| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ningning Guo, Xin Wang, Muran Xu, Jie Bai, Hao Yu, Le Zhan. PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression. Pharmacological research. 2024-07-11. PMID:38992850. |
numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. |
2024-07-11 |
2024-07-14 |
Not clear |
| Weixing Ding, Lulu Wang, Lei Li, Hongyan Li, Jianfa Wu, Jing Zhang, Jing Wan. Pathogenesis of depression and the potential for traditional Chinese medicine treatment. Frontiers in pharmacology. vol 15. 2024-07-10. PMID:38983910. |
contemporary research has explored the potential pathogenesis of depression from various angles, encompassing genetics, neurotransmitter systems, neurotrophic factors, the hypothalamic-pituitary-adrenal axis, inflammation, and intestinal flora, among other contributing factors. |
2024-07-10 |
2024-07-12 |
Not clear |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
prevailing hypotheses on the mechanisms of antidepressant action posit that antidepressants directly counteract deficiencies in major neurotransmitter signaling systems that underlie depression. |
2024-07-02 |
2024-07-06 |
mouse |
| Cem Yamali, Merve Nenni, Mehtap Tugrak Sakarya, Hasan Alper Kapla. Pharmaceutical Studies on Piperazine-Based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters. Mini reviews in medicinal chemistry. 2024-06-24. PMID:38910275. |
multiple factors, such as genetic factors and abnormalities in neurotransmitter levels, contribute to the development of depression. |
2024-06-24 |
2024-06-26 |
Not clear |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
erβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the tph2/5-ht pathway. |
2024-06-08 |
2024-06-11 |
rat |
| Kaustav Nag, Deepak Solanki, Muthukumar Serva Peddha, Seema Mehdi, Rajan Logesh, Tamsheel Fatima Roohi, Nabeel Kinattingal, Faiyaz Shakee. Effect of cyclodextrin-complexed lyophilized nanosuspension of Nigella sativa seeds oleoresin on chronic unpredictable mild stress (CUMS)-induced depression in mice. Neuroscience letters. 2024-05-31. PMID:38821203. |
these results suggest that nano-nsor ameliorates cums-induced depression by modulating neurotransmitter levels, reducing inflammation, and enhancing neuroprotection. |
2024-05-31 |
2024-06-02 |
mouse |
| Nasar Ullah Khan Niazi, Chengyi Huang, Zhiyou Yang, Yongping Zhang, Cai Son. Comparison between sub-chronic and chronic sleep deprivation-induced behavioral and neuroimmunological abnormalities in mice: focusing on glial cell phenotype polarization. Behavioural brain research. 2024-05-25. PMID:38795845. |
although neuroinflammation triggered by microglial phenotype m1 activation, leading to neurotransmitter dysfunction and aβ aggregation, is considered as the leading cause of depression and ad, whether and how sub-chronic or chronic sleep deprivation (sd) contribute to the onset and development of these diseases remains unclear. |
2024-05-25 |
2024-05-31 |
mouse |
| Shashi B Singh, Atit Tiwari, Maanya R Katta, Riju Kafle, Cyrus Ayubcha, Krishna H Patel, Yash Bhattarai, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revhei. The utility of PET imaging in depression. Frontiers in psychiatry. vol 15. 2024-05-08. PMID:38711875. |
studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, gaba, and glutamate, which are linked to the pathophysiology of depression. |
2024-05-08 |
2024-05-27 |
Not clear |
| Victoria Jiménez Carretero, Ninfa Liccardi, Maria Arribas Tejedor, Ricardo de Pascual, Jorge Hernández Campano, Jesús M Hernández-Guij. Lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells. Toxicology. 2024-04-22. PMID:38648961. |
lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells. |
2024-04-22 |
2024-04-26 |
cattle |
| Liuting Xu, Sizhe Wang, Linlin Wu, Hui Cao, Yichun Fan, Xi Wang, Zheng Yu, Manfei Zhou, Rong Gao, Jun Wan. Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation. Journal of affective disorders. 2024-04-22. PMID:38649105. |
it is becoming evident that neurotransmitter imbalance and gut microbiota dysbiosis are prominent causes of depression. |
2024-04-22 |
2024-04-26 |
mouse |
| Aletta Me Millen, William Mu Daniels, Sooraj Baijnat. Depression, an unmet health need in Africa: Understanding the promise of ketamine. Heliyon. vol 10. issue 7. 2024-04-11. PMID:38601594. |
despite this, the treatment of depression is one-dimensional focussing on outdated theories of depression and mainly targeting dysfunctional neurotransmitter pathways. |
2024-04-11 |
2024-04-13 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
the neurotransmitter serotonin has drawn the most attention concerning depression. |
2024-04-09 |
2024-04-11 |
Not clear |
| Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng, Tiemin Liu, Wei Ji. Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity. Cell metabolism. 2024-04-06. PMID:38582087. |
we observed depleted gut bacterial species, including bifidobacterium longum and roseburia intestinalis, and the neurotransmitter homovanillic acid (hva) in individuals with depression and mouse depression models. |
2024-04-06 |
2024-04-10 |
mouse |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
the neurotransmitter serotonin plays a pivotal role in mood and depression. |
2024-03-20 |
2024-03-23 |
Not clear |
| Svenja Bremshey, Juliana Groß, Kim Renken, Olivia Andrea Massec. The role of serotonin in depression-A historical roundup and future directions. Journal of neurochemistry. 2024-03-13. PMID:38477031. |
we will review the evolution of antidepressant treatments, systemic research on depression over the years, and future research applications that will help to bridge the gap between systemic research and neurotransmitter dynamics using biosensors. |
2024-03-13 |
2024-03-15 |
Not clear |
| Zhen Wang, Hui Xu, Zheng Wang, Hang Zhou, Lijuan Zhang, Yu Wang, Miaoxiu Li, Yunfeng Zho. Effect of tuina on sleep quality, psychological state and neurotransmitter level in patients with insomnia: a systematic review and meta-analysis. Frontiers in neurology. vol 15. 2024-03-07. PMID:38450067. |
numerous studies have shown that tuina can improve the symptoms of sleep disorders in patients with insomnia while relieving anxiety and depression and regulating neurotransmitter levels. |
2024-03-07 |
2024-03-09 |
Not clear |
| Fanhao Meng, Long Wan. Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 48. issue 10. 2024-03-03. PMID:38432881. |
pathological alterations of depression and insomnia may perturb the production and release of neurotransmitter, dendritic spine remodeling and elimination, which converges and reflects in aberrant synaptic dynamics. |
2024-03-03 |
2024-03-06 |
Not clear |
| Yayun Wu, Lijuan Liu, Ya Zhao, Xiong Li, Junhong Hu, Hanlin Li, Ruizhi Zha. Xiaoyaosan promotes neurotransmitter transmission and alleviates CUMS-induced depression by regulating the expression of Oct1 and Oct3 in astrocytes of the prefrontal cortex. Journal of ethnopharmacology. 2024-02-17. PMID:38367929. |
xiaoyaosan promotes neurotransmitter transmission and alleviates cums-induced depression by regulating the expression of oct1 and oct3 in astrocytes of the prefrontal cortex. |
2024-02-17 |
2024-02-20 |
Not clear |
| Xiling Li, Chun Chien, Yifu Han, Zihan Sun, Xun Chen, Dion Dickma. Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression. Science advances. vol 7. issue 49. 2024-02-14. PMID:34851664. |
homeostatic modulation of presynaptic neurotransmitter release is a fundamental form of plasticity that stabilizes neural activity, where presynaptic homeostatic depression (phd) can adaptively diminish synaptic strength. |
2024-02-14 |
2024-02-16 |
Not clear |
| Yang Gao, Kexin Nie, Hongzhan Wang, Hui Dong, Yueheng Tan. Research progress on antidepressant effects and mechanisms of berberine. Frontiers in pharmacology. vol 15. 2024-02-06. PMID:38318145. |
this review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory status in order to provide a reference for further research and clinical application of berberine. |
2024-02-06 |
2024-02-09 |
Not clear |