| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Becker, Karin Abaev, Albert Pinhasov, Asher Orno. S-Adenosyl-Methionine alleviates sociability aversion and reduces changes in gene expression in a mouse model of social hierarchy. Behavioural brain research. 2022-04-03. PMID:35367299. |
we treated pregnant submissive (sub) mice exhibiting depressive-like phenotype with same during days 12-14 of gestation aiming to alleviate the depressive - like symptoms in their offspring and normalize the expression in their prefrontal cortex of several genes possibly involved in depression. |
2022-04-03 |
2023-08-13 |
mouse |
| Chun-Hung Chang, Wen-Lung Wang, Yu-Hui Shieh, Han-Yuan Peng, Chen-Syuan Ho, Hsin-Chi Tsa. Case Report: Low-Frequency Repetitive Transcranial Magnetic Stimulation to Dorsolateral Prefrontal Cortex and Auditory Cortex in a Patient With Tinnitus and Depression. Frontiers in psychiatry. vol 13. 2022-03-31. PMID:35356711. |
case report: low-frequency repetitive transcranial magnetic stimulation to dorsolateral prefrontal cortex and auditory cortex in a patient with tinnitus and depression. |
2022-03-31 |
2023-08-13 |
Not clear |
| Chun-Hung Chang, Wen-Lung Wang, Yu-Hui Shieh, Han-Yuan Peng, Chen-Syuan Ho, Hsin-Chi Tsa. Case Report: Low-Frequency Repetitive Transcranial Magnetic Stimulation to Dorsolateral Prefrontal Cortex and Auditory Cortex in a Patient With Tinnitus and Depression. Frontiers in psychiatry. vol 13. 2022-03-31. PMID:35356711. |
here, we report a case of a 62-year-old man with treatment-refractory tinnitus and depression whose symptoms markedly improved after undergoing low-frequency rtms over the right-side dorsolateral prefrontal cortex and left auditory cortex area. |
2022-03-31 |
2023-08-13 |
Not clear |
| Xiaoyan Xue, Jin Pan, Hongxiu Zhang, Yanting Lu, Qiancheng Mao, Ke M. Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via miRNA-144-3p mediated GABA synthesis and release. Journal of ethnopharmacology. 2022-03-26. PMID:35337919. |
baihe dihuang (lilium henryi baker and rehmannia glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via mirna-144-3p mediated gaba synthesis and release. |
2022-03-26 |
2023-08-13 |
Not clear |
| Ying Shen, Cuiping Zhang, Kaimin Xiao, Dixiu Liu, Guangping Xi. CELF4 regulates spine formation and depression-like behaviors of mice. Biochemical and biophysical research communications. vol 605. 2022-03-20. PMID:35306363. |
the prefrontal cortex is one of the core brain areas involved in pathological development and behavior changes in depression. |
2022-03-20 |
2023-08-13 |
mouse |
| Ying Shen, Cuiping Zhang, Kaimin Xiao, Dixiu Liu, Guangping Xi. CELF4 regulates spine formation and depression-like behaviors of mice. Biochemical and biophysical research communications. vol 605. 2022-03-20. PMID:35306363. |
here, we reported that the protein and mrna expression levels of celf4 in the pfc were decreased in the csds depression model, as well as the spine number. |
2022-03-20 |
2023-08-13 |
mouse |
| Joseph M Trombello, Crystal M Cooper, Cherise Chin Fatt, Bruce D Grannemann, Thomas J Carmody, Manish K Jha, Taryn L Mayes, Tracy L Greer, Uma Yezhuvath, Sina Aslan, Diego A Pizzagalli, Myrna M Weissman, Christian A Webb, Daniel G Dillon, Patrick J McGrath, Maurizio Fava, Ramin V Parsey, Melvin G McInnis, Amit Etkin, Madhukar H Trived. Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial. Journal of psychiatric research. vol 149. 2022-03-15. PMID:35290819. |
the brain circuitry of depression and anxiety/fear is well-established, involving regions such as the limbic system and prefrontal cortex. |
2022-03-15 |
2023-08-13 |
Not clear |
| Zhu-Qing Zhang, Ming-Hao Yang, Zhi-Peng Guo, Dan Liao, Peter Sörös, Meng Li, Martin Walter, Lihong Wang, Chun-Hong Li. Increased prefrontal cortex connectivity associated with depression vulnerability and relapse. Journal of affective disorders. 2022-02-27. PMID:35219743. |
increased prefrontal cortex connectivity associated with depression vulnerability and relapse. |
2022-02-27 |
2023-08-13 |
Not clear |
| Jing Wu, Tingjia Chai, Hanping Zhang, Yu Huang, Seth W Perry, Yifan Li, Jiajia Duan, Xunmin Tan, Xi Hu, Yiyun Liu, Juncai Pu, Haiyang Wang, Jinlin Song, Xin Jin, Ping Ji, Peng Zheng, Peng Xi. Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model. Translational psychiatry. vol 12. issue 1. 2022-02-23. PMID:35194021. |
together our findings suggest that altered dg levels and structure in the pfc are hallmarks of the dl macaque, thus providing a new framework for understanding the gut microbiome's role in depression. |
2022-02-23 |
2023-08-13 |
monkey |
| Shobha Mehta, Jonathan Downar, Benoit H Mulsant, Daphne Voineskos, Zafiris J Daskalakis, Cory R Weissman, Fidel Vila-Rodriguez, Daniel M Blumberge. The Effect of High Frequency Versus Theta-Burst Repetitive Transcranial Magnetic Stimulation on Suicidality in Patients with Treatment Resistant Depression. Acta psychiatrica Scandinavica. 2022-02-21. PMID:35188677. |
to investigate the effect of 10hz repetitive transcranial magnetic stimulation (rtms) and intermittent theta-burst stimulation (itbs) on suicidality in patients with treatment resistant depression (trd) methods: we used data from a three-site randomized clinical trial comparing 10hz and itbs rtms applied to the left dorsolateral prefrontal cortex (dlpfc) in patients with trd. |
2022-02-21 |
2023-08-13 |
Not clear |
| Tobias Bracht, Nicolas Mertse, Sebastian Walther, Karin Lüdi, Sigrid Breit, Andrea Federspiel, Roland Wiest, Niklaus Denie. Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression. NeuroImage. Clinical. vol 34. 2022-02-13. PMID:35152053. |
there was an increase in fc between the vta and right medial pfc in patients with depression. |
2022-02-13 |
2023-08-13 |
human |
| Jing Gao, Ming-Yin Lai, Thi Tanh-Tam Mai, Wen Fu, Meng-Yu Wang, Bai-le Ning, Wen-Bin F. [Effects of electroacupuncture on BNDF/mTORC1 signaling pathway and synaptic plasticity in prefrontal cortex of rats exposed to chronic unpredictable mild stress]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 1. 2022-02-07. PMID:35128865. |
to investigate the effects of electroacupuncture (ea) on the expression of related proteins in the brain-derived neurotrophic factor (bdnf)/mammalian target of rapamycin complex 1 (mtorc1) signaling pathway and synapse-associated proteins and the density of dendrite spines in the prefrontal cortex (pfc) of depression model rats, and to reveal the underlying mechanism by which ea regulates the synaptic plasticity to improve depressive symptoms. |
2022-02-07 |
2023-08-13 |
rat |
| Chukwuemeka V Onyilo, William V McCall, Peter Rosenquis. Transcranial Magnetic Stimulation Therapy of Major Depressive Disorder Improves Heart Rate Variability. The journal of ECT. 2022-01-30. PMID:35093970. |
we describe a patient whose depression score remained unchanged after 10 single daily intermittent thetaburst transcranial magnetic stimulation sessions targeting f3 in the dorsolateral prefrontal cortex and our efforts to modify the technique and monitor progress with heart rate variability (hrv) measures. |
2022-01-30 |
2023-08-13 |
Not clear |
| Arsalan Mir-Moghtadaei, Shan H Siddiqi, Kamran Mir-Moghtadaei, Daniel M Blumberger, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Michael D Fox, Jonathan Downa. Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression. Brain stimulation. 2022-01-27. PMID:35085817. |
updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression. |
2022-01-27 |
2023-08-13 |
Not clear |
| Arsalan Mir-Moghtadaei, Shan H Siddiqi, Kamran Mir-Moghtadaei, Daniel M Blumberger, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Michael D Fox, Jonathan Downa. Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression. Brain stimulation. 2022-01-27. PMID:35085817. |
recent work investigating whole-brain maps of circuits associated with depression and its successful treatment has identified foci of interest within the dorsolateral prefrontal cortex (dlpfc). |
2022-01-27 |
2023-08-13 |
Not clear |
| Takuji Izuno, Takashi Saeki, Nobuhide Hirai, Takuya Yoshiike, Masataka Sunagawa, Motoaki Nakamur. Local and Transient Changes of Sleep Spindle Density During Series of Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With a Major Depressive Episode. Frontiers in human neuroscience. vol 15. 2022-01-24. PMID:35069146. |
fourteen male inpatients diagnosed with medication-resistant unipolar or bipolar depression were recruited and subjected to 10 daily rtms sessions targeting the left dorsolateral prefrontal cortex (dlpfc). |
2022-01-24 |
2023-08-13 |
Not clear |
| Li Ma, Jiancheng Zhang, Yuko Fujita, Youge Qu, Jiajing Shan, Xiayun Wan, Xingming Wang, Tamaki Ishima, Kenta Kobayashi, Long Wang, Kenji Hashimot. Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine. Translational psychiatry. vol 12. issue 1. 2022-01-22. PMID:35064103. |
in conclusion, our data implicate a novel nfatc4 signaling pathway in the pfc underlying the prophylactic effects of (r)-ketamine for inflammation-related depression. |
2022-01-22 |
2023-08-13 |
mouse |
| Marjolein E A Barendse, Nicholas B Allen, Lisa Sheeber, Jennifer H Pfeife. The Impact of Depression on Mothers' Neural Processing of Their Adolescents' Affective Behavior. Social cognitive and affective neuroscience. 2022-01-09. PMID:34999900. |
relative to non-depressed mothers, those with depression showed more aggressive and less positive affective behavior during the interaction task; and more activation in bilateral insula, superior temporal gyrus and striatum but less in lateral prefrontal cortex while viewing aggressive and neutral affect. |
2022-01-09 |
2023-08-13 |
Not clear |
| Katherine S Young, Camilla Ward, Meghan Vinograd, Kelly Chen, Susan Y Bookheimer, Robin Nusslock, Richard E Zinbarg, Michelle G Crask. Individual differences in threat and reward neural circuitry activation: testing dimensional models of early adversity, anxiety and depression. The European journal of neuroscience. 2022-01-06. PMID:34989038. |
we examined functional brain activity during a face processing task in threat (amygdala, ventromedial prefrontal cortex) and reward (ventral striatum, orbitofrontal cortex) regions of interest among a sample (n = 103) of young adults (aged 18-19 years) in relation to dimensional measures of early life adversity and symptoms of anxiety and depression. |
2022-01-06 |
2023-08-13 |
Not clear |
| Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Y. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-03. PMID:34978026. |
in conclusion, this study demonstrates that microglial nlrp3 inhibition prevents stress-induced neuroinflammation in the prefrontal cortex and suggests that microglial nlrp3 could be one of the potential therapeutic targets for depression treatment. |
2022-01-03 |
2023-08-13 |
mouse |