| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Schmaus. Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 4. 2003-11-10. PMID:12934707. |
studies on mice revealed that 5-ht2c pre-mrna editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-ht2c mrna isoforms. |
2003-11-10 |
2023-08-12 |
mouse |
| Poul Videbech, Barbara Ravnkilde, Salomeh Kristensen, Annette Egander, Karin Clemmensen, Niels Anton Rasmussen, Albert Gjedde, Raben Rosenber. The Danish PET/depression project: poor verbal fluency performance despite normal prefrontal activation in patients with major depression. Psychiatry research. vol 123. issue 1. 2003-10-03. PMID:12738343. |
therefore, the result supports the notion that abnormalities in the prefrontal cortex in depression are qualitative in nature rather than quantitative; this suggests depression involves dys-coordination of neural activity in the frontal lobes rather than a simple reduction in activity. |
2003-10-03 |
2023-08-12 |
Not clear |
| Kazuya Iwamoto, Tadafumi Kat. RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neuroscience letters. vol 346. issue 3. 2003-09-30. PMID:12853111. |
here we examined rna editing efficiencies of site a and d of htr2c in the prefrontal cortex samples of patients with bipolar disorder, schizophrenia, and major depression as well as control subjects by using primer extension combined with denaturing high performance liquid chromatography. |
2003-09-30 |
2023-08-12 |
mouse |
| K Mizoguchi, A Ishige, M Aburada, T Tabir. Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809708. |
since dysfunction of the pfc or hippocampus is implicated in the pathogenesis of depression, the present findings would help to understand the mechanisms underlying the disrupted feedback system and its relation to brain dysfunction in depression. |
2003-09-12 |
2023-08-12 |
human |
| XingBao Li, Ziad Nahas, Mikhael Lomarev, Stewart Denslow, Ananda Shastri, Daryl E Bohning, Mark S Georg. Prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 16. issue 2. 2003-09-02. PMID:12799599. |
prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression. |
2003-09-02 |
2023-08-12 |
Not clear |
| XingBao Li, Ziad Nahas, Mikhael Lomarev, Stewart Denslow, Ananda Shastri, Daryl E Bohning, Mark S Georg. Prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 16. issue 2. 2003-09-02. PMID:12799599. |
to determine whether transcranial magnetic stimulation over the left dorsolateral prefrontal cortex produces pathologic changes or leakage of the blood-brain barrier in patients with depression by using apparent diffusion coefficient magnetic resonance imaging. |
2003-09-02 |
2023-08-12 |
Not clear |
| I D Grachev, T S Ramachandran, P S Thomas, N M Szeverenyi, B E Fredrickso. Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 3. 2003-08-07. PMID:12658377. |
the present study examines the interrelationships between regional brain n-acetyl aspartate (naa) levels (as identified by in vivo proton magnetic resonance spectroscopy in the right and left dorsolateral prefrontal cortex [dlpfc], orbitofrontal cortex, cingulate and thalamus), depression (as measured by the beck depression inventory), and pain (as measured by short form of the mcgill pain questionnaire) in 10 chronic back pain (cbp) patients with depression, and compared to the relationship between regional brain naa levels and depression in 10 normal subjects (sex and age-matched). |
2003-08-07 |
2023-08-12 |
human |
| Muriel Grange-Midroit, Jesús A García-Sevilla, Marcel Ferrer-Alcón, Romano La Harpe, Philippe Huguelet, José Guimó. Regulation of GRK 2 and 6, beta-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654503. |
regulation of grk 2 and 6, beta-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression. |
2003-07-16 |
2023-08-12 |
human |
| Wayne C Drevet. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724175. |
taken together with converging evidence from neuroendocrine, lesion analysis, and postmortem studies of clinically depressed subjects, these data suggest that emotional/stress-response systems that include the amygdala are pathologically activated in major depression and that this activity is associated with dysfunction of the prefrontal cortex and monoamine neurotransmitter systems that normally modulate such responses. |
2003-06-17 |
2023-08-12 |
human |
| Deanna M Barch, Yvette I Sheline, John G Csernansky, Abraham Z Snyde. Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. Biological psychiatry. vol 53. issue 5. 2003-05-29. PMID:12614990. |
working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. |
2003-05-29 |
2023-08-12 |
Not clear |
| Jean-Gaël Barbara, Nathalie Auclair, Marie-Paule Roisin, Satoru Otani, Emmanuel Valjent, Jocelyne Caboche, Philippe Soubrie, Francis Crepe. Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex. The European journal of neuroscience. vol 17. issue 5. 2003-05-15. PMID:12653974. |
at proximal synapses from layer v pyramidal neurons from the rat prefrontal cortex, activation of group ii metabotropic glutamate receptors (group ii mglu) by (2s,2'r,3'r)-2-(2',3'-dicarboxycyclopropyl) glycine (dcg iv) induced a long-lasting depression of excitatory postsynaptic currents. |
2003-05-15 |
2023-08-12 |
rat |
| Alan J Thomas, Robert Perry, Rajesh N Kalaria, Arthur Oakley, William McMeekin, John T O'Brie. Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression. International journal of geriatric psychiatry. vol 18. issue 1. 2003-03-05. PMID:12497551. |
neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression. |
2003-03-05 |
2023-08-12 |
Not clear |
| Guoqiang Xing, Mikulas Chavko, Li-Xin Zhang, Shutong Yang, Robert M Pos. Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. Schizophrenia research. vol 58. issue 1. 2002-12-24. PMID:12363386. |
decreased calcium-dependent constitutive nitric oxide synthase (cnos) activity in prefrontal cortex in schizophrenia and depression. |
2002-12-24 |
2023-08-12 |
Not clear |
| M C Austin, R E Whitehead, C L Edgar, J E Janosky, D A Lewi. Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide. Neuroscience. vol 114. issue 3. 2002-12-20. PMID:12220580. |
the present study used immunocytochemical methods and an antibody against the serotonin transporter to examine the relative density of serotonin axons in the dorsolateral prefrontal cortex of suicide victims with a diagnosis of major depression. |
2002-12-20 |
2023-08-12 |
human |
| K Sawada, C E Young, A M Barr, K Longworth, S Takahashi, V Arango, J J Mann, A J Dwork, P Falkai, A G Phillips, W G Hone. Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness. Molecular psychiatry. vol 7. issue 5. 2002-12-13. PMID:12082566. |
we investigated the presynaptic proteins complexin (cx) i and cx ii in postmortem prefrontal cortex in schizophrenia (n = 13; six suicide, seven nonsuicide), major depression (n= 11, all suicide) and controls (n = 11) with an enzyme-linked immunoadsorbent assay (elisa). |
2002-12-13 |
2023-08-12 |
rat |
| David W Volk, Joseph N Pierri, Jean-Marc Fritschy, Sungyoung Auh, Allan R Sampson, David A Lewi. Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 10. 2002-11-15. PMID:12217970. |
because the alpha(2) subunit of the gaba(a) receptor is preferentially localized at pyramidal neuron ais, we quantified alpha(2) subunit immunoreactive ais in tissue sections containing prefrontal cortex area 46 from 14 matched triads of subjects with schizophrenia, subjects with major depression and control subjects. |
2002-11-15 |
2023-08-12 |
human |
| Jan Jaracz, Janusz Rybakowsk. [Studies of cerebral blood flow in metabolism in depression using positron emission tomography (PET)]. Psychiatria polska. vol 36. issue 4. 2002-11-08. PMID:12298190. |
during depression metabolism of dorsolateral prefrontal cortex (dlpf) was decreased but metabolism of subgenual cingulate was increased. |
2002-11-08 |
2023-08-12 |
human |
| Alan J Thomas, I Nicol Ferrier, Rajesh N Kalaria, Sue Davis, John T O'Brie. Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. The British journal of psychiatry : the journal of mental science. vol 181. 2002-10-04. PMID:12151283. |
cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. |
2002-10-04 |
2023-08-12 |
Not clear |
| Alan J Thomas, I Nicol Ferrier, Rajesh N Kalaria, Sue Davis, John T O'Brie. Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. The British journal of psychiatry : the journal of mental science. vol 181. 2002-10-04. PMID:12151283. |
neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (dlpfc) and anterior cingulate cortex (acc) in major depression. |
2002-10-04 |
2023-08-12 |
Not clear |
| Victoria Arango, Mark D Underwood, J John Man. Serotonin brain circuits involved in major depression and suicide. Progress in brain research. vol 136. 2002-09-19. PMID:12143401. |
we examined whether prefrontal cortical (pfc) serotonin transporter sites (sert) differ in major depression and suicide by quantitative receptor autoradiography. |
2002-09-19 |
2023-08-12 |
Not clear |