| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ardesheer Talati, Guia Guffanti, Zagaa Odgerel, Iuliana Ionita-Laza, Heli Malm, Andre Sourander, Alan S Brown, Priya J Wickramaratne, Jay A Gingrich, Myrna M Weissma. Genetic variants within the serotonin transporter associated with familial risk for major depression. Psychiatry research. vol 228. issue 1. 2016-01-08. PMID:25920807. |
genetic variants within the serotonin transporter associated with familial risk for major depression. |
2016-01-08 |
2023-08-13 |
Not clear |
| Curtis Benson, Katherine Mifflin, Bradley Kerr, Sam J B Jesudasan, Serdar Dursun, Glen Bake. Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression. Modern trends in pharmacopsychiatry. vol 30. 2016-01-07. PMID:26437459. |
it appears that numerous neurotransmitters and neuromodulators are involved, and this chapter focuses on the monoamine neurotransmitters noradrenaline, 5-hydroxytryptamine (5-ht, serotonin), and dopamine and the amino acid neurotransmitters gaba (γ-aminobutyric acid) and glutamate in chronic pain and depression. |
2016-01-07 |
2023-08-13 |
Not clear |
| Curtis Benson, Katherine Mifflin, Bradley Kerr, Sam J B Jesudasan, Serdar Dursun, Glen Bake. Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression. Modern trends in pharmacopsychiatry. vol 30. 2016-01-07. PMID:26437459. |
numerous preclinical and clinical neurochemical, neuroanatomical, pharmacological and molecular biological studies as well as clinical pharmacological treatment investigations implicate noradrenaline, 5-ht and, to a lesser extent, dopamine in the etiology of pain and depression. |
2016-01-07 |
2023-08-13 |
Not clear |
| Jeremy D Coplan, Cindy J Aaronson, Venkatesh Panthangi, Younsuk Ki. Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches. World journal of psychiatry. vol 5. issue 4. 2016-01-07. PMID:26740928. |
serotonin reuptake inhibitors are considered first-line treatment in uncomplicated depression comorbid with a spectrum of anxiety disorders. |
2016-01-07 |
2023-08-13 |
Not clear |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) that is clinically used for the treatment of depression in human patients. |
2016-01-04 |
2023-08-13 |
mouse |
| Raffaele Cozzolongo, Piero Porcelli, Filomena Cariola, Vito Giannuzzi, Elsa Lanzilotta, Mattia Gentile, Gabriella Sonnante, Gioacchino Leandr. Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C. Journal of affective disorders. vol 183. 2015-12-31. PMID:26001668. |
serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis c. ifn-induced depression is a suitable model for investigating vulnerability to depression. |
2015-12-31 |
2023-08-13 |
Not clear |
| Diana M Norden, Raymond Devine, Sabahattin Bicer, Runfeng Jing, Peter J Reiser, Loren E Wold, Jonathan P Godbout, Donna O McCarth. Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. Physiology & behavior. vol 140. 2015-12-28. PMID:25554480. |
reduced serotonin availability in the brain and increased production of alternative neuroactive metabolites of tryptophan are thought to contribute to the development of depression and fatigue. |
2015-12-28 |
2023-08-13 |
mouse |
| Diana M Norden, Raymond Devine, Sabahattin Bicer, Runfeng Jing, Peter J Reiser, Loren E Wold, Jonathan P Godbout, Donna O McCarth. Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. Physiology & behavior. vol 140. 2015-12-28. PMID:25554480. |
the purpose of this study was to determine the effects of fluoxetine, a selective serotonin reuptake inhibitor (ssri), on brain cytokines and behavioral measures of fatigue and depression in tumor-bearing mice. |
2015-12-28 |
2023-08-13 |
mouse |
| Mark Pitzer, Jordan Lueras, Anna Warden, Sydney Weber, Jodi McBrid. Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice. Brain research. vol 1608. 2015-12-24. PMID:25732261. |
while the depression in hd patients is often treated with serotonin agonists, there is scant experimental evidence that the depression in hd responds well to these serotonin treatments or in a similar manner to how non-hd depression tends to respond. |
2015-12-24 |
2023-08-13 |
mouse |
| Mark Pitzer, Jordan Lueras, Anna Warden, Sydney Weber, Jodi McBrid. Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice. Brain research. vol 1608. 2015-12-24. PMID:25732261. |
the drn provides the majority of the serotonin to the forebrain and exhibits cell loss in non-hd depression. |
2015-12-24 |
2023-08-13 |
mouse |
| Tania Rivera-Baltanas, Roberto Carlos Agis-Balboa, Raquel Romay-Tallon, Lisa E Kalynchuk, Jose Manuel Olivares, Hector J Carunch. Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depressive patients treated with antidepressant medication. Annals of general psychiatry. vol 14. 2015-12-23. PMID:26697099. |
we have shown that serotonin transporter (sert) clustering in blood lymphocytes is altered in major depression and correlates with pharmacological therapeutic responses measured with the hamilton scale. |
2015-12-23 |
2023-08-13 |
Not clear |
| Wan-wan Liu, Lu Xu, Xian-zhe Dong, Xiao Tan, Shi Wang, Wei-yu Zhu, Ping Li. [Effects of Kaixin San formulas on behavioristics and central monoamine neurotransmitters of chronic stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 11. 2015-12-17. PMID:26552177. |
the classic isolation method and the chronic unpredictable mild stress (cums) depression model were combined to investigate the changes in contents in hippocampus and monoamine neurotransmitters (ne, da, 5-ht) and the components of some formulas in plasma with hplc and uplc-q-tof-mse methods. |
2015-12-17 |
2023-08-13 |
rat |
| Paulo Magalhães, Gilberto Alves, Adrián LLerena, Amílcar Falcã. Clinical drug-drug interactions: focus on venlafaxine. Drug metabolism and personalized therapy. vol 30. issue 1. 2015-12-15. PMID:24964257. |
venlafaxine (ven) is an antidepressant agent widely used nowadays as an alternative to selective serotonin reuptake inhibitors (ssris), particularly for the treatment of ssri-resistant depression. |
2015-12-15 |
2023-08-13 |
Not clear |
| Konstantinos N Fountoulakis, Maria Gazouli, John Kelsoe, Hagop Akiska. The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in bipolar disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25596883. |
the original model suggests that a constellation of effects on different receptors are necessary but the serotonin reuptake inhibition does not seem to play a significant role for bipolar depression. |
2015-12-15 |
2023-08-13 |
Not clear |
| K Vijaya Kumar, Anjuman Rudra, M V Sreedhara, T Siva Subramani, Durga Shiva Prasad, Manish Lal Das, Senthil Murugesan, Rajbharan Yadav, Ravi Kumar Trivedi, Justin V Louis, Yu-Wen Li, Linda J Bristow, Pattipati S Naidu, Reeba Kannimel Vikramadithya. Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice. Brain, behavior, and immunity. vol 42. 2015-12-14. PMID:25016199. |
bacillus calmette-guérin vaccine induces a selective serotonin reuptake inhibitor (ssri)-resistant depression like phenotype in mice. |
2015-12-14 |
2023-08-13 |
mouse |
| Vlasios Brakoulia. Managing obsessive compulsive disorder. Australian prescriber. vol 38. issue 4. 2015-12-09. PMID:26648639. |
patients with obsessive compulsive disorder respond to selective serotonin reuptake inhibitors at a slower rate than those with depression. |
2015-12-09 |
2023-08-13 |
Not clear |
| Eszter Kirilly, Xénia Gonda, György Bagd. [Antidepressants, stressors and the serotonin 1A receptor]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 17. issue 2. 2015-12-04. PMID:26192901. |
human genetic studies revealed the role of 5-ht(1a) receptors in cognitive processes playing a role in the development of depression such as impulsiveness or response to environmental stress. |
2015-12-04 |
2023-08-13 |
human |
| Anniek K D Visser, Jelle Kleijn, Martijn H J R van Faassen, Eliyahu Dremencov, Gunnar Flik, Ido P Kema, Johan A Den Boer, Aren van Waarde, Rudi A J O Dierckx, Fokko J Boske. Serotonin-2C antagonism augments the effect of citalopram on serotonin and dopamine levels in the ventral tegmental area and nucleus accumbens. Neurochemistry international. vol 81. 2015-12-03. PMID:25542858. |
many patients with major depression do not respond to selective serotonin reuptake inhibitors (ssris). |
2015-12-03 |
2023-08-13 |
rat |
| Robert A Comley, Jasper van der Aart, Balázs Gulyás, Martine Garnier, Laura Iavarone, Christer Halldin, Eugenii A Rabine. In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography. Neuropharmacology. vol 92. 2015-12-01. PMID:25476970. |
gsk588045 is a novel compound with antagonist activity at 5-ht1a/1b/1d receptors and nanomolar affinity for the serotonin transporter, which was in development for the treatment of depression and anxiety. |
2015-12-01 |
2023-08-13 |
monkey |
| Paul W Andrews, Aadil Bharwani, Kyuwon R Lee, Molly Fox, J Anderson Thomso. Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response. Neuroscience and biobehavioral reviews. vol 51. 2015-12-01. PMID:25625874. |
the role of serotonin in depression and antidepressant treatment remains unresolved despite decades of research. |
2015-12-01 |
2023-08-13 |
Not clear |