| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen Wong, Josien Levenga, Peter Cain, Beverly Rothermel, Eric Klann, Charles Hoeffe. RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease. Acta neuropathologica. vol 130. issue 6. 2016-08-24. PMID:26497675. |
patients with down syndrome (ds) develop symptoms consistent with early-onset ad, suggesting that overexpression of chromosome 21 genes such as regulator of calcineurin 1 (rcan1) plays a role in ad pathogenesis. |
2016-08-24 |
2023-08-13 |
mouse |
| Melissa J Alldred, Sang Han Lee, Eva Petkova, Stephen D Ginsber. Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:25031177. |
expression profile analysis of hippocampal ca1 pyramidal neurons in aged ts65dn mice, a model of down syndrome (ds) and alzheimer's disease (ad). |
2016-08-19 |
2023-08-13 |
mouse |
| Melissa J Alldred, Sang Han Lee, Eva Petkova, Stephen D Ginsber. Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:25031177. |
down syndrome (ds) is caused by the triplication of human chromosome 21 (hsa21) and is the most common genetic cause of intellectual disability, with individuals having deficits in cognitive function including hippocampal learning and memory and neurodegeneration of cholinergic basal forebrain neurons, a pathological hallmark of alzheimer's disease (ad). |
2016-08-19 |
2023-08-13 |
mouse |
| Jeffrey N Johnston, Sheldon L Kaplan, Edward O Mason, Kristina G Hulte. Characterization of Staphylococcus aureus infections in children with Down syndrome. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. vol 21. issue 11. 2016-08-19. PMID:26386776. |
staphylococcus aureus infections in the down syndrome (ds) population have not been well characterized. |
2016-08-19 |
2023-08-13 |
Not clear |
| Allain A Bueno, Annette Brand, Marita M Neville, Catherine Lehane, Nina Brierley, Michael A Crawfor. Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings. The British journal of nutrition. vol 113. issue 1. 2016-08-18. PMID:25418850. |
the majority of children with down syndrome (ds) develop alzheimer's disease (ad) at an early age. |
2016-08-18 |
2023-08-13 |
Not clear |
| Fabio Coppedè, Maria Denaro, Pierpaola Tannorella, Lucia Miglior. Increased MTHFR promoter methylation in mothers of Down syndrome individuals. Mutation research. vol 787. 2016-08-18. PMID:26926955. |
despite that advanced maternal age at conception represents the major risk factor for the birth of a child with down syndrome (ds), most of ds babies are born from women aging less than 35 years. |
2016-08-18 |
2023-08-13 |
human |
| Marisse Meeus, Sandra Kenis, Marek Wojciechowski, Berten Ceuleman. Epilepsy in children with Down syndrome: not so benign as generally accepted. Acta neurologica Belgica. vol 115. issue 4. 2016-08-17. PMID:25894349. |
down syndrome (ds) is one of the most common causes of mental retardation in children. |
2016-08-17 |
2023-08-13 |
Not clear |
| Nobuhiro Kurabayashi, Minh Dang Nguyen, Kamon Sanad. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model. EMBO reports. vol 16. issue 11. 2016-08-16. PMID:26373433. |
down syndrome (ds) arises from triplication of genes on human chromosome 21 and is associated with anomalies in brain development such as reduced production of neurons and increased generation of astrocytes. |
2016-08-16 |
2023-08-13 |
mouse |
| Nevena Dimitrova, Şeyda Özçalışkan, Lauren B Adamso. Parents' Translations of Child Gesture Facilitate Word Learning in Children with Autism, Down Syndrome and Typical Development. Journal of autism and developmental disorders. vol 46. issue 1. 2016-08-15. PMID:26362150. |
we ask whether this pattern holds for children with autism (au) and with down syndrome (ds) who show delayed vocabulary development. |
2016-08-15 |
2023-08-13 |
Not clear |
| M Salemi, C Barone, C Romano, M G Salluzzo, M Giambirtone, M C Morale, A E Calogero, L Grillo, P Bosco, C Roman. A peculiar VNTR in the cystathionine β-synthase gene is a risk factor for Down Syndrome. Cellular and molecular biology (Noisy-le-Grand, France). vol 61. issue 5. 2016-08-15. PMID:26475388. |
in the present study, we analysed a 31bp variable number of tandem repeats (vntr) of the cystathionine ß-synthase (cbs) gene in 427 subjects: 127 patients with down syndrome (ds) and in 60 of their mothers; 172 age-and sex-matched controls and in 68 of their mothers. |
2016-08-15 |
2023-08-13 |
human |
| Maria Paola Cecchini, Dario Viviani, Marco Sandri, Antje Hähner, Thomas Hummel, Carlo Zancanar. Olfaction in People with Down Syndrome: A Comprehensive Assessment across Four Decades of Age. PloS one. vol 11. issue 1. 2016-08-10. PMID:26730728. |
down syndrome (ds) shows neuropathology similar to alzheimer disease, which presents olfactory impairment. |
2016-08-10 |
2023-08-13 |
Not clear |
| D M Walsh, E Doran, W Silverman, A Tournay, N Movsesyan, I T Lot. Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status. Journal of intellectual disability research : JIDR. vol 59. issue 11. 2016-08-09. PMID:26031550. |
adults with down syndrome (ds) are at risk of developing dementia and cognitive assessment is a fundamental part of the diagnostic process. |
2016-08-09 |
2023-08-13 |
Not clear |
| Xiaolan Wang, Zhihua Yang, Yinan Sun, Hanjing Zhou, Guangpin Chu, Jing Zhang, Xianfang Men. Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25319570. |
single-minded 2 (sim2), a transcriptional repressor, is reportedly involved in diseases that impair learning and memory, such as down syndrome (ds) and alzheimer's disease. |
2016-08-08 |
2023-08-13 |
Not clear |
| Lauren C Nisbet, Nicole N Phillips, Timothy F Hoban, Louise M O'Brie. Characterization of a sleep architectural phenotype in children with Down syndrome. Sleep & breathing = Schlaf & Atmung. vol 19. issue 3. 2016-08-08. PMID:25500979. |
evidence suggests that while the high prevalence of obstructive sleep apnea (osa) in children with down syndrome (ds) likely contributes to sleep fragmentation, their poor sleep is only partly attributable to the presence of osa. |
2016-08-08 |
2023-08-13 |
Not clear |
| Janet L Hauck, Dale A Ulric. Acute Effects of a Therapeutic Mobility Device on Physical Activity and Heart Rate in Children With Down Syndrome. Research quarterly for exercise and sport. vol 86. issue 3. 2016-08-08. PMID:26115435. |
the purpose of this feasibility study was to provide an opportunity to increase physical activity (pa) and heart rate (hr) for children with down syndrome (ds) during unstructured group exercise utilizing a riding device called the power pumper®. |
2016-08-08 |
2023-08-13 |
Not clear |
| Eduardo Benedetti Parisotto, Andréia Gonçalves Giaretta, Ariane Zamoner, Emilia Addison Machado Moreira, Tânia Silvia Fröde, Rozangela Curi Pedrosa, Danilo Wilhelm Filh. Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome. Research in developmental disabilities. vol 45-46. 2016-08-02. PMID:26207872. |
this study examined the effect of an antioxidant intervention in biomarkers of inflammation and oxidative stress (os) in the blood of down syndrome (ds) children and teenagers during four different stages. |
2016-08-02 |
2023-08-13 |
cat |
| Silvia Lanfranchi, Federica Aventaggiato, Olga Jerman, Renzo Vianell. Numerical skills in children with Down syndrome. Can they be improved? Research in developmental disabilities. vol 45-46. 2016-08-02. PMID:26233764. |
the present study aims to explore the impact of a numerical skills training program on the basic mathematical skills and logical thinking in children with down syndrome (ds). |
2016-08-02 |
2023-08-13 |
Not clear |
| Simon D Holzapfel, Shannon D R Ringenbach, Genna M Mulvey, Amber M Sandoval-Menendez, Megan R Cook, Rachel O Ganger, Kristen Bennet. Improvements in manual dexterity relate to improvements in cognitive planning after assisted cycling therapy (ACT) in adolescents with down syndrome. Research in developmental disabilities. vol 45-46. 2016-08-02. PMID:26280691. |
we have previously reported beneficial effects of acute (i.e., single session) assisted cycling therapy (act) on manual dexterity and cognitive planning ability in adolescents with down syndrome (ds). |
2016-08-02 |
2023-08-13 |
human |
| Jose Luis Olmos-Serrano, Hyo Jung Kang, William A Tyler, John C Silbereis, Feng Cheng, Ying Zhu, Mihovil Pletikos, Lucija Jankovic-Rapan, Nathan P Cramer, Zygmunt Galdzicki, Joseph Goodliffe, Alan Peters, Claire Sethares, Ivana Delalle, Jeffrey A Golden, Tarik F Haydar, Nenad Sesta. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. vol 89. issue 6. 2016-08-02. PMID:26924435. |
trisomy 21, or down syndrome (ds), is the most common genetic cause of developmental delay and intellectual disability. |
2016-08-02 |
2023-08-13 |
mouse |
| Megan Stringer, Irushi Abeysekera, Karl J Dria, Randall J Roper, Charles R Goodlet. Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. Pharmacology, biochemistry, and behavior. vol 138. 2016-07-28. PMID:26363314. |
down syndrome (ds) or trisomy 21 causes intellectual disabilities in humans and the ts65dn ds mouse model is deficient in learning and memory tasks. |
2016-07-28 |
2023-08-13 |
mouse |