| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Mann, Y Y Huang, M D Underwood, S A Kassir, S Oppenheim, T M Kelly, A J Dwork, V Arang. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of general psychiatry. vol 57. issue 8. 2000-08-22. PMID:10920459. |
we assayed prefrontal cortical (pfc) 5-htt binding in major depression and suicide and examine the relationship to the 5-httlpr allele. |
2000-08-22 |
2023-08-12 |
Not clear |
| J L Bradshaw, D M Sheppar. The neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralization. Brain and language. vol 73. issue 2. 2000-08-16. PMID:10856179. |
the frontostriatal system (dorsolateral prefrontal cortex, lateral orbitofrontal cortex, anterior cingulate, supplementary motor area, and associated basal-ganglia structures) is subject to a range of neurodevelopmental disorders: tourette's syndrome (ts), obsessive compulsive disorder (ocd), attention deficit hyperactivity disorder (adhd), schizophrenia (scz), autism, and probably depression. |
2000-08-16 |
2023-08-12 |
human |
| F C Murphy, B J Sahakian, J S Rubinsztein, A Michael, R D Rogers, T W Robbins, E S Payke. Emotional bias and inhibitory control processes in mania and depression. Psychological medicine. vol 29. issue 6. 2000-01-31. PMID:10616937. |
the disinhibited behaviour characteristic of mania and evidence that subgenual prefrontal cortex is differentially activated in mania and depression both suggest that dissociable deficits will emerge on tasks that require inhibitory control and are subserved by ventromedial prefrontal cortex. |
2000-01-31 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
these findings suggest a close coupling between mglu2/3 and 5-ht(2a) receptors in the prefrontal cortex that may be relevant for novel therapeutic approaches in the treatment of neuropsychiatric syndromes such as depression and schizophrenia. |
2000-01-27 |
2023-08-12 |
Not clear |
| C C Teneback, Z Nahas, A M Speer, M Molloy, L E Stallings, K M Spicer, S C Risch, M S Georg. Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 4. 1999-12-13. PMID:10570754. |
changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal tms. |
1999-12-13 |
2023-08-12 |
human |
| C C Teneback, Z Nahas, A M Speer, M Molloy, L E Stallings, K M Spicer, S C Risch, M S Georg. Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 4. 1999-12-13. PMID:10570754. |
at medication-free baseline, across all subjects, blood flow in the bilateral medial temporal lobes, left prefrontal cortex, and caudate significantly declined with increased depression severity. |
1999-12-13 |
2023-08-12 |
human |
| D K Kim, B L Kim, S E Sohn, S W Lim, D G Na, C H Paik, K R Krishnan, B J Carrol. Candidate neuroanatomic substrates of psychosis in old-aged depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 5. 1999-12-02. PMID:10509375. |
pfc may be one of the candidate neuroanatomic substrates underlying delusional thought disorder in old-aged depression. |
1999-12-02 |
2023-08-12 |
human |
| G Juckel, A Mendlin, B L Jacob. Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 3. 1999-10-19. PMID:10457536. |
decreased activity of the prefrontal cortex (pfc), as well as reduced serotonergic neurotransmission, is considered as a characteristic feature of major depression. |
1999-10-19 |
2023-08-12 |
rat |
| V Klimek, G Rajkowska, S N Luker, G Dilley, H Y Meltzer, J C Overholser, C A Stockmeier, G A Ordwa. Brain noradrenergic receptors in major depression and schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 1. 1999-09-01. PMID:10379521. |
the binding of [125i]p-iodoclonidine to alpha-2, and/or [125i]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (brodmann's area 10) and right hippocampus from subjects with dsm-iii-r diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). |
1999-09-01 |
2023-08-12 |
human |
| W J Triggs, K J McCoy, R Greer, F Rossi, D Bowers, S Kortenkamp, S E Nadeau, K M Heilman, W K Goodma. Effects of left frontal transcranial magnetic stimulation on depressed mood, cognition, and corticomotor threshold. Biological psychiatry. vol 45. issue 11. 1999-08-26. PMID:10356626. |
the pathophysiology of depression may include synaptic hypoactivity of left prefrontal cortex. |
1999-08-26 |
2023-08-12 |
Not clear |
| J L Pric. Prefrontal cortical networks related to visceral function and mood. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415660. |
lesions of the ventromedial prefrontal cortex result in sociopathic behavior and difficulty in making appropriate choices, whereas functional imaging studies indicate that subjects with unipolar and bipolar depression have abnormal activity in medial and orbital prefrontal areas. |
1999-08-10 |
2023-08-12 |
human |
| W C Drevet. Prefrontal cortical-amygdalar metabolism in major depression. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415674. |
functional neuroimaging studies of the anatomical correlates of familial major depressive disorder (mdd) and bipolar disorder (bd) have identified abnormalities of resting blood flow (bf) and glucose metabolism in depression in the amygdala and the orbital and medial prefrontal cortical (pfc) areas that are extensively connected with the amygdala. |
1999-08-10 |
2023-08-12 |
Not clear |
| J H Meyer, S Kapur, S Houle, J DaSilva, B Owczarek, G M Brown, A A Wilson, S H Kenned. Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study. The American journal of psychiatry. vol 156. issue 7. 1999-07-30. PMID:10401447. |
prefrontal cortex 5-ht2 receptors in depression: an [18f]setoperone pet imaging study. |
1999-07-30 |
2023-08-12 |
Not clear |
| R J Davidson, H Abercrombie, J B Nitschke, K Putna. Regional brain function, emotion and disorders of emotion. Current opinion in neurobiology. vol 9. issue 2. 1999-06-15. PMID:10322186. |
particular emphasis has been placed on the prefrontal cortex, anterior cingulate, parietal cortex, and the amygdala as critical components of the circuitry that may be dysfunctional in both depression and anxiety. |
1999-06-15 |
2023-08-12 |
Not clear |
| M J Webster, M P Vawter, W J Free. Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depression. Molecular psychiatry. vol 4. issue 1. 1999-05-07. PMID:10089008. |
immunohistochemical localization of the cell adhesion molecules thy-1 and l1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depression. |
1999-05-07 |
2023-08-12 |
human |
| M J Webster, M P Vawter, W J Free. Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depression. Molecular psychiatry. vol 4. issue 1. 1999-05-07. PMID:10089008. |
quantifying the intensity of immunostaining in the prefrontal cortex of patients with schizophrenia, bipolar disorder and depression failed to reveal any significant differences when compared to that of normal controls. |
1999-05-07 |
2023-08-12 |
human |
| H Kishimoto, K Yamada, E Iseki, K Kosaka, T Okosh. Brain imaging of affective disorders and schizophrenia. Psychiatry and clinical neurosciences. vol 52 Suppl. 1999-04-07. PMID:9895149. |
one study used fluorine-18-labeled deoxyglucose positron emission tomography (pet) in patients with unipolar depression and bipolar depression, and found hypometabolism in the left anterolateral prefrontal cortex. |
1999-04-07 |
2023-08-12 |
human |
| P Hrdina, G Faludi, Q Li, C Bendotti, K Tekes, P Sotonyi, M Palkovit. Growth-associated protein (GAP-43), its mRNA, and protein kinase C (PKC) isoenzymes in brain regions of depressed suicides. Molecular psychiatry. vol 3. issue 5. 1998-12-14. PMID:9774774. |
given the role of gap-43 in the establishment and reorganization of synaptic connections, the finding of selective reduction of this protein in prefrontal cortex suggests that a dysfunctional synaptic organization in this region may be associated with depression and suicidal behaviour. |
1998-12-14 |
2023-08-12 |
Not clear |
| W C Drevets, D Ongür, J L Pric. Reduced glucose metabolism in the subgenual prefrontal cortex in unipolar depression. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672886. |
reduced glucose metabolism in the subgenual prefrontal cortex in unipolar depression. |
1998-10-08 |
2023-08-12 |
Not clear |
| C A Stockmeie. Neurobiology of serotonin in depression and suicide. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616801. |
in suicide victims with major depression and psychiatrically normal control subjects, we have examined various indices of serotonergic neurotransmission in axonal projection areas such as prefrontal cortex and hippocampus, and cell bodies of origin within the dorsal raphe nucleus (dr). |
1998-06-24 |
2023-08-12 |
human |