cytoplasmic inheritance. Clinical genetics. vol 60. issue 6. 2002-04-02. PMID:11846739. |
the frequently observed familial aggregation of down syndrome (ds) 47,+21 and other aneuploidies and the phenomenon of double aneuploidy involving ds cannot be accounted for by chance alone. |
2002-04-02 |
2023-08-12 |
Not clear |
| L S Cornejo, G A Zak, S T Dorronsoro de Cattoni, S E Calamari, A I Azcurra, L J Battellin. Bucodental health condition in patients with Down syndrome of Cordoba City, Argentina. Acta odontologica latinoamericana : AOL. vol 9. issue 2. 2002-04-01. PMID:11885251. |
the oral health condition of children and youngsters with down syndrome (ds) was evaluated on a sample of 86 mongolic subjects ages 3 to 19, both sexes, residents in the city of córdoba (argentina), and compared with control groups. |
2002-04-01 |
2023-08-12 |
human |
| R Nabbout, I Melki, B Gerbaka, O Dulac, C Akatcheria. Infantile spasms in Down syndrome: good response to a short course of vigabatrin. Epilepsia. vol 42. issue 12. 2002-03-18. PMID:11879370. |
to evaluate the efficacy of vigabatrin (vgb) in the treatment of infantile spasms (iss) associated with down syndrome (ds) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. |
2002-03-18 |
2023-08-12 |
Not clear |
| Talin Gulesserian, Seong Hwan Kim, Michael Fountoulakis, Gert Lube. Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain. Biochemical and biophysical research communications. vol 291. issue 1. 2002-03-15. PMID:11829462. |
down syndrome (ds, trisomy 21) is the most frequent genetic cause of mental retardation. |
2002-03-15 |
2023-08-12 |
Not clear |
| H Orton, R Rickard, L Mille. Using active medical record review and capture-recapture methods to investigate the prevalence of Down Syndrome among live-born infants in Colorado. Teratology. vol 64 Suppl 1. 2002-03-04. PMID:11745839. |
in a 1994 comparison of down syndrome (ds) birth prevalence rates between 17 states (cdc '94), the average rate for the 17 states was 9.2 per 10,000 live-born infants. |
2002-03-04 |
2023-08-12 |
Not clear |