| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara J Strupp, Brian E Powers, Ramon Velazquez, Jessica A Ash, Christy M Kelley, Melissa J Alldred, Myla Strawderman, Marie A Caudill, Elliott J Mufson, Stephen D Ginsber. Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. Current Alzheimer research. vol 13. issue 1. 2016-09-19. PMID:26391046. |
although down syndrome (ds) can be diagnosed prenatally, currently there are no effective treatments to lessen the intellectual disability (id) which is a hallmark of this disorder. |
2016-09-19 |
2023-08-13 |
mouse |
| Eric D Hamlett, Heather A Boger, Aurélie Ledreux, Christy M Kelley, Elliott J Mufson, Maria F Falangola, David N Guilfoyle, Ralph A Nixon, David Patterson, Nathan Duval, Ann-Charlotte E Granhol. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer research. vol 13. issue 1. 2016-09-19. PMID:26391050. |
down syndrome (ds) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the united states of america. |
2016-09-19 |
2023-08-13 |
mouse |
| Huntington Potter, Antoneta Granic, Julbert Caneu. Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease. Current Alzheimer research. vol 13. issue 1. 2016-09-19. PMID:26651340. |
trisomy 21 and the consequent extra copy of the amyloid precursor protein (app) gene and increased beta-amyloid (aβ) peptide production underlie the universal development of alzheimer's disease (ad) pathology and high risk of ad dementia in people with down syndrome (ds). |
2016-09-19 |
2023-08-13 |
mouse |
| Marius Walus, Elizabeth Kida, Ausma Rabe, Giorgio Albertini, Adam A Golabe. Widespread cerebellar transcriptome changes in Ts65Dn Down syndrome mouse model after lifelong running. Behavioural brain research. vol 296. 2016-09-15. PMID:26304719. |
our previous study showed an improvement in locomotor deficits after voluntary lifelong running in ts65dn mice, an animal model for down syndrome (ds). |
2016-09-15 |
2023-08-13 |
mouse |
| Nejla Canbulat, Meltem Demirgöz Bal, Mehtap Çopl. Emotional reactions of mothers who have babies who are diagnosed with Down syndrome. International journal of nursing knowledge. vol 25. issue 3. 2016-09-12. PMID:24602179. |
the aim of this study was to explore a deeper insight into experiences of turkish mothers living with/diagnosed with down syndrome (ds) baby. |
2016-09-12 |
2023-08-12 |
Not clear |
| E Phelan, R Pal, L Henderson, K M J Green, I A Bruc. The management of children with Down syndrome and profound hearing loss. Cochlear implants international. vol 17. issue 1. 2016-09-12. PMID:26252564. |
although, the association between down syndrome (ds) and conductive hearing loss is well recognized, the fact that a small proportion of these children may have a severe to profound sensorineural hearing loss that could benefit from cochlear implantation (ci) is less well understood. |
2016-09-12 |
2023-08-13 |
Not clear |
| Xiaoling Jiang, Chunhong Liu, Tao Yu, Li Zhang, Kai Meng, Zhuo Xing, Pavel V Belichenko, Alexander M Kleschevnikov, Annie Pao, Jennifer Peresie, Sarah Wie, William C Mobley, Y Eugene Y. Genetic dissection of the Down syndrome critical region. Human molecular genetics. vol 24. issue 22. 2016-09-12. PMID:26374847. |
down syndrome (ds), caused by trisomy 21, is the most common chromosomal disorder associated with developmental cognitive deficits. |
2016-09-12 |
2023-08-13 |
mouse |
| David Hessl, Stephanie M Sansone, Elizabeth Berry-Kravis, Karen Riley, Keith F Widaman, Leonard Abbeduto, Andrea Schneider, Jeanine Coleman, Dena Oaklander, Kelly C Rhodes, Richard C Gersho. The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions. Journal of neurodevelopmental disorders. vol 8. issue 1. 2016-09-07. PMID:27602170. |
recent advances in understanding molecular and synaptic mechanisms of intellectual disabilities (id) in fragile x syndrome (fxs) and down syndrome (ds) through animal models have led to targeted controlled trials with pharmacological agents designed to normalize these underlying mechanisms and improve clinical outcomes. |
2016-09-07 |
2023-08-13 |
human |
| A Hagen, M Albig, T Keller, M Stumm, M Entezam. Suspicious Prenasal Skin Thickness-to-Nasal Bone Length Ratio: Prevalence and Correlation with Other Markers in Second and Third Trimester Fetuses with Down Syndrome. Ultraschall in der Medizin (Stuttgart, Germany : 1980). vol 36. issue 5. 2016-09-01. PMID:26091004. |
to assess the prevalence and value of a suspicious prenasal skin thickness-to-nasal bone length ratio (pt/nb ratio) in comparison to other established markers in a large population of down syndrome (ds) fetuses. |
2016-09-01 |
2023-08-13 |
Not clear |
| Rebecca Jermyn Graves, J Carolyn Graff, Anna J Esbensen, Donna K Hathaway, Jim Y Wan, Mona Newsome Wick. Measuring Health-Related Quality of Life of Adults With Down Syndrome. American journal on intellectual and developmental disabilities. vol 121. issue 4. 2016-09-01. PMID:27351699. |
this study examined self- and caregiver-reported health-related quality of life (hrqol) of 60 adults with down syndrome (ds) using the qualitymetric short form-12 version 2 (sf-12v2). |
2016-09-01 |
2023-08-13 |
Not clear |
| Aila Nica J Bandong, Gilbert O Madriaga, Edward James R Gorgo. Reliability and validity of the Four Square Step Test in children with cerebral palsy and Down syndrome. Research in developmental disabilities. vol 47. 2016-08-31. PMID:26318393. |
little is known about the measurement properties of clinical tests of stepping in different directions for children with cerebral palsy (cp) and down syndrome (ds). |
2016-08-31 |
2023-08-13 |
Not clear |
| Nanda de Knegt, Ruth Defrin, Carlo Schuengel, Frank Lobbezoo, Heleen Evenhuis, Erik Scherde. Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome. Research in developmental disabilities. vol 47. 2016-08-31. PMID:26460852. |
these functions seem impaired in children with down syndrome (ds), but have not been extensively examined in adults. |
2016-08-31 |
2023-08-13 |
human |
| Takuro Nakamur. The role of Trib1 in myeloid leukaemogenesis and differentiation. Biochemical Society transactions. vol 43. issue 5. 2016-08-31. PMID:26517931. |
trib1 is also involved in a certain type of human aml and a trib1 somatic point mutation r107l was identified in a case of down syndrome (ds)-related acute megakaryocytic leukaemia. |
2016-08-31 |
2023-08-13 |
mouse |
| b' Jamie O Edgin, Ursula Tooley, Bianca Demara, Casandra Nyhuis, Payal Anand, Goffredina Span\\xc3\\xb. Sleep Disturbance and Expressive Language Development in Preschool-Age Children With Down Syndrome. Child development. vol 86. issue 6. 2016-08-30. PMID:26435268.' |
this study examined variation in language ability in 29 toddlers with down syndrome (ds) in relation to levels of sleep disruption. |
2016-08-30 |
2023-08-13 |
Not clear |
| Jenifer Lavigne, Christianne Sharr, Al Ozonoff, Lisa Albers Prock, Nicole Baumer, Campbell Brasington, Sheila Cannon, Blythe Crissman, Emily Davidson, Jose C Florez, Priya Kishnani, Angela Lombardo, Jordan Lyerly, Jessica B McCannon, Mary Ellen McDonough, Alison Schwartz, Kathryn L Berrier, Susan Sparks, Kara Stock-Guild, Tomi L Toler, Kishore Vellody, Lauren Voelz, Brian G Skotk. National down syndrome patient database: Insights from the development of a multi-center registry study. American journal of medical genetics. Part A. vol 167A. issue 11. 2016-08-29. PMID:26249752. |
the down syndrome study group (dssg) was founded in 2012 as a voluntary, collaborative effort with the goal of supporting evidenced-based health care guidelines for individuals with down syndrome (ds). |
2016-08-29 |
2023-08-13 |
human |
| Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Moble. An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PloS one. vol 11. issue 3. 2016-08-29. PMID:27023444. |
in down syndrome (ds) or trisomy of chromosome 21, the β-amyloid (aβ) peptide product of the amyloid precursor protein (app) is present in excess. |
2016-08-29 |
2023-08-13 |
mouse |
| Rosane Costa Gomes, Jussara Cerqueira Maia, Ricardo Fernando Arrais, Carlos André Nunes Jatobá, Maria Auxiliadora Carvalho Rocha, Maria Edinilma Felinto Brito, Ana Laissa Oliveira Nazion, Clarissa Marques Maranhão, Hélcio De Sousa Maranhã. The celiac iceberg: from the clinical spectrum to serology and histopathology in children and adolescents with type 1 diabetes mellitus and Down syndrome. Scandinavian journal of gastroenterology. vol 51. issue 2. 2016-08-26. PMID:26339731. |
the objective of this study is to investigate the occurrence of gastrointestinal (gi) and extraintestinal symptoms in children and adolescents with type 1 diabetes mellitus (dm1) and down syndrome (ds) and their association with specific antibodies and histopathology of celiac disease (celd), representing its clinical forms in the iceberg. |
2016-08-26 |
2023-08-13 |
Not clear |
| Gaëlle Naert, Valentine Ferré, Johann Meunier, Emeline Keller, Susanna Malmström, Laurent Givalois, François Carreaux, Jean-Pierre Bazureau, Tangui Mauric. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26381812. |
dual-specificity tyrosine phosphorylation-regulated kinases (dyrks) and cdc2-like kinases (clks) are implicated in the onset and progression of down syndrome (ds) and alzheimer's disease (ad). |
2016-08-26 |
2023-08-13 |
mouse |
| Tatjana Begenisic, Gabriele Sansevero, Laura Baroncelli, Giovanni Cioni, Alessandro Sal. Early environmental therapy rescues brain development in a mouse model of Down syndrome. Neurobiology of disease. vol 82. 2016-08-24. PMID:26244989. |
down syndrome (ds), the most common genetic disorder associated with intellectual disabilities, is an untreatable condition characterized by a number of developmental defects and permanent deficits in the adulthood. |
2016-08-24 |
2023-08-13 |
mouse |
| Andrea Giacomini, Fiorenza Stagni, Stefania Trazzi, Sandra Guidi, Marco Emili, Elizabeth Brigham, Elisabetta Ciani, Renata Bartesagh. Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease. vol 82. 2016-08-24. PMID:26254735. |
neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in down syndrome (ds). |
2016-08-24 |
2023-08-13 |
mouse |