| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Florencia Iulita, Alison Ower, Concetta Barone, Rowan Pentz, Palma Gubert, Corrado Romano, Rita Anna Cantarella, Flaviana Elia, Serafino Buono, Marilena Recupero, Carmelo Romano, Sabrina Castellano, Paolo Bosco, Santo Di Nuovo, Filippo Drago, Filippo Caraci, A Claudio Cuell. An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 11. 2017-12-01. PMID:27452424. |
given that alzheimer's pathology develops silently over decades in down syndrome (ds), prognostic biomarkers of dementia are a major need. |
2017-12-01 |
2023-08-13 |
Not clear |
| Jenifer Lavigne, Christianne Sharr, Ibrahim Elsharkawi, Al Ozonoff, Nicole Baumer, Campbell Brasington, Sheila Cannon, Blythe Crissman, Emily Davidson, Jose C Florez, Priya Kishnani, Angela Lombardo, Jordan Lyerly, Mary Ellen McDonough, Alison Schwartz, Kathryn Berrier, Susan Sparks, Kara Stock-Guild, Tomi L Toler, Kishore Vellody, Lauren Voelz, Brian G Skotk. Thyroid dysfunction in patients with Down syndrome: Results from a multi-institutional registry study. American journal of medical genetics. Part A. vol 173. issue 6. 2017-12-01. PMID:28332275. |
the goals of this undertaking were to assess the outcomes of thyroid screening tests and adherence to thyroid screening guidelines across five down syndrome (ds) specialty clinics in various states. |
2017-12-01 |
2023-08-13 |
human |
| Clotilde Mircher, Jeanne Toulas, Cécile Cieuta-Walti, Isabelle Marey, Martine Conte, Laura González Briceño, Marie-Laure Tanguy, Marie-Odile Rethore, Aime Rave. Anthropometric charts and congenital anomalies in newborns with Down syndrome. American journal of medical genetics. Part A. vol 173. issue 8. 2017-12-01. PMID:28574650. |
the objectives of this study were to obtain updated neonatal measurements in french newborns with down syndrome (ds) according to their gestational age, and to assess the frequency and distribution of congenital anomalies. |
2017-12-01 |
2023-08-13 |
Not clear |
| Goffredina Spanò, Jamie Ogline Edgi. Everyday memory in individuals with Down syndrome: Validation of the Observer Memory Questionnaire - Parent Form. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. vol 23. issue 5. 2017-11-29. PMID:26981787. |
the memory profile of individuals with down syndrome (ds) has mainly been examined through traditional laboratory tasks, often revealing substantial deficits in episodic and declarative memory. |
2017-11-29 |
2023-08-13 |
Not clear |
| Tomer Halevy, Juan-Carlos Biancotti, Ofra Yanuka, Tamar Golan-Lev, Nissim Benvenist. Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation. Stem cell reports. vol 7. issue 4. 2017-11-21. PMID:27618722. |
down syndrome (ds) is the leading genetic cause of mental retardation and is caused by a third copy of human chromosome 21. |
2017-11-21 |
2023-08-13 |
human |
| b' Maria Esther Leiva Portocarrero, Anik M C Gigu\\xc3\\xa8re, Johanie L\\xc3\\xa9pine, Mirjam M Garvelink, Hubert Robitaille, Agathe Delano\\xc3\\xab, Isabelle L\\xc3\\xa9vesque, Brenda J Wilson, Fran\\xc3\\xa7ois Rousseau, France L\\xc3\\xa9gar\\xc3\\xa. Use of a patient decision aid for prenatal screening for Down syndrome: what do pregnant women say? BMC pregnancy and childbirth. vol 17. issue 1. 2017-11-21. PMID:28320334.' |
we sought to identify factors influencing pregnant women's use of a patient decision aid for deciding about prenatal screening for down syndrome (ds). |
2017-11-21 |
2023-08-13 |
Not clear |
| Ambreen Asim, Sarita Agarwal, Inusha Panigrahi, Aditya Narayan Sarangi, Srinivasan Muthuswamy, Aditya Kapoo. CRELD1 gene variants and atrioventricular septal defects in Down syndrome. Gene. vol 641. 2017-11-17. PMID:29054759. |
in the present study, we evaluated the association and significance of creld1 variants with avsd in down syndrome (ds) patients. |
2017-11-17 |
2023-08-13 |
Not clear |
| Vani Rupela, Shelley L Velleman, Mary V Andrianopoulo. Motor speech skills in children with Down syndrome: A descriptive study. International journal of speech-language pathology. vol 18. issue 5. 2017-11-16. PMID:27063682. |
motor speech characteristics of children with down syndrome (ds) have historically been viewed as either childhood dysarthria (cd) or, more infrequently, as childhood apraxia of speech (cas). |
2017-11-16 |
2023-08-13 |
Not clear |
| Tiina Annus, Liam R Wilson, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Young T Hong, Tim D Fryer, Jonathan P Coles, David K Menon, Shahid H Zaman, Anthony J Holland, Peter J Nesto. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiology of aging. vol 53. 2017-11-16. PMID:28192686. |
people with down syndrome (ds) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. |
2017-11-16 |
2023-08-13 |
Not clear |
| Harry LeVine, H Peter Spielmann, Sergey Matveev, Francesca Macchiavello Cauvi, M Paul Murphy, Tina L Beckett, Katie McCarty, Ira T Lott, Eric Doran, Frederick Schmitt, Elizabeth Hea. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiology of aging. vol 54. 2017-11-16. PMID:28385551. |
beta-amyloid (aβ) deposition in brain accumulates as a function of age in people with down syndrome (ds) with subsequent development into alzheimer disease neuropathology, typically by 40 years of age. |
2017-11-16 |
2023-08-13 |
Not clear |
| James H Cole, Tiina Annus, Liam R Wilson, Ridhaa Remtulla, Young T Hong, Tim D Fryer, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Robert Smith, David K Menon, Shahid H Zaman, Peter J Nestor, Anthony J Hollan. Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline. Neurobiology of aging. vol 56. 2017-11-16. PMID:28482213. |
individuals with down syndrome (ds) are more likely to experience earlier onset of multiple facets of physiological aging. |
2017-11-16 |
2023-08-13 |
human |
| Joseph H Lee, Annie J Lee, Lam-Ha Dang, Deborah Pang, Sergey Kisselev, Sharon J Krinsky-McHale, Warren B Zigman, José A Luchsinger, Wayne Silverman, Benjamin Tycko, Lorraine N Clark, Nicole Schup. Candidate gene analysis for Alzheimer's disease in adults with Down syndrome. Neurobiology of aging. vol 56. 2017-11-16. PMID:28554490. |
individuals with down syndrome (ds) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the alzheimer's disease (ad) neuropathology. |
2017-11-16 |
2023-08-13 |
Not clear |
| Brian E Powers, Christy M Kelley, Ramon Velazquez, Jessica A Ash, Myla S Strawderman, Melissa J Alldred, Stephen D Ginsberg, Elliott J Mufson, Barbara J Strup. Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. Neuroscience. vol 340. 2017-11-07. PMID:27840230. |
the ts65dn mouse model of down syndrome (ds) and alzheimer's disease (ad) exhibits cognitive impairment and degeneration of basal forebrain cholinergic neurons (bfcns). |
2017-11-07 |
2023-08-13 |
mouse |
| Fiorenza Stagni, Andrea Giacomini, Sandra Guidi, Marco Emili, Beatrice Uguagliati, Maria Elisa Salvalai, Valeria Bortolotto, Mariagrazia Grilli, Roberto Rimondini, Renata Bartesagh. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS. Experimental neurology. vol 298. issue Pt A. 2017-11-06. PMID:28882412. |
intellectual disability is the unavoidable hallmark of down syndrome (ds), with a heavy impact on public health. |
2017-11-06 |
2023-08-13 |
mouse |
| Fiorenza Stagni, Andrea Giacomini, Sandra Guidi, Marco Emili, Beatrice Uguagliati, Maria Elisa Salvalai, Valeria Bortolotto, Mariagrazia Grilli, Roberto Rimondini, Renata Bartesagh. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS. Experimental neurology. vol 298. issue Pt A. 2017-11-06. PMID:28882412. |
our study in a mouse model of ds provides novel evidence that treatment with 7,8-dhf during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-dhf may represent a possible breakthrough for down syndrome. |
2017-11-06 |
2023-08-13 |
mouse |
| Alejandro González-Agüero, Ángel Matute-Llorente, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José A Casajú. Percentage of body fat in adolescents with Down syndrome: Estimation from skinfolds. Disability and health journal. vol 10. issue 1. 2017-11-02. PMID:27436427. |
adolescents with down syndrome (ds) have a unique morphology and body shape, and this needs to be taken into account when assessing body fat percentage (bf%). |
2017-11-02 |
2023-08-13 |
Not clear |
| Elizabeth Kay-Raining Bird, Fred Genesee, Ludo Verhoeve. Bilingualism in children with developmental disorders: A narrative review. Journal of communication disorders. vol 63. 2017-10-31. PMID:27461977. |
in this first article of the special issue, we review research on the timing and amount of bilingual exposure and outcomes of either direct language intervention or educational placements in three groups of children with dd: specific language impairment (sli), autism spectrum disorders (asd), and down syndrome (ds). |
2017-10-31 |
2023-08-13 |
Not clear |
| Gary E Martin, Jamie Barstein, Jane Hornickel, Sara Matherly, Genna Durante, Molly Los. Signaling of noncomprehension in communication breakdowns in fragile X syndrome, Down syndrome, and autism spectrum disorder. Journal of communication disorders. vol 65. 2017-10-31. PMID:28161297. |
the current study examined the ability to signal noncomprehension across different types of confusing message conditions in children and adolescents with fragile x syndrome (fxs), down syndrome (ds), autism spectrum disorder (asd), and typical development (td). |
2017-10-31 |
2023-08-13 |
Not clear |
| Brian G Skotko, Eric A Macklin, Marco Muselli, Lauren Voelz, Mary Ellen McDonough, Emily Davidson, Veerasathpurush Allareddy, Yasas S N Jayaratne, Richard Bruun, Nicholas Ching, Gil Weintraub, David Gozal, Dennis Rose. A predictive model for obstructive sleep apnea and Down syndrome. American journal of medical genetics. Part A. vol 173. issue 4. 2017-10-30. PMID:28124477. |
obstructive sleep apnea (osa) occurs frequently in people with down syndrome (ds) with reported prevalences ranging between 55% and 97%, compared to 1-4% in the neurotypical pediatric population. |
2017-10-30 |
2023-08-13 |
Not clear |
| Francisco Javier Martínez-Macías, Lucina Bobadilla-Morales, Janet González-Cruz, Moisés Quiles-Corona, Alfredo Corona-Rivera, Christian Peña-Padilla, Mireya Orozco-Vela, Rocío Silva-Cruz, Fernando Velarde-Rivera, Jorge Román Corona-River. Descriptive study of the complete blood count in newborn infants with Down syndrome. American journal of medical genetics. Part A. vol 173. issue 4. 2017-10-30. PMID:28168815. |
the usefulness of the complete blood count (cbc) during the first week of life in infants with down syndrome (ds) has been recognized; however, studies are limited and have evaluated only some of the parameters of the cbc. |
2017-10-30 |
2023-08-13 |
Not clear |