| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon H Cline, Joao P Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I Santos, Yury V Bukhman, Aslan Kubatiev, Harry W M Steinbusch, Klaus-Peter Lesch, Tatyana Strekalov. Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression. Frontiers in behavioral neuroscience. vol 9. 2015-03-13. PMID:25767439. |
dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, rem sleep, hippocampal pgsk3 beta and mrnas of nmda receptor subunits in mouse models of depression. |
2015-03-13 |
2023-08-13 |
mouse |
| Brandon H Cline, Joao P Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I Santos, Yury V Bukhman, Aslan Kubatiev, Harry W M Steinbusch, Klaus-Peter Lesch, Tatyana Strekalov. Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression. Frontiers in behavioral neuroscience. vol 9. 2015-03-13. PMID:25767439. |
central insulin receptor-mediated signaling is attracting the growing attention of researchers because of rapidly accumulating evidence implicating it in the mechanisms of plasticity, stress response, and neuropsychiatric disorders including depression. |
2015-03-13 |
2023-08-13 |
mouse |
| Brandon H Cline, Joao P Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I Santos, Yury V Bukhman, Aslan Kubatiev, Harry W M Steinbusch, Klaus-Peter Lesch, Tatyana Strekalov. Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression. Frontiers in behavioral neuroscience. vol 9. 2015-03-13. PMID:25767439. |
compounds enhancing neuronal insulin receptor-mediated transmission exert an antidepressant-like effect in several pre-clinical paradigms of depression; similarly, such properties for ds were found with a stress-induced anhedonia model. |
2015-03-13 |
2023-08-13 |
mouse |
| Adam G Tabák, Tasnime N Akbaraly, G David Batty, Mika Kivimäk. Depression and type 2 diabetes: a causal association? The lancet. Diabetes & endocrinology. vol 2. issue 3. 2015-02-23. PMID:24622754. |
the evidence for an association between depression and glycaemic traits (eg, glucose, insulin, insulin sensitivity, and insulin secretion) is also mixed. |
2015-02-23 |
2023-08-12 |
Not clear |
| David E Kemp, Martha Schinagle, Keming Gao, Carla Conroy, Stephen J Ganocy, Faramarz Ismail-Beigi, Joseph R Calabres. PPAR-γ agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression. CNS drugs. vol 28. issue 6. 2015-01-22. PMID:24715548. |
insulin resistance and other cardio-metabolic risk factors predict increased risk of depression and decreased response to antidepressant and mood stabilizer treatments. |
2015-01-22 |
2023-08-13 |
Not clear |
| Deepali Gupta, Yeshwant Kurhe, Mahesh Radhakrishna. Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system. Physiology & behavior. vol 129. 2014-12-15. PMID:24582678. |
insulin is believed to have antidepressant effects in depression associated with diabetes; however, the mechanism underlying the postulated effect is poorly understood. |
2014-12-15 |
2023-08-12 |
mouse |
| Deepali Gupta, Yeshwant Kurhe, Mahesh Radhakrishna. Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system. Physiology & behavior. vol 129. 2014-12-15. PMID:24582678. |
collectively, the data indicate that insulin exhibits antidepressant effects in depression associated with stz induced diabetes in mice through the elevation of the brain serotonin levels. |
2014-12-15 |
2023-08-12 |
mouse |
| S Zelber-Sagi, S Toker, G Armon, S Melamed, S Berliner, I Shapira, Z Halpern, E Santo, O Shibole. Elevated alanine aminotransferase independently predicts new onset of depression in employees undergoing health screening examinations. Psychological medicine. vol 43. issue 12. 2014-08-22. PMID:23522007. |
similarly, patients with depression exhibit insulin resistance and increased inflammatory markers. |
2014-08-22 |
2023-08-12 |
Not clear |
| Yosef Levenbrown, Scott Penfil, Elena Rodriguez, Yan Zhu, Jobayer Hossain, A Majeed Bhat, Anne Hesek, Karen B O'Neil, Kelly Tobin, Thomas H Shaffe. Use of insulin to decrease septic shock-induced myocardial depression in a porcine model. Inflammation. vol 36. issue 6. 2014-07-14. PMID:23887895. |
use of insulin to decrease septic shock-induced myocardial depression in a porcine model. |
2014-07-14 |
2023-08-12 |
Not clear |
| Yosef Levenbrown, Scott Penfil, Elena Rodriguez, Yan Zhu, Jobayer Hossain, A Majeed Bhat, Anne Hesek, Karen B O'Neil, Kelly Tobin, Thomas H Shaffe. Use of insulin to decrease septic shock-induced myocardial depression in a porcine model. Inflammation. vol 36. issue 6. 2014-07-14. PMID:23887895. |
insulin is known to attenuate septic shock-induced myocardial depression. |
2014-07-14 |
2023-08-12 |
Not clear |
| Yosef Levenbrown, Scott Penfil, Elena Rodriguez, Yan Zhu, Jobayer Hossain, A Majeed Bhat, Anne Hesek, Karen B O'Neil, Kelly Tobin, Thomas H Shaffe. Use of insulin to decrease septic shock-induced myocardial depression in a porcine model. Inflammation. vol 36. issue 6. 2014-07-14. PMID:23887895. |
the objective of this study was to determine whether the mechanism of action of insulin in attenuating septic shock-induced myocardial depression is through an immunomodulatory effect. |
2014-07-14 |
2023-08-12 |
Not clear |
| Qiuhua Shen, Sandra Bergquist-Beringe. Relationship between major depression and insulin resistance: does it vary by gender or race/ethnicity among young adults aged 20-39 years? Journal of diabetes. vol 5. issue 4. 2014-07-01. PMID:23489875. |
relationship between major depression and insulin resistance: does it vary by gender or race/ethnicity among young adults aged 20-39 years? |
2014-07-01 |
2023-08-12 |
Not clear |
| Qiuhua Shen, Sandra Bergquist-Beringe. Relationship between major depression and insulin resistance: does it vary by gender or race/ethnicity among young adults aged 20-39 years? Journal of diabetes. vol 5. issue 4. 2014-07-01. PMID:23489875. |
to examine the relationship between major depression and insulin resistance by gender and race/ethnicity among young adults without diabetes mellitus. |
2014-07-01 |
2023-08-12 |
Not clear |
| P Grant, D Dworakowska, N DeZoysa, D Barne. The impact of anxiety and depression on patients within a large type 1 diabetes insulin pump population. An observational study. Diabetes & metabolism. vol 39. issue 5. 2014-06-24. PMID:24076359. |
the impact of anxiety and depression on patients within a large type 1 diabetes insulin pump population. |
2014-06-24 |
2023-08-12 |
Not clear |
| R Jorde, G Grimnes, M S Hutchinson, M Kjærgaard, E Kamycheva, J Svartber. Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 9. 2014-05-07. PMID:23686706. |
a cross-sectional population based study was designed with pooled data from 3 vitamin d randomized clinical trials (rcts) performed in tromsø with weight reduction, insulin sensitivity, and depression scores as endpoints, and one testosterone rct in subjects with low serum testosterone (<11.0 nmol/l) and with body composition as endpoint. |
2014-05-07 |
2023-08-12 |
human |
| Mohammad Shamsul Ol. Effect of hyperglycemia on insulin receptor signaling in the cultured retinal Müller glial cells. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24462861. |
however, it is not known whether diabetic induced hyperglycemia causes a depression to the insulin signaling. |
2014-04-30 |
2023-08-12 |
Not clear |
| Tomoyuki Kawad. Comment on: Kan et al. A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes Care 2013;36:480-489. Diabetes care. vol 36. issue 8. 2014-03-17. PMID:23881976. |
a systematic review and meta-analysis of the association between depression and insulin resistance. |
2014-03-17 |
2023-08-12 |
Not clear |
| Carol Kan, Naomi Silva, Sherita Hill Golden, Ulla Rajala, Markku Timonen, Daniel Stahl, Khalida Ismai. Response to Comment on: Kan et al. A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes Care 2013;36:480-489. Diabetes care. vol 36. issue 8. 2014-03-17. PMID:23881977. |
a systematic review and meta-analysis of the association between depression and insulin resistance. |
2014-03-17 |
2023-08-12 |
Not clear |
| Maite Solas, Bárbara Aisa, Rosa M Tordera, María C Mugueta, María J Ramíre. Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1832. issue 12. 2014-02-20. PMID:24090692. |
it is becoming evident that chronic exposure to stress not only might result in insulin resistance or cognitive deficits, but may also be considered a risk factor for pathologies such as depression or alzheimer's disease (ad). |
2014-02-20 |
2023-08-12 |
mouse |
| Undine E Lang, Stefan Borgward. Molecular mechanisms of depression: perspectives on new treatment strategies. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 6. 2014-02-18. PMID:23735822. |
as a metabolic disorder depression has been associated with obesity, diabetes, insulin sensitivity, neuropeptide y, glucose regulation, poor glycemic control, glucagone-like peptide-1, cholezystokinin, ghrelin, leptin, the endocannabinoid system, insulin-like growth factor and gastrin-releasing peptide. |
2014-02-18 |
2023-08-12 |
Not clear |